• Journal of Biomedical Engineering Research
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• v.38 no.3
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• pp.123-128
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• 2017

Background and aims: The KCNQ1 S140G mutation involved in $I_{ks}$ channel is a typical gene mutation affecting atrial fibrillation. However, despite the possibility that the S140G gene mutation may affect not only atrial but also ventricular action potential shape and ventricular responses, there is a lack of research on the relationship between this mutation and ventricular fibrillation. Therefore, in this study, we analyzed the correlation and the influence of the KCNQ1 S140G mutant gene on ventricular fibrillation through computer simulation studies. Method: This study simulated a 3-dimensional ventricular model of the wild type(WT) and the S140G mutant conditions. It was performed by dividing into normal sinus rhythm simulation and reentrant wave propagation simulation. For the sinus rhythm, a ventricular model with Purkinje fiber was used. For the reentrant propagation simulation, a ventricular model was used to confirm the occurrence of spiral wave using S1-S2 protocol. Results: The result showed that 41% shortening of action potential duration(APD) was observed due to augmented $I_{ks}$ current in S140G mutation group. The shortened APD contributed to reduce wavelength 39% in sinus rhythm simulation. The shortened wavelength in cardiac tissue allowed re-entrant circuits to form and increased the probability of sustaining ventricular fibrillation, while ventricular electrical propagation with normal wavelength(20.8 cm in wild type) are unlikely to initiate re-entry. Conclusion: In conclusion, KCNQ1 S140G mutation can reduce the threshold of the re-entrant wave substrate in ventricular cells, increasing the spatial vulnerability of tissue and the sensitivity of the fibrillation. That is, S140G mutation can induce ventricular fibrillation easily. It means that S140G mutant can increase the risk of arrhythmias such as cardiac arrest due to heart failure.

• Journal of computational fluids engineering
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• v.4 no.1
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• pp.27-33
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• 1999

Spiral tube heat exchangers can find numerous applications in many engineering fields. Flow in spiral tubes is interest to engineers due to occurrence of secondary flow which enhances the cross-sectional mixing and the heat transfer rate. In the present study, an incompressible viscous 3-D flow in spiral tubes with rectangular cross-section of various torsion rate and Reynolds number is studied by using a finite volume method. It is shown that the axial velocity profile is affected by the secondary flow motion. Because there is some difference from correlation proposed by Hur et al., a lot of analysis and arrangement of experimental results are needed. This study showed the results of variation of hydrodynamic entry length for torsion and Re numbers.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.05a
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• pp.168-171
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• 2003

Generally RF AGC (Roll Force Automatic Gauge Control) controls the roll gap using the variation of rolling force caused by the roll eccentricity and the entry thickness of material, but RE AGC takes the bad effect of the roll eccentricity. The Feed-forward (FF) AGC method, which controls the next stand roll gap by the estimation of the thickness variation due to skid mark is needed to supplement the shortage of RF AGC. In this paper, an adaptive filtering method which takes account of the kind of material, the final objective thickness and the rolling speed is proposed to predict skid mark thickness variation. In addition, an improved estimation method of control point using a speedometer and looper angle is suggested. Via on line test, the performance improvement of the suggested FF AGC method is verified.

• Journal of electromagnetic engineering and science
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• v.18 no.4
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• pp.231-241
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• 2018

In this paper, we consider the anti-attack procedure of a ballistic missile defense system (BMDS) at different operating frequencies at its phased-array radar station. The interception performance is measured in terms of lateral divert (LD), which denotes the minimum acceleration amount available in an interceptor to compensate for prediction error for a successful intercept. Dependence of the frequency on estimation accuracy that leads directly to prediction error is taken into account, in terms of angular measurement noises. The estimation extraction is performed by means of an extended Kalman filter (EKF), considering two typical re-entry trajectories of a non-maneuvering ballistic missile (BM). The simulation results show better performance at higher frequency for both tracking and intercepting aspects.

• International Journal of Aeronautical and Space Sciences
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• v.15 no.1
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• pp.63-73
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• 2014

For robust stability analysis of parameters uncertainty missiles, the traditional frequency domain method can only analyze each respective channel at several interval points within uncertain parameter space. Discontinuous calculation and couplings between channels will lead to inaccurate analysis results. A method based on the ${\nu}$-gap metric is proposed, which is able to comprehensively evaluate the robust stability of missiles with uncertain parameters; and then a genetic-simulated annealing hybrid optimization algorithm, which has global and local searching ability, is used to search for a parameters combination that leads to the worst stability within the space of uncertain parameters. Finally, the proposed method is used to analyze the robust stability of a re-entry missile with uncertain parameters; the results verify the feasibility and accuracy of the method.

• Journal of information and communication convergence engineering
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• v.18 no.2
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• pp.82-87
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• 2020

This paper discusses how to design a game server that is scalable, adaptable, and re-buildable with components. Furthermore, it explains how various implementation issues were resolved. To support adaptability, the server comprises three layers: network, user, and database. To ensure independence between the layers, each layer was designed to communicate with each other only via message queues. In this architecture, each layer can have an arbitrary number of threads; thus, scalability is guaranteed for each layer. The network layer uses input/output completion ports(IOCP), which shows the best performance on the Windows platform, it can handle up to 5,000 simultaneous connections on a typical entry-level computer, despite being built with a single-threaded user layer. To completely separate the database from the game server, the SQL code was not directly embedded in the database layer.

• 한국전산유체공학회:학술대회논문집
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• 1998.11a
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• pp.62-69
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• 1998

Spiral tube heat exchangers can find numerous applications in many engineering field. Flow in spital tubes is interest to engineers due to occurrence of secondary flow which enhances the cross-sectional mixing and the heat transfer rate. In the present study, an incompressible viscous 3-D flow in spiral tubes with rectangular cross-section of various torsion rate and Reynolds number is studied by using a finite volume method. It is shown that the axial velocity profile is affected by the secondary flow motion. Because there is some difference from correlation proposed by Hur et al., a lot of analysis and arrangement of experimental results are needed. This study showed the results of variation of hydrodynamic entry length for torsion and Re numbers.

• Journal of Chest Surgery
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• v.27 no.3
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• pp.230-233
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• 1994

A 21-year-old man with atrioventricular[AV] reentry tachycardia secondary to concealed accessory AV connection underwent surgical division of two accessory pathways following failure of radiofrequency catheter ablation. pathways were located in the left free wall area.Before cardiopulmonary bypass, the epicardial mapping confirmed the existence and localization of two accessory pathways. The patient was approached through a left atriotomy with a dissection of the left free wall area beginning with an internal mapping was carried out after separation from cardiopulmonary bypass to confirm the absence of retrograde conduction of accessory pathway. Five weeks after surgery, the electrophysiololgic study demonstrated no retrograde conduction through two accessory pathways.

• Biomaterials and Biomechanics in Bioengineering
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• v.5 no.1
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• pp.51-64
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• 2020

In this study, the mathematical model that describes blood cell development in the bone marrow (i.e., hematopoiesis) has been studied via the Homotopy Perturbation Method (HPM). The results from the present work compared very well with the numerical solutions from published literature. This work has shown that the HPM is viable for solving delay differential equations born from hematopoiesis problem. The influence of the proliferating cells loss rate, time delay rate and the phase re-entry rate on the population densities of both the proliferating and resting cells were also determined through the underlined procedure.

• Fire Science and Engineering
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• v.5 no.2
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• pp.21-35
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• 1991

As a part of studies of drag reduction phenomenon, at the entrance flow region of abrupt contraction tube flowing water, dilute and concentrated drag reducing polymer solutions contraction losses are estimated experimentally. Futher more, entrance lengths are considered theoretically and are measured experimentally. In the present experiment, fluid temperature is fixed l$0^{\circ}C$ and flow rates are 3,000