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Effect of Exercise on Neurotrophins, BDNF, NT-3, GAP43 Protein Expression and Axonal Regeneration after Sciatic Nerve Injury in F344 Rats (운동이 좌골신경 손상 F344쥐의 Neurotrophins, BDNF, NT-3, GAP-43 단백질 발현과 축삭재생에 미치는 영향)

  • Yoon Jin-Hwan;Seo Tae-Beom
    • Journal of Life Science
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    • v.16 no.3 s.76
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    • pp.464-471
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    • 2006
  • Peripheral nerve injuries are a commonly encountered clinical problem and often result in severe functional deficits. In the present study, the effects of treadmill exercise on neurotrophin expressions and functional recovery following sciatic crushed nerve injury were investigated. Animals were randomly assigned into four groups: the sciatic nerve injury group, the sciatic nerve injury and 3-day-exercise, the sciatic nerve injury and 7-days-exercise, and the sciatic nerve injury and 14-days-exercise groups. Sciatic nerve injury was caused by crushing the right sciatic nerve for 30 s using a surgical clip. A the light-exercise was applied to each of the exercise group over the respective number of days. In the present results, we identified enhanced axonal re-growth in the distal stump of the sciatic nerve 3-14 days after crush injury with treadmill training. Dorsal root ganglion (DRG) neuron when cultured from animals with nerve injury and treadmill training showed more enhanced neurite outgrowth than that of sedentary animals. Nerve growth factor (NGF) protein levels in low-intensity treadmill training group were highly induced in the injured sciatic nerves 3, 7 and 14 days after injury compared with sedentary group, and brain-derived neurotrophin factor (BDNF) protein levels in treadmill exercise group were highly induced in the injured sciatic nerve 3 days after injury compared with sedentary group. Then, treadmill exercise increased neurotrophic factors induced in the regenerating nerves. We further demonstrate that motor functional recovery after sciatic nerve injury was promoted by treadmill exercise. Thus, the present data provide a new evidence that treadmill exercise enhanced neurotrophins expression and axonal regeneration after sciatic nerve injury in rats.

The Evaluation on Applicability of Leakage-prevented Sealing Packer Out of Grouted Rockbolt Hole (록볼트 그라우팅 시 역류방지용 밀봉 패커의 적용성 평가)

  • Yang, Taeseon;Kim, Jichang;Jeong, Jongki;Yoo, Dongho;Choi, HakYun;Baek, Seungcheol
    • Journal of the Korean GEO-environmental Society
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    • v.17 no.11
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    • pp.15-21
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    • 2016
  • Nowadays, some studies have been performed for rockbolt method widely used in Korea. To make large slopes, tunnels or rock structures stable, supporting systems, such as anchor bolt, rock bolt which are developed recently, are commonly used. In this study, laboratory pullout tests were carried out to compare the characteristics of rock bolt that is most widely used with ones of rock bolt by newly developed circular model testers. Re-pullout test for the rock bolt in which loading and unloading cycles are repeated several times showed that the maximum pullout load is almost constant irrespective of the number of loading cycles, which may be due to no failure between rock bolt and filler that is filled with soils and concrete as a substitute. A development of rock bolt fillers as supporters using to protect people in tunnels and slopes is reviewed as a probable man-made hazard after excavation works. The functions of the grouted rock bolts associated with reinforcement effects also should be assessed in this study, which develop the sealing apparatus preventing from overflowing mortar out of a rock bolt hole for securing safety in the tunnel and slopes in order to secure stability named the sealing packer.

The Use of Hyalomatrix$^{(R)}$ in the Treatment of Difficult To Heal Wound (치료하기 어려운 창상에서 하이알로매트릭스$^{(R)}$의 사용)

  • Koo, Hyun-Kook;Kim, Young-Seok;Hong, Jong-Won;Roh, Tai-Suk;Rah, Dong-Kwun
    • Archives of Plastic Surgery
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    • v.37 no.5
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    • pp.600-606
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    • 2010
  • Purpose: Although traditional and current treatment strategies may demonstrate success, persistence or recurrence of difficult-to-heal wounds remain significant problems. A novel product, Hyalomatrix$^{(R)}$ (Fidia Advanced Biopolymer, Abano Terme, Italy) is a bilayer of an benzyl esterified hyaluronan scaffold beneath a silicone membrane. The scaffold delivers hyaluronan to the wound, and the silicone membrane acts as a temporary epidermal barrier. We present the results obtained with Hyalomatrix$^{(R)}$ in the treatment of difficult-to-heal wounds. Methods: From November, 2008 to March, 2010, Hyalomatrix$^{(R)}$ has been used on total 10 patients with wounds that were expected difficult to heal with traditional and other current strategies. After average 37.4 days from development of wounds, Hyalomatrix$^{(R)}$ was applied after wound debridement. On the average, Hyalomatrix$^{(R)}$ application period was 17.6 days. After average 16.5 days from removal of Hyalomatrix$^{(R)}$, skin grafts was performed. Results: In all cases, regeneration of fibrous granulation tissues and edge re-epithelization were present after the application of the Hyalomatrix$^{(R)}$. And all of the previous inflammatory signs were reduced. After skin grafts, no adverse reactions were recorded in 9 cases. But in one case, postoperative wound infection occured due to a lack of efficient fibrous tissues. In this model, the Hyalomatrix$^{(R)}$ acts as a hyaluronan delivery system and a barrier from the external environments. In tissue repair processes, the hyaluronan performs to facilitate the entry of a large number of cells into the wounds, to orientate the deposition of extracellular matrix fibrous components and to change the microenvironment of difficult-to-heal wounds. Conclusion: Our study suggests that Hyalomatrix$^{(R)}$ could be a good and feasible approach for difficult-to-heal wounds. The Hyalomatrix$^{(R)}$ improves microenvironments of difficult-to-heal wounds, reduces infection rates and physical stimulus despite of aggravating factors.

Survey on Radiographic Works in Hospitals and Clinics (병(病)-의원(醫院)의 X선촬영업무(線撮影業務)에 관한 실태조사(實態調査))

  • Choi, Song-Hak;Jeon, Man-Jin;Park, Sung-Ock;Lim, Han-Young;Kim, Keon-Chung;Huh, Joon;Choi, Jong-Woon
    • Journal of radiological science and technology
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    • v.7 no.1
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    • pp.3-11
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    • 1984
  • The major findings of this investigation on radiographic works in 125 medical institutions around Seoul and Kyung-Ki area, from March 1983 to February 1984, are summarized as follows. 1. The number of references provided on radiographic techniques were 3 to 5 in general hospitals (52.1%), in hospitals (58.5%), and clinics (44.5%), and only the 10.4% of general hospitals had 11 or more. 2. The relatively high percentages of 75.0% of general hospitals and 68.3% of hospitals have established the standardized radiographic methods for regions examined, but most clinics (61.1%) have not. 3. As a log system for the radiographic request, the method of "routine study, or all the x-ray examinations are marked as 0 on a printed form" was most commonly used by general hospitals (62.5%) and hospitals (51.2%), and "the doctors employ their own methods" in most clinics (44.6%). 4. In the 85.4% of general hospitals, the 68.3% of hospitals and the 38.9% of clinics, the data such as diagnosis, clinic history, purpose of x-ray examination were recorded on a radiographic request at all times, or at least in part. 5. On a scale of hardness and easiness of order of doctors, the greatest response was "fairly easy to understand", and the 37.5% of general hospitals responded as "sometimes hard". 6. In determining the standards for radiographic factors, the general hospitals (62.5%) and hospitals (65.9%) adapted mostly "a departmental check list", and the clinics (61.1%) used mainly "a personal decision". 7. In using the immobilizing devices, angligner, and radiographic accessories, the Percentages were high in general hospitals and hospitals on the one hand, and were low in clinics on the other. 8. A consideration with regard to the devices for an improvement of examination of the same patients was totally ignored by the 50.0% of clinics, the 26.8% of hospitals and the 20.8% of general hospitals. 9. The causes of re-examination were due largely to patients (33.6%), and followed proportionately by incorrect exposure (22.8%), errors in positioning (22.0%), film processing faults (9.2%), conditions of x-ray equipments (8.8%), and quality of x-ray films (3.6%). 10. The conference on radiography was conducted regularly or irregularly by the 87.5% of general hospitals, the 56.1% of hospitals, and the 27.7% of clinics, and the meeting was proceeded only by radiologic technologists.

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Rhinotomy for Chronic Rhinitis by Nasal Foreign Body in a Dog (비강 내 이물에 의한 만성 비염 치료를 위해 비강절개술 적용 증례)

  • Kim, Ji-Hye;Park, Jin-Uk;Kim, Jong-Min;Park, Seong-Kyu;Son, Jin-Na;Chang, Dong-Woo;Na, Ki-Jeong;Choi, Seok-Hwa;Kim, Gon-Hyung
    • Journal of Veterinary Clinics
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    • v.28 no.4
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    • pp.452-456
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    • 2011
  • 5 year-old female Siberian husky which was 27 kg had presented with a recurrent rhinitis with chronic discharge and cough. A nasal foreign material had been suggested by a finding of a bone density ($0.3{\times}0.3$ cm) in the left nasal cavity on X-ray and CT-scanning. Soft tissue opacity in frontal sinus and nasal cavity was increased and foreign material was located beside turbinate bone in the left nasal. We found that there was the increase in the number of eosinophil and mast cell by the nasal cytology test. These results mentioned above indicated that the rhinitis by nasal foreign body was suspicious. We decided that the transfrontal rhinotomy could be the proper procedure to approach the material in this case. After rhinotomy, the foreign body and severe sticky discharge were removed. Drain was placed through the hole and into the frontal sinus and nasal cavity which were flushed two times a day for 7 days. The clinical signs such as cough and nasal discharge were shown to be improved in the every visiting for the re-check. On the $40^{th}$ day after surgery, we could confirm that the most of soft tissue density in the frontal sinus and nasal cavity was decreased by CT-scanning. However, foreign body was not identified by histological examination. For the treatment of chronic rhinitis caused by foreign body, the surgical method such as rhinotomy can be applied, when it is difficult to remove it in the guide of the nasal endoscope.

Development of School Health Nursing Phenomena in Korea by Retrospective Method of ICNP (ICNP의 후향적 개발방법에 의한 한국의 학교간호현상)

  • Kim, Young-Im;Young, Soon-Ok;Wang, Myoung-Ja;Kim, Chung-Nam;Kim, Hyeon-Suk;Park, Tae-Nam;Chung, Mi-Ja;Hyun, Hye-Jin
    • Research in Community and Public Health Nursing
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    • v.13 no.4
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    • pp.595-607
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    • 2002
  • The objectives of this study were to identify the phenomena of school health nursing at schools in Korea and to contribute to building a school health domain of International Classification for Nursing Practice. A retrospective method was used in this study to develop ICNP during the period from July to October 200l. The procedure of the study involved choosing nursing phenomena using preliminary terms from the reports on the field of school health nursing practice documented by nursing students in 10 different nursing colleges. The detail procedures of the study were as follows. 1) Choosing nursing phenomena by using preliminary terms 2) Choosing the characteristics of school health nursing practice from the selected nursing phenomena 3) In order to make a consensus regarding the appropriate characteristics of phenomena. 15 study group members re-categorized the nursing phenomena through 5 times of cyber meetings and 3 times of formal meetings. 4) To verify each characteristic, 5 community nursing faculties and 25 school health nurses participated in the procedure to give scores on nursing characteristics. 5) Classification of the definite nursing phenomena and characteristics. Following the 5 step procedures, school health nursing phenomena were categorized into human and environmental domains. Human domains were classified into human behavioral and functional domains. Environmental domains were classified into physical and psychosocial domains. The essential characteristics of each phenomena were selected when it obtains the mean score of 3.0 or over at the related characteristics. The human behavioral domain consisted of 7 phenomena including risk for spinal disorder, inadequate dietary habit, inadequate weight control, smoking and substance abuse, inadequate stress management, inadequate sex related coping strategies and inadequate accident management. The human functional domain consisted of 6 phenomena including inadequate eye care and visual management, risk for respiratory disorder, inadequate dental health care, inappropriate infectious disease control, risk for gastrointestinal disorder, and lack of sexual identity. The physical environmental domain consisted of 6 phenomena including risk for incident at inside classroom, risk for incident at outside classroom, risk for incident around school, risk for exposure to hazardous facilities around school. inadequate garbage and disposal management, and inadequate physical environment for learning. The psychosocial domain included impaired social interaction at school. Each phenomenon was composed of 2 to 8 characteristics and all phenomena will include a total number of 85 characteristics. The phenomena of school health nursing in Korea partially confirmed school health architecture of ICNP. Further study on verification of school health nursing phenomena in Korea needs to be done to support the findings of this study through review of literature on nursing classifications or field studies.

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Spatial Information Search Features Shown in Eye Fixations and Saccades (시선의 고정과 도약에 나타난 공간정보 탐색 특성)

  • Kim, Jong-Ha
    • Korean Institute of Interior Design Journal
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    • v.26 no.2
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    • pp.22-32
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    • 2017
  • This research is to analyze the spatial information search features which shown by Eye fixation and movement and conducted eye tracking experiment for targeting sports shop spatial images which it are same but looks different. This is able to find out the eye movement feature according to placement of goods from the eye movement and movement distance of spatial visitor, and the result can be defined as following. First, the whole original-reverse left / right images have a higher number of observations in the [IN] area than in the [OUT] area. This is because after eye taking high observations in LA area of [IN] have been jump-over [OUT], performed search activities in low eye fixation without high eye fixation. Second, there was a difference in the frequency of the observation data as the composition of the images changed. The original image has been often fixed the eyes in LA area, and the one that has been observed for a long time is reverse left / right image. Also, fixation point was shown higher at the reverse left / right image as jump-over from [OUT] area to [IN] area. If LA area seen as reverse left / right image, it is located in right-hand side. The case where the dominant area is on the right side has a characteristic that the eye fixation is longer. This can be understand that the arrangement of products for attract the customer's attention in the commercial space might be more effective when it is on the right side. Third, the moving distance(IN ${\rightarrow}$ OUT) of the sight pointed to external from LA area was long in the both original-reverse left / right images, but it is no relation with search direction([IN${\rightarrow}$OUT] [IN${\rightarrow}$OUT]) of the sight. In other words, the sight that entered in LA area can be seen as visual perception activity for re-searching after big jump-over, in the case go in to outward (OUT area) after searching for more than certain time. The fact that the moving distance of eye is relatively short in the [IN ${\rightarrow}$ OUT] process considered as that the gaze that stays outside the LA area naturally enters in to LA area.

Analysis of Accuracy of Apparent Activity According to Calibration Method for High Dose Rate Brachytherapy Source (측정용 전리함에 따른 고 선량율 근접치료용 방사성 선원의 겉보기 활성도의 정확도 비교 분석)

  • Huh, Hyun-Do;Choi, Jin-Ho;Choi, Sang-Hyoun;Kim, Seong-Hoon;Kim, Woo-Chul;Kim, Hun-Jeong;Lee, Re-Na;Kim, Kum-Bae;Hong, Seong-Eon;Shin, Dong-Oh
    • Progress in Medical Physics
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    • v.19 no.4
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    • pp.305-312
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    • 2008
  • The aim of this study is to introduce the accuracy of Ir-192 source's apparent activity using the well-type chamber and the Farmer-type ionization chamber in the high dose rate brachytherapy. We measured the apparent activity of Ir-192 that each medical center in the country has and the apparent activity of calibration certificate provided by manufacturer is compared with that by our experimental measurement. The number of sources used for the activity comparison was 5. The accuracy of the measured activity was in the range of -2.8% to -1.0% and -2.1% to 0.2% for the Farmer-type chamber system (Jig) and for the well-type, respectively. The maximum difference was within 1.0% for comparison with two calibration's tool. Our results demonstrate that well-type chamber as wall as Farmer-type chamber is a appropriate system as the routine source calibration procedures in HDR brachytherapy. Whenever a new source is installed to use in clinics, by periods, a source calibration should be carried out.

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Consumption Values on the Intention to Re-use on Geriatric Hospitals (노인요양병원 재이용 의사에 영향을 미치는 소비가치 요인)

  • Kwon, Jin
    • The Journal of the Korea Contents Association
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    • v.13 no.12
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    • pp.921-930
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    • 2013
  • Objective: After introduction of the Elderly Long Term Care Insurance, number of geriatric hospitals increased greatly. However, few studies were conducted on the satisfaction of the patients of the geriatric hospitals especially on the intention to reuse geriatric hospitals. Methods: The current study modified Sheth's consumption value model, useful for the development of an effective marketing strategy for geriatric hospitals, and tested it in Korean circumstances. The survey was conducted at two municipal hospitals and three private hospitals in Seoul and Gyeonggi Province between August 1 and September 30 of 2012. Data were collected from 472 inpatients who are 60 years or older. The structured research tool was developed and distributed. Factor analysis and hierarchical logistic regression analysis were conducted using SPSS(version 14.0) Results: The result of the research suggested that the satisfaction on rehabilitation services, which is a functional value, among the consumption values was the strongest factor on the intention to reuse geriatric hospitals. Impression of high-end luxury, reliability of care, and outside locus of control on health followed. Conclusion: It is recommended that geriatric hospitals ought to improve rehabilitation programs, facilities, and equipments and enhance kindness of staff to encourage intention to reuse geriatric hospitals.

Consideration for difference of recognition between company and animation specialities : Mainly focused on attempting for indi-animation (애니메이션 전공자와 산업체간의 인식의 차이에 대한 고찰 : 창작 애니메이션 활성화 방안을 중심으로)

  • Choi, Ji-Won
    • Cartoon and Animation Studies
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    • s.14
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    • pp.115-128
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    • 2008
  • The animation is in a boom as the one of rising media content industry of 21st century. So it is very affective to education. For example, in primary or secondary schools, there are extra-animation class after school, and in universities, there are a lot of the department of animation nowadays. In every years, a number of high-educated professionals are coming to the manpower market. This was an affirmative phenomenon for many animation companies to upgrade from OEM(Original Equipment Manufacturing) system to very creative system. They might believed that young, well-educated animators have qualified skills, and creative mind. But, 10 years later, now, there is few professionals who was well-educated in system of Korean animation. Companies still can not hire enough animators. Even if they can find an high-educated person, this person do not have enough skills to do his or her works, so companies need to re-educate this animator for awhile. But, why is very hard to find a skillful new animator? From this question, we will talk about educational condition of animation departments, and condition of employment to markets. And then, we will find the causes of problems which give bad effect to lack of manpower. Finally, we will summarize about policies for supporting animation, so hope to contribute for making better atmosphere for creating animations.

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