• IMMUNE NETWORK
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• v.4 no.3
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• pp.131-142
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• 2004

In recent years, adjuvants have received much attention because of the development of purified subunit and synthetic vaccines which are poor immunogens and require adjuvants to evoke the immune response. Therefore, immunologic adjuvants have been developed and testing for most of this century. During the last years much progress has been made on development, isolation and chemical synthesis of alternative adjuvants such as derivatives of muramyl dipeptide, monophosphoryl lipid A, liposomes, QS-21, MF-59 and immunostimulating complexes (ISCOMS). Biodegradable polymer microspheres are being evaluated for targeting antigens on mucosal surfaces and for controlled release of vaccines with an aim to reduce the number of doses required for primary immunization. The most common adjuvants for human use today are aluminum hydroxide and aluminum phosphate. Calcium phosphate and oil emulsions have been also used in human vaccination. The biggest issue with the use of adjuvants for human vaccines is the toxicity and adverse side effects of most of the adjuvant formulations. Other problems with the development of adjuvants include restricted adjuvanticity of certain formulations to a few antigens, use of aluminum adjuvants as reference adjuvant preparations under suboptimal conditions, non-availability of reliable animal models, use of non-standard assays and biological differences between animal models and humans leading to the failure of promising formulations to show adjuvanticity in clinical trials. The availability of hundreds of different adjuvants has prompted a need for identifying rational standards for selection of adjuvant formulations based on safety and sound immunological principles for human vaccines. The aim of the present review is to put the recent findings into a broader perspective to facilitate the application of these adjuvants in general and experimental vaccinology.

• Journal of Korean Society of Forest Science
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• v.96 no.1
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• pp.40-47
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• 2007

The objectives of this study were to derive site index and stem volume prediction equation based on stem analysis data for Larix leptolepis in Jinan region. The function for site index was developed by algebraic difference equation method. Polymorphic site index family curves with base age of 40 were presented based on the Schumacher height equation. The best stem volume prediction equation was suggested as $V=0.00260+0.00000399D^2H$. The simultaneous F-test using this equation showed that the estimated tree stem volumes were not significantly different (${\alpha}=0.05$ level) from the observed stem volumes for model evaluation. Therefore, site index and volume prediction equations prepared in this study could provide an indication of site quality and basic information for making of yield table, and could be used for rational forest management of Larix leptolepis stands grown in Jinan region.

• 한국지형공간정보학회:학술대회논문집
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• 2002.03a
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• pp.145-149
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• 2002

CORONA는 미국이 1960년에서 1972년까지 냉전시대 관심지역에 대한 첩보영상을 취득하기 위하여 운영한 영상취득시스템으로 1995년 일반에 자료가 공개됨에 따라 과거의 고해상도 영상자료를 이용할 수 있는 길이 열리게 되었다. 그러나 현재까지 CORONA 영상처리를 위한 모듈을 제공하는 원격탐측 소프트웨어가 개발되어 있지 않기 때문에 CORONA 영상을 이용하여 수치표고모형이나 정사영상을 제작하기 위해서는 적절한 모델링 방법이 필요하다. CORONA 영상은 파노라마 영상으로 필름 가장자리로 갈수록 왜곡이 많이 생기며 사진기 지표가 없고 위성의 궤도와 위치, 자세, 속도, IMC(Image Motion Compensation)에 대한 자세한 자료를 제공하지 않는 문제점이 있다. 따라서 본 논문에서는 지형복원을 위하여 지상기준점을 이용하는 2가지 모델링 방법을 이용하였다. 첫 번째는 파노라마 왜곡과 촬영 비행체 이동에 의한 왜곡, IMC에 의한 왜곡을 보정하는 모형식을 구성하여 이용하였으며, 두 번째는 위성과 센서에 대한 정보를 필요로 하지 않는 다항식비례모형(RFM; Rational Function Model)을 이용하였다. 대상지역은 서울지역의 입체영상으로 대략 $33km{\times}26km$ 지역이다. 영상은 지상해상도 약 2.7m로 스캐닝하였고 1:1000 수치지도를 통해 20개의 기준점과 36개의 검사점을 관측하였다. 검사점의 위치정확도를 평가해 본 결과 첫 번째 방법은 수평방향으로 평균 3.9m(X), 2.8m(Y)의 오차를 보였으며 표고의 경우 4.2m의 오차를 보여주었다. 두 번째 방법은 수평방향으로 평균 3.2m(X), 2.8m(Y)의 오차를 보였으며 표고의 경우 5.5m의 오차를 보여주었다. 지형복원 정확도를 검증하기 위하여 첫 번째 방법을 이용하여 대상지역 중 일부인 서울 남산지역에 대해 정사영상과 10m간격의 DEM을 제작하였으며 1:1000 수치지도를 통해 제작된 DEM과 비교한 결과 총 43990개 격자점의 표고 차이는 평균 5.98m였다.

• 한국지형공간정보학회:학술대회논문집
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• 2002.11a
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• pp.73-80
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• 2002

RFM is believed to be universally applicable to any type of the sensor. Most of researches carried out lately are concentrated on terrain-independent method, but the researches about approvement of accuracy by way of terrain-dependent method are required to increase a practical use of satellite imagery in nonprofessional groups. This research focused on a means to improve RFM solution, a matching technique, and a generation of DEM through a correlation analysis, with terrain-dependent solution. The result shows that accuracy problem which is caused by over-parameterization on RFCs was removed through correlation analysis, and it was possible to generate a accurate DEM with terrain-dependent solution. And also, the application of RFM with different satellite images show sensor independent characteristics of RFM

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3D
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• pp.535-540
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• 2006

This paper presented an effective strategy to extract the buildings and to reconstruct 3-D buildings using high-resolution multispectral stereo satellite images. Proposed scheme contained three major steps: building enhancement and segmentation using both BDT (Background Discriminant Transformation) and ISODATA algorithm, conjugate building identification using the object matching with Hausdorff distance and color indexing, and 3-D building reconstruction using photogrammetric techniques. IKONOS multispectral stereo images were used to evaluate the scheme. As a result, the BDT technique was verified as an effective tool for enhancing building areas since BDT suppressed the dominance of background to enhance the building as a non-background. In building recognition, color information itself was not enough to identify the conjugate building pairs since most buildings are composed of similar materials such as concrete. When both Hausdorff distance for edge information and color indexing for color information were combined, most segmented buildings in the stereo images were correctly identified. Finally, 3-D building models were successfully generated using the space intersection by the forward RFM (Rational Function Model).

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.803-810
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• 2007

An analytical method capable of predicting various stress-strain responses in axially loaded concrete confined with FRP (fiber reinforced polymers) composites in a rational manner is presented. Its underlying idea is that the volumetric expansion due to progressive microcracking in mechanically loaded concrete is an important measure of the extent of damage in the material microstructure, and can be utilized to estimate the load-carrying capacity of concrete by considering the corresponding accumulated damage. Following from this, an elastic modulus expressed as a function of area strain and concrete porosity, the energy-balance equation relating the dilating concrete to the confining device interactively, the varying confining pressure, and an incremental calculation algorithm are included in the solution procedure. The proposed method enables the evaluation of lateral strains consecutively according to the related mechanical model and the energy-balance equation, rather than using an empirically derived equation for Poisson's ratio or dilation rate as in other analytical methods. Several existing analytical methods that can predict the overall response were also examined and discussed, particularly focusing on the way of considering the volumetric expansion. The results predicted by the proposed and Samaan's bilinear equation models correlated with observed results with a reasonable degree, however it can be judged that the latter is not capable of predicting the response of lateral strains correctly due to incorporating the initial Poisson's ratio and the final converged dilation rate only. Further, the proposed method seems to have greater benefits in other applications by the use of the fundamental principles of mechanics.

• Magazine of the Korean Society of Agricultural Engineers
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• v.19 no.1
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• pp.4296-4311
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• 1977

This study was conducted to derive an Instantaneous Unit Hydrograph for the accurate and reliable unitgraph which can be used to the estimation and control of flood for the development of agricultural water resources and rational design of hydraulic structures. Eight small watersheds were selected as studying basins from Han, Geum, Nakdong, Yeongsan and Inchon River systems which may be considered as a main river systems in Korea. The area of small watersheds are within the range of 85 to 470$\textrm{km}^2$. It is to derive an accurate Instantaneous Unit Hydrograph under the condition of having a short duration of heavy rain and uniform rainfall intensity with the basic and reliable data of rainfall records, pluviographs, records of river stages and of the main river systems mentioned above. Investigation was carried out for the relations between measurable unitgraph and watershed characteristics such as watershed area, A, river length L, and centroid distance of the watershed area, Lca. Especially, this study laid emphasis on the derivation and application of Instantaneous Unit Hydrograph (IUH) by applying Nash's conceptual model and by using an electronic computer. I U H by Nash's conceptual model and I U H by flood routing which can be applied to the ungaged small watersheds were derived and compared with each other to the observed unitgraph. 1 U H for each small watersheds can be solved by using an electronic computer. The results summarized for these studies are as follows; 1. Distribution of uniform rainfall intensity appears in the analysis for the temporal rainfall pattern of selected heavy rainfall event. 2. Mean value of recession constants, Kl, is 0.931 in all watersheds observed. 3. Time to peak discharge, Tp, occurs at the position of 0.02 Tb, base length of hlrdrograph with an indication of lower value than that in larger watersheds. 4. Peak discharge, Qp, in relation to the watershed area, A, and effective rainfall, R, is found to be {{{{ { Q}_{ p} = { 0.895} over { { A}^{0.145 } } }}}} AR having high significance of correlation coefficient, 0.927, between peak discharge, Qp, and effective rainfall, R. Design chart for the peak discharge (refer to Fig. 15) with watershed area and effective rainfall was established by the author. 5. The mean slopes of main streams within the range of 1.46 meters per kilometer to 13.6 meter per kilometer. These indicate higher slopes in the small watersheds than those in larger watersheds. Lengths of main streams are within the range of 9.4 kilometer to 41.75 kilometer, which can be regarded as a short distance. It is remarkable thing that the time of flood concentration was more rapid in the small watersheds than that in the other larger watersheds. 6. Length of main stream, L, in relation to the watershed area, A, is found to be L=2.044A0.48 having a high significance of correlation coefficient, 0.968. 7. Watershed lag, Lg, in hrs in relation to the watershed area, A, and length of main stream, L, was derived as Lg=3.228 A0.904 L-1.293 with a high significance. On the other hand, It was found that watershed lag, Lg, could also be expressed as {{{{Lg=0.247 { ( { LLca} over { SQRT { S} } )}^{ 0.604} }}}} in connection with the product of main stream length and the centroid length of the basin of the watershed area, LLca which could be expressed as a measure of the shape and the size of the watershed with the slopes except watershed area, A. But the latter showed a lower correlation than that of the former in the significance test. Therefore, it can be concluded that watershed lag, Lg, is more closely related with the such watersheds characteristics as watershed area and length of main stream in the small watersheds. Empirical formula for the peak discharge per unit area, qp, ㎥/sec/$\textrm{km}^2$, was derived as qp=10-0.389-0.0424Lg with a high significance, r=0.91. This indicates that the peak discharge per unit area of the unitgraph is in inverse proportion to the watershed lag time. 8. The base length of the unitgraph, Tb, in connection with the watershed lag, Lg, was extra.essed as {{{{ { T}_{ b} =1.14+0.564( { Lg} over {24 } )}}}} which has defined with a high significance. 9. For the derivation of IUH by applying linear conceptual model, the storage constant, K, with the length of main stream, L, and slopes, S, was adopted as {{{{K=0.1197( {L } over { SQRT {S } } )}}}} with a highly significant correlation coefficient, 0.90. Gamma function argument, N, derived with such watershed characteristics as watershed area, A, river length, L, centroid distance of the basin of the watershed area, Lca, and slopes, S, was found to be N=49.2 A1.481L-2.202 Lca-1.297 S-0.112 with a high significance having the F value, 4.83, through analysis of variance. 10. According to the linear conceptual model, Formular established in relation to the time distribution, Peak discharge and time to peak discharge for instantaneous Unit Hydrograph when unit effective rainfall of unitgraph and dimension of watershed area are applied as 10mm, and $\textrm{km}^2$ respectively are as follows; Time distribution of IUH {{{{u(0, t)= { 2.78A} over {K GAMMA (N) } { e}^{-t/k } { (t.K)}^{N-1 } }}}} (㎥/sec) Peak discharge of IUH {{{{ {u(0, t) }_{max } = { 2.78A} over {K GAMMA (N) } { e}^{-(N-1) } { (N-1)}^{N-1 } }}}} (㎥/sec) Time to peak discharge of IUH tp=(N-1)K (hrs) 11. Through mathematical analysis in the recession curve of Hydrograph, It was confirmed that empirical formula of Gamma function argument, N, had connection with recession constant, Kl, peak discharge, QP, and time to peak discharge, tp, as {{{{{ K'} over { { t}_{ p} } = { 1} over {N-1 } - { ln { t} over { { t}_{p } } } over {ln { Q} over { { Q}_{p } } } }}}} where {{{{K'= { 1} over { { lnK}_{1 } } }}}} 12. Linking the two, empirical formulars for storage constant, K, and Gamma function argument, N, into closer relations with each other, derivation of unit hydrograph for the ungaged small watersheds can be established by having formulars for the time distribution and peak discharge of IUH as follows. Time distribution of IUH u(0, t)=23.2 A L-1S1/2 F(N, K, t) (㎥/sec) where {{{{F(N, K, t)= { { e}^{-t/k } { (t/K)}^{N-1 } } over { GAMMA (N) } }}}} Peak discharge of IUH) u(0, t)max=23.2 A L-1S1/2 F(N) (㎥/sec) where {{{{F(N)= { { e}^{-(N-1) } { (N-1)}^{N-1 } } over { GAMMA (N) } }}}} 13. The base length of the Time-Area Diagram for the IUH was given by {{{{C=0.778 { ( { LLca} over { SQRT { S} } )}^{0.423 } }}}} with correlation coefficient, 0.85, which has an indication of the relations to the length of main stream, L, centroid distance of the basin of the watershed area, Lca, and slopes, S. 14. Relative errors in the peak discharge of the IUH by using linear conceptual model and IUH by routing showed to be 2.5 and 16.9 percent respectively to the peak of observed unitgraph. Therefore, it confirmed that the accuracy of IUH using linear conceptual model was approaching more closely to the observed unitgraph than that of the flood routing in the small watersheds.

• Korea Real Estate Review
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• v.28 no.1
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• pp.23-37
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• 2018

The genetic algorithm (GA) and branch and bound (B&B) methods are the useful methods of searching the optimal project combination (combinatorial optimization) to maximize the project effect considering the budget constraint and the balance of regional development with regard to the Urban Regeneration New Deal policy, the core real estate policy of the Moon Jae-in government. The Ministry of Land, Infrastructure, and Transport (MOLIT) will choose 13 central-city-area-type projects, 2 economic-base-type projects, and 10 public-company-proposal-type projects among the numerous projects from 16 local governments while each government can apply only 4 projects, respectively, for the 2017 Urban Regeneration New Deal project. If MOLIT selects only those projects with a project effect maximization purpose, there will be unselected regions, which will harm the balance of regional development. For this reason, an optimization model is proposed herein, and a combinatorial optimization method using the GA and B&B methods should be sought to satisfy the various constraints with the object function. Going forward, it is expected that both these methods will present rational decision-making criteria if the central government allocates a special-purpose-limited budget to many local governments.

• Journal of Korean Society of Forest Science
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• v.108 no.3
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• pp.357-363
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• 2019

This study was conducted to develop a stem volume table for Quercus acutissima in Korea by using Kozak's stem taper equation. In total, 2700 tree samples were collected around the country, and growth performance was investigated through compiling data on diameters by stem height and stem analysis. In order to test the stem taper equation's fitness, the fitness index (FI), bias, and mean absolute deviation (MAD) were analyzed. The fitness of the equation was estimated at 97%, bias as 0.017, and MAD turned out to be 1.118, respectively. Furthermore, there was a statistically significant volume difference between the current volume table and the new volume table (p = 0.0008, <0.005). The result indicates that using the new volume table that reflects the actual forest will reduce the loss when assessing wood resources and will improve the accuracy of forest statistics for national and local governments. A stem volume table, the main result of this research, which is utilized in the estimated stem taper equation, will provide growth information for Quercus acutissima, one of the main broadleaf species in Korea, and will function as a management indicator for rational forest management.

• Journal of the Korean Geotechnical Society
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• v.25 no.10
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• pp.87-97
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• 2009

The seismic site coefficients are often used with the seismic hazard maps to develop the design response spectrum at the surface. The site coefficients are most commonly developed deterministically, while the seismic hazarde maps are derived probabilistically. There is, hence, an inherent incompatibility between the two approaches. However, they are used together in the seismic design codes without a clear rational basis. To resolve the fundamental imcompatibility between the site coefficients and hazard maps, this study uses a novel probabilistic seismic hazard analysis (PSHA) technique that simulates the results of a standard PSHA at a rock outcrop, but integrates the site response analysis function to capture the site amplification effects within the PSHA platform. Another important advantage of the method is its ability to model the uncertainty, variability, and randomness of the soil properties. The new PSHA was used to develop fully probabilistic site coefficients for site classes of the seismic design code and another sets of site classes proposed in Korea. Comparisons highlight the pronounced discrepancy between the site coefficients of the seismic design code and the proposed coefficients, while another set of site coefficients show differences only at selected site classes.