• Tuberculosis and Respiratory Diseases
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• 제68권6호
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• pp.334-344
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• 2010

Background: Based on the known immunoregulatory functions of moxifloxacin on phagocytes, the therapeutic effect of moxifloxacin on oleic acid (OA)-induced acute lung injury (ALI) was investigated. Methods: Moxifloxacin (10 mg/kg) was given to male Sprague-Dawley rats that had been given oleic acid (OA, $30{\mu}L$) intravenously. Five hours after OA injection, parameters demonstrating ALI were assessed to measure the effects of moxifloxacin on acute lung injury. Results: The pathological findings of OA-induced ALI's was diminished by moxifloxacin. Through ultrastructural and $CeCl_3$ EM histochemistry, moxifloxacin was confirmed to be effective in decreasing oxidative stress in the lung as well. Indices of ALI, such as lung weight/body weight ratio, protein content in bronchoalveolar lavage fluid, and lung myeloperoxidase were decreased by moxifloxacin. In diaminobenzidine immunohistochemistry, fluorescent immunohistochemistry, and Western blotting of the lung, moxifloxacin had decreased the enhanced expression of secretory phospholipase $A_2$ ($sPLA_2$) by OA. Conclusion: We concluded that moxifloxacin was effective in lessening acute inflammatory pulmonary edema caused by OA, by inhibiting the neutrophilic respiratory burst, which was initiated by the activation of $sPLA_2$.

• 보건교육건강증진학회지
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• 제29권2호
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• pp.23-32
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• 2012

Objectives: This study evaluated the association between osteoarthritis (OA) and health-related quality of life (HRQoL) in elderly Korean women. Methods: We selected participants (n=2,597) aged 50 years or older from Korea National Health and Nutrition Examination Survey [KNHANES] 2005-2008. Demographic and personal characteristics, medical history of OA, and EQ-5D were extracted from the KNHANES data. Results: We found that demographic variables, including age, education level, income, and personal characteristics, were important covariates associated with the prevalence of OA and with HRQoL. In this study, OA was an important factor affecting HRQoL in women. The adjusted odds ratio for HRQoL in participants with OA was 2.92 [(95% confidence interval (CI)=2.43-3.51, p<.001)] in mobility, 2.60 (95% CI=2.17-3.10, p<.001) in pain/discomfort, 2.17 (95% CI=1.78-2.65, p<.001) in usual activities, 1.65 (95% CI=1.22-2.24, p=.001) in self care, and 1.47 (95% CI=1.22-1.77, p<.001) in anxiety/depression. After adjustment of covariates, HRQoL was significantly decreased in participants with OA. Conclusions: Our findings reveal that there is a strong association between OA and HRQoL. Preventing and controlling OA may significantly improve the quality of life for elderly Korean women.

• 한국전기전자재료학회논문지
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• 제25권1호
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• pp.33-36
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• 2012

In this study, the thickness effects of $Al_2O_3$ layer on the sensing properties of $SiO_2/Al_2O_3$ (OA) stacked membrane were investigated using electrolyte-insulator-semiconductor (EIS) structure for high quality pH sensor. The $Al_2O_3$ layers with a respective thickness of 5 nm, 15 nm, 23 nm, 50 nm, and 100 nm were deposited on the 5-nm-thick $SiO_2$ layers. The electrical characteristics and sensing properties of each OA membranes were investigated using metal-insulator-semiconductor (MIS) and EIS devices, respectively. As a result, the OA stacked membrane with 23-nm-thick $Al_2O_3$ layer shows the excellent characteristics as a sensing membrane of EIS sensor, which can enhance the signal to noise ratio.

• 대한지하수환경학회지
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• 제4권2호
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• pp.103-108
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• 1997

본 연구에서는 일련의 회분식 실험을 통하여 소수성 유기오염물질로 오염된 토양에 혼합 계면활성제를 이용한 토양세척기법을 적용함에 있어서 필요한 기본 운전조건을 도출하고자 하였다. 혼합 계면활성제는 계면활성제 각각이 단독으로 존재할 때와는 상이한 분자 집합구조를 형성하게 되므로 세척효율을 향상시키기 위하여 적용하였다. 세척효율에 크게 영향을 미치는 요소인 혼합되는 계면활성제의 종류, 혼합비, 총 적용농도 등을 변경하며 적용하였다. 대상 오염물질로는 n-dodecane을 사용하였으며, 토양은 서울 녹천역 부근의 야산에서 채취된 토양중 #4체(4.75 mm) 통과 토양만을 사용하였으며, pH는 4.4, 유기물질함량은 1.6%(중량비), 양이온 치환능력(cation exchange capacity, CEC)은 4.08 meq/100 g이었다. Polyoxyethylene oleyl ester계를 중심으로 제조된 혼합 계면활성제의 세척력을 조사한 결과, OA-5와 OA-l4가 1:1 (중량비)로 혼합된 5% 용액이 86%의 세척효율을 보였다. 또한 음이온계 계면활성제인 SDS와 OA-5가 1:1(중량비)로 혼합된 4% 용액을 적용한 결과 최고 95%의 세척효율을 보였다.

• 한국비블리아학회지
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• 제22권3호
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• pp.373-391
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• 2011

본 연구는 KCI 등재지 1,438종을 대상으로 오픈액세스 학술지를 식별해내고, 이들 학술지의 원문공개 채널, 분야별 차이, 발행기관별 차이를 파악하고자 하였다. 조사 결과, 등재지의 21%는 상용DB를 통한 서비스를 하지 않는 오픈액세스 학술지였으며, 34%는 무료공개와 상용DB를 통한 원문서비스를 동시에 하고 있었으며, 나머지 34%는 오직 상용DB에서만 원문서비스하고 있음을 알 수 있었다. 또한 오픈액세스 학술지의 48%는 무료원문 DB를 통하여, 52%는 발행기관 홈페이지를 통하여 원문을 공개하고 있었다. 원문공개 채널은 분야별로 차이가 있었다. 즉, 인문, 사회과학 분야 학술지는 주로 발행기관 홈페이지, 과학기술 및 의학 분야 학술지는 주로 무료DB에 원문을 공개하고 있었다. 전체 오픈액세스 학술지 중 약 30%는 의학 분야 학술지였으며, 사회과학 분야 학술지도 25%를 차지하였다. 그러나 분야별 분포로 볼 때 사회과학과 인문학 분야 학술지의 오픈액세스 비율은 약 15%정도에 불과하였다. 이에 비해 의학 분야의 경우 약 60%가 오픈액세스 학술지였으며, 자연과학과 공학 분야도 각각 33%, 24%가 오픈액세스 학술지였다.

• Journal of Acupuncture Research
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• 제35권1호
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• pp.21-27
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• 2018

Background: Examination of the effects of deer antler, old antler, and antler glue on postmenopausal osteoporosis in an ovariectomized Sprague-Dawley rat model. Methods: The study involved 7 experimental groups; SHAM (sham-operated rats), OVX (ovariectomized rats), E2 (ovariectomized rats with estradiol $10{\mu}g/kg$ daily, orally), DA (ovariectomized rats with deer antler extract 5.83 mg/kg), OA (ovariectomized rats with old antler extract 3.8 mg/kg), low-AG (ovariectomized rats with low dose of antler glue powder 12.5 mg/kg), high-AG (ovariectomized rats with high dose of antler glue powder 37.5 mg/kg). After 6 weeks of treatment, body weight, blood calcium, phosphorus, estradiol, liver [alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT)] and kidney [blood urea nitrogen (BUN)/creatinine ratio] function, and femoral bone mineral density (BMD) were measured. Results: The body weights of DA, OA, low-AG, and high-AG groups did not significantly differ from OVX group. Blood estradiol levels were significantly increased in the DA, low-AG, and high-AG groups compared to the OVX group. Blood calcium, phosphorus, ALP, AST, and ALT levels and BUN/creatinine ratio did not show significant changes in the DA, OA, low-AG, and high-AG groups. BMDs of the femur, and femoral head and neck were significantly increased in the low-AG group. In the OA group, the BMD of the femoral head and neck was significantly increased. Conclusion: Treatment with deer antler, or antler glue for 6 weeks was effective for increasing estradiol and femoral BMD in ovariectomized rats, suggesting that this may be of therapeutic benefit for osteoporosis.

• Clinical and Experimental Reproductive Medicine
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• 제38권3호
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• pp.142-147
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• 2011

Objective: This study was performed to evaluate testicular sperm chromatin condensation using aniline blue-eosin (AB-E) staining and its effects on IVF-ET. Methods: Chromatin condensation was analyzed using AB-E staining in 27 cases of testicular sperm extraction. There were 19 cases of obstructive azoospermia (OA) and 8 cases of non-obstructive azoospermia (NOA) in IVF-ET. Mature sperm heads were stained red-pink whereas immature sperm heads were stained dark blue. The percentage of sperm chromatin condensation was calculated from the ratio of the number of red-pink sperm to the total number of sperm analyzed. Results: The overall percentages of chromatin condensation in OA and NOA were $31.1{\pm}11.2%$ and $26.3{\pm}14.4%$, respectively. The fertilization rate was significant higher in OA than NOA ($p$ <0.05); however, the rates of good embryos and clinical pregnancy did not show statistical differences. In OA and NOA, statistical differences were not observed in the rate of chromatin condensation, fertilization, good embryos, and clinical pregnancy between the pregnant group and non-pregnant group. Conclusion: Chromatin condensation is less stable than OA and showed a low fertilization rate in NOA. While there were no significant differences in chromatin condensation results between NOA and OA, we propose that a pattern of decreased chromatin condensation in NOA is one of the factors of low fertilization results requiring further study.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.697-701
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• 2018

Background and Objectives The aim of this study was to evaluate surgical completeness in endoscopic total thyroidectomy with central neck dissection via unilateral axillo-breast approach (UABA) compared with bilateral axillo-breast (BABA) and open approach (OA) by means of the radioactive iodine uptake (RAIU) ratio and thyroglobulin (Tg) of remnant thyroid. Subjects and Method From July 2010 to March 2013, 82 patients who had underwent total thyroidectomy with central neck dissection and postoperative radioactive iodine (RAI) ablation for papillary thyroid carcinoma were enrolled. Of these patients, 27 patients underwent UABA, 24 patients BABA, and 31 patients OA. Clinicopathologic data, surgical outcome, stimulated Tg and RAIU ratio on the first postoperative RAI ablation scan were compared among 3 groups. Results Patients in the endoscopic surgery groups (UABA, BABA) were younger than those in the OA groups. Invasiveness such as operation time, postoperative pain, and drain amount in UABA was less than that in BABA and severer than that in OA. Other variables regarding clinicopathologic and surgical data were not significantly different. Stimulated Tg and RAIU ratio did not show significant differences among 3 groups (p=0.659 and p=0.664). Conclusion The completeness of UABA was comparable with that of BABA and OA. The UABA may be a safe option for patients who need endoscopic thyroidectomy for papillary thyroid carcinoma.

• 한국엔터테인먼트산업학회논문지
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• 제14권7호
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• pp.633-640
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• 2020

본 연구는 국민건강영양조사 제5기(2010-2012) 원시자료를 이용하여 한국 농어업종사자의 무릎 OA 유병률을 파악하고 관련요인을 알아보기 위해 시행하였다. 국민건강영양조사 5기(2010-2012) 원시자료 중 50세 이상 농어업에 종사하는 50세 이상 성인 1,264명(2010년 440명, 2011년 448명, 2012년 376명)을 연구대상자로 선정하였다. 연구대상자 중 X-ray 판독 결과 Kellgren Lawrence grade가 2 이상이고 최근 3개월 동안 30일 이상 무릎관절통이 있었다고 응답한 215명과 X-ray 판독 결과 Kellgren Lawrence grade가 1 이하이고 최근 3개월 동안 30일 이상 무릎관절통이 없었다고 응답한 601명, 총 816명을 최종 연구대상자로 선정하였고 무릎 OA 유병률과 인구사회학적 또는 건강관련 요인별 유병교차비를 분석하였다. 연구결과 무릎 OA 유병률은 26.3%였고, 인구사회학적 측면에서 여성, 연령이 증가할수록, 교육수준이 낮을 수록, 월소득이 적을수록 무릎 OA 유병률은 증가하였다. 건강관련 요인에서는 비흡연군, BMI가 높을수록 무릎 OA 유병률이 증가하였다.

• Animal Bioscience
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• 제35권6호
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• pp.916-926
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• 2022

Objective: This study was conducted to evaluate the effects of medium chain triglycerides (MCT) with organic acids (OA) on growth performance, fecal score, blood profiles, intestinal morphology, and nutrient digestibility in weaning pigs. Methods: A total of 120 weaning pigs ([Yorkshire×Landrace]×Duroc) with an average body weight (BW) of 8.00±0.87 kg were assigned in five treatments considering sex and initial BW in 3 replications with 8 pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal based basal diet with or without 0.1% or 0.2% MCT and 0.1% OA. The pigs were fed the diets for 5 weeks (phase 1, 0 to 2 weeks; phase 2, 3 to 5 weeks). A total of 15 barrows with an average BW of 12.48±0.37 kg were used to evaluate the nutrient digestibility by total collection method. The BW and feed intake were measured at the end of each phase. Blood samples and small intestine samples were collected at the end of each phase, too. Results: Supplementing 0.1% MCT with 0.1% OA showed greater BW for week 5 and average daily gain (ADG) for overall period than control diet. Supplementing 0.1% MCT increased (p<0.05) ADG and improved (p<0.05) gain:feed ratio for phase 1. Dietary MCT and OA did not affect the fecal score and blood concentration of cortisol, immunoglobulin G, tumor necrosis factor-α, interleukin-1β (IL-1β), IL-6, and IL-10 in weaning pigs. Pigs fed the diets with 0.1% MCT had greater (p<0.05) villus height of duodenum and ileum for phase 1. Also, pigs fed the diet with 0.1% OA showed greater (p<0.05) villus height and villus height to crypt depth ratio of duodenum for phase 2. There was no significant difference in nutrient digestibility and nitrogen retention of pigs. Conclusion: Addition of 0.1% MCT with 0.1% OA in weaning pig's diet improved growth performance partly by enhancing intestinal morphology in weaning pigs.