• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3067-3072
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• 2015

Cervical cancer is the most common malignant cancer of the female reproductive organs worldwide. Currently, cervical cancer can be prevented by vaccination and detected at an early stage via various screening methods. Malaysia, as a developing country faces a heavy disease burden of cervical cancer as it is the second most common cancer among Malaysian women. This population based study was carried out to fulfil the primary aim of determining the survival rates of Malaysian women with cervical cancer and associated factors. Data were obtained from two different sources namely, the Malaysian National Cancer Registry (MNCR) and National Health Informatics Centre (NHIC) from 1st January 2000 to 31st December 2005. Kaplan Meier analyses were conducted to identify the overall survival rates and median survival time. Differences in survival among different ethnic and age group were compared using the log-rank test. A total of 5,859 patients were included. The median survival time for cervical cancer in this study was 65.8 months and the 5-year survival rate was 71.1%. The overall observed survival rates at 1, 3 and 5 years were 94.1%, 79.3% and 71.1% respectively. The log-rank test finding also showed that there were significant differences in the 5-year survival rate among different ethnic groups. Malays had the lowest survival rate of 59.2% followed by Indians (69.5%) and Chinese (73.8%). The overall 5-year survival rate among patients with cervical cancer in Malaysia is relatively good. Age and ethnic groups remain as significant determining factors for cervical cancer survival rate.

• Journal of Gastric Cancer
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• 제10권4호
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• pp.155-161
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• 2010

Purpose: The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. Materials and Methods: A total of 243 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2010. We evaluated the effectiveness of the ATP-CRA assay in determining the chemosensitivity of gastric cancer specimens using eleven chemotherapeutic agents - etoposide, doxorubicin, epirubicin, mytomicin, 5-fluorouracil, oxaliplatin, irinotecan, docetaxel, paclitaxel, methotraxate, and cisplatin - for chemosensitivity studies using ATP-CRA. We assessed the failure rate, the cell death rate, and the chemosensitivity index. Results: The failure rate of ATP-CRA was 1.6% (4/243). The mean coefficient of variation for triplicate ATP measurements was 6.5%. Etoposide showed the highest cell death rate (35.9%) while methotrexate showed the lowest (16.6%). The most active chemotherapeutic agent was etoposide, which most frequently ranked highest in the chemosensitivity test: 31.9% (51/160). Oxaliplatin was more active against early gastric cancers than advanced gastric cancers, whereas docetaxel was more active against advanced cancers. The lymph node negative group showed a significantly higher cell death rate than the lymph node positive group when treated with doxorubicin, epirubicin, and mitomycin. Conclusions: ATP-CRA is a stable and clinically applicable in vitro chemosensitivity test with a low failure rate. The clinical usefulness of ATP-CRA should be evaluated by prospective studies comparing the regimen guided by ATP-CRA with an empirical regimen.

• Macromolecular Research
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• 제11권5호
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• pp.311-316
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• 2003

The kinetics of photoinitiated polymerization of dimethacrylate macromonomers have been studied to determine the diffusion-controlled reaction parameters using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). A predicted kinetic rate expression with a diffusion control factor was employed to estimate an effective rate constant and to define the reaction-controlled and diffusion-controlled regimes in the photopolymerization. An effective rate constant, k$_{e}$, can be obtained from the predicted kinetic rate expression. At the earlier stages of polymerization, the average values of kinetic rate constants do not vary during the reaction time. As the reaction conversion, $\alpha$, reaches the critical conversion, $\alpha$$_{c}$, in the predicted kinetic expression, the reaction becomes to be controlled by diffusion due to the restricted mobility of dimethacrylate macromonomers. A drop in value of effective rate constant causes a drastic decrease of reaction rate at the later stages of polymerization. By determining the effective rate constants, the reaction-controlled and diffusion-controlled regimes were properly defined even in the photopolymerization reaction system.m.m.

• 대한전기학회논문지:전력기술부문A
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• 제54권10호
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• pp.496-499
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• 2005

In many parts of the world, the electric power industry is undergoing unprecedented changes. Therefore, in order to reform the electric power industry efficiently and minimize the confusion of this restructuring, the systematic studies related to transmission pricing and transmission cost allocation issues are required essentially. However, even now, the basis of transmission cost allocation rate is not equipped so that the regulation body has determined the allocating rate under the common practice. In this paper, we demonstrate that the decision of transmission cost allocation rate is the regulation body's own right. For this analysis, we apply game theory to the procedure determining this rate and the competition to determine this rate between gencos and distcos is modeled as the arbitration game.

• 한국정보통신학회논문지
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• 제25권6호
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• pp.792-798
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• 2021

본 논문에서는 인공지능 기반의 빅데이터 분석과 예측을 통하여 정수장의 공정 중 약품투입곤정에서 응집제 투입률을 결정하는 알고리즘을 도출하였다. 또한, 빅데이터 기술 및 인공지능 알고리즘 적용 방법에 대한 분석 및 기존의 학문적, 기술적 자료를 검토하여 유사 분야 적용 사례를 분석 검토하였다. 이를 통한 최적 응집제 투입률 제시를 목표로 운영 근무자의 의사결정 패턴을 입력 변수와 출력변수의 관계 패턴으로 학습한 후 학습된 패턴을 실제 응집제 주입 공정에 적용하여 침전수 탁도가 목표치에 근사한 일정 수준을 유지할 수 있도록 운영이 가능하였다. 데이터 범위 산정과 전처리를 거친 변수를 선정하여 알고리즘 수행을 준비한 후 군집화와 분류 알고리즘을 적용하여 알고리즘 수행과 결과에 대한 피드백을 반복하여 학습을 진행하였다.

• 대한산업공학회지
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• 제20권3호
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• pp.117-124
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• 1994

In this paper an inventory model is presented for determining the ordering schedule in which the demand rate is changing linearly with time and the decay is assumed to be a constant rate of the on-hand inventory. An easy to use heuristic is developed to find the times and sizes of replenishments so as to keep the total of ordering, inventory carrying and deteriorating costs as low as possible. Solutions of the model to test problems show that our heuristic model outperforms other existing models in the literature without sacrificing the computational complexity. When there is no deterioration, the model developed is related to the corresponding model of nondeteriorating items.

• 품질경영학회지
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• 제28권3호
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• pp.11-17
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• 2000

This paper presents a model for determining the optimal number of general repairs and supplementary input cost limit rate in addition to minimal repair cost rate to implement preventive maintenance. The basic concept parallels the periodic replacement model with minimal repair at failure introduced by Barlow and Hunter(1960) and Park(1979), only difference being the replacement signalled by the number of previous general repairs performed on the system. A general repair brings the state of the system to a certain better state than before repaired. Numerical examples are provided.

• 품질경영학회지
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• 제14권1호
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• pp.61-66
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• 1986

Many papers have suggested various models how to decide an optimal time for replacing equipment. In this study, Dynamic Programming is applied to establish a model of replacing equipment and a new algorithm is developed for computerization to meet the increased number of variables. It is possible to predict the real situation with higher accuracy by employing the proposed model including more variables such as planning horizon, original cost, salvage value, decreasing rate, operating and maintenance costs, increasing rate, and so on.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2001년도 춘계학술대회
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• pp.199-203
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• 2001

In today's business transactions, it is more and more common to see that the buyers are allowed some grace period before they settle the account with the supplier. In this regard, we analyze the problem of determining the buyer's EOQ when the supplier allows day-terms credit. For the analysis, it is assumed that the buyer's demand rate is a function of the on -hand inventory level and the relevant mathematical model is developed.

• Bulletin of the Korean Chemical Society
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• 제9권1호
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• pp.17-21
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• 1988

A mechanistic study on the chemiluminescence resulting from the reaction between bis(2,4,6-trichlorophenyl)oxalate(TCPO) and hydrogen peroxide in the presence of fluorescent polycyclic aromatic hydrocarbons in a viscous phthalate medium has been conducted. The rate determining step, decay rate constants, and relative quantum efficiencies yielded by varying the concentration of reagents generally support an existing mechanism. However, a reaction between TCPO and sodium salicylate was not observed.