• 대한의생명과학회지
• /
• 제25권1호
• /
• pp.32-39
• /
• 2019

Conventional high-flux hemodialysis (HD) is not as good as normal kidney function. Morbidity and mortality rates of patients receiving HD are still very high. To increase mid-to-large molecule clearance by combining diffusion and convection, on-line hemodiafiltration (HDF) is required. The objective of this study was to compare long-term survival rate of patients treated with on-line HDF to those who received conventional high-flux HD by reviewing data from Chonnam National University Hospital (CNUH). We selected patients who attended the 'CUNH dialysis center' and agreed to participate in the study. Overall, 40 patients with ESRD switched from high flux HD to on-line HDF or started on-line HDF from August 2007 to December 2009. Additionally, a total of 42 patients receiving conventional high-flux HD during the same period were enrolled. We then reviewed long-term survival rate of patients receiving on-line HDF over the next seven years. When we compared survival rates for seven years, the survival rate of the group receiving on-line HDF was 65% (26/40) while that of the group receiving the conventional high-flux HD was 54.8% (23/42). Although the number of patients was small to see survival difference clearly by one specific dialysis modality, there was somewhat difference in survival rate between the two groups. Indicators such as anemia, calcium-phosphate metabolism, nutritional status, treatment adequacy, and hospitalization were also improved in the group receiving HDF. Overall, results of our study showed beneficial effects of on-line HDF on clinical outcomes and survival in chronic HD patients.

• 한국환경과학회지
• /
• 제30권5호
• /
• pp.399-406
• /
• 2021

The dissolution of ionized gas in dielectric barrier plasma, similar to the principle of ozone generation, is a major performance-affecting factor. In this study, the plasma gas dissolving performance of a gas mixing-circulation plasma process was evaluated using an experimental design methodology. The plasma reaction is a function of four parameters [electric current (X₁), gas flow rate (X₂), liquid flow rate (X₃) and reaction time (X₄)] modeled by the Box-Behnken design. RNO (N, N-Dimethyl-4-nitrosoaniline), an indictor of OH radical formation, was evaluated using a quadratic response surface model. The model prediction equation derived for RNO degradation was shown as a second-order polynomial. By pooling the terms with poor explanatory power as error terms and performing ANOVA, results showed high significance, with an adjusted R² value of 0.9386; this indicate that the model adequately satisfies the polynomial fit. For the RNO degradation, the measured value and the predicted values by the model equation agreed relatively well. The optimum current, gas flow rate, liquid flow rate and reaction time were obtained for the highest desirability for RNO degradation at 0.21 A, 2.65 L/min, 0.75 L/min and 6.5 min, respectively.

• The Journal of Asian Finance, Economics and Business
• /
• 제8권7호
• /
• pp.393-402
• /
• 2021

This study aims to examine whether symmetric effects or asymmetric effects of exchange rates exist in determining the money demand in Indonesia. Simple-sum money and Divisia money were included in different models for comparison due to the financial developments in Indonesia. This study uses time-series data from 1996Q1 to 2019Q4 for the estimation. The nonlinear autoregressive distributed lag (NARDL) model is utilized to verify the asymmetric effects of exchange rates on money demand. The Augmented Dickey-Fuller and Phillips-Perron unit root tests were performed to verify the order of integration of the variables. The findings of this study revealed that the exchange rate is one of the most important determinants of money demand in Indonesia and the effect is asymmetric. The findings further indicated that money demand function, which incorporates Divisia monetary aggregate is parsimonious. Monetary targets such as money supply and interest rates are critical for monetary policy conduct to achieve inflation levels set by government. As the adoption of an inflation targeting framework needs to be in keeping with the flexible exchange rate system, the asymmetric effect of exchange rate changes can be used in exchange rate policy conduct to achieve financial system and price stability.

• Journal of Microbiology and Biotechnology
• /
• 제3권4호
• /
• pp.292-297
• /
• 1993

Aspergillus niger No. PFST-38 was grown on complex media in 30L agitated fermentors at various aeration rates and stirrer speeds. We could correlate the mixing time as a function of the Reynolds number and the apparent viscosity, as follows. ${\theta}_M=2.95\;\NRe^{-0.52},\;{\theta}_M=1.88\;{\eta_a}^{0.57}$ Also, the effects of the apparent viscosity (${\theta}_a$), the impeller rotational speed (N), the air flow rate ($V_s$), and the mixing time (${\theta}_M$) on the oxygen transfer coefficient, $K_L a$ were determined experimentally, and equated as follows. $K_La=12.04N^{0.88}Vs^{0.71}{n_a}^{-0.83},\;K_La=30.2N^{0.88}Vs^{0.71}{\theta_M}^{-1.45}$ $K_La$ increased as the agitation speed and the air flow rate increased. The rate of $K_La$ increase was dependent more on the rotational speed of impeller than on the air flow rate. The glucoamylase production increased with the increase of the agitation speed upto at 500 rpm and increased with the increase of air flow rate upto at 1.0 vvm. The values calculated from the above equation confirmed that the experimental maximum production of glucoamylase was achieved when the $K_La$ and the apparent viscosity of the broth were $260\;hr^{-1}$ and 1800 cps, respectively.

• 수면정신생리
• /
• 제11권2호
• /
• pp.100-105
• /
• 2004

목 적：본 연구의 목적은 주요우울장애환자를 대상으로 Heart Rate Variability(HRV) 검사를 이용하여 비침습적으로 자율신경계의 기능, 심혈관조절체계 및 항상성을 측정하여 정상대조군과 비교해보고 생리학적, 임상적 의미를 고찰해보는 것이다. 방 법：DSM-Ⅳ의 진단기준에 의하여 주요우울장애로 진단받은 환자 30명과 정상대조군 30명을 대상으로 하였다. 검사는 SA-2000E 기기를 사용하여 HRV parameter를 측정한 후 시(time) 영역과 주파수(frequency)영역별로 분석하였다. 결 과：Heart rate(HR)는 환자군에서 유의하게 증가된 소견을 나타내었으며 the standard deviation of the NN interval(SDNN), the root square of successive differences(RMSSD)도 환자군에서 유의하게 낮은 소견을 보였다. Total power(TP) band, very low frequency(VLF：$0.003{\sim}0.04\;Hz$) band, low frequency(LF：$0.04{\sim}0.15\;Hz$) band, high frequency(HF：$0.15{\sim}0.4\;Hz$) band는 환자군에서 유의하게 낮은 수치를 보였고, LF/HF의 비는 유의한 차이를 나타내지 않았다. 결 론：우울증 환자는 심박수의 증가와 HRV의 감소를 보였으며, 교감 신경과 미주 신경의 불균형이 높은 심혈관계 사망률과 부분적으로 연관이 있는 것 같다. 우울증 환자들은 심장에서 자율신경기능의 이상을 나타내며 이렇게 교감/부교감 신경활성 조절능력이 저하되어 균형이 깨짐으로써 높은 심혈관계 사망률을 보인다고 할 수 있다.

• 생물환경조절학회지
• /
• 제27권4호
• /
• pp.326-331
• /
• 2018

작물 생육 모델은 작물의 생육을 이해하고 통합하기 위해 유용한 도구이다. 완전제어형 식물공장에서 엽채류로 활용하기 위한 퀴노아(Chenopodium quinoa Willd.)의 초장, 광합성률, 생장 모델을 예측하기 위한 모델을 1차식, 2차식 및 비선형 및 선형지수 등식을 사용하여 개발하였다. 식물 생육과 수량은 정식 후 5일간격으로 측정하였다. 광합성과 생장 곡선 모델을 계산하였다. 초장과 정식 후 일수(DAT)간의 선형 및 곡선 관계를 얻었으나, 초장을 정확하게 예측하기 위한 모델은 선형 등식이었다. 광합성률 모델을 비선형 등식을 선택하였다. 광보상점, 광포화점, 및 호흡률은 각각 29, 813 and $3.4{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$였다. 지상부 생체중과 건물중은 선형관계를 보였다. 지상부 건물중의 회귀계수는 0.75 ($R^2=0.921^{***}$)였다. 선형지수 수식을 사용하여 시간 함수에 따른 퀴노아의 지상부 건물중 증가를 비선형 회귀식으로 수행하였다. 작물생장률과 상대생장률은 각각 $22.9g{\cdot}m^{-2}{\cdot}d^{-1}$ and $0.28g{\cdot}g^{-1}{\cdot}d^{-1}$였다. 이러한 모델들은 정확하게 퀴노아의 초장, 광합성률, 지상부 생체중과 건물중을 예측할 수 있다.

• 무역학회지
• /
• 제42권4호
• /
• pp.1-20
• /
• 2017

본 연구는 우리나라를 대상으로 국제 자본이동과 주요 통화대비 원화 환율 간의 동태적 관계를 분석하고 있다. 우선 그랜저 인과관계 검정 결과에 의하면 국제 자본이동은 단기적으로 주요 통화대비 원화 환율의 변동성에 Granger-cause하는 것으로 나타났다. 하지만 시간이 흐를수록 환율의 변동성이 국제 자본이동에 Granger-cause하는 것을 확인할 수 있었다. 글로벌 금융위기를 기준으로 전과 후를 구분하여 분석한 결과에 의하면 글로벌 금융위기 전에는 국제 자본이동이 원/달러 환율의 변동성에만 유의한 영향을 미치는 것으로 나타났지만, 글로벌 금융위기 이후의 기간에서는 환율의 변동성이 오히려 국제 자본이동에 Granger-cause하는 것으로 나타났다. VAR모형을 바탕으로 일반화된 충격반응함수의 그래프를 살펴보면 국제 자본이동과 환율 변동성은 금융위기를 기준으로 다른 양상을 보이고 있다. 글로벌 금융위기가 발생한 후에는 환율의 변동성이 국제 자본이동을 촉진하지만 시간이 흐르면서 그 영향력이 축소되는 반면 이전 기간에는 이러한 관계가 성립하지 않는다는 것을 알 수 있다. 이러한 실증분석 결과를 종합해보면 우리나라에서는 외환시장의 불확실성이 국제 자본이동에 중요하게 작용한다는 것을 알 수 있다. 따라서 국제 자본이동에 대한 직접적인 규제보다는 외환시장의 불확실성을 적절하게 통제하는 것이 더 효과적인 정책수단이 될 수 있을 것이다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제23권3호
• /
• pp.355-365
• /
• 2010

The aim of this study was to investigate the effect of supplemental recombinant bovine somatotropin (rbST) and cooling with misters and fans on renal function in relation to regulation of body fluids in different stages of lactation in crossbred Holstein cattle. Ten, 87.5% crossbred Holstein cattle were divided into two groups of 5 animals each, housing in a normal shaded barn (NS) and in a shaded barn with a mister-fans cooling system (MF). The experiment in each group was divided into 3 phases, early- (Day 75 postpartum), mid- (Day 135 postpartum), and late stage of lactation (Day 195 postpartum). The pre-treatment study was conducted on the starting day of each stage of lactation and the treatment study was performed after the end of the pre-treatment, during which the animal was injected with 500 mg of rbST (POSILAC) every 14 days for three times. During the study, ambient temperature at the hottest period daily in the MF barn was significantly lower, while relative humidity was higher than that of the NS barn. The temperature humidity index (THI) in both barns ranged from 79-85 throughout the periods of study. Cows in the MF barn showed a lower rectal temperature and respiration rate as compared with cows in the NS barn. The effect of rbST administration increased both rectal temperature and respiration rates of cows housed in either the NS or MF barn. Milk yield significantly increased in cows treated with rbST in all stages of lactation. Increases in mammary blood flow, accompanied by increases of total body water (TBW), extracellular fluid (ECF), blood volume (BV) and plasma volume (PV), were observed in both groups of cows receiving rbST in all stages of lactation. No alterations of renal blood flow and glomerular filtration rate were observed in cows receiving rbST, but decreases in urinary excretion and fractional excretion of sodium, potassium and chloride ions appeared to correlate with reduction in the rate of urine flow and osmolar clearance during rbST administration. These results suggest that the effect of rbST supplementation to cows housed either in NS or MF barns on body fluid volume expansion is attributable to changes in the rate of electrolyte excretion by the kidney. The increased availability of renal tubular reabsorption of sodium, potassium and chloride ions during rbST treatment was a major factor in retaining body water through its colligative properties in exerting formation of an osmotic force mechanism.

• 대한토목학회논문집
• /
• 제35권2호
• /
• pp.417-426
• /
• 2015

도로 기하구조를 구성하는 설계요소에는 대표적으로 종단경사, 평면곡선반경, 편경사, 완화곡선 등이 있다. 이러한 도로 기하구조의 설계요소들은 도로의 기능별로 설계기준이 제시되어 있으며, 설계기준의 범위 안에서 다양한 조합을 통해 설계된다. 본 연구에서는 다양한 조합을 통해 건설된 고속도로를 종단경사와 평면곡선반경을 기준으로 동질구간으로 분할한 후 분석에 필요한 자료를 매칭하였으며, 구축된 자료를 활용하여 종단경사와 평면곡선반경에 대한 안전성능함수를 구축하고, 교통사고 노출률을 설명할 수 있는 사고수정계수를 산출하였다. 평면곡선반경 R=1,000m를 기준(1.0)으로 설정한 후 산출한 R=300m의 사고수정계수는 1.33으로 사고노출률이 33% 증가하는 것으로 나타났다. 또한, 종단경사 0%를 기준(1.0)으로 설정한 후 오르막 경사와 내리막 경사에 대한 사고수정계수를 산출한 결과, 오르막 경사에서는 사고노출률이 감소하고 내리막 경사에서는 사고노출률이 증가함을 확인하였다. 본 연구의 결과는 향후 고속도로의 신설 및 개량 노선의 사업시행 전 선형설계 시 기초자료로 활용이 가능할 것으로 판단된다.

• 산업경영시스템학회지
• /
• 제27권3호
• /
• pp.90-96
• /
• 2004

The objective of this study was to develop a model for safe work load based on a physiological model of metabolic energy of manual material handling tasks. Fifteen male subjects voluntarily participated in this study. Lifting activities with four different weights, 0, 8, 16, 24kg, and four different working frequencies (2, 5, 8, 11 lifts/min) for a lifting range from floor to the knuckle height of 76cm were considered. Oxygen consumption rates and heart rates were measured during the performance of sixteen different lifting activities. Simplified predictive equations for estimating the oxygen consumption rate and the heart rate were developed. The oxygen consumption rate and the heart rate could be expressed as a function of task variables; frequency and the weight of the load, and a personal variable, body weight, and their interactions. The coefficients of determination ($r^2$) of the model were 0.9777 and 0.9784, respectively, for the oxygen consumption rate and the heart rate. The model of oxygen consumption rate was modified to estimate the work load for the given oxygen consumption rate. The overall absolute percent errors of the validation of this equation for work load with the original data set was 39.03%. The overall absolute percent errors were much larger than this for the two models based on the US population. The models for the oxygen consumption rate and for the work load developed in this study work better than the two models based on the US population. However, without considering the biomechanical approach, the developed model for the work load and the two US models are not recommended to estimate the work loads for low frequent lifting activities.