• Environmental Analysis Health and Toxicology
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• 제1권1호
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• pp.81-86
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• 1986

$^{14}$ C로 표지된 $N^{G}$ -mono［$^{14}$ C-methyl］-L-arginine을 흰쥐에 경구투여 하여 7일동안에 66.3%의 방사능이 회수되었다. 회수된 총방사능의 86.2%는 처음 24시간내에 배설되었으며, 그 분포는 산성 물질, 염기성물질, 중성물질 및 회수된 $N^{G}$ -monomethyl-L-arginine에 서 각각 33.3%, 40.2%, 12.5% 및 0.3%이었다. 중성물질 방사능의 약 50%는 N-monomethylurea에 해당하며 이는 투여한 전체방사능의 6%이었다.

• Journal of Nutrition and Health
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• 제31권6호
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• pp.1031-1038
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• 1998

The present study was carried out to investigate the effects of magnesium supplement levels and periods on calcium, magnesium, and phosphorus metabolism in male Sprague-Dawley rats given low protein and magnesium deficient diets for 2 weeks. Serum calcium content was significantly lower in the magnesium supplement group than in the magnesium-deficient group, but calcium excretion in urine and feces was significantly increased as magnesium level and period was increased. Increasing the dietary magnesium level and periods raised serum content and excretion of magnesium in urine k feces. Urinary excretion of phosphorus in two week group was significantly lower in the magnesium supplement group than in the magnesium-deficient group. fecal phosphorus excretion in supplement group (Mg 800mg/kg diet) was significantly higher than that of other group. (Korean J Nutrition 31(6) : 1031-1038, 1998)

• 생약학회지
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• 제31권3호
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• pp.364-372
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• 2000

The Youngkaechulgamtang(Y) is composed of four herbal drugs, including Hoelen(H), Cinnamomi Ramulus(C), Atractylodis Rhizoma Alba(A) and Glycyrrhizae Radix(G). In oriental medicine literatures, Youngkaechulgamtang is described to be effective in headache, inflammation, uremia, gastritis, diarrhea, hypertension. To estimate the clinical effectiveness of Youngkaechulgamtang, several pharmacological experiments were carried out. The results are summarized as follows: On $HgCl_2-induced$ renal failure rat, Youngkaechulgamtang showed the significant increase of $Na^+,\;K^+,\;Cl^-$ contents in urine and the significant decrease of creatinine and BUN concentrations in serum. Youngkaechulgamtang was more effective than mixture of 4 ingredients in the urine volume and excretion of electrolytes. In the diuretic effect, Hoelen and Atractylodis Rhizoma Alba were more effective than other drugs.

• Korean Journal of Acupuncture
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• 제27권2호
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• pp.121-140
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• 2010

Objectives & Methods : The purpose of this study is to observe the effects of Bupleuri Radix Herbal-acupuncture at GB34(Yangneungcheon) of hyperlipidemic rats. The author performed several items to analyze body-weight of the rats, weight of its liver, serum as well as urine changes in each group. Results : 1. Bupleuri Radix herbal-acupuncture(BR-HA) infused solution (MCR-HAS) increased both DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. BR-HA at GB34 significantly decreased the level of serum total cholesterol and atherogenic index(AI), while significantly increased the ratios of high-density lipoprotein (HDL)/total cholesterol and phospholipid/total cholesterol in hyperlipidemic rats. 3. BR-HA at GB34 significantly decreased urine glucose in hyperlipidemic rats. Conclusions : From the results above, it is suggested that Bupleuri Radix herbal -acupuncture at GB34 has a therapeutic effect on hyperlipidemia.

• Archives of Pharmacal Research
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• 제7권1호
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• pp.65-68
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• 1984

Mechanism of the monoamine oxidase inhibition by tranylcypromine was studied in relation to its metabolism to reactive apecies. A metabolic study performed to collect general biotransformation pathway in rats provided GC/MS evidence for the detection of two new metabolites, N-acetyl and hydroxylated N-acetyltranylacypromine.

• Archives of Pharmacal Research
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• 제7권2호
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• pp.141-143
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• 1984

A metabolic study was performed in order to characterize the in vivo MAO-inhibitory activity of benzyl trans-2-phenylcylopropanecarbamate which was reported to be twice as potent as the tranylcypromine. In the rat urine which was obtained after the administration of the benzyl trans-2-pheny-lcyclopropanecarbamate (40mg/kg) through oral route, a metabolic product, tranylcypromine as well as the intact drug was detected by GC/MS.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.130.1-130.1
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• 2003

The metabolism of a novel anticancer agent 1-{3- [3-(4-Cyano -benzyl)-3H-imidazol-4-yl]-propyl }-3-(6-methoxy-pyridin-3-yl)-1-(2-trifluoromethyl-benzyl)-thiourea (YH3945) were investigated in the Sprague-Dawley rat after single oral and i.v. administration of [14C]-YH3945. Bile, feces, urine and plasma were collected and analyzed by an HPLC system equipped with multiple detectors. (omitted)

• 약학회지
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• 제35권6호
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• pp.504-508
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• 1991

In order to investigate whether the function of distal nephron is disturbed in adenine-induced renal failure rats, we measured the urinary kallikrein level in adenine-ingesting rats fed on 0.75% adenine diet for 1 to 10 days. Administration of 0.75% adenine to rats significantly increased blood urea nitrogen level and urine volume, while the level of kallikrein along with the urinary excretions of urea and inorganic phosphate were significantly decreased. From these results, it is suggested that adenine-induced renal failure is caused by early deterioration of distal nephron as well as proximal nephron.

• Biomolecules & Therapeutics
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• 제4권4호
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• pp.349-353
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• 1996

The present study examined pharmacokinetic profiles of KBP31705-Cl27 and KBP30603-901, new platinum coordination complexes synthesized as anticancer candidates, in comparison with two well-known platinum-containing anticancer agents, cisplatin and carboplatin in rats. Under sodium pentobarbital anesthesia of male Sprague-Dawley rats, urinary bladder, and femoral artery and vein were catheterized for urine collection, blood sampling and drug injection, respectively Following i.v. administration of cisplatin (2 mg/kg), KBP31705-C127 (2 mg/kg), carboplatin (20 mg/kg) or KBP30603-901 (20 mg/kg), blood samples were collected at 2, 4, 6, 8, 10, 15, 20, 30, 45, 60 and 120 minutes. Urine samples were collected at 1-hr interval for 4 hr. Platinum concentrations in plasma and urine were measured using an inductively coupled plasmamass spectrometer. The plasma concentration-time curves were biphasic for all drugs during the time period studied. Compared with cisplatin, KBP31705-C127 showed similar decay patters in the alpha- and betaphases with slightly lower plasma concentrations. Urinary platinum excretion for cisplatin and KBP31705-C 127 was 56 and 52% of the administered dose in 4 hr, respectively. With regard to carboplatin and KBP 30603-901, a similar decay pattern was also observed in the alpha-phase. The half life of KBP30603-901 in the beta-phase, however, was much longer than that of carboplatin, which was consistent with the urinary excretion results that 46 and 59% of the administered dose were excreted in the urine in 4hr, respectively. The results suggest that platinum coordination complexes are primarily excreted via the renal route and KBP30603-901 can elicit longer duration of action due to slower renal excretion compared to carboplatin.

• 한국임상수의학회지
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• 제20권4호
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• pp.449-457
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• 2003

To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.