YAKHAK HOEJI (약학회지)
- Volume 35 Issue 6
- /
- Pages.504-508
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- 1991
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Urinary Change of Kallikrein in Adenine-Induced Renal Failure Rat
Adenine 유발 신부전 흰쥐에서의 뇨중 Kallikrein의 변화
- Lee, Tae-Woong (College of Pharmacy, Pusan National University) ;
- Seo, Suk-Soo (College of Pharmacy, Pusan National University) ;
- Lee, Kyung-Hee (College of Pharmacy, Pusan National University) ;
- Young, Han-Suk (College of Pharmacy, Pusan National University) ;
-
Chung, Joon-Ki
(Department of Fish Pathology, National Fisheries University of Pusan)
;
-
Choi, Jae-Sue
(Department of Nutrition and Food Science, National Fisheries University of Pusan)
- 이태웅 (부산대학교 약학대학) ;
- 서석수 (부산대학교 약학대학) ;
- 이경희 (부산대학교 약학대학) ;
- 양한석 (부산대학교 약학대학) ;
-
정준기
(부산수산대학교 어병학과)
;
-
최재수
(부산수산대학교 식품영양학과)
- Published : 1991.12.28
Abstract
In order to investigate whether the function of distal nephron is disturbed in adenine-induced renal failure rats, we measured the urinary kallikrein level in adenine-ingesting rats fed on 0.75% adenine diet for 1 to 10 days. Administration of 0.75% adenine to rats significantly increased blood urea nitrogen level and urine volume, while the level of kallikrein along with the urinary excretions of urea and inorganic phosphate were significantly decreased. From these results, it is suggested that adenine-induced renal failure is caused by early deterioration of distal nephron as well as proximal nephron.