• CELLMED
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• v.8 no.3
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• pp.15.1-15.5
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• 2018

Helminthiasis is one of the most common worm diseases which causes a range of adverse health problems in humans. Ayurveda is one of the most prominent and ancient systems of traditional medicines in India. Most Ayurvedic drugs used against intestinal helminths have been developed by traditional wisdom and therefore lack a proper validation through controlled studies. The aim of the present study was to scientifically validate the in vitro efficacy of three common Indian Ayurvedic anthelmintic drugs, viz. Krimimudgar Ras, Kriminol and Vidangasava in relation to the synthetic broad-spectrum anthelmintic drugs, praziquantel and albendazole. The in vitro testing of Ayurvedic anthelmintics was done against an intestinal cestode, Raillietina sp. and a nematode, Syphacia obvelata, employing 10 mg/ml, 30 mg/ml and 50 mg/ml concentrations of each medicine. The anthelmintic efficacy was judged on the basis of paralysis and mortality time of worms after exposing to these Ayurvedic drugs. Of the three tested Ayurvedic medicines, Krimimudgar ras (KR) showed the most prominent efficacy, against both the cestode and nematode parasites. At 50 mg/ml concentration, KR caused mortality of cestodes in $7.53{\pm}0.15hr$, and of nematodes in $7.61{\pm}0.19hr$. Vidangasava was found to be comparatively less effective against the tested helminth parasites. The results of this study indicate that Ayurvedic formulations do possess significant anthelmintic effects, however, an evidence-based research is required to validate all currently used Ayurvedic anthelmintics, using proper controlled studies.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.1138-1142
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• 2005

The tidal river is a river affected by tide, which causes the water level to rise and fall two times everyday periodically. The local velocity across the river could be very fast because of the cross-sectional characteristics of the river even though it's not a rainy season. Therefore extreme local scour could take place around hydraulic structures such as piers and caissons due to backward flow velocity. For the construction of pier foundation of Ilsan-bridge In the Han River, the field observations were performed to get the velocity and water level. The numerical analysis was performed by HEC-RAS(UNET). The relationship between measured maximum velocity and calculated mean velocity is achieved, which is used to estimate the velocity and water level as the construction is proceeding. Countermeasures for scour were designed with the results of the hydraulic analysis to avoid potential damage during construction work. According to the results of monitoring, the velocity increase after temporary road embankment was negligible, from which it is considered that the degradation of main channel compensated for the constriction of cross-section by embankment.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.900-904
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• 2009

연구에서는 HEC-RAS 모형을 이용한 부등류 모의를 통하여 댐 방류수의 유하시간을 산정하고 이를 실시간 댐 방류수의 봉부자 추적실험에서 산정된 유하시간과 비교검증 하였다. 대상구간은 충주댐지점부터 여주대교까지 총 63.6km에 이르는 남한강 본류 구간으로 164개 단면으로 나누어 부등류 모의를 하였다. 유하시간 실험은 센서가 내장된 봉부자를 최초 시작지점에 투척하여 주요 교량에서 봉부자를 관측하여 최초 투척된 시간으로부터 교량을 통과하는 시간을 관측하는 방법을 사용하였다. HEC-RAS 부등류 모의 결과 2007년 8월 7일 방류량(680CMS)의 유하시간은 약 13시간으로 산정되었고 봉부자 추적자 실측자료를 통한 유하시간은 11.5시간으로 산정되어 실측치가 모의치보다 유하시간이 빠른 것으로 나타났다. 구간별로 살펴보면 HEC-RAS 모형의 모의결과는 수행교에서 충주조정지는 1.4시간 느리게, 목계교에서 남한강교는 1.0시간 빠르게 모의되었으나 나머지 구간에서는 실측치와 대체로 일치하였다. 본 연구는 유하시간 실험 구간 및 구간과 동일한 조건으로 모의함으로서 모형을 보정하기 위한 실측 유하시간 자료를 확보하였으며, 이러한 실측자료를 토대로 보정된 모형의 매개변수를 이용함으로서 대상 수계의 방류량별 유하시간을 산정하는데 정확성을 제고하고 홍수기 댐 운영 및 홍수예경보에 반영될 수 있을 것으로 기대된다.

• Journal of The Korean Society of Agricultural Engineers
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• v.46 no.5
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• pp.107-116
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• 2004

A GIS-based paddy inundation simulation system which is capable of simulating temporal and spatial inundation processes was established and applied in this paper. The system is composed of HEC-GeoHMS, and HEC-GeoRAS modules which interface the GIS and flood runoff models, and HEC-HMS, and HEC-RAS models which estimate the flood runoff. It was used to simulate storm runoff and inundation for a small rural watershed, the Baran HP#7, which is 10.69 $km^2$ in size. The simulated peak runoff, time to peak, and total direct runoff for eight storms were compared with the observed data. The results showed that the coefficient of determination ($R^2$) for the observed peak runoff was 0.99 and an error, RMSE, 11.862 $m^3$/s for calibration stages. In the model verification, $R^2$ was 0.99 and RMSE 1.296 $m^3$/s. Paddy inundation for each paddy growing stages in study watershed were estimated using verified inundation simulation system when probability rainfall was applied.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.4
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• pp.684-690
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• 2003

In this paper, a contention-based reservation access control algorithm and a slot allocation algorithm are proposed for non-real-time bursty traffic services in the wireless ATM networks. In order to reduce the collisions of the reservation request packets, the base station scheduler calculates the transmission probability using the number of RAS minislots and the estimated load of the reservation request packets. And it broadcasts the calculated transmission probability over the downlink control channel. Mobile terminals, which have traffic burst, select randomly a RAS minislot and transmit the reservation request packet by the received transmission probability. The reservation request packet contains the number of packets in the buffer. The slot allocation is based on the buffer status of the received reservation request packets. The base station scheduler allocates slots in proportion to the total number of slots that are requested by each terminal.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.100-100
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• 2011

최근 지구온난화와 같은 기상이변으로 인하여 많은 재해가 유발되고 있으며, 태풍이나 집중호우와 같은 강우현상으로 하천의 범람 등의 홍수피해가 해마다 증가하고 있다. 이러한 가운데 하천에서의 홍수 피해 발생을 예방하기 위한 방법의 하나로 홍수 예 경보 시스템의 구축이 있으며, 우리나라에서는 1974년부터 한강홍수통제소에서 홍수 예 경보 시스템을 구축하여 운영하고 있다. 남한강 유역의 경우 북한강보다 유역면적은 1.6배 넓지만 홍수조절능력을 지닌 구조물로는 충주댐이 유일하며, 충주댐의 저수량은 북한강의 소양강댐보다도 적기 때문에 북한강보다 홍수의 위험이 더 높다고 볼 수 있다. 이에 충주댐에서의 저수위와 방류량은 남한강 유역의 홍수발생에 직접적 영향을 미치며, 실제로 2006년 집중호우 당시 상류의 단양지역과 하류의 여주지역에서는 충주댐의 저수위와 방류량 운영을 두고 많은 논쟁이 야기된 적이 있었다. 본 연구에서는 남한강 유역의 홍수 예 경보 활용을 위하여 HEC-RAS 모형을 이용한 수리학적 모형을 구축하였다. 수리학적 모형을 구축하기 위해 하도측량 자료와 하천정비기본계획서를 이용하여 모형의 단면을 구축하였다. 또한 모형의 정확성을 위하여 최근 가장 큰 홍수피해가 발생한 2006년 홍수사상 자료를 이용하여 모형의 보정을 실시하였으며, 적용성과 신뢰성 검토를 위하여 2003년~2005년, 2007년~2008년에 발생한 홍수사상 자료를 이용하여 모형의 검증을 실시하였다.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.7
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• pp.1309-1314
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• 2007

The assignment of cells to reporting or non-reporting cells is an NP-hard problem having an exponential complexity in the Reporting Cell Location Management (RCLM) system. Frequent location update may result in degradation of quality of service due to interference. Miss on the location of a mobile terminal will necessitate a search operation on the network when a call comes in. The number of reporting cells and which cell must be reporting cell should be determined to balance the registration (location update) and search (paging) operations to minimize the cost of RCLM system. T1is paper compares Max-Min ant system (MMAS), rank-based ant system (RAS) and hybrid method of MMAS and RAS that generally used to solve combinatorial optimization problems. Experimental results demonstrate that hybrid method of MMAS and RAS is an effective and competitive approach in fairly satisfactory results with respect to solution quality and execution time for the optimal design of location management system.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.106-106
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• 2001

Matrix metalloproteases (MMPs) 는 다양한 세포에서 전이와 침윤성에 중요한 역할을 한다. MMP의 내인성 저해제인 tissue inhibitor of motalloprotease-2 (TIMP-2) 는 MMP-2에 높은 특이성을 지닌다. MMP-2와 TIMP-2사이의 불균형은 침윤성과 전이와 같은 병리학적 과정과 관계되는 extracellular matrix (ECM)의 퇴화를 일으킨다. TIMPs는 분비되는 분자이기 때문에 특정한 암의 유전자 치료에 사용될 가능성을 지닌다. 본 연구에서는 MMP-2가 H-ras에 의해 유도된 침윤성에 책임지는 것으로 보여지는 H-ras MCF10A 세포에 TIMP-2 유전자를 함유하는 retrovirus를 이용하여 연구하였다. TIMP-2 유전자를 함유하는 재조합 retrovirus는 PG13 세포를 infection 시키는데 사용되었다. H-ras MCF10A 세포는 PGl3 세포의 conditioned media로 처리되었을 때, gelatin zymography에서 MMP-2의 분비가 농도의존적으로 저해되었다. 또한 retrovirus에 의한 TIMP-2의 과잉 발현은 농도의존적으로 H-ras MCF10A 세포의 침윤성과 이동성을 상당히 감소시킨다. 이와 같은 실험 결과는 TIMP-2가 H-ras MCF10A 세포에서 MMP-2 분비와 세포의 침윤성, 이동성을 감소시키는 역할을 지닌다는 것과 TIMP-2 유전자를 함유하는 retrovirus가 효과적으로 MMP-2 분비, 세포 침윤성, 세포 이동성을 감소시켰다는 것을 보여 준다. 이는 암의 예방과 치료를 위한 유전자 치료법의 적용에 상당한 가능성을 제시한다.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4511-4515
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• 2016

Background: K-RAS and N-RAS gene mutations cause resistance to treatment in patients with colorectal cancer. Based on this, awareness of mutation of these genes is considered a clinically important step towards better diagnosis and appropriate treatment. Materials and Methods: Fifty paraffin-embedded blocks of colorectal cancer were obtained from Imam Reza Hospital of Birjand, Iran. Following DNA extraction, the samples were analyzed for common mutations of exons 2, 3 and 4 of KRAS and NRAS genes using real time PCR and pyrosequencing. Results: According to this study, the prevalence of mutations was respectively 28% (14 out of 50) and 2% (1 out of 50) in KRAS and NRAS genes. All the mutations were observed in patients >50 years old. Conclusions: Mutations were found in both KRAS and NRAS genes in colorectal cancers in Iranian patients. Determining the frequency of these mutations in each geographical region may be necessary to benefit from targeted cancer therapy.

• Journal of Environmental Science International
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• v.25 no.1
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• pp.41-56
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• 2016

In recent localized heavy rainfalls have been arising from abnormal climate change. People are concerning about damages with increasing the frequency of flooding. Therefore, we need to understand river hydraulic characteristics and management to reduce damage from flooding. To study hydraulic characterization of Sincheon experimental catchment HEC-RAS (Hydrologic Engineering Center River Analysis System) model which provided by U.S Army Corps of Engineers (USACE) was applied. This study analyzed and compared water level the frequency flood for 100 years and 200 years by clark unit Hydrography. The change of the water level of Daejeon bridge, Sincheon bridge and Singi bridge showed increased for all conditions. The flow rate for the Daejeon bridge and the Sincheon bridge showed an increase, but the Sinki bridge showed a decreasing flow rate overally, except for 1hour-100 years. The verification result showed that the model was able to simulate the water level with 0.4709 coefficient of determination and error ration ranging from 1 to 3%.