• Asian-Australasian Journal of Animal Sciences
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• 제18권8호
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• pp.1088-1097
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• 2005

Main objectives of this study were to investigate accuracy, bias and power of linear and threshold model segregation analysis methods for detection of major genes in categorical traits in farm animals. Maximum Likelihood Linear Model (MLLM), Bayesian Linear Model (BALM) and Bayesian Threshold Model (BATM) were applied to simulated data on normal, categorical and binary scales as well as to disease data in pigs. Simulated data on the underlying normally distributed liability (NDL) were used to create categorical and binary data. MLLM method was applied to data on all scales (Normal, categorical and binary) and BATM method was developed and applied only to binary data. The MLLM analyses underestimated parameters for binary as well as categorical traits compared to normal traits; with the bias being very severe for binary traits. The accuracy of major gene and polygene parameter estimates was also very low for binary data compared with those for categorical data; the later gave results similar to normal data. When disease incidence (on binary scale) is close to 50%, segregation analysis has more accuracy and lesser bias, compared to diseases with rare incidences. NDL data were always better than categorical data. Under the MLLM method, the test statistics for categorical and binary data were consistently unusually very high (while the opposite is expected due to loss of information in categorical data), indicating high false discovery rates of major genes if linear models are applied to categorical traits. With Bayesian segregation analysis, 95% highest probability density regions of major gene variances were checked if they included the value of zero (boundary parameter); by nature of this difference between likelihood and Bayesian approaches, the Bayesian methods are likely to be more reliable for categorical data. The BATM segregation analysis of binary data also showed a significant advantage over MLLM in terms of higher accuracy. Based on the results, threshold models are recommended when the trait distributions are discontinuous. Further, segregation analysis could be used in an initial scan of the data for evidence of major genes before embarking on molecular genome mapping.

• 한국방사선학회논문지
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• 제12권2호
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• pp.173-178
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• 2018

병원에서 방사선을 차폐하는데 있어 납은 매우 유용하게 사용되고 있다. 하지만 납은 독성을 가지고 있고 대체물질에 대한 연구가 많이 이루어지고 있으며, 대표적으로 텅스텐을 대체물질로 한 연구가 많이 이루어지고 있다. 이에 본 연구에서 납과 텅스텐의 물리적 특성 및 반가층 실험을 진행한 결과 원자번호가 높은 납 원소의 반응단면적이 텅스텐에 비해 높게 나타났으나, 텅스텐의 밀도가 높아 동일한 크기일 경우 텅스텐의 전자밀도가 납에 비해 약 1.7배 높은 것으로 나타났다. MCNPX를 이용한 모의 모사에서도 에너지 따라 다소 차이가 있지만 텅스텐이 납에 비해 약 1.4배 차폐효과가 높은 것으로 나타났으며, 텅스텐이 납에 비해 우수한 차폐효율을 갖고 있는 것으로 확인 되었다. 하지만 경제적 측면을 고려할 때 텅스텐은 희소금속으로 납에 비해 가격이 약 25배 높아 납에 대한 대체물질로는 부적당한 것으로 사료되었다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.167-167
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• 2010

Indium tin oxide (ITO) has been widely used as transparent conductive oxides (TCOs) for transparent electrodes of various optoelectronic devices, such as liquid crystal displays (LCD) and organic light emitting diodes (OLED). However, indium has become increasingly expensive and rare because of its limited resources. In addition, ITO thin films have some problems for OLED and flexible displays, such as imperfect work function, chemical instability, and high deposition temperature. Therefore, multi-component TCO materials have been reported as anode materials. Among the various materials, IZTO thin films have been gained much attention as anode materials due to their high work function, good conductivity, high transparency and low deposition temperature. IZTO thin films with a thickness of 200nm were deposited on Corning glass substrate at different substrate temperature by pulsed DC magnetron sputtering with a sintered ceramic target of IZTO (In2O3 70 wt%, ZnO 15 wt%, SnO2 15 wt%). We investigated the electrical, optical, structural properties of IZTO thin films. As the substrate temperature is increased, the electrical properties of IZTO are improved. All IZTO thin films have good optical properties, which showed an average of transmittance over 80%. These IZTO thin films were used to fabricate organic light emitting diodes (OLEDs) as anode and the device performances studied. As a result, IZTO has utility value of TCO electrode although it reduced indium and we expect it is possible for the IZTO to apply to flexible display due to the low processing temperature.

• 한국환경농학회지
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• 제39권3호
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• pp.228-236
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• 2020

BACKGROUND: The closed chamber method is the most commonly used for measuring greenhouse gas emissions from rice fields. This method has the advantages of being simple, easily available and economical. However, a measurement result using the chamber method is an estimated value and is complete when the uncertainty is estimated. The methane emissions from a rice paddy account for the largest portion of the greenhouse gas emissions in the agriculture sectors. Although assessment of uncertainty components affecting methane emission from a rice paddy is necessary to take account of dispersion characteristics, research on these uncertainty components is very rare to date. The goal of this study was to elucidate influencing factors on measurement uncertainty of methane concentrations measured by a closed automated chamber system from a rice paddy. METHODS AND RESULTS: The methane sampling system is located in the rice paddy in Gyeonggi-do Agricultural Research and Extension Services (37°13'15"N, 127°02'22"E). The primary measurement uncertainty components influencing methane concentrations (influencing factors) investigated in this research were repeatability, reproducibility and calibration in the aspects of methane sampling and analytical instrumentation. The magnitudes of the relative standard uncertainty of each influencing factor were quantified and compared. CONCLUSION: Results of this study showed what influencing factors were more important in determination of methane concentrations measured using the chamber system and analytical instrumentation located in the monitoring site. Quantifying the measurement uncertainty of the methane concentrations in this study would contribute to improving measurement quality of methane fluxes.

• 디지털융복합연구
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• 제14권3호
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• pp.243-250
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• 2016

글로벌 시장에서 플랫폼비즈니스의 중요성이 높아지고 있지만 국내에서는 글로벌 경쟁력을 갖춘 플랫폼비즈니스가 출현하지 않고 있다. 이에 따라 본 연구는 국내 플랫폼비즈니스와 글로벌 플랫폼비즈니스의 6가지 성공요소에 대한 경쟁력을 비교 분석하였다. 이를 위해 국내 ICT 분야 종사자 104명을 대상으로 SNS서비스(카카오톡 페이스북), 모바일결제 시스템(삼성페이 애플페이), 디지털 콘텐트(네이버 유투브), 직접구매(G마켓 아마존), 교육(K-MOOC MOOC) 등의 경쟁력을 설문 조사했다. 그 결과 국내 플랫폼비즈니스는 미국의 비즈니스에 비해 창조역량과 새로운 가치 창출, 비용 절감과 네트워크 효과, 새로운 생태계를 조성, 끊임없이 변화하고 진화하는 역량이 열세인 것으로 나타났다.

• Bulletin of the Korean Chemical Society
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• 제29권4호
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• pp.805-810
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• 2008

Using metallic Ti powder as raw materials and 1,2-diaminocyclohexane (DACH) as the trial template, two novel reduced titanophosphate open-structures were hydrothermally isolated by varying the $H_3PO_4/H_2O$ ratio to adjust the pH value. TiPO-1 crystallizes in orthorhombic Pbca space group with cell parameters a = 21.956(3) $\AA$, b = 8.6268(11) $\AA$, c = 7.2883(9) $\AA$, V = 1380.5(3) $\AA^3$, Z = 4. TiPO-2 crystallizes in triclinic space group P$\bar{1}$ with parameters a = 5.1620(10) $\AA$, b = 8.815(2) $\AA$, c = 10.655(3) $\AA$, $\alpha$ = $99.45^{\circ}$, $\beta$ = $102.94^{\circ}$, $\gamma$ = $91.06^{\circ}$, V = 465.34 $\AA^3$. TiPO-1 is constructed by infinite -Ti-O-Ti-O- linkage that is capped by $PO_4$ groups to form a chain structure with protonated DACH molecules occupying the interchain spaces. TiPO-2 represents a rare 3-D reduced titanophosphate with 12-MR channels. The structure of TiPO-2 is a neutral framework with water molecules located in the channels.

• Journal of Genetic Medicine
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• 제15권1호
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• pp.28-33
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• 2018

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by the deficiency of ${\alpha}$-galactosidase A. Patients with classical FD present acroparesthesia, hypohidrosis, cornea verticillata, disseminated angiokeratoma, and microalbuminuria in childhood, and develop life-threatening renal, cardiac, and cerebrovascular complications typically after the fourth decade of life. To date, more than 700 mutations responsible for FD have been identified in the human GLA gene. Herein, we report a novel GLA mutation, c.1117_1141del25 (p.Gly373Profs*10), identified in an 11-year-old Korean boy with FD presenting early cardiac and neurologic manifestation and in other affected family members. The boy had acroparesthesia, hypohidrosis, cornea verticillata, and left ventricular hypertrophy. His mother and sister also had acroparesthesia. Two males on the mother's side had similar pain and died of unknown causes. The plasma ${\alpha}$-galactosidase A activity (4.1 nmol/hr/mg protein) of the patient was markedly lower than the mean value of the controls. The plasma level of globotriaosylsphingosine was elevated in the patient and all the carriers. We concluded the novel GLA mutation c.1117_1141del25 is a pathogenic mutation for FD, probably related to the early cardiac manifestation of FD.

• 융합정보논문지
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• 제10권11호
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• pp.117-130
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• 2020

본 연구는 웹툰 및 웹소설 기업인 카카오 페이지의 사례를 관찰하여, 문화 콘텐츠 산업 시장에서 롱-테일 전략과 기업의 역량과의 관계에 대해서 밝히고 있다. 본 연구는 카카오 페이지의 다양한 확장 전략에 대해 조사하였으며, VRIO 분석 방식을 통해 전략의 강점을 조사하였다. 카카오 페이지의 가장 큰 강점은 66,000개에 이르는 제품의 양이며, 롱-테일로서의 메리트를 얻게 할 뿐만 아니라, 수직적 통합과 다양한 확장 전략의 핵심이 된다. 이 연구는 시장에 접근하려는 플랫폼 콘텐츠 기업에게 다양한 제품을 확보할 역량이 필수적임을 지적함과 동시에, 콘텐츠 플랫폼 및 롱-테일에 관련한 후속 연구의 필요성을 촉구한다.

• 디지털융복합연구
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• 제18권8호
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• pp.97-102
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• 2020

본 논문에서는 한·중 양국의 다양해진 문화관광산업에 대해 개념 정리를 하고 이를 통해 연구방향을 제시하였다. 또한 문화관광산업의 특징과 현황을 분석하였다. 한·중 양국의 문화관광산업의 특징으로 공연, 테마파크, 축제, 박물관 등 유사한 문화관광 형태를 보였으며, 한국은 한류문화관광이라는 특유의 문화관광 형태가 있었고, 중국 또한 한국에서 희소한 문화예술 단지를 세워 문화관광을 발전시켜 왔다. 한국 문화관광산업의 강점은 문화자원이 풍부하며 문화적 내용을 담은 많은 자산을 보유하고 있었으며, 중국 문화관광산업의 강점은 풍부한 관광자원과 거대한 경제력을 갖추고 있다는 점이다. 이와 같이 유사점이 많은 한·중 양국은 미래 고부가가치 산업으로 성장하는 문화관광산업에 많은 관심과 가능성이 높은 나라임을 알 수 있었다. 아울러 문화관광산업을 지속적이고 안정적으로 발전시키기 위해서는 양국이 서로 상생할 수 있도록 부단한 노력과 관심, 그리고 그에 합당한 연구가 진행 되어야 할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제72권1호
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• pp.72-76
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• 2012

We observed a very rare case of primary lung cancer producing alpha-fetoprotein (AFP). A 70-year-old male with a history of smoking 50 packs per year was diagnosed with large cell carcinoma of the lung. The clinical stage was T2bN3M0 (IIIB), and serum AFP was 23,247 ng/mL. There was no evidence of metastasis to the liver, scrotum or other organs. While undergoing chemotherapy for 1 year, as the cancer progressed the AFP value steadily increased. The patient died of respiratory failure due to pneumonia 12 months after being diagnosed with lung cancer.