Browse > Article
http://dx.doi.org/10.4046/trd.2012.72.1.72

A Case of Primary Lung Cancer Producing Alpha-fetoprotein  

Yu, Ji-Hyun (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Ahn, Joong-Hyun (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Chung, Han-Hee (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Kim, Young-Wook (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Yu, Jin-Sok (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Kim, Ju-Sang (Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.72, no.1, 2012 , pp. 72-76 More about this Journal
Abstract
We observed a very rare case of primary lung cancer producing alpha-fetoprotein (AFP). A 70-year-old male with a history of smoking 50 packs per year was diagnosed with large cell carcinoma of the lung. The clinical stage was T2bN3M0 (IIIB), and serum AFP was 23,247 ng/mL. There was no evidence of metastasis to the liver, scrotum or other organs. While undergoing chemotherapy for 1 year, as the cancer progressed the AFP value steadily increased. The patient died of respiratory failure due to pneumonia 12 months after being diagnosed with lung cancer.
Keywords
alpha-Fetoproteins; Lung Neoplasms; Carcinoma, Large Cell;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Gitlin D, Perricelli A, Gitlin GM. Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 1972;32:979-82.
2 Ruoslahti E, Seppälä M. alpha-Fetoprotein in cancer and fetal development. Adv Cancer Res 1979;29:275-346.
3 Javadpour N. The National Cancer Institute experience with testicular cancer. J Urol 1978;120:651-9.
4 Adachi Y, Tsuchihashi J, Shiraishi N, Yasuda K, Etoh T, Kitano S. AFP-producing gastric carcinoma: multivariate analysis of prognostic factors in 270 patients. Oncology 2003;65:95-101.
5 Chang YC, Nagasue N, Kohno H, Taniura H, Uchida M, Yamanoi A, et al. Clinicopathologic features and long-term results of alpha-fetoprotein-producing gastric cancer. Am J Gastroenterol 1990;85:1480-5.
6 O'Conor GT, Tatarinov YS, Abelev GI, Uriel J. A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer 1970;25:1091-8.
7 Liebman HA, Furie BC, Tong MJ, Blanchard RA, Lo KJ, Lee SD, et al. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 1984;310:1427-31.
8 No EJ, Hur JW, Lee SS, Lee YM, Lee HP, Kim JI, et al. A case of alpha-fetoprotien producing adenocarcinoma of the lung. Tuberc Respir Dis 2006;61:70-3.
9 Yasunami R, Hashimoto Z, Ogura T, Hirao F, Yamamura Y. Primary lung cancer producing alpha-fetoprotein: a case report. Cancer. 1981;47:926-9.
10 Saka H, Sakai S, Kondo N, Ito M, Shimokata K. Successful resection of alpha-fetoprotein-producing lung cancer. Chest 1988;94:879-80.
11 Kitada M, Ozawa K, Sato K, Matsuda Y, Hayashi S, Tokusashi Y, et al. Alpha-fetoprotein-producing primary lung carcinoma: a case report. World J Surg Oncol 2011;9:47.
12 Hirota F, Hosaka K, Funahashi K, Oota M, Ikeda A, Oobayashi Y, et al. Effective treatment of AFP-producing lung cancer with UFT. Gan To Kagaku Ryoho 1999;26:381-4.
13 Takahashi Y, Inoue T, Fukusato T. Protein induced by vitamin K absence or antagonist II-producing gastric cancer. World J Gastrointest Pathophysiol 2010;1:129-36.
14 Ishikura H, Kanda M, Ito M, Nosaka K, Mizuno K. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma. Virchows Arch A Pathol Anat Histopathol 1990; 417:73-80.
15 Arnould L, Drouot F, Fargeot P, Bernard A, Foucher P, Collin F, et al. Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein- producing lung tumor. Am J Surg Pathol 1997;21: 1113-8.