• 정보교육학회논문지
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• 제17권1호
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• pp.43-52
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• 2013

로봇은 프로그래밍 교육의 도구로서 창의적 문제해결능력과 논리적 사고력 신장에 효과적이다. 또한 학습자에게 실제적, 조작적 학습경험을 제공하므로 교과학습의 도구로 활용될 때 학습내용의 구체적 이해를 돕고 능동적인 학습참여를 이끌어 낼 수 있다. 본 연구는 초등학교 수학 수업에서 로봇의 도구적 쓰임에 주안을 두고자 한다. 따라서 로봇의 기능 분석, 기능별 교육적 활용 방안 추출 후 4학년 수학교과와 연계된 수업 액티비티를 개발하였다. 로봇활용 수학수업을 10차시 실시한 후 성취도 평가, 학생 호감도 조사하였다. 연구 결과 성취도에서 유의미한 차이는 확인되지 않았다. 하지만 설문에서 로봇이 수학 수업의 흥미와 적극적 수업참여를 이끌어내며 수학개념을 이해하는 데 도움을 준 것으로 나타났다. 면담 결과에서도 기존의 수학수업에선 찾기 힘든 역동적이고 협력적인 의사소통, 체험적, 실천적인 수업 등의 긍정적 반응이 나타났다.

• 대한미생물학회지
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• 제21권2호
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• pp.171-179
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• 1986

The HLA class II region encodes a series of polymorphic glycoproteins that form cell surface heterodimers each consisting of one $\alpha$ and one $\beta$ chain. Thess class II molecules are encoded by genes clustered within three loci. DP, DQ, and DR are functfonally implicated as regulatory signals in intercellular communication during the immune resposes. The phenotypic hallmark of the HLA complex is a high degree of structural and functional polymorphism. Detailed analysis. of such polymorphisms should aid in understanding the molecular basis for associations between HLA and diseases. We have used techniques of restriction enzyme fragment analysis by Southern blotting to investigate polymorphisms associated with DQ $\beta$ class II genes on haplotypes expressing the HLA-DR4 and -DQw3 specificities. The endonucleases Hind III and Bam HI were used to identify a specific DQ $\beta$ genomic polymorphism that precisely corrresponds with the reactivity of a monoclonal antibody A-10-83, previously shown to define a serologic split of DQw3. This study identifies two allelic DQ va. riants. DQw3.1 and DQw3.2. We used these specific genotypic markers to investigate the genomic basis of the association of DR4 with insulin-dependent diabetes mellitus(IDDM) and seropositive juvenile rheumatoid arthritis(JRA). The DR4 positive IDDM demonstrate the predominant expression of DQw3.2 and the very rare expression of DQw3.l. However, in haplotype matched siblings from two IDDM families, all of the DR4 positive siblings display a IDDM-associated DQw3.2 allele. Thus, both affected and healthy individuals can carry the same haplotypes and genomic markers, demonstrating that thess specific allelic variants are genetic elements that indicate a increased risk of IDDM but are not in fact disease specific. We contrasted this result with a similar analysis of patients with another DR4-associated disease, JRA. In contrast to the preponderance of the DQw3.2 allele in IDDM, the JRA patients expressed either the DQw3.1 or the DQw3.2 allele and sometimes both, without apparent association with disease expession. The different genomic markers reported here within HLA-DQ region potentially an analysis of HLA-associated function and disease susceptibility.

• 한국습지학회지
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• 제11권2호
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• pp.17-28
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• 2009

광주광역시 도심 영산강 수계의 관속식물은 91과 265속 386종 49변종 및 2품종으로 총 437분류군이 확인되었다. 수생식물 중 정수식물은 16분류군, 부엽식물은 10분류군, 침수식물은 10분류군, 부유식물은 3분류군 그리고 습생식물은 14분류군으로 총 53분류군이었다. 희귀 및 멸종위기종은 자라풀, 가시연꽃, 낙지다리, 왕벚나무, 좀어리연꽃 등 5분류군이었다. 특정식물종 I급종은 10분류군, II급종 2분류군, III급종 2분류군, IV급종 3분류군 그리고 V급종 5분류군이 확인되었다. 귀화식물은 15과 44속 59종 3변종으로 총 62분류군이 확인되었고 귀화율은 14.19%였다. 환경부 생태계 교란종은 돼지풀, 물참새피 및 도깨비가지 등이었다.

• 한국자원식물학회지
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• 제20권2호
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• pp.201-211
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• 2007

본 연구는 월출산국립공원지역 내 자연휴식년제 구간인 무위사${\rightarrow}$미왕재, 미왕재${\rightarrow}$동원농장, 장군봉 일원에서 확인된 관속식물 중 희귀식물과 특산식물 및 식물구계학적 특정식물, 귀화식물을 제시함으로써, 자연휴식년제 구간에서의 종 다양성과 식물자원의 보전을 위한 자료를 구축하고자 수행한 바, 다음과 같은 결론을 도출하였다. 월출산국립공원 자연휴식년제 구간에서의 관속식물상은 86과 205속 283종 1아종 36변종 5품종으로 총 325종류가 확인되었다. 관속식물 중 양치식물은 8과 11속 16종류(4.9%), 나자식물은 3과 3속 3종류(0.9%)가, 피자식물은 75과 191속 306종류(94.2%)가 확인되었다. 희귀식물에는 땅나리(보존우선순위: 191번), 태백제비꽃(202번), 산닥나무(120번)가 확인되었으며, 특산식물에는 지리대사초, 털중나리, 소사나무, 할미밀망, 노각나무, 자란초, 병꽃나무, 털잔대까지 8종류가 확인되었다. 또한, 특정식물은 27과 40속 43종 1변종 총 44종류가 확인되었으며, 이중 IV등급에는 산복사와 등나무가, III등급에는(흰)새덕이, 모새나무, 이삭귀개 등의 9종류, II등급에는 개시호, 큰참나물, 도깨비 엉겅퀴 등의 5종류, I등급에는 진황정, 사스레피나무, 자란초 등의 28종류로 분석되었다. 귀화식물에는 소리쟁이, 아까시나무, 큰개불알풀, 개망초, 미국가막사리, 큰방가지똥 등의 4과 6속 9종류, 귀화율은 2.8%로 분석되었다. 월출산국립공원 자연휴식년제 구간의 모니터링을 2000년도부터 현재까지 7년 동안 수행되었으며, 무위사에서 미왕재 및 동원농장 구간과 장군봉 일원은 본래의 자연식생으로 복원된 것으로 사료된다. 특히, 장군봉 일원은 급경사로 인해 인위적인 접근이 어려운 지역임으로 현 구간을 장기적으로 보전하는 것보다 다른 구간을 자연휴식년제로 선정하여 보전구간을 점차적으로 확대해야 할 필요성이 있을 것으로 판단된다.

• 한국환경복원기술학회지
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• 제9권4호
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• pp.24-35
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• 2006

The vascular plants of the studied area was listed 384 taxa of 90 families, 234 genera, 331 species, 1 subspecies, 45 varieties and 7 forms. The flora of each reservoir, 285 taxa of 83 families, 190 genera, 247 species, 1 subspecies, 30 varieties, 7 forms in Osongjae, 117 taxa of 39 families, 87 genera, 100 species, 17 varieties in Ogongjae, 83 taxa of 30 families, 67 genera, 73 species, 8 varieties, 2 forms in Shinyongjae and 86 taxa of 33families, 70 genera, 75 species, 1 subspecies, 10 varieties in Eodujae. Based on the list of the rare plants by the Forest Research Institute, 3 taxa were recorded in the studied areas; Magnolia kobus (Preservation priority order : No. 187), Penthorum chinense (No. 144), Prunus yedoensis (No. 110) and based on the list of Korean endemic plants, 4 taxa were recorded; Populus tomentiglandulosa, Clematis trichotoma, Prunus yedoensis, Paulownia coreana. Specific plant species by floral region were total 15 taxa; Prunus yedoensis in class V, 2 taxa (Carex idzuroei, Magnolia kobus) in class IV, 2 taxa (Monochoria korsakowi, Poncirus trifoliata ) in class III, 10 taxa (Sagittaria aginashi, Salix glandulosa, Clematis brachyura, Nymphoides peltata, etc.) in class I. The naturalized plants in this site were 13 families, 29 genera, 43 species, 1 varieties, 44 taxa and naturalization rate was 11.5% and based on the list of an ecosystem disturbance plants, 3 taxa were recorded in the studied areas : Paspalum distichum, Solanum carolinense, Ambrosia artemisiifolia var. elatior. The hydrophytes was listed 31 taxa of 15 families, 20 genera, 29 species, 2 varieties and Eleocharis mamillata var. cyclocarpa, Penthorum chinense, Soirodela polyrhiza were recorded in Osongjae, Sagittaria aginashi, Eleocharis kuroguwai, Scirpus juncoides, Scirpus triqueter, Monochoria korsakowi, Monochoria vaginalis var. plantaginea were recorded in Ogongjae. Besides, Scirpus fluviatilis, Trapa pseudoincisa were recorded in Shinyongjae and Scirpus triangulatus, Nymphoides peltata, Myriophyllum verticillatum were recorded in Eodujae. This site is located in the urban area and ecosystem-disturbing wild animal and plant has been imported here, therefore ecosystem has been disturbed more and more. The wetland here rapidly has changed into upland, so it needs conservation measures through long-term monitoring.

• 한국환경복원기술학회지
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• 제13권1호
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• pp.14-23
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• 2010

The vascular plants in the Haksan, Jeonju were listed 394 taxa; 94 families, 260 genera, 339 species, 1 subspecies, 46 varieties and 8 forms. Divided into woody plants were 111 taxa (28.2%) and herbaceous plants were 283 taxa (71.8%). Based on the list of rare plants by the Korea Forest Service; Viola albida (Preservation priority order : No. 202), Korean endemic plants, 6 taxa were recorded; Lespedeza maximowiczii for. tomentella, Indigofera koreana, Weigela subsessilis, etc. Specific plant species by floral region were total 19 taxa (4.8% of all 394 taxa of vascular plants); Wistaria floribunda (Planted species) in class IV, Acer palmatum (Planted species) and Melothrua japonica in class III, Nymphoides indica in class II, 15 taxa (Botrychium virginianum, Hosta capitata, Salix glandulosa, Quercus variabilis, Rhynchosia acuminatifolia, Ilex macropoda, Impatiens nolitangere, Grewia biloba var. parviflora, Vaccinium oldhami and Lonicera praeflorens, etc.) in class I. The naturalized plants in the surveyed sites were 14 families, 30 genera, 32 taxa (Bromus rigidus, Rumex obtusifolius, Chenopodium ficifloium, Amaranthus lividus, Phytolacca americana, Lepidium apetalum, Amorpha fruticosa, Geranium carolinianum, Ailanthus altissima, Euphorbia supina, Oenothera biennis, Ipomoea purpurea, Veronica persica, Bidens frondosa, etc.) and naturalization rate was 8.1% of all 394 taxa of vascular plants. The ecosystem disturbing wild plants, Rumex acetocella, Aster pilosus and Ambrosia artemisiaefolia having manage to designation with Ministry of Environment.

• 한국환경과학회지
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• 제10권3호
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• pp.225-231
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• 2001

The fish species collected in the Keumho River basin are 42 species 31 genera belonging to 15 Families. This report was investigated for the evaluation of water quality in the Keumho River system which is a tributary of Nakdong River in Korea on september in 1999. The fishes collected were 42 species, 31 genera belonging to 15 Families. The dominant species were 5 species; Zacco platypus, Zacco temmincki, Squalidus chankaensis tsuchigae, Moroco oxycephalus, Squalidus gracilis majimae, and 8 species; Hemibarbus longirostris, Pseudogobio esocinus, Culter brevicauda, Cobitis rotundicaudata, Pseudobagrus fulvidraco, Pungitius sinensis kaibarae, Monopterus albus, Channa argus were rare species. The relationship among the GPI, EC and BOD by the organic pollutants were over 0.9. The group pollution index(GPI) was lowest at St. 1(0.85) and highest at St. 1(0.85) and highest at St. 5(2.33). The water quality of the Keumho river divided into 3 parts; the water of upper reaches in river(St. 1) was 1st class(oligotrophic condition), middle parts(St. 2, 3, 4) were 3rd class($\alpha$-mesosaprobic condition) and lower part(St. 5) was 4th class(Polysaprobic condition) as the source of tap water, respectively. And the tributary which are the Sinryeong Stream(St. 6), the Sincheon(St. 7) and the Donghwa Stream(St. 9) in Keumho river were 2nd class as the source of tap water. The results in this study was represented same patterns as the result by the use of indicator species like as algae and invertebrates for the discrimination of water quality. So, some freshwater fish species can be use applicant for the discrimination of water quality.

• 한국자원식물학회지
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• 제29권2호
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• pp.241-263
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• 2016

석병산 일대를 대상으로 2015년 3월부터 10월까지 관속식물 상에 대한 계절별 현지 조사를 실시한 결과는 다음과 같다. 석병산 일대에 자생하는 관속식물은 102과 295속 454종 4아종 51변종 7품종으로 총 516분류군이 분포하는 것으로 나타났으며, 한국특산식물은 17과 24속 25종 1변종으로 총 26분류군이 나타났고, 이는 한국특산식물 360분류군의 7.2%에 해당한다. 산림청 지정 희귀식물은 21과 33속 33종 3변종 36분류군이 조사되었고, 환경부 지정 적색식물목록은 13과 17속 17종 1변종 총 18분류군이 조사되었다. 그 중 멸종위기 야생식물 II급에 해당하는 복주머니란과 개병풍이 포함되었다. 석회암지대의 지표식물은 총 36분류군으로 조사되었다. 이는 산림청이 제시한 109개 분류군의 33.0%이며, 석병산에서 조사된 519분류군 중 6.9%에 해당한다. 식물구계학적 특정식물은 V등급 9분류군, IV등급 20분류군, III등급 35분류군, II등급 26분류군, I등급 42분류군으로 총 132분류군으로 나타났다. 귀화식물은 18분류군이 나타났으며, 귀화율은 3.4%, 도시화지수는 5.6%이었고, 기후변화 적응 대상식물은 특산식물 13분류군, 남방계식물 2분류군, 북방계식물 33분류군으로, 총 29과 41속 47종 1변종 총 48분류군이 발견되었다. 위 결과를 종합해 보면, 본 조사지역인 석회암지대 석병산 일대는 백두대간의 한 축으로서 다양한 식물상을 보여주며, 식물 구계학적으로 매우 중요한 지역임과 동시에, 희귀·멸종위기식물과 북방계 식물 및 기후변화 취약식물들의 중요한 피난처 역할을 수행하고 있는 반면, 각종 개발로 인한 많은 훼손의 위험성을 가지고 있다고 할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1995-1997
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• 2012

Background: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Methods: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. Results: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. Conclusion: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

• 한국환경과학회지
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• 제30권2호
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• pp.119-133
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• 2021

The purpose of this study was to provide basic information for rational management plans for sustainable conservation and utilization by comprehensive analyzing the flora distributed in Yongchu valley, Changwon-si. The flora of Yongchu valley were summarized as 319 taxa including 93 families, 212 genera, 285 species, 3 subspecies, 6 forms and 25 varieties. The endemic plants were 5 taxa such as Chrysosplenium pilosum var. fulvum, Impatiens koreana, Lespedeza maritima, Thalictrum acteifolium and Weigela subsessilis. The rare plants were 11 taxa including I. koreana, Prunus yedoensis and Magnolia kobus. The specific plants by floristic region were 38 taxa including I. koreana, Jeffersonia dubia., M. kobus and P. yedoensis which are class V. The naturalized plants were 11 taxa including Solanum americanum, Aster pilosus, Crassocephalum crepidioides and Cerastium glomeratum and so forth and invasive alien plants among these plants was 1 taxa of A. pilosus. The target plants adaptable to climate change were 8 taxa including Corydalis turtschaninovii of northern plant, I. koreana of endemic plant, and Meliosma myriantha of southern plant.