• YAKHAK HOEJI
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• v.49 no.3
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• pp.212-216
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• 2005

A rapid, sensitive and selective electrospray tandem mass spectrometric (ESI-LC/MS/MS) method for the quantitation of gliquidone in human plasma was developed. A bioavailability study of gliquidone tablet (30 mg gliquidone, Boehringer Ingelheim Korea Co.) was performed using the validated ESI-LC/MS/MS method. The dose of 30 mg of gliquidone (1 tablet) was orally administered to 9 healthy Korean subjects. After administration, blood was taken at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 7, 9, 12, 24, and 33 hour. The validation data were as follows; the standard curve was linear ($r^2$=0.999) over the concentration range of $10\~1000 ng/ml$. The coefficient of variation for intra- and inter-day assay were $8.30\~18.86$, and $2.19\~12.92\%$, respectively. The lower limit of quantification for gliquidone was 10 ng/ml. The pharmacokinetic parameters obtained were as follows; $AUC_t$ was 3861.17$\pm$1328.61 ng-hr/ml, $C_{max}$ was 831.02$\pm$227.99 ng/ml, $T_{max}$ was $2.94{\pm}0.77 hr,\;K_e$, was 0.19$\pm$0.06 1/hr, and $t_{l/2}$ was 4.47$\pm$3.52 hr. Based on the validated analytical method and pharmacokinetic parameters, a standard guideline of the bioavailability test of gliquidone dosage forms was prepared successfully and could be used for the bioequivalence test of gliquidone preparation.

• YAKHAK HOEJI
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• v.49 no.3
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• pp.225-229
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• 2005

A rapid, sensitive and selective tandem mass spectrometric method (LC-MS/MS) for the quantitation of nicorandil in human plasma was developed. A bioavailability study of Sigmat tablet (5 mg nicorandil, Choongwae Co.) was per-formed using the validated LC-MS/MS method. The dose of 5 fig of nicorandil (1 tablet) was orally administered to 9 healthy Korean subjects. After administration, blood was taken at 0.25, 0.5, 1, 2, 3, 4, 5, 6, 9, 12, and 24 hour. The validation data were as follows; the standard curve was linear ($r^2$=0.999) over the concentration range of $0.5\~200.0 ng/ml$. The coefficient of variation for intra- and inter-day assay were $3.55\~7.44$, and $2.17\~9.102\%$, respectively. The lower limit of quantification for nicorandil was 0.5 ng/ml. The pharmacokinetic parameters obtained were as follows; $AUC_t$ was 145.9$\pm$83.0 ng-hr/ml, Cmax was 83.8$\pm$32.2 ng/ml, $C_{max}$ was 0.42$\pm$0.13 hr, $K_e$ was 0.56$\pm$0.23 l/hr, and $t_{l/2}$ was 1.42$\pm$0.52 hr. Based on the validated analytical method and pharmacokinetic parameters, a standard guideline of the bioavailability test of nicorandil dos-age forms was prepared successfully and could be used for the bioequivalence test of nicorandil preparation.

• The Research Journal of the Costume Culture
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• v.21 no.2
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• pp.195-205
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• 2013

Eco T-shirts have become a part of environmental campaigns following social trends toward eco-friendly designs. With the demand for such designs expected to grow, there has arisen a need for higher product variety. In the past, eco T-shirts were designed to convey messages about the protection of nature through the use of environmentally friendly text or images. However, in order to respond to the preferences and emotional needs of Koreans, designs should cater to their characteristics and tastes. To this end, this study used a Whan-ki Kim-inspired motif to develop an eco-friendly design tailored to Korean perspectives. It is believed that this process can not only result in a distinctive eco T-shirt design, but also make it globally competitive. With regard to research methodology, a total of 41 paintings of Whan-ki Kim were analyzed and classified into four major themes or key values expressed in modern eco-friendly fashion designs: naturalness, indigenousness, harmony between nature and man, and harmony between natural and artificial beauty. Employing a wide range of CAD techniques and varying forms, the themes were developed into 28 T-shirt designs after their forms, tones, and textures were fully explored. This study demonstrates the possibility of designing creative, aesthetic, and high value-added eco T-shirts through motif development. In addition, it successfully integrates Korean paintings in the development of T-shirt designs aimed at communicating environmentally friendly messages.

• Structural Engineering and Mechanics
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• v.24 no.3
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• pp.375-393
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• 2006

Under high velocity, pulse type near source earthquakes semi-active control systems are very effective in reducing seismic response base isolated structures. Semi-active control systems can be classified as: 1) independently variable stiffness, 2) independently variable damping, and 3) combined variable stiffness and damping systems. Several researchers have studied the effectiveness of independently varying damping systems for seismic response reduction of base isolated structures. In this study effectiveness of a combined system consisting of a semi-active independently variable stiffness (SAIVS) device and a magnetorheological (MR) damper in reducing seismic response of base isolated structures is analytically investigated. The SAIVS device can vary the stiffness, and hence the period, of the isolation system; whereas, the MR damper enhances the energy dissipation characteristics of the isolation system. Two separate control algorithms, i.e., a nonlinear tangential stiffness moving average control algorithm for smooth switching of the SAIVS device and a Lyapunov based control algorithm for damping variation of MR damper, are developed. Single and multi degree of freedom systems consisting of sliding base isolation system and both the SAIVS device and MR damper are considered. Results are presented in the form of nonlinear response spectra, and effectiveness of combined variable stiffness and variable damping system in reducing seismic response of sliding base isolated structures is evaluated. It is shown that the combined variable stiffness and variable damping system leads to significant response reduction over cases with variable stiffness or variable damping systems acting independently, over a broad period range.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.9
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• pp.774-779
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• 2016

This study was performed to study the possibility of TMCP's application for side shell plating curved structures through mechanical property testing to understand if the rules and regulations of DNV and the quality standard of IACS after line heating for TMCP steel and normalizing DH32 material steel could be satisfied. Experimental results showed that TMCP's strength was measured to YS = 385 MPa, 18% higher than the required 315 MPa and TS = 525 MPa, complying with the required range of between 440 and 570 MPa. The minus 20 degree impact test for the Charpy V-Notch complied with the required standard and in addition the hardness test satisfied the requirement of 'Hv10 = 130 ~ 320' by reaching an average of T : 216 and L : 275 respectively.

• Journal of the Korean Chemical Society
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• v.55 no.1
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• pp.81-85
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• 2011

$V_{0.9}Sb_{0.1}O_x$ systems, bulk and deposited on different supports (five types of $\gamma$-aluminas, $\alpha$-alumina, silica-alumina, silica gel, magnesium oxide), have been tested in the oxidative dehydrogenation (ODH) of iso-butane. Catalytic performance of VSb oxides has shown to be highly dependent on the support and the nature of the support decreasing in a series: $\gamma$-$Al_2O_3$ > $\alpha$-$Al_2O_3$ > Si-Al-O > $SiO_2$ $\approx$ MgO $\gg$ unsupported. Variation of the V-Sb-O-loading in the studied range of coverage (0.5-2 theoretical monolayer) only slightly influences the catalysts' activity and selectivity. The best catalytic performance of $\gamma$-alumina-supported $V_{0.9}Sb_{0.1}O_x$ systems can be explained by the optimal surface interaction between support and supported components resulting in the formation of well-spread amorphous active $VO_x$-component with vanadium in a high oxidation state.

• Korean Journal of Soil Science and Fertilizer
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• v.46 no.2
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• pp.129-135
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• 2013

This study was conducted to investigate the soil characteristics of newly reclaimed tidal land and the effect of green manure crops on soil properties. Summer green manure crops such as sesbania (Sesbania grandiflora), barnyard grass (Echinochloa spp.) and sorghum${\times}$sudangrass hybrid (Sorghum bicolor L.) were cultivated at Hwaong, Ewon, Saemangeum and Yongsangang area. Soil pH of reclaimed tidal land was relatively high, but organic matter and available phosphorus contents were lower compared to the optimum range for common upland crops. Soil nutrient contents were unbalanced for upland crop growth. Yield of green manure crops had a wide spatial variation. Nitrogen content in green manure crops was the greater in Sesbania and it was estimated that major nutrient ($N-P_2O_5-K_2O$) supply amount were 150-40-370, 220-50-170 and 140-50-250 $kg\;ha^{-1}$ from sorghum${\times}$sudangrass hybrid, sesbania and barnyard grass, respectively. Based on these results, desalination is required to grow the upland crops at newly reclaimed tidal lands and management practices are necessary to reduce the salt damage by resalinization during the growing seasons. To improve the productivity and increase the nutrient utilization rate, soil physicochemical properties need to be improved to the level for upland crops by application of organic matter and fertilizer.

• Journal of the Korean Society for Heat Treatment
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• v.29 no.5
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• pp.220-226
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• 2016

The mechanical properties of Ti-6Al-4V can be improved by microstructural control through the heat treatment in ${\alpha}+{\beta}$ region. The heat treatment was carried out with a variety of heat treatment temperatures and holding times to find the optimized heat treatment conditions and it was analyzed by linking the microstructural characteristics and mechanical properties. The part of ${\beta}$ phase with $10{\pm}2wt%$ vanadium was transformed into ${\alpha}^{{\prime}{\prime}}$ martensite phase after quenched, so the hardness and tensile properties were decreased below $900^{\circ}C$. The higher the heat treatment temperature is, the smaller is the vanadium-rich region, which leads to transformation into hcp ${\alpha}^{\prime}$ martensite above $900^{\circ}C$. The hardness and tensile properties were improved due to the hard ${\alpha}^{\prime}$ martensite. As the holding times were longer, the hardness and tensile properties decreased below $900^{\circ}C$ because of the softening effect by the grain growth. When varying the holding times above $900^{\circ}C$, the change of mechanical properties was slight because the softening effect of grain growth and the strengthening effect of ${\alpha}^{\prime}$ phase were counteractive. Therefore, the best conditions of heat treatment, which is in the range of $920{\sim}960^{\circ}C$, 40 min, WQ, can effectively improve the mechanical properties of Ti-6Al-4V.

• Structural Engineering and Mechanics
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• v.67 no.2
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• pp.105-113
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• 2018

To improve the prediction accuracy of the strong-unloading rock slope performance and obtain the range of variation in the slope displacement, a new displacement time-series prediction model is proposed, called the fuzzy information granulation (FIG)-genetic algorithm (GA)-back propagation neural network (BPNN) model. Initially, a displacement time series is selected as the training samples of the prediction model on the basis of an analysis of the causes of the change in the slope behavior. Then, FIG is executed to partition the series and obtain the characteristic parameters of every partition. Furthermore, the later characteristic parameters are predicted by inputting the earlier characteristic parameters into the GA-BPNN model, where a GA is used to optimize the initial weights and thresholds of the BPNN; in the process, the numbers of input layer nodes, hidden layer nodes, and output layer nodes are determined by a trial method. Finally, the prediction model is evaluated by comparing the measured and predicted values. The model is applied to predict the displacement time series of a strong-unloading rock slope in a hydropower station. The engineering case shows that the FIG-GA-BPNN model can obtain more accurate predicted results and has high engineering application value.

• Wind and Structures
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• v.17 no.3
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• pp.317-343
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• 2013

When evaluating flutter instability, it is often assumed that incident wind is normal to the longitudinal axis of a bridge and the flutter critical wind speed estimated from this direction is most unfavorable. However, the results obtained in this study via oblique sectional model tests of four typical types of bridge decks show that the lowest flutter critical wind speeds often occur in the yaw wind cases. The four types of bridge decks tested include a flat single-box deck, a flat ${\Pi}$-shaped thin-wall deck, a flat twin side-girder deck, and a truss-stiffened deck with and without a narrow central gap. The yaw wind effect could reduce the critical wind speed by about 6%, 2%, 8%, 7%, respectively, for the above four types of decks within a wind inclination angle range between $-3^{\circ}$ and $3^{\circ}$, and the yaw wind angles corresponding to the minimal critical wind speeds are between $4^{\circ}$ and $15^{\circ}$. It was also found that the flutter critical wind speed varies in an undulate manner with the increase of yaw angle, and the variation pattern is largely dependent on both deck shape and wind inclination angle. Therefore, the cosine rule based on the mean wind decomposition is generally inapplicable to the estimation of flutter critical wind speed of long-span bridges under skew winds. The unfavorable effect of yaw wind on the flutter instability of long-span bridges should be taken into consideration seriously in the future practice, especially for supper-long span bridges in strong wind regions.