• 약학회지
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• 제49권1호
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• pp.1-5
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• 2005

Near-infrared (NIR) spectroscopy has been widely applied in various field, since it is nondestructive and no sample preparation is required. In this paper, NIR spectroscopy was used for the determination of naproxen in a commercial pharmaceutical preparation. NIR spectroscopy was used to determine the content of naproxen in intact naproxen tablets containing 250 mg ($65.8\%$ nominal concentration) by collecting NIR spectra in the range of $1100{\sim}1750nm$. The laboratory-made samples had $46.1{\sim}85.5\%$ nominal naproxen concentration. The measurements were made by reflection using a fiber-optic probe and calibration was carried out by partial least square regression (PLSR). Model validation was performed by randomly splitting the data set into calibration and validation data set (63 samples as a calibration data set and 42 samples as a validation data set). The developed NIR calibration gave results comparable to the known values of tablets in a laboratorial manufacturing process with standard error of calibration (SEC) and standard error of prediction (SEP) of $1.06\%\;and\;1.04\%$, respectively. The NIR method showed good accuracy and repeatability. NIR spectroscopic determination in intact tablets allowed the potential use of real time monitoring for a running production process.

• 제어로봇시스템학회논문지
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• 제20권12호
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• pp.1267-1271
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• 2014

There have been many autonomous robot calibration methods which form closed loop structures through the various attached sensors and mechanical fixtures. Single point calibration among them has been used for on-site calibration due to its convenience of implementation. The robot can reach a single point with infinitely many configurations so that single point calibration algorithm can be set up and easily implemented relative to the other methods. However, it is not still easy to drive the robots' sharp edge to its corresponding edge of the fixture. This is error-prone process. In this paper, we propose a 3 dimensional small displacement measuring sensor and a robot calibration algorithm based on this sensor. This method relieves the difficulty of matching two edges in the single point calibration and improves the resulting robot accuracy. Simulated study is carried out on a Hyundai HA06 robot to show the effectiveness of the proposed method over the single point calibration. And also, the resulting robot accuracy is compared with that from 3D laser tracker based calibration to show the dependency of robot accuracy on range of the workspace where the measurement data are collected.

• 대한화학회지
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• 제46권4호
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• pp.309-317
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• 2002

형광분광법에 의하여 주성분 회귀분석(principal component regression, PCR)과 부분 최소자승법(Partial least squares, PLS)을 이용하여 아미노산(Tryptophan and Tyrosine)을 동시에 정량하는 방법에 대하여 연구하였다. 아미노산 혼합물의 형광 스펙트럼은 들뜸파장을257nm로 고정하여 측정하였다. 두 가지 아미노산이 서로 다른 농도로 혼합되어 있는 32개의 시료용액을 280nm∼500nm 범위에서 스펙트럼들을 얻었고 이를 이용하여 PCR과 PLS회귀모델을 얻었다. 두 가지 아미노산이 서로 다른 농도로 포함된 6개의 외부검정용 시료들의 스펙트럼들을 이용해서 회귀모델의 적합성을 검정하기 위하여 외부검정용 시료의 농도를 계산하였다. 계산된 농도를 이용하여 relative standard error of prediction($RSEP_a$)를 얻었고 같은 방법으로 overall relative standard error of prediction($RSEP_m$) 도 구하였다

• 한국측량학회지
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• 제39권3호
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• pp.123-132
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• 2021

근거리 사진측량에서 스테레오 카메라를 이용하여 3차원 위치를 결정하기 위해 카메라의 내부표정요소뿐만 아니라 카메라 간의 상호표정요소를 결정하는 카메라 캘리브레이션이 선행되어야 한다. 카메라 캘리브레이션을 수행하고 나서 시간이 흐르면 비측량용 카메라의 경우 내부적인 불안정성이나 외부적인 요인에 의해 내부표정요소와 상호표정요소가 변할 수 있다. 본 연구에서는 스테레오 카메라 안정성을 평가하기 위해 두 대의 단일 카메라와 스테레오 카메라의 안정성을 분석뿐만 아니라 검사점을 이용하여 3차원 위치 정확도를 평가하였다. 4개월간 3회의 카메라 캘리브레이션을 수행한 실험을 통해 단일 카메라의 안정성을 평가한 결과 평균제곱근오차는 ±0.001mm로 나타났으며, 스테레오 카메라의 평균제곱근오차는 ±0.012mm ~ ±0.025mm로 나타났다. 또한, 검사점을 이용한 거리정확도를 평가한 결과 ±1mm로 나타나 다시기에 걸쳐 추정한 스테레오 카메라의 내부표정요소와 상호표정요소는 안정적인 것으로 판단되었다.

• 약학회지
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• 제47권5호
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• pp.261-265
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• 2003

Near-infrared (NIR) system was used to determine rapidly and simply indomethacin in buffer solution for a dissolution test of tablets and capsules. Indomethacin standards were prepared ranging from 10 to 50 ppm using the mixture of phosphate buffer (pH 7.2) and water (1 : 4). The near-infrared (NIR) transmittance spectra of indomethacin standard solutions were collected by using a quartz cell in 1 mm and 2 mm pathlength. Partial least square regression (PLSR) was explored to develop calibration models over the spectral range 1100∼1700 nm. The model using 1 mm quartz cell was better than that using 2 mm quartz cell. The PLSR models developed gave standard error of prediction (SEP) of 0.858 ppm. In order to validate the developed calibration model, routine analysis was performed using another standard solutions. The NIR routine analysis showed good correlation with actual values. Standard error of prediction (SEP) is 1.414 ppm for 7 indomethacin samples in routine analysis and its error was permeable in the regulation of Korean Pharmacopoeia (VII). These results show the potential use of the real time monitoring for indomethacin during a dissolution test.

• Current Optics and Photonics
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• 제7권4호
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• pp.428-434
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• 2023

The compensators used in spectroscopic ellipsometers are usually assumed to be ideal linear waveplates. In reality, however, they are elliptical waveplates, because they are usually made by bonding two or more linear waveplates of different materials with slight misalignment. This induces systematic error when they are modeled as linear waveplates. We propose an improved calibration method based on an optical model that regards an elliptical waveplate as a combination of a circular waveplate (rotator) and a linear waveplate. The method allows elimination of the systematic error, and the residual error of optic axis measurement is reduced to 0.025 degrees in the spectral range of 450-800 nm.

• 한국식품저장유통학회지
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• 제6권1호
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• pp.29-36
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• 1999

Using Fuji apple fruits cultivated in Kyungpook prefecture, the calibration model for firmness evaluation of fruits by near infrared(NIR) reflectance spectroscopy was developed, and the various influence factors such as instrument variety, measuring method, sample group, apple peel and selection of firmness point were investigated. Spectra of sample were recorded in wavelength range of 1100∼2500nm using NIR spectrometer (InfraAlyzer 500), and data were analyzed by stepwise multiple linear regression of IDAS program. The accuracy of calibration model was the highest when using sample group with wide range, and the firmness mean values obtained in graph by texture analyser(TA) were used as standard data. Chemometrics models were developed using a calibration set of 324 samples and an independent validation set of 216 samples to evaluate the predictive ability of the models. The correlation coefficients and standard error of prediction were 0.84 and 0.094kg, respectively. Using developed calibration model, it was possible to monitor the firmness change of fruits during storage frequently. Time, which was reached to firmness high value in graph by TA, is possible to use as new parameter for freshness of fruit surface during storage.

• 대한방사선기술학회지:방사선기술과학
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• 제42권6호
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• pp.435-440
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• 2019

This is to study the accuracy of the actual size according to the TOD(table object distance; TOD) change when measuring blood vessels using angiography equipment, and to help the optimal selection of the device used accordingly. Balls similar to the size of common vessels were calibrated with TOD using 30 mm, 20 mm, 10 mm, 5 mm and acrylic phantoms, catheter calibration from 0 cm to 10 cm, 20 cm and 30 cm, respectively. It was measured whether there was a change in the measured value according to the change. The equipment used was GE Innova 3131 IQ equipment, and the image reconstruction method was GE AW4.7 post processing program. Two radiotechnologists were scanned three times by catheter calibration method and 3DRA(3dimension rotational angiography; 3DRA) volume rendering method. The independent sample T-test showed 0.981 (p> 0.05) to verify the significance between the two observers. As a result, in case of catheter calibration, the error rate at TOD 0 mm and 10 mm is within ± 10%, but when the TOD is changed to 20 mm and 50 mm respectively, the tolerance is ± 10% except for 30 mm ball exceeded. On the other hand, 3DRA was included within the tolerance range of ± 10% overall even when the TOD was changed from 0 mm to 50 mm. In the catheter calibration method, the larger the TOD, the larger the error range, and the 3DRA method was able to measure vascular vessels accurately close to the actual measurement without any consideration of the TOD.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1995년도 춘계학술대회 논문집
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• pp.637-642
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• 1995

For measuring the error motion of ultra-precision spindle, eliminating the geometric errors is a must. Unless it is achieved, geometric errors will be dominant in data. Here, the roundness error and alignment error between spindle and sensor are to be removed. That's because typical error range of such spindle is muchless than geometric one. A capacitive transducer of cylidricalshape was developed, which takes full advantage of the spatial-averaging effect by using large area compared tpo the geometric error. This idea was first proposed by Chapman and here it is modified for better performance with nomical gap of 50 .mu. m and with newly designed guards which encompass the respective sensor to rectify the electrical field distribution in good shape. The measurement system is made to get the orbit of Ultra-Precision Air Spindle which is supposed to have its runout under 1 .mu. m. The Calibration data of this sensor is presented and the spindle orbit from 2000rpm to 5500rpm is showed. It is quite reasonable to use this sensor in the range of 60 .mu. m with an accuracy of several tens of nm.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 춘계학술대회 논문집
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• pp.387-393
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• 2004

General purpose of cylindrical capacitive displacement sensor(CCS) is measuring run-out motion and deflection of rotor. If CCS has narrow sensing range, its sensitivity coefficients must be calibrated precisely. And x, y component of CCS output can be coupled. In this research, CCS calibration procedure is automated with automatic calibration program and PC-controlled stage. And, coupled-terms of CCS signals were removed and the errors between measured position and mapped CCS signal were reduced obviously by sensitivity matrix that linearly.