• Title/Summary/Keyword: Randomized controlled trials

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한방 암 치료에 대한 최근 10년간 임상연구 고찰: 국내 데이터베이스를 중심으로 (Review of Clinical Study over the Last 10 Years on Korean Medicine Treatment for Cancer: Focusing on Korean Database)

  • 최지원;남연경;이정한;우현준
    • 한방재활의학과학회지
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    • 제31권4호
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    • pp.75-86
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    • 2021
  • Objectives This study aimed to analyze the research trends in clinical studies on the traditional Korean medicine used for cancer treatment between 2011 and 2020. Methods We searched 7 Korean web databases (Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies Information Service System [KISS], Korean Medical database [KMBASE], DBpia, Korea Institute of Science and Technology Information [KISTI], and KoreaMed) and classified collected papers dated between 2011 and 2020 by the year of publication, publication journal, study design, type of cancer affecting the patients, interventions used, evaluation system used, and combination with conventional medicine. Results A total of 167 papers were collected. More than 10 papers were published annually. The papers were mainly published in the Journal of Korean Traditional Oncology (28.7%). The predominant type of the study was case study (67.7%). The main type of cancer was breast cancer, affecting 262 patients. Most of the studies reported using multiple traditional Korean medicine treatments (55.1%). Eighty-nine studies reported using clinical laboratory tests for evaluation. Most of the patients took conventional medicine simultaneously (608 patients). Conclusions Research related to Korean medicine for cancer patients is at a rudimentary level. Therefore, for further clarity, high evidence-based researches, including randomized controlled trials and cohort studies, should be conducted.

회전근개 수술 후 침 치료의 효과: 체계적 문헌고찰 (Effects of Acupuncture after Rotator Cuff Surgery: A Systematic Review)

  • 이상진;고유미;박정식;박태용;이정한;조재흥;황의형;김경자;최미영;송윤경
    • 한방재활의학과학회지
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    • 제31권4호
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    • pp.25-34
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    • 2021
  • Objectives This study was conducted to evaluate the therapeutic effect of acupuncture after rotator cuff surgery. Methods Key words such as rotator cuff surgery and acupuncture were searched in 10 databases (Ovid-Medline, Ovid-EMBASE, Ovid-AMED, Cochrane Library, China National Knowledge Infrastructure [CNKI], National Digital Science Library [NDSL], Koreanstudies Information Service System [KISS], Oriental medicine Advanced Searching Integrated System [OASIS], KoreaMed, KMBASE), and only suitable randomized controlled trials (RCTs) were selected. Results 6 RCTs were finally selected, and acupuncture showed positive results for pain relief and functional recovery after rotator cuff surgery. However, the analyzed 6 RCTs showed a high overall risk of bias. Conclusions In the future, RCTs with a higher level of evidence on the effect of acupuncture after rotator cuff surgery need to be continuously conducted.

슬관절 전치환술 후 한약 치료의 효과: 체계적 문헌고찰과 메타분석 (Effects of Herbal Medicine after Total Knee Arthroplasty: A Systematic Review and Meta-Analysis)

  • 이상진;고유미;박정식;박태용;이정한;조재흥;황의형;김경자;최미영;송윤경
    • 한방재활의학과학회지
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    • 제31권4호
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    • pp.35-47
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    • 2021
  • Objectives This study was conducted to evaluate the therapeutic effect of herbal medicine after total knee arthroplasty. Methods Key words such as total knee arthroplasty and herbal medicine were searched in 10 databases (Ovid-Medline, Ovid-EMBASE, Ovid-AMED, Cochrane Library, China National Knowledge Infrastructure [CNKI], National Digital Science Library [NDSL], Koreanstudies Information Service System [KISS], Oriental medicine Advanced Searching Integrated System [OASIS], KoreaMed, KMBASE), and only suitable randomized controlled trials (RCTs) were selected. Results 8 RCTs were finally selected, and herbal medicine showed positive results for pain relief and functional recovery after total knee arthroplasty. However, the analyzed 8 RCTs showed a high overall risk of bias. Conclusions In the future, RCTs with a higher level of evidence on the effect of herbal medicine after total knee arthroplasty need to be continuously conducted.

경혈경락이론에 근거한 체외충격파 치료가 무릎 관절염에 미치는 영향: 체계적 문헌 고찰 (Extracorporeal Shock Wave Therapy with Meridian and Acupoint Theory for Knee Osteoarthritis: Systematic Review)

  • 김병준;이상현;김현태;박혜진;박선영;허인;황만석;신병철;황의형
    • 한방재활의학과학회지
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    • 제31권2호
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    • pp.41-48
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    • 2021
  • Objectives To determine the evidence of effectiveness and safety of extracorporeal shock wave therapy (ESWT) with meridian and acupoint theory for knee osteoarthritis. Methods By March 3, 2021, five foreign electronic databases and six Korean medical electronic databases were reviewed with the key words 'extracorporeal shock wave' and '(acupoint OR acupuncture point)'. This key words was set up to increase the sensitivity of the search. After the search, knee osteoarthritis study was selected based on the title and abstract and then included after full-texts were read. Results Five randomized controlled trials were eligible in our inclusion criteria. The meta-analysis of three studies showed positive results for the using ESWT with meridian and acupoint theory for knee osteoarthritis compared with the control group on efficancy rate, visual analog scale and lysholm knee score. but there remains a conundrum regarding the safety of ESWT in the treatment of knee osteoarthritis. Conclusions Most of studies showed ESWT with meridian and acupoint theory were statistically effective to knee osteoarthritis. However there are limitations that the number of selected studies was small, risk of bias was unclear. So use of ESWT with meridian and acupoint theory for knee arthritis has limited evidence compared to usual care.

복압성 요실금에 대한 보중익기탕의 효과 : 체계적 문헌고찰과 메타분석 (The Effect of Bojungikgi-tang on Stress Urinary Incontinence: A Systematic Review and Meta-Analysis)

  • 남현서;백태현
    • 대한한방내과학회지
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    • 제42권3호
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    • pp.293-307
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    • 2021
  • Objectives: This study investigates the effects and safety of Bojungikgi-tang for stress urinary incontinence by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: RCTs were selected from articles published until December 2019 in seven domestic and foreign databases. The quality of the literature was evaluated using Cochrane's risk of bias (RoB) tool, and RevMan 5.3 was used to synthesize the results. Results: A total of 694 patients with stress urinary incontinence participated in eight RCTs. Meta-analysis showed that the total effective rate of treatment that combines pelvic floor muscle training (PFMT) and Bojungikgi-tang was significantly higher than that of PFMT alone. The volume of urine leakage per hour after the combined treatment was significantly lower than that of PFMT alone. The International Consultation on Insurance Questionnaire-Short Form (ICIQ-SF) scores from combining PFMT and Bojungikgi-tang were significantly lower than those for PFMT alone. Conclusion: This study suggests that Western medical treatment combined with Bojungikgi-tang for urinary incontinence from stress might be more effective in improving symptoms than conventional Western medical treatment alone. However, the number of studies included in the meta-analysis was insufficient, and the quality of the selected literature was generally low. Therefore, high-quality clinical studies on herbal medicine treatment for urinary incontinence would be required in the future.

만성 골반염의 한약 치료에 대한 무작위 대조 임상시험 연구 분석 (Review of Randomized Controlled Trials of Traditional Herbal Medicine for Chronic Pelvic Inflammatory Disease)

  • 노언지;안수연;김동철
    • 대한한방부인과학회지
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    • 제34권4호
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    • pp.46-61
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    • 2021
  • Objectives: The purpose of this review is to overview the studies of traditional herbal medicine for chronic pelvic inflammatory disease. Methods: We searched relevant studies using seven databases (The Journal of Korean obstetrics & gynecology, National Digital Science Library (NDSL), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Pubmed, Cochrane, Chinese National Knowledge Infrastructure (CNKI)). Data retrieval was carried out on April 5, 2021 and the papers published from January 1, 2015 to March 31, 2021 were included. The risk of bias was assessed by using Cochrane's risk of bias tool. Results: 524 studies were searched in domestic and foreign databases, and 7 studies were finally selected. In all studies, the treatment group was treated with oral traditional herbal medicine and the control group was treated with western medicine. Although the evaluation index was slightly different for each study, all studies used total efficacy rate index. In all 7 studies, the treatment group was more effective than the control group. Conclusions: Traditional herbal medicine can be an effective option in treating chronic pelvic inflammatory disease. Further high quality studies which include large number should be carried out to confirm the evidence and safety of traditional herbal medicine treatment.

Acupotomy for Osteoarthritis of the Knee; A Systematic Review and Meta-Analysis

  • Lee, Seung Min;Lee, Cham Kyul;Kim, Kyung Ho;Kim, Eun Jung;Jung, Chan Yung;Seo, Byung-Kwan;Goo, Bon Hyuk;Baek, Yong Hyeon;Lee, Eun Yong
    • Journal of Acupuncture Research
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    • 제38권2호
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    • pp.96-109
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    • 2021
  • The purpose of this study was to evaluate the effectiveness and safety of acupotomy for the treatment of patients with knee osteoarthritis. There were 9 databases searched to retrieve randomized controlled trials until August 3, 2019 regarding acupotomy versus conventional Western medicine, conventional Western medicine treatment with and without acupotomy, and Korean medicine treatment with and without acupotomy, and meta-analysis was performed. Of 303 potentially relevant studies retrieved, 43 were systematically reviewed. All studies were conducted in China. Effective rate, visual analogue scale, and Western Ontario and McMaster Universities Osteoarthritis index were used as the evaluation scales. The Ashi point was selected most frequently. In all studies, the intervention group was more effective than the control group. Meta-analysis revealed that acupotomy showed statistically significant beneficial results. Although acupotomy had a beneficial effect on knee osteoarthritis, the risk of bias of the included studies was not low. The majority of the results from the evaluation scales used were highly heterogeneous (> 50%) which reduced confidence in the estimation of effect, or had a small sample size. Further clinical research and development is required in the future.

Efficacy Comparison of Different Acupuncture Treatments for Hot Flashes: A Systematic Review with Network Meta-Analysis

  • Jo, Hyo Rim;Choi, Seong Kyeong;Sung, Won Suk;Kim, Eun Jung;Choi, Su Ji;Kim, Dong Il;Noh, Eun Ji
    • Journal of Acupuncture Research
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    • 제38권2호
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    • pp.110-121
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    • 2021
  • The objective of this study was to conduct a systematic review and network meta-analysis to evaluate and compare the effectiveness of various types of acupuncture for menopausal hot flashes (HF). Randomized controlled trials (RCTs) were retrieved from 8 electronic databases, and the risk of bias was evaluated for the included studies. Pairwise meta-analysis and network meta-analysis were performed using Review Manager and R software for indirect comparison and ranking, respectively. In total, 23 RCTs (2,302 patients) were eligible for systematic review, of which 10 were included in network meta-analysis. Network meta-analysis showed manual acupuncture (MA) had the highest probability of reducing HF frequency and severity, followed by sham acupuncture (SA), electroacupuncture, usual care, or no treatment; furthermore, warm acupuncture significantly improved menopause-specific quality of life compared with MA or electroacupuncture. Compared with hormone replacement therapy, acupuncture had less efficacy in reducing HF frequency but enhanced menopause-specific quality of life. There was no significant difference between MA and SA in mitigating HF. The existing evidence showed that MA could be used for alleviating menopausal HF. However, it is recommended that more high-quality RCTs should be performed.

뇌졸중 환자의 실어증에 대한 전침 치료 : 체계적 문헌 고찰 (Electro-Acupuncture on Aphasia after Stroke: A Systemic Review of Randomized Controlled Trials)

  • 하정빈;이수정;양지수;유재환
    • 대한한방내과학회지
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    • 제42권3호
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    • pp.323-339
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    • 2021
  • Objectives: This study investigates the effect of electro-acupuncture on aphasia after stroke. Methods: A search of OASIS, NDSL, PubMed, Cochrane, and CNKI was executed between 4 January 2021 and 4 February 2021, with no limitation on publication year. Extraction and selection from the studies were made by 3 authors. The quality of the studies was evaluated using Cochrane's risk of bias (RoB) tool. Results: 10 studies met the selection criteria. As the treatment site for electro-acupuncture, GV20 (Baihui) was used the most. In all studies, the region located on the head was used for treatment without distinguishing between acupoints and areas of scalp acupuncture, and the stimulation was organized into 3 conditions: speed, intensity, and time. The outcome indicators used before and after treatment focused on the evaluation of language function and the degree of aphasia. The results showed that using electro-acupuncture with speech rehabilitation therapy for aphasia after stroke was more effective than using speech rehabilitation therapy alone. Conclusions: In this review, electro-acupuncture for aphasia after stroke was found to have a significant effect compared to the previous treatment alone. However, because of limitations, information was not reliable enough. Additional research is needed to produce more objective evidence.

소아의 식욕부진에 대한 한약치료의 최신 임상연구 동향 - 중국 RCT 연구를 중심으로 - (Recent Trends in Clinical Research of Herbal Medicine Treatment for Anorexia in Children - Focused on Chinese Randomized Controlled Trials -)

  • 신혜진;박용석;이지홍;장규태
    • 대한한방소아과학회지
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    • 제33권4호
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    • pp.1-25
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    • 2019
  • Objectives The purpose of this study is to analyze the trends of Chinese clinical research in the last 5 years of Chinese herbal medicine treatment for anorexia in children, and to find ways to utilize the diagnostic criteria and herbal medicine treatment for children who have anorexia in Korea. Methods The authors searched literatures using China National Knowledge Infrastructure published from January 1, 2015 to June 18, 2019. Selected literatures were collected in order of recent publication year. And then, demographic data, duration of illness, intervention, treatment period, outcome, and adverse events were analyzed. In addition, the diagnostic criteria for anorexia in children are categorized and presented in chart. Results A total of 50 papers were included in the analysis of this study. In the selected studies, the most commonly used diagnostic criteria for anorexia in children were ${\ll}$Zhu Futang Practice of Pediatrics${\gg}$ in Western medicine and ${\ll}$Diagnostic and therapeutic criteria for TCM syndromes${\gg}$ in traditional Chinese medicine. As a result, in all the studies reporting total efficacy, the total effective rate of the treatment group treated with herbal medicine was significantly higher than that of the control group. Also, appetite recovery rate and weight gain were significantly higher, gastric emptying time and appetite recovery time were significantly shorter in the treatment group. Conclusions Herbal medicine treatment can help improve anorexia in children. In Korea, diagnostic criteria for anorexia in children should be established. In addition, criteria should be established to evaluate the effectiveness of herbal medicine treatment.