• Genomics & Informatics
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• 제12권3호
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• pp.114-120
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• 2014

Bone mineral density (BMD) is one of the quantitative traits that are genetically inherited and affected by various factors. Over the past years, genome-wide association studies (GWASs) have searched for many genetic loci that influence BMD. A recent meta-analysis of 17 GWASs for BMD of the femoral neck and lumbar spine is the largest GWAS for BMD to date and offers 64 single-nucleotide polymorphisms (SNPs) in 56 associated loci. We investigated these BMD loci in a Korean population called Korea Association REsource (KARE) to identify their validity in an independent study. The KARE population contains genotypes from 8,842 individuals, and their BMD levels were measured at the distal radius (BMD-RT) and midshaft tibia (BMD-TT). Thirteen genomic loci among 56 loci were significantly associated with BMD variations, and 3 loci were involved in known biological pathways related to BMD. In order to find putative functional variants, nearby SNPs in relation to linkage equilibrium were annotated, and their possible functional effects were predicted. These findings reveal that tens of variants, not a single factor, may contribute to the genetic architecture of BMD; have an important role regardless of ethnic group; and may highlight the importance of a replication study in GWASs to validate genuine loci for BMD variation.

• Asian Journal of Atmospheric Environment
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• 제9권1호
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• pp.91-99
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• 2015

The Multi-wavelength Raman LIDAR (MRL) system was developed to enable a better understanding of the complex properties of aerosols in the atmosphere. In this study, the microphysical, optical, and radiative properties of mixed aerosols were retrieved using the discrete aerosol observation products from the MRL. The dust mixing ratio, which is the proportion of dust particles to the total mixed, was derived using the particle depolarization ratio. It was employed in the retrieval of backscattering and extinction coefficient profiles for dust and non-dust particles. The vertical profiles of aerosol optical properties were then used as input parameters in the inversion algorithm for the retrieval of microphysical parameters including the effective radius, refractive index, and the single scattering albedo (SSA). Those products were successfully applied to an analysis of radiative flux using a radiative transfer model. The relationship between the MRL derived extinction and aerosol radiative forcing (ARF) in short-wavelength was assessed over Gwangju, Korea. The results clearly demonstrate that the MRL-derived extinction profiles are a good surrogate for use in the estimation of optical, microphysical, and radiative properties of aerosols. It is considered that the analytical results shown in this study can be used to provide a better understanding of air quality and the variation of local radiative effects due to aerosols.

• 한국군사과학기술학회지
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• 제2권1호
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• pp.30-37
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• 1999

흙으로 침투하는 전파의 투과도와 흙에 의한 신호감쇄량을 계산하였다 대상 복합매질을 이층구조로 모델링한 후, 적분형태로 주어진 전계 표현식을 보였다. 불균일 복합매질에서는 체적산란이 일어나며, 이의 영향이 감안된 전파특성을 분석하기 위하여 반복법인 본(Born) 근사법을 사용하였다. 또한 불균일 복합매질이 가진 랜덤성의 정도는 분산과 상관길이에 의해 정해지도록 하였다. 흙에 함유된 수분량, 흙 입자의 반경, 온도 및 주파수를 변수로 하는 투과도 및 신호감쇄량 식을 제안하였다. 제안된 식으로부터 이들 변수에 따른 투과도 및 신호감쇄량의 변화를 보였다. 분석 결과, 수분이 함유된 경우에는 신호감쇄량의 변동폭이 온도에 따라서 크게 달라짐을 보게 되었고, 그 변동치는 일반적인 예상치를 훨씬 초과하였으며 그 물리적 이유를 설명하였다.

• 소성∙가공
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• 제18권8호
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• pp.640-645
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• 2009

Recently, boss and rib test based on backward extrusion process was proposed to quantitatively evaluate the interfacial friction condition in bulk forming process. In this test, the tube-shaped punch with hole pressurizes the workpiece so that the boss and rib are formed along the hole and outer surface of the punch. It was experimentally and numerically revealed that the height of boss is higher than that of the rib under the severe friction condition. This work is focused on the effect of the punch design and flow stress on deformation pattern in boss and rib test. From the boss and rib test simulations, it was found that there is slight variation in both the heights of boss and rib according to the length of punch land, nose radius, and face angle. However the hole diameter of the punch and the clearance between the punch and die have a significant influence on the calibration curves showing the heights of the boss and rib. In addition, the effect of flow stress on the calibration curves was investigated through FE simulations. It was found that there is no effect of strength coefficient of the workpiece on the calibration curves for estimation of friction condition. On the other hand, the strain-hardening exponent of the workpiece has a significant influence on the calibration curve.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 춘계학술대회논문집
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• pp.440-443
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• 2008

Plume radiation has been measured during ground tests of KSLV-I kick motor in order to predict the thermal load on the equipment around the kick motor at flight. The measuring positions are the kick motor base, and the measured heats were about 2${\sim}$5 w/cm$^2$. The measured heat showed a lot of shot fluctuation in their values, and the radiative heats at the latter half of time are higher than those of the first half. A plausible explanation for these phenomena was given as the variation of alumina particles with time. The radiative heats along the plume axis were also measured recently at 8 positions with 1.5m radius from plume axis, but only the initial parts of the results could be acceptable because the sensor were damaged by the accumulated heat. The strongest heat occurred at the middle of the plume, which can be explained with different view factors. Despite of the plausible explanation, it seems to need more analysis because the plume structure such as temperature, alumina particle, after burning has not been revealed until yet. The measure heat flux has been reflected in the prediction of the plume radiation at high altitude where the kick motor operates.

• 대한기계학회논문집B
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• 제27권9호
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• pp.1282-1289
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• 2003

Transport of a scalar quantity, such as chemical concentration or temperature, is important in many engineering applications and environmental flows. Here we report on results obtained from the large eddy simulations of flow and concentration fields inside the tank performed using a spectral multi-domain technique. The computations were driven by specifying the impeller-induced flow at the blade tip radius (Yoon et al.). This study focused on the concentration development at different molecular diffusivities in a stirred tank operated under turbulent conditions. The main objective of the work presented here is to study the large-scale mixing structure at different molecular diffusivities in a stirred tank by using the large eddy simulation. The time sequence of concentration and flow fields shows the flow dependency of the concentration development. The presence of spatial inhomogenieties is detailed by observing the time variation oflocal concentration at different positions.

• Molecules and Cells
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• 제20권3호
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• pp.325-330
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• 2005

Ancient cattle bones were excavated from archaeological sites in Jeju, Korea. We used molecular genetic techniques to identify the species and establish its relationship to extant cattle breeds. Ancient DNA was extracted from four sources: a humerus (Gonae site, A.D. 700-800), two fragments of radius, and a tooth (Kwakji site, A.D. 0-900). The mitochondrial DNA (mtDNA) D-loop regions were cloned, sequenced, and compared with previously reported sequences of various cattle breeds (9 Asian, 8 European, and 3 African). The results revealed that these bones were of the breed, Bos taurus, and a phylogenetic tree indicated that the four cattle bones formed a monophyletic group with Jeju native black cattle. However, the patterns of sequence variation and reports from archaeological sites suggest that a few wild cattle, with a different maternal lineage, may have existed on Jeju Island. Our results will contribute to further studies of the origin of Jeju native cattle and the possible existence of local wild cattle.

• Journal of Astronomy and Space Sciences
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• 제30권4호
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• pp.213-221
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• 2013

We present the first BVRI CCD photometric observations of V345 Cas made on 22 nights during the observing seasons in 2007-2008. Our light curves, resembling those of EB-type binary stars, are analyzed with the 2003 version of the Wilson-Devinney binary code. The photometric study shows that V345 Cas is a typical semi-detached binary system with the primary star being about ${\Delta}T$ = 2400 K hotter, two times more massive, but only 17% larger than the secondary star being filled with it's Roche-lobe. The orbit has a relatively large inclination of about $88^{\circ}$. A cool spot on the secondary component is modeled to explain a small light curve asymmetry. Absolute dimensions and related radiometric parameters of the eclipsing pair are calculated and their evolutionary states are discussed with the HR diagrams of mass-radius and temperature-luminosity. A period analysis of all available times of minima, including our measurements, indicates that the orbital period may vary in a cyclical way, unfortunately the secondary period for the variation can not be uniquely determined because of lack of present timing data.

• Advances in aircraft and spacecraft science
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• 제10권5호
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• pp.419-437
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• 2023

This paper presents the study of the effects of rigid-body motion simultaneously with the presence of the effects of temporal variation due to the existence of morphing speed on the aeroelastic stability of the two-stage telescopic wings, and hence this is the main novelty of this study. To this aim, Euler-Bernoulli beam theory is used to model the bending-torsional dynamics of the wing. The aerodynamic loads on the wing in an incompressible flow regime are determined by using Peters' unsteady aerodynamic model. The governing aeroelastic equations are discretized employing a finite element method based on the beam-rod model. The effects of rigid-body motion on the length-based stability of the wing are determined by checking the eigenvalues of system. The obtained results are compared with those available in the literature, and a good agreement is observed. Furthermore, the effects of different parameters of rigid-body such as the mass, radius of gyration, fuselage center of gravity distance from wing elastic axis on the aeroelastic stability are discussed. It is found that some parameters can cause unpredictable changes in the critical length and frequency. Also, paying attention to the fuselage parameters and how they affect stability is very important and will play a significant role in the design.

• 한국공간구조학회논문집
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• 제12권3호
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• pp.97-104
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• 2012

하이퍼볼릭 쉘로 구성된 냉각탑에서 쉘의 형상은 풍하중에 대하여 냉각탑 전체의 동적 거동에 민감하게 응답한다. 이에 따라 냉각탑 설계 시 기하형상의 결정은 매우 중요하며 일반적으로 고유진동수를 기반으로 하여 산정한다. 본 연구의 목적은 냉각탑 쉘의 구조적 거동에서 형상변수가 미치는 영향을 파악하고자 한다. 기존의 냉각탑 형상변수를 변화시켜 32개의 모델을 선정하였고 이를 1차 고유진동수를 기반으로 하여 분석한 후, 3개의 대표적인 형상을 선택하여 선형 해석을 수행하였다. 그 결과, 전체적으로 작은 반지름을 가지는 기하형상이 높은 1차 고유진동수를 나타내고 풍하중에 대하여 덜 민감한 시스템이 되는 것을 알 수 있었다.