• 대한방사선협회지
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• 제29권1호
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• pp.225-225
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• 2003

• 대한방사선기술학회지:방사선기술과학
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• 제32권3호
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• pp.293-298
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• 2009

배경/목적 : 담낭결석은 담도계의 가장 흔한 질환이며 급성복통을 유발하는 질환이다. 담낭결석으로 인한 담낭염이 자주 발생하고 담낭암의 발생 가능성이 높아진다. 본 연구의 목적은 지역사회의 담낭결석 유병률과 위험요인을 알아보고자 한다. 대상 및 방법 : 2008년 7월 한 달 동안 제주도 10곳에서 60세 이상 노인의 남자 297명, 여자 529명 총 826명을 대상으로 하였다. 대상자는 신장, 체중을 측정하고 혈액검사와 상복부초음파 검사를 시행하였다. 통계학적 검증은 T-test, chi-square test로 검정하여 p < 0.05 이하일 경우 유의한 결과로 판정하였다. 결 과 : 담낭결석 유병률은 5.9%(49/826명)이었다. 남성은 6.1%, 여성은 5.8%로 남성이 여성보다 1.03배 높게 나타났다. 연령별로는 $70{\sim}74$세에서 8.0%로 가장 높은 유병률을 보였다. 담낭결석 집단에서 과체중 이상이 69.3%로 높게 나타났으며, 집단 간의 유의한 차이를 보였다(p < 0.047). 결 론 : 연령의 증가에 따라 담낭결석의 발생률이 높게 나타났다. 비만은 담낭결석 위험요인으로 나타났으며 적절한 체중 관리와 식이조절을 한다면 어느 정도 담낭결석 발생을 줄일 수 있을 것으로 생각된다.

• BMB Reports
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• 제47권10호
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• pp.575-580
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• 2014

In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). A dose dependent relationship between arsenite and reduced cell growth is demonstrated, as well as induced ${\gamma}H2AX$ foci formation in both U87MG-neo and U87MG-E6 cells at low concentrations of arsenite. Senescence was induced by arsenite with senescence-associated ${\beta}$-galactosidase staining. Dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation was accompanied by p21 accumulation only in U87MG-neo but not in U87MG-E6 cells. This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. p21 and p53 siRNA consistently decreased H3TMK9 foci formation in U87M G-neo but not in U87MG-E6 cells after arsenite treatment. Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.

• 대한방사선기술학회지:방사선기술과학
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• 제46권4호
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• pp.303-313
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• 2023

This study aimed to investigate the relevance of cardiovascular disease risk factors AI and AIP, divided into three groups, among 300 individuals who underwent health checkups at the hospital. Various variables such as Age, Sex, BMI, WC, TC, TG, HDL-C, LDL-C, FBS, HbA1C, SBP, DBP, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were analyzed using statistical methods including frequency analysis, cross-tabulation, one-way ANOVA, Pearson's correlation analysis, and multiple linear regression analysis. The cross-analysis based on cardiovascular disease risk criteria revealed that men and individuals in their 50s had higher cardiovascular disease risk based on AI and AIP. Significant differences were observed in TG, TC, HDL-C, LDL-C, SBP, DBP, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) according to AI criteria. For the AIP criteria, TG, TC, HDL-C, FBS, HbA1C, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were identified as cardiovascular disease risk factors. FBS and HbA1c showed the highest positive correlation In the correlation analysis, followed by TC and LDL-C. The lowest positive correlation was observed between LDL-C and DBP. In terms of negative correlation, HDL-C and AI had the highest negative correlation, while LDL-C and TG showed the lowest negative correlation. Multiple regression analysis indicated that the AI and AIP risk criteria had explanatory powers of 73.6% and 72.5%, respectively. HDL-C had the greatest negative effect on the AI risk criterion, while TG had the most significant influence on the AIP risk criterion. In conclusion, while other serological variables are important, managing HDL-C and TG levels may help reduce the risk of cardiovascular disease.

• 대한방사선기술학회지:방사선기술과학
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• 제45권1호
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• pp.19-29
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• 2022

The study is conducted with the subjects who have under gone coronary angiography to examine the influential factors for the severity of coronary stenosis. Four indicators related to hypertension, diabetes, dyslipidemia, obesity of metabolic syndrome were used as influential factors. As a result of the study, metabolic syndrome such as diabetes and dyslipidemia had 3.3 times and 7.7 times higher chance to lead to 1VD, respectively. In 2VD, diabetes showed 2.9 times higher risk, and dyslipidemia showed 8.5 times higher risk. In 3VD, diabetes was found to be 5 times higher and dyslipidemia was 17.5 times higher in risk. Therefore, it was confirmed that dyslipidemia showed the highest correlation among metabolic syndromes. According to this study, it was confirmed that dyslipidemia and diabetes were closely related to the influential factors for coronary artery stenosis.

• Nuclear Engineering and Technology
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• 제56권2호
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• pp.707-714
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• 2024

Different degrees of natural radioactivity found in quartz can have negative consequences on health. Quartz vein along the investigated Abu Ramad area, Egypt, had its natural radioactivity assessed. The HPGe spectrometer was used to determine the role played by the radionuclides ²³⁸U, ²³²Th, and ⁴⁰K in the gamma radiation that was emitted, and the results showed that these concentrations are 484.64 ± 288.4, 36.8 ± 13.1 and 772.2 ± 134.6 Bq kg^-1 were higher than the corresponding reported global limits of 33, 45, and 412 Bq kg^-1 for each radionuclide (²³⁸U, ²³²Th, and ⁴⁰K). Among the radiological hazard parameters, the excess lifetime cancer risk (ELCR) is estimated and it's mean value of ELCR (1.2) is higher than the permissible limit of 0.00029. The relationship between the radionuclides and the associated radiological hazard characteristics was investigated based on multivariate statistical methods including Pearson correlation, principal component analysis (PCA), and hierarchical cluster analysis (HCA). According to statistical research, the radioactive risk of quartz is primarily caused by the ²³⁸U, ²³²Thand ⁴⁰K. Finally, applying quartz to building materials would pose a significant risk to the public.

• Journal of Korean Neurosurgical Society
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• 제57권2호
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• pp.108-113
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• 2015

Objective : Although the L5-S1 has distinct structural features in comparison with other lumbar spine segments, not much is known about adjacent segment degeneration (ASD) at the L5-S1 segment. The aim of study was to compare the incidence and character of ASD of the cephalad and L5-S1 segments after L5 floating lumbar fusion. Methods : From 2005 to 2010, 115 patients who underwent L5 floating lumber fusion were investigated. The mean follow-up period was 46.1 months. The incidence of radiological and clinical ASD of the cephalad and the L5-S1 segments was compared using survival analysis. Risk factors affecting ASD were analyzed using a log rank test and the Cox proportional hazard model. Results : Radiological ASD of the L5-S1 segment had a statistically significant higher survival rate than that of the cephalad segment (p=0.001). However, clinical ASD of the L5-S1 segment was significantly lower survival rates than that of the cephalad segment (p=0.038). Risk factor analysis showed that disc degeneration of the cephalad segment and preoperative spinal stenosis of the L5-S1 segment were risk factors. Conclusion : In L5 floating fusion, radiological ASD was more common in the cephalad segment and clinical ASD was more common in the L5-S1 segment. At the L5-S1 segment, the degree of spinal stenosis appears to be the most influential risk factor in ASD incidences, unlike the cephalad segment.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1095-1103
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• 2020

Objective: The present study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters offer an incremental risk stratification benefit over the CT ventricular diameter ratio in patients with acute pulmonary embolism (PE) by using propensity score analysis. Materials and Methods: This study was conducted on 480 patients with acute PE who underwent CT pulmonary angiography (CTPA) or DECT pulmonary angiography (DE CT-PA). This propensity-matched study population included 240 patients with acute PE each in the CTPA and DECT groups. Altogether, 260 (54.1%) patients were men, and the mean age was 64.9 years (64.9 ± 13.5 years). The primary endpoint was all-cause death within 30 days. The Cox proportional hazards regression model was used to identify associations between CT parameters and outcomes and to identify potential predictors. Concordance (C) statistics were used to compare the prognoses between the two groups. Results: In both CTPA and DECT groups, right to left ventricle diameter ratio ≥ 1 was associated with an increased risk of all-cause death within 30 days (hazard ratio: 3.707, p < 0.001 and 5.573, p < 0.001, respectively). However, C-statistics showed no statistically significant difference between the CTPA and DECT groups for predicting death within 30 days (C-statistics: 0.759 vs. 0.819, p = 0.117). Conclusion: Quantitative measurement of lung perfusion defect volume by DECT had no added benefit over CT ventricular diameter ratio for predicting all-cause death within 30 days.

• 대한방사선기술학회지:방사선기술과학
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• 제43권3호
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• pp.177-185
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• 2020

This study investigated the relationship between metabolic syndrom risk factors to patients with left atrial enlargement according to the results of echocardiography. Male were 269(8.9%) and female were 46(1.5%) that of the total 315 patients (10.5%) with left atrial enlargement. In the obesity factors analysis, BMI, WC, and WHtR were associated with left atrial enlargement. Among them, WHtR included the many obese people with left atrial enlargement. In the analysis of blood pressure, The systolic blood pressure was the highest in the borderline hypertension group in the left atrial enlargement and the diastolic blood pressure was the highest in the normal range group in the left atrial enlargement. In the blood result analysis, there was no correlation with left atrial enlargement that total cholesterol, HDL, LDL cholesterol, triglyceride, and fasting blood glucose level were within the normal range. Therefore, obesity and systolic blood pressure were associated with the left atrial enlargement group. However, the systolic blood pressure did not show pathological condition due to borderline hypertension, and the distribution of the left atrial enlargement group was smaller than that of obesity. Obesity, which includes the largest number of left atrial enlargement group, has been identified to be the highest risk factor for left atrial enlargement.

• 대한방사선기술학회지:방사선기술과학
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• 제39권4호
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• pp.549-555
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• 2016

본 연구는 다운증후군 위험도의 예측을 위해 통합선별검사를 실시한 산모를 대상으로, 각 표지자의 유의성에 대한 평가를 하였다. 초음파로 측정한 NT 영상, 산모혈청 PAPP-A, AFP, uE3, hCG, 인히빈 A의 상관성을 후향적으로 분석하였다. 그 결과 NT, uE3, hCG, 인히빈 A와 유의한 상관관계를 보였다(p<.001). ROC분석에서 인히빈 A의 AUC가 0.851로 다운증후군의 가장 큰 예측인자로 분석되었으며. cut-off value 1.33 MoM(민감도 87.5%, 특이도 71.5%)으로 결정되었다. 결론적으로 통합선별검사에서 인히빈 A가 다운증후군을 예측하는 가장 유용한 인자로 나타났다. 이에 각 표지자(parameter)들의 cut-off value를 바탕으로 통합선별검사의 단점을 보완한다면 다운증후군 선별의 독립적인 지표로 사용될 수 있을 것으로 사료된다.