• 제목/요약/키워드: Radioisotopes

검색결과 193건 처리시간 0.024초

Arylthallium ditrifluoroacetate를 중간체(中間體)로 하는 방사성의약품(放射性醫藥品)의 합성법(合成法) (Preparation of Radiopharmaceuticals through Arylthallium Ditrifluoroacetate Intermediate)

  • 김유선
    • 대한핵의학회지
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    • 제17권2호
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    • pp.71-77
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    • 1983
  • Amino acids such as L-tyrosine, L-histidine, and tryptophan, which bear an aromatic ring in the molecule, could successfully be labelled by radioactive iodine through arylthallium ditrifluoroacetate intermediate. Generally, the labelling reaction could proceed in a short labelling time(ca, 20 minutes) and resulted in a high labelling yields and purity of the labelled product. This procedure has, therefore, been proved to be effective as the labelling method of short labelling time and high specific activity. Labelling proteins such as oval albumin and human albumin could also be achieved in $34\sim48%$ net labelling yield by thallating them at the low temperature $(0\sim10^{\circ}C)$, whereas the labelled products were mainly composed of various denatured products by thallating them at the high temperature$(35\sim40^{\circ}C)$, though the radioactivity was highly retained in the labelled products. Uracil and hippuric acid could also be labelled in a short labelling time though their thallation required a prolonged heating procedure. It was proved that this procedure may be effective to label these compounds by short lived radioisotopes. The labelling yields were, however, lower than 30%.

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악골 골수염의 조기 진단 (EARLY DIAGNOSIS OF OSTEOMYELITIS OCCURRED IN THE JAWS)

  • 최은숙;나승목;이언경;고광준
    • 치과방사선
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    • 제24권2호
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    • pp.479-487
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    • 1994
  • Early diagnosis and treatment of osteomyelitis provide good prognosis and prevent severe complications. Therefore, it is important to early diagnose and treat before the bony changes are observed in conventional radiograms. Authors experienced three cases of early osteomyelitis, and scintigrams were useful to differentiate them from other diseases. The purpose of this report was to aid in the early diagnosis and treatment of osteomyelitis occurred in the jaws. The characteristic features were as follows: 1. In clinical examination, the patients complained mild pain and localized swelling in the jaws. 2. In radiographic findings, the conventional radiograms showed relatively mild bony changes in the jaws. 3. The more severe periosteal reactions were observed in radiograms in children than in adult patient. 4. It showed marked increased uptake of radioisotopes in all scintigrams. 5. The three phase bone scannings were helpful to differentiate osteomyelitis from soft tissue diseases.

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Ir-192 산업용 방사선원의 생산을 위한 저항용접기술 개발 (Development of resistance welding technology for producing Ir-192 industrial radiation sources)

  • 한인수;손광재;이준식;장경덕;박울재
    • 대한용접접합학회:학술대회논문집
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    • 대한용접접합학회 2007년 추계학술발표대회 개요집
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    • pp.288-290
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    • 2007
  • Ir-192 source is one of the most widely used radioisotopes in the field of non-destructive testing applications. To obtain radiation safety it is necessary to take into consideration integrity of welded joint in the production of sealed radiation source. Generally, the quality of a resistance welded joint is strongly influenced by process parameters during the welding process such as current, welding time and applied force. In this study, resistance welding technology and system were developed for sealing of Ir-192 industrial radiation source capsules. In order to evaluate the weld quality in real time, quantitative relationships between process parameters and electrode displacement were also established.

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Experimental and Simulated Efficiency of a HPGe Detector in the Energy Range of $0.06{\sim}11$ MeV

  • Park Chang Su;Sun Gwang Min;Choi H.D.
    • Nuclear Engineering and Technology
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    • 제35권3호
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    • pp.234-242
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    • 2003
  • The full energy peak efficiency of a hyper pure germanium (HPGe) detector was calibrated in a wide energy range from 0.06 to 11 MeV. Both the experimental technique and the Monte Carlo method were used for the efficiency calibration. The measurement was performed using the standard radioisotopes in the low energy region of $60{\sim}1408$ keV, which was further extended up to 11 MeV by using the $^{14}N(n,r)\;and\;^{35}Cl(n,r)$ reactions. The GEANT Monte Carlo code was used for efficiency calculation. The calculated efficiency had the same dependency on the r-ray energy with the measurement, and the discrepancy between the calculation and the measurement was minimized by fine-tuning of the detector geometry. From the calculated result, the efficiency curve of the HPGe detector was reliably determined particularly in the high energy region above several MeV, where the number of measured efficiency points is relatively small despite the wide energy region. The calculated efficiency agreed with the measurement within about $7\%$. In addition to the efficiency calculation, the origin of the local minimum near 600 keV on the efficiency curve was analyzed as a general characteristics of a HPGe detector.

대기를 통하여 한반도 지표면으로 공급되는 방사성 핵종( $^137Cs$$^210Pb$)에 관한 연구 (A Study on the Atmospheric Deposition of Radionuclides($^137Cs$ and $^210Pb$) on the Korean Peninsula)

  • 이윤구;김석현;홍기훈;이광우
    • 한국대기환경학회지
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    • 제11권4호
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    • pp.351-359
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    • 1995
  • In order to investigate geochemical behaviors of artificial radionuclide($^{137}$ Cs), the fallout deposition of arificial radioisotope($^{137}$ Cs) was measured from May to October in 1994 at the Korea Ocean Research & Development Institute(KORDI), Ansan, Kyunggido, Korea. And to study radioisotopic behavior and cumulative action in soil, soil samples were collected from Kwang-Leung Forest, Kyunggidom and artificial radioisotope ($^{137}$ Cs) and natural radioisotope($^{210}$ Pb) were identified. The amount of $^{137}$ Cs in atmosphere collected by wet deposition process in May was found to be 4.95 to 11.96mBq m$^{-2}$ whereas the amounts of $^{137}$ Cs by dry deposition process in May and October were found to be 4.0mBq g$^{-1}$ and 3.0mBq g$^{-1}$ , respectively. The amount of $^{137}$ Cs accumulated in soil was measured to be 311mBq cm$^{-2}$ , which contained 83% of the total inputs from atmospheric fallout (374 mBq cm$^{-2}$ ) since 1960s. In addition, the accumulation rate and the annual flux of $^{210}$ Pb into soils were 0.32cm yr$^{-1}$ and 34 mBq cm$^{-2}$ yr$^{-1}$ , respectively. Conclusively, it was found that arificial radioisotopes were mainly from the stratosphere and soil resupension of continental China through the troposphere.

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Karlsruhe 원자력연구소 주변의 환경방사능 측정자료로부터 실효선량당량계산 (A Calculation of Effective Dose Equivalent from Data of Environmental Monitoring around the Karlsruhe Nuclear Research Center)

  • 이창우;이정호
    • Journal of Radiation Protection and Research
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    • 제15권2호
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    • pp.75-85
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    • 1990
  • Kalsruhe원자력 연구소(KfK) 주변의 방사능 측정자료로부터 피폭선량을 계산하였다. 식물성 식품의 섭취가 가장 중요한 피폭 경로였고, 식품중의 자연방사성 동위원소인 K-40 과 Pb-210이 주요 피폭원이었다. 인공방사능에의한 피폭은 대부분 지표에 침척된 Cs-134 와 Cs-137으로부터 방출되는 감마선 때문이었다. KfK주변환경에서의 유효선량당량은 ICRP의 권고제한치보다 훨씬 적은 값이었다.

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MACCS II 코드를 이용한 국내 경수로 및 중수로형 원전의 소외결말분석 (Off-Site Consequence Analysis for PWR and PHWR Types of Nuclear Power Plants Using MACCS II Code)

  • 전호준;지문구;황석원
    • 한국안전학회지
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    • 제26권5호
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    • pp.105-109
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    • 2011
  • Since a severe accident, which happens in low frequency, can cause serious damages, the interests in off-site consequence analysis for a nuclear power plant have been increased after Chernobyl, TMI and Fukushima accidents. Consequences, which are the effects on health and environment caused by released radioisotopes, are evaluated using MACCS II code based on the method of Level 3 PSA. To perform a consequence analysis for the reference plants, the input data of the code were generated such as meteorological data, population distribution, release fractions, and so on. Using these input data, acute and lifetime dose as an organ, CCDF for early fatalities and latent cancer fatalities, and average individual risk were analyzed by using MACCS II code in this study. These results might contribute to establishing accident management plan and quantitative health object.

Estimation of nuclear heating by delayed gamma rays from radioactive structural materials of HANARO

  • Noh, Tae-yang;Park, Byung-Gun;Kim, Myong-Seop
    • Nuclear Engineering and Technology
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    • 제50권3호
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    • pp.446-452
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    • 2018
  • To improve the accuracy and safety of irradiation tests in High flux Advanced Neutron Application ReactOr (HANARO), the nuclear energy deposition rate, which is called nuclear heating, was estimated for an irradiation capsule with an iridium sample in the irradiation hole in order. The gamma rays emitted from the radioisotopes (RIs) of the structural materials such as flow tubes of fuel assemblies and heavy water reflector tank were considered as radiation source. Using the ORIGEN2.1 code, emission rates of delayed gamma rays were calculated in consideration of the activation procedure for 8 years and 2 months of HANARO operation. Calculated emission rates were used as a source term of delayed gamma rays in the MCNP6 code. By using the MCNP code, the nuclear heating rates of the irradiation capsules in the inner core, outer core, and heavy water reflector tank were estimated. Calculated nuclear heating in the inner core, outer core, and heavy water reflector tank were 200-260 mW, 80-100 mW, and 10 mW, respectively.

방사성 히알루론산 합성 (Synthesis of 125I-Labeled Hyaluronic Acid)

  • 마소영;이동은;박상현
    • 방사선산업학회지
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    • 제8권2호
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    • pp.77-81
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    • 2014
  • Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and N-acetylglucosamine, and is a glycosaminoglycan. It is widely distributed in animal connective tissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to protein in the body, and thus maintains and lubricates tissue structures. In addition, its antibiotic properties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an object of great interest at cosmetic and pharmaceutical companies. $^{125}I$ has a longer half-life (59.4 days) than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facile and efficient procedure for the synthesis of $^{125}I$-labeled hyaluronic acid has been designed for in vivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the development of new drugs.

RI-Biomics 분야 기술정보 표준분류체계 개발 및 적용 (Development of the Standard Classification System of Technical Information in the Field of RI-Biomics and Its Application to the Web System)

  • 장솔아;김주연;박태진
    • 방사선산업학회지
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    • 제8권3호
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    • pp.155-159
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    • 2014
  • RI-Biomics is a new concept that combines radioisotopes (RI) and Biomics. For efficient collection of information, establishment of database for technical information system and its application to the system, there is an increasing need for constructing the standard classification system of technical information by its systematical classification. In this paper, we have summarized the development process of the standard classification system of technical information in the field of RI-Biomics and its application to the system. Constructing the draft version for the standard classification system of technical information was based on that standard classification one in national science and technology in Korea. The final classification system was then derived through the reconstruction and the feedback process based on the consultation from the 7 experts. These results were applied to the database of technical information system after transforming as standard code. Thus, the standard classification system were composed of 5 large classifications and 20 small classifications, and those classification are expected to establish the foundation of information system by achieving the circular structure of collection-analysis-application of information.