• 제목/요약/키워드: Radiation-induced

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방사선 유도 돌연변이체 블랙베리로 제조한 발효음료의 간 손상 회복 효과 (Effect of Fermented Blackberry Drinks Formed from Radiation-induced Mutant on Liver Repair Capacity in Rats)

  • 조병옥;소양강;이창욱;조정근;우현심;진창현;정일윤
    • 방사선산업학회지
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    • 제7권1호
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    • pp.81-85
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    • 2013
  • This study was conducted to investigate the effect of fermented blackberry drinks (BD) on carbon tetrachloride ($CCl_4$)-induced liver injury in rats. Male Sprague-Dawley rats were randomly divided into four groups with 6 rats per group: control, $CCl_4$, $CCl_4$ plus BD $3ml\;kg^{-1}$, and $CCl_4$ plus BD $6ml\;kg^{-1}$. We found that the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly increased and the activity of antioxidant enzyme glutathione peroxidase (GPx) in the liver was decreased in rats treated with $CCl_4$ alone when compared with the control group. However, the administration of BD attenuated the levels of serum AST and ALT in $CCl_4$-treated rats. Moreover, the administration of BD significantly increased the activity of GPx in $CCl_4$-treated rat livers. Taken together, these results suggest that BD could protect the liver from $CCl_4$-induced hepatic damage.

Radiation-induced Tumorigenesis

  • Kim, In-Gyu;Lee, Yun-Sil
    • BMB Reports
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    • 제36권1호
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    • pp.144-148
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    • 2003
  • During the past 2 decades, radiation tumorigenesis researchers have focused on cellular and molecular mechanisms. We reviewed some of these research fields, since they may specifically relate to the induction of cancer by ionizing radiation. First, radiation-mediated mutation was discussed. Then the initiating event in radiation carcinogenesis, as well as other genetic events that may by involved, is discussed in terms of the possible role of the activation of genes and the loss of cell-cycle checkpoints.

Preparation and Characterization of Poly(styrenesulfonic acid)-grafted Fluoropolymer Membrane for Direct Methanol Fuel Cell

  • Choi, Jae-Hak;Kang, Phil-Hyun;Lim, Youn-Mook;Sohn, Joon-Yong;Shin, Jun-Hwa;Jung, Chan-Hee;Jeun, Joon-Pyo;Nho, Young-Chang
    • Korean Membrane Journal
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    • 제9권1호
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    • pp.52-56
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    • 2007
  • A proton exchange membrane was prepared by ${\gamma}-irradiation-induced$ grafting of styrene into poly(tetrafluoro-ethylene-co-perfluoropropyl vinyl ether) (PFA) and subsequent sulfonation reaction. The degree of grafting (DOG) increased with an increase in the absorbed dose. The prepared membranes showed high ion exchange capacity reaching 3.0 meq/g, which exceeded the performance of commercially available perfluorosulfonic acid membranes such as Nafion. The proton conductivity of PFA-g-PSSA membrane increased with the DOG and reached 0.17 S/cm for the highest sample at room temperature. The DMFC performance of the prepared membranes with 50% DOG was comparable to that of Nafion membrane.

Implementation of a Radiation-hardened I-gate n-MOSFET and Analysis of its TID(Total Ionizing Dose) Effects

  • Lee, Min-Woong;Lee, Nam-Ho;Jeong, Sang-Hun;Kim, Sung-Mi;Cho, Seong-Ik
    • Journal of Electrical Engineering and Technology
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    • 제12권4호
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    • pp.1619-1626
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    • 2017
  • Electronic components that are used in high-level radiation environment require a semiconductor device having a radiation-hardened characteristic. In this paper, we proposed a radiation-hardened I-gate n-MOSFET (n-type Metal Oxide Semiconductors Field Effect Transistors) using a layout modification technique only. The proposed I-gate n-MOSFET structure is modified as an I-shaped gate poly in order to mitigate a radiation-induced leakage current in the standard n-MOSFET structure. For verification of its radiation-hardened characteristic, the M&S (Modeling and Simulation) of the 3D (3-Dimension) structure is performed by TCAD (Technology Computer Aided Design) tool. In addition, we carried out an evaluation test using a $Co^{60}$ gamma-ray source of 10kGy(Si)/h. As a result, we have confirmed the radiation-hardened level up to a total ionizing dose of 20kGy(Si).