• Radiation Oncology Journal
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• 제31권4호
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• pp.191-198
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• 2013

Purpose: To observe long-term clinical outcomes for patients with early-stage breast cancer treated with forward intensity-modulated radiation therapy (IMRT), including local control and clinical toxicities. Materials and Methods: We retrospectively analyzed a total of 214 patients with stage I-II breast cancer who were treated with breast conserving surgery followed by adjuvant breast radiation therapy between 2001 and 2008. All patients were treated using forward IMRT. The whole breast was irradiated to a dose of 50 to 50.4 Gy followed by an 8 to 12 Gy electron boost to the surgical bed. Results: The median age was 46 years (range, 21 to 82 years) and the medial follow-up time was 7.3 years (range, 2.4 to 11.7 years). Stage T1 was 139 (65%) and T2 was 75 (35%), respectively. Ipsilateral breast recurrence was observed in 3 patients. The 5- and 10-year local control rates were 99.1% and 97.8%, respectively. The cosmetic outcome was evaluated according to the Harvard scale and 89.4% of patients were scored as excellent or good. Conclusion: The whole breast radiation therapy as an adjuvant treatment using a forward IMRT technique showed excellent long-term local control as well as favorable outcomes of toxicity and cosmesis.

• Radiation Oncology Journal
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• 제26권2호
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• pp.126-130
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• 2008

대퇴골두 무혈성괴사는 혈류장애로 인해 대퇴골두의 골세포 괴사가 나타나는 것으로 여러 원인 중 방사선치료도 하나의 원인으로 알려져 있으나 발병률에 대해서는 보고된 바 없는 상태이다. 저자들은 삼성서울병원에서 전골반 방사선치료를 받은 자궁암환자 577명 중 2명의 환자에서 대퇴골두 무혈성괴사를 경험하였다. 2예 모두 전형적인 방사선학적 소견을 보였다. 골반 방사선치료 후 발생하는 대퇴골두 무혈성괴사는 매우 드물게 나타나지만 방사선 조사 범위에 국한된 특징적인 영상의학적 소견을 보이므로 진단에 유념해야 하겠다.

• Biomolecules & Therapeutics
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• 제20권4호
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• pp.357-370
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• 2012

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제20권4호
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• pp.379-382
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• 1998

The 44 years old man was consulted to our department due to restriction of mouth opening. On radiograph, we found bony expansive lesion at right mandibular ramus and temporal bone that it was suspected malignant tumor. So we had performed incisional bone biopsy at right ramus through skin incision. The result of biopsy was osteosarcoma. Then, he had experienced radiation therapy for the protection of recurrence after several times surgery of nasopharyngeal angiofibroma, 28 years ago. So, we concluded radiation induced osteosarcoma from his radiation therapy history. He had referred to the department of hematooncology because of severe expansion to skull base and was received 4 times chemotherapy with cisplatin and adriamycin, but he was expired just after 4th chemotherapy. Such radiation induced osteosarcoma have relative good prognosis due to rare metastasis from other reports. So if it will early detect from close follow up after radiation therapy, survival rate will rise up. But we missed early detection of our case. So, we report a case of rare radiation induced osteosarcoma. Ly detection of our case.

• 한국의학물리학회지:의학물리
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• 제22권4호
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• pp.178-183
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• 2011

본 연구에서는 토모테라피를 이용한 폐종양의 방사선수술 치료계획을 수립한 후 기존의 선형가속기를 사용하였을 경우와 비교, 분석하여 선량분포 측면에서 유효성 및 타당성을 살펴보았다. 종양의 움직임이 5 mm 이하인 10명의 환자 CT 영상을 대상으로 기존의 선형가속기를 이용한 세기조절방사선수술에서와 동일한 처방선량과 동일한 조건의 중요장기 선량제한치로 토모테라피 치료계획을 수립한 후 선량분포를 비교하였다. 토모테라피를 이용한 결과에서도 기존의 선형가속기를 이용한 세기조절방사선수술과 동일하게 중요장기의 선량제한치를 충족시키면서 GTV에 처방선량을 부여할 수있음을 확인하였다. 방사선조사로 인한 폐의 정상조직합병증확률과 종양 반대편 폐의 등가균일선량 측면에서는 토모테라피가 기존 선형가속기보다 상대적으로 더 우수한 결과를 보였으나, 종양 내 치료선량 분포의 균일도에서는 기존 선형 가속기가 더 양호한 결과를 보였다. 치료 빔 전달 시간측면에서는 토모테라피가 기존 선형가속기 경우보다 2배 이상의 시간이 소요되었다. 이와 같은 본 연구의 결과 분석을 통해 폐종양 부위의 움직임이 적은 경우, 환자의 상태와 선량분포의 적합성 등을 고려한 최적의 치료계획을 세운다면 토모테라피를 사용하는 방사선 수술이 유효성 및 타당성이 있음을 확인할 수 있었다.

• Radiation Oncology Journal
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• 제34권2호
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• pp.135-144
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• 2016

Purpose: The purpose of this study was to evaluate the efficacy of art therapy to control fatigue in cancer patients during course of radiotherapy and its impact on quality of life (QoL). Materials and Methods: Fifty cancer patients receiving radiotherapy received weekly art therapy sessions using famous painting appreciation. Fatigue and QoL were assessed using the Brief Fatigue Inventory (BFI) Scale and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) at baseline before starting radiotherapy, every week for 4 weeks during radiotherapy, and at the end of radiotherapy. Mean changes of scores over time were analyzed using a generalized linear mixed model. Results: Of the 50 patients, 34 (68%) participated in 4 sessions of art therapy. Generalized linear mixed models testing for the effect of time on mean score changes showed no significant changes in scores from baseline for the BFI and FACIT-F. The mean BFI score and FACIT-F total score changed from 3.1 to 2.7 and from 110.7 to 109.2, respectively. Art therapy based on the appreciation of famous paintings led to increases in self-esteem by increasing self-realization and forming social relationships. Conclusion: Fatigue and QoL in cancer patients with art therapy do not deteriorate during a period of radiotherapy. Despite the single-arm small number of participants and pilot design, this study provides a strong initial demonstration that art therapy of appreciation for famous painting is worthy of further study for fatigue and QoL improvement. Further, it can play an important role in routine practice in cancer patients during radiotherapy.

• 대한방사선치료학회지
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• 제12권1호
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• pp.85-90
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• 2000

• 대한방사선치료학회지
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• 제1권1호
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• pp.93-103
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• 1985

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.937-938
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• 2016

Stereotactic body radiation therapy (SBRT) appears an effective and safe treatment modality for spinal bone metastasis, which can enhance local control and improve quality of life. Life expectation, predicted fracture risk, localization, quality, size and number of metastasis and presence or absence of nerve compression seem to be important factors in decision-making for treatment. Further studies are needed to identify subsets of patient which will most benefit from treatment.

• 전자공학회논문지SC
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• 제43권6호
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• pp.68-75
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• 2006

고 에너지 방사선을 이용하여 종양을 치료하는 과정 중 발생되는 오차를 확인하여 보다 정교한 치료를 수행함으로써 방사선치료 효율을 향상시킬 수 있다. 본 논문에서는 지금까지 주로 사용되어진 필름을 이용한 아날로그 방식대신 실 시간적으로 영상을 얻을 수 있는 디지털 방식의 비디오 기반 전자 포탈 영상 장치를 개발하였다. 시스템은 $Gd_2O_2S$ 인광판, $45^{\circ}$반사경 및 후레임 그래버를 이용 비디오 기반 전자 포탈 영상 장치를 제작하였으며 이를 방사선치료기의 QA장치로 활용하고자 하였다. 이 장치를 이용 치료기 자체의 정확도를 검증하기 위해 방사선 조사면 검증을 수행하였다. 방사선 조사면이 콜리메이터 회전오차에 의해 약 $0.6^{\circ}$틀어짐을 전자 포탈 영상 장치를 통해 획득된 영상의 윤곽선을 검출한 후 알 수 있어서 치료 위치 설정 중 발생할 수 있는 오차 확인을 위한 방사선 치료장치의 Q.A도구로 사용할 수 있었다.