• Radiation Oncology Journal
• /
• v.37 no.1
• /
• pp.13-21
• /
• 2019

Purpose: Glioblastoma (GBM) carries a high propensity for in-field failure despite trimodality management. Past studies have failed to show outcome improvements with dose-escalation. Herein, we examined trends and outcomes associated with dose-escalation for GBM. Materials and Methods: The National Cancer Database was queried for GBM patients who underwent surgical resection and external-beam radiation with chemotherapy. Patients were excluded if doses were less than 59.4 Gy; dose-escalation referred to doses ≥66 Gy. Odds ratios identified predictors of dose-escalation. Univariable and multivariable Cox regressions determined potential predictors of overall survival (OS). Propensity-adjusted multivariable analysis better accounted for indication biases. Results: Of 33,991 patients, 1,223 patients received dose-escalation. Median dose in the escalation group was 70 Gy (range, 66 to 89.4 Gy). The use of dose-escalation decreased from 8% in 2004 to 2% in 2014. Predictors of escalated dose were African American race, lower comorbidity score, treatment at community centers, decreased income, and more remote treatment year. Median OS was 16.2 months and 15.8 months for the standard and dose-escalated cohorts, respectively (p = 0.35). On multivariable analysis, age >60 years, higher comorbidity score, treatment at community centers, decreased education, lower income, government insurance, Caucasian race, male gender, and more remote year of treatment predicted for worse OS. On propensity-adjusted multivariable analysis, age >60 years, distance from center >12 miles, decreased education, government insurance, and male gender predicted for worse outcome. Conclusion: Dose-escalated radiotherapy for GBM has decreased over time across the United States, in concordance with guidelines and the available evidence. Similarly, this large study did not discern survival improvements with dose-escalation.

• Journal of Radiation Industry
• /
• v.5 no.1
• /
• pp.47-54
• /
• 2011

In this study, we investigated to evaluate differential expression of genes encoding lipid transfer proteins (LTP) by acute and chronic gamma irradiation in rice. After acute and chronic gamma irradiation by 100 Gy and 400 Gy to rice plant, necrotic lesion was observed in the leaf blade and anthocyanin contents were increased. We isolated a total of 21 rice lipid transfer protein (LTP) genes in the TIGR database, and these genes were divided into four different groups on the basis of nucleotide sequences. The LTP genes also were classified as different four classes according to expression pattern using RT-PCR. Group A, B contained genes with increased expression and decreased expression in acute and chronic, respectively. Group C contained genes with contrasted expression pattern. Group D wasn't a regular pattern. But the specific affinity was not obtained between two grouping.

• Radiation Oncology Journal
• /
• v.38 no.1
• /
• pp.11-17
• /
• 2020

Purpose: Definitive radiotherapy remains a primary treatment option for early stage glottic cancer. Intensity-modulated radiation therapy (IMRT) has emerged as the standard treatment technique for advanced head and neck cancers, whereas three-dimensional conformal radiotherapy (3D-CRT) has remained standard for early glottic cancers. We used the National Cancer Database (NCDB) to identify predictors of IMRT use and effect on outcome in these patients. Materials and Methods: We queried the NCDB from 2004-2015 for squamous cell carcinoma of the glottic larynx staged Tis-T2N0 treated with radiation alone. Logistic regression was used to identify predictors of IMRT. Cox regression was used to identify factors predictive of overall survival. Propensity matching was conducted to account for indication bias. Results: We identified 15,627 patients, of which 11% received IMRT. IMRT use rose from 2% in 2004 to 16% in 2015. Predictors of IMRT include: increased comorbidity, T2 stage, urban location, chemotherapy, treatment at an academic center, and later treatment year. Predictors of improved survival were female gender, higher income, lower stage, no chemotherapy, academic facility, and more remote year. There was no difference in survival between 3D-CRT and IMRT across all stages. Conclusions: The rate of IMRT use for early stage glottic laryngeal cancer has increased over time. There was no difference in outcome in patients receiving IMRT versus 3D-CRT across the cohort.

• Nuclear Engineering and Technology
• /
• v.55 no.10
• /
• pp.3854-3859
• /
• 2023

Background: This study aims to develop an evaluator that can quickly and accurately evaluate the shielding of low-energy industrial radiation generators. Methods: We used PyQt to develop a graphical user interface (GUI)-based program and employed the calculation methodology reported in the National Council on Radiation Protection and Measurements (NCRP)-49 for shielding calculations. We gathered the necessary factors for shielding evaluation using two libraries designed for Python, pandas and NumPy, and processed them into a database. We verified the effectiveness of the proposed program by comparing the results with those from safety reports of six domestic facilities. Results: After verifying the effectiveness of the program using the NCRP-49 example, we obtained an average error rate of 1.73%. When comparing the facility safety report and results obtained using the program, we found that the error rate was between 1.09% and 6.51%. However, facilities that did not use a defined shielding methodology were underestimated by 31.82% compared with the program (the final barrier thickness satisfied the shielding standard). Conclusion: The developed program provides a fast and accurate shielding evaluation that can assist personnel that work in radiation generator facilities and government officials in reviewing safety.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2003.11a
• /
• pp.354-357
• /
• 2003

In decommissioning activities of nuclear facilities, the analyses and evaluations of data(man power, radiation exposure, waste outputs, equipments, etc ) is very important to accomplish effective decommissioning and dismantling. To handle the data from decommissioning activities of research reactor, we developed its database system. By using database system, we come to filter and analyze the date of decommissioning activities and we can evaluate the extraordinary decommissioning features of research reactor. It is likely to lay out and estimate the optimal plan of decommissioning. We expect that the database system of effective decommissioning activities build up the foundation of commercial reactor decommissioning.

• Journal of Korean Society of Rural Planning
• /
• v.22 no.4
• /
• pp.71-80
• /
• 2016

Meanwhile, reference evapotranspiration(ET0) is important information for agricultural management including irrigation planning and drought assessment, the database of reference evapotranspiration for future periods was rarely constructed especially at districts unit over the country. The Coupled Model Intercomparison Project Phase 5 (CMIP5) provides several meteorological data such as precipitation, average temperature, humidity, wind speed, and radiation for long-term future period at daily time-scale. This study aimed to build a database for reference evapotranspiration using the climate forecasts at high resolution (the outputs of HadGEM3-RA provided by Korea Meteorological Administration (KMA)). To estimate reference evapotranspiration, we implemented four different models such as FAO Modified Penman, FAO Penman-Monteith, FAO Blaney-Criddle, and Thornthwaite. The suggested database system has an open architecture so that user could add other models into the database. The database contains 5,050 regions' data for each four models and four Representative Concentration Pathways (RCP) climate change scenarios. The developed database system provides selecting features by which the database users could extract specific region and period data.

• Proceedings of the Korean Nuclear Society Conference
• /
• 2004.10a
• /
• pp.1197-1198
• /
• 2004

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.515-521
• /
• 2013

Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.

• Journal of Photoscience
• /
• v.9 no.2
• /
• pp.463-465
• /
• 2002

RIKEN Structural Genomics Beamlines have been constructed for the crystallographic analysis in the structural genomics research at synchrotron radiation facility SPring-8. Synchrotron radiation accelerates the crystallographic analysis of protein structure. The target of the research and development is focused on the automatic beamline operation to maximize beamline efficiency. We are developing the sample management system, which is composed of the sample auto-changer and the database system, for high-throughput data collection. The sample management system and the beamline operating system make it possible to execute automatic data collection without any operators. The beamlines will be ready for user operation in autumn 2002. The concept of automatic beamline operation and the present status of RIKEN Structural Genomics Beamlines will be presented.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.6 no.2
• /
• pp.20-34
• /
• 2003

The good sea-keeping capability of the SWATH(Small Waterplane Area Twin Hull) ship has been attractive for research or surveillance vessels. Especially, for the naval ships accomplishing the underwater acoustic missions, it is necessary to access and minimize the underwater radiated noise level generated by the ships. Therefore, acoustic signature management and control are very important topics for these vessels. Underwater radiation pattern in the low frequency range is dominated by the tonals from the vibration of onboard machinery. In this work, the radiated noise level generated by the propulsion machine in the submerged hull is predicted using the transfer function technique and the hull transfer function for the submerged hull is determined by analyzing the longitudinal/circumferential stiffened infinitely long cylindrical shell and considering the empirical database of the previous vessels. It is confirmed that the transfer function technique can give useful information for identifying the noise source and estimating its contribution to the total radiatied noise level.