• 대한한방소아과학회지
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• 제14권1호
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• pp.9-38
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• 2000

It has been widely said in Korea that early administrations of Cervi cornu parvum (deer antler) to febrile infants affect brain functions. Traditional Oriental Medicine states that the head is easily affected by fever and only an excess of heat causes headaches. Traditional Oriental Medicine also states that Cervi cornu parvum cannot be used in febrile conditions. With the aim of investigating different febrile response to LPS, experiments using intravenous injection of LPS have been carried out on Cervi comu parvum(CCP) and Soahbohyul - tang combined with Cervi comu parvum(SB-CCP) administered rabbits. Experiments were also conducted to evaluate the effects of early administration of CCP on learning and memory in 3 week old rats with LPS fever. These were evaluated by using the Morris water maze and the radial arm maze. Changes in body weight were also observed during this period. The results of these experiments are as follows. 1. In the experiments with febrile rabbits, the CCP and SB-CCP administered group showed statistically significant reductions of fever (p<0.05). 2. In the experiments with febrile rabbits, CCP and SB-CCP administered rabbits resulted in the tendency of lower body temperatures and shorter fever periods than the control group. 3. There were no differences of mean body weight and fever patterns among the 4 groups in the experiments on young rats with LPS fever. 4. There was no statistical difference of mean response latencies among the rats in Group I (DDW administered), GroupIII (CCP administered), and groupIV (SB-CCP administered) in the Morris water maze. However, Group Ⅱ (the scopolamine administered group) showed delayed latencies on the second day of the first session (p<0.05), and the second and third day of the second session (p< 0.05). 5. There were no statistical differences of mean response latencies among the rats in Group I, III and Ⅳ in the radial arm maze, but Group Ⅱ showed delayed latencies on the first and third day of the first session (p<0.05). 6. There was no influence from the administration of CCP and SB-CCP on the general behavior of the rats in Irwin´s test. These results suggest that Cervi cornu parvum and Soahbohyul - tang combined with Cervi comu parvum have anti-pyretic actions on LPS fever. The results also suggest that these drugs have no influence on learning and memory in young rats with LPS fever in the Morris water maze and the radial arm maze.

• 한국유체기계학회 논문집
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• 제16권5호
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• pp.5-10
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• 2013

The regenerative pump is a kind of turbomachine which is capable of developing high pressure rise at relatively lower flow rates compared to the centrifugal and axial pumps. Although the efficiency of regenerative pumps is much lower than other turbomachines, still they have been widely used in many industrial applications for working at low specific speeds. There are some theoretical models to analysis the pump performance, however, the effect of the blade angle on the pump performance has not been covered in any model to date. In the present study, experimental study on the regenerative pump performance according to the impeller blade angle and its shape has been carried out. The straight radial blades with forward, backward and chevron blades which have inclined angles of $15^{\circ}$, $30^{\circ}$ and $45^{\circ}$ were tested. The pump performance characteristics as the pressure head, efficiency were obtained depending on the flow rate for every impeller, and their results, expressed in appropriate non-dimensional coefficients, were compared and analysed in detail. From the experimental results, it was found that the pressure head and the efficiency depend strongly on the blade angles as well as the blade type. These experimental data has made it possible to better understand the effects of the blade angle on the pump performance, and widen the applicability of the current performance analysis and design models with including the effect of blade angles.

• 대한기계학회논문집B
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• 제41권7호
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• pp.445-453
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• 2017

본 연구에서는 RO용 고압 다단 펌프의 수력 부 성능에 대해서 연구를 수행하였다. 수력 부 설계는 크게 임펠러 설계와 레이디얼 디퓨저 설계로 나뉠 수 있다. 임펠러의 자오면 형상 변화에 따른 유동분포와 성능을 수치 해석적으로 연구하였으며, 임펠러 외경, 출구 폭, eye dia 등은 고정시킨 상태에서 반응 표면 기법을 이용하여 허브 및 쉬라우드 자오면 곡선을 변화 시키면서 성능을 최적화하였다. 해석결과 양정에 가장 큰 영향을 미치는 설계 변수는 ${\varepsilon}Ds$로 나타났으며 효율은 허브 입구 길이 및 쉬라우드 곡선이 가장 큰 영향을 주는 것을 알 수 있었다. 자오면 프로파일을 변경한 결과 기준모델(case 25)에 비해 약 0.5% 효율이 개선됨을 확인할 수 있었다.

• Applied Microscopy
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• 제44권1호
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• pp.21-29
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• 2014

Retinal glial responses to hypertensive glaucomatous injury were spatiotemporally surveyed. Retinas as a whole or vertical sections were processed for anti-glial fibrillary acidic protein (GFAP), anti-Iba1, anti-nerve growth factor (NGF), and anti-tumor necrosis factor (TNF)-${\alpha}$ immunohistochemistry for confocal microscopic analyses. The optic nerve head of paired controls was processed for electron microscopy. GFAP positive astrocytes appeared in the nerve fiber layer in the glaucomatous and control retinas, changing from fine protoplasmic to stout fibrous parallel to glaucomatous duration. Iba1 positive microglia appeared in both retinas, and enormous reaction appeared at the latest glaucomatous. M$\ddot{u}$ller reaction detected by GFAP reactivity expanded from the end feet to whole profile following to duration in the glaucomatous. NGF reactivity expended from the end feet to the proximal radial processes of the M$\ddot{u}$ller cells in both retinas according to glaucomatous duration. TNF-${\alpha}$ immunoreactivity in the nerve fiber layer was stronger in both the glaucomatous and controls than in the normal, and exceptionally at the latest glaucomatous was even lower than the normal. The astrocytes in the optic nerve head are interconnected with each other via gap junction. These results demonstrate that astrocyte reaction propagates to the contralateral via physical links, and TNF-${\alpha}$ is correlated with NGF production for neuroprotection in response to hypertensive glaucomatous injury.

• Smart Structures and Systems
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• 제16권3호
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• pp.415-433
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• 2015

Tendon failures in bonded post-tensioned bridges over the last two decades have motivated ongoing investigations on various aspects of unbonded tendons and their monitoring methods. Recent research shows that change of strain distribution in anchor heads can be useful in detecting wire breakage in unbonded construction. Based on this strain variation, this paper develops a damage detection model that enables an automated tendon monitoring system to identify and locate wire breaks. The first part of this paper presents an experimental program conducted to study the strain variation in anchor heads by generating wire breaks using a mechanical device. The program comprised three sets of tests with fully populated 19-strand anchor head and evaluated the levels of strain variation with number of wire breaks in different strands. The sensitivity of strain variation with wire breaks in circumferential and radial directions of anchor head in addition to the axial direction (parallel to the strand) were investigated and the measured axial strains were found to be the most sensitive. The second part of the paper focuses on formulating the wire breakage detection framework. A finite element model of the anchorage assembly was created to demonstrate the algorithm as well as to investigate the asymmetric strain distribution observed in experimental results. In addition, as almost inevitably encountered during tendon stressing, the effects of differential wedge seating on the proposed model have been analyzed. A sensitivity analysis has been performed at the end to assess the robustness of the model with random measurement errors.

• Radiation Oncology Journal
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• 제33권4호
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• pp.344-349
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• 2015

Late complications of head and neck cancer survivors include neck muscle atrophy and soft-tissue fibrosis. We present an autopsy case of neck muscle atrophy and soft-tissue fibrosis (sternocleidomastoid, omohyoid, digastric, sternohyoid, sternothyroid, and platysma muscles) within the radiation field after modified radical neck dissection type I and postoperative radiotherapy for floor of mouth cancer. A 70-year-old man underwent primary tumor resection of the left floor of mouth, left marginal mandibulectomy, left modified radical neck dissection type I, and reconstruction with a radial forearm free flap. The patient received adjuvant radiotherapy. The dose to the primary tumor bed and involved neck nodes was 63 Gy in 35 fractions over 7 weeks. Areas of subclinical disease (left lower neck) received 50 Gy in 25 fractions over 5 weeks. Adjuvant chemotherapy was not administered.

• 대한기계학회논문집B
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• 제26권6호
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• pp.795-804
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• 2002

The optimal design code of an axial flow pump has been developed to determine geometric and fluid dynamic variables under hydrodynamic as well as mechanical design constraints. The design code includes the optimization of the complete radial distribution of the geometry by determining the coefficients of 2$^{nd}$ order polynomials to represent the three-dimensional geometry. The optimization problem has been formulated with a nonlinear multivariable objective function, maximizing the efficiency and stall margin, while minimizing the net positive suction head required. Calculation of the objective function is based on the mean streamline analysis and through-flow analysis using the present state-of-the-art model. The optimal solution is calculated using the penalty function method in which the genetic optimizer is employed. The optimized efficiency and design variables are presented in this paper as a function of non-dimensional specific speed in the range, 2$\leq$ $n_{s}$ $\leq$10. The results can be used in preliminary design of axial flow pumps.

• 한국소음진동공학회논문집
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• 제15권1호
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• pp.39-45
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• 2005

This research develops an experimental method to measure the motion of a FDB spindle system with a 3.5' disk by using three capacitance probes fixed on the xyz-micrometers, and it shows that a FDB spindle system has the whirling, flying and tilting motion. It also shows that the whirling, flying and tilting motion converge very quickly to the steady state at the same time when the rotor reaches the steady-state speed. However, they are quite large even at the steady state when they are compared with the 10nm flying height of a magnetic head. For the FDB spindle system used in this experiment, the whirl radius and the peak-to-peak variation of flying height and tilting angle at the steady-state speed of 7,200rpm are 0.675m, 30nm and $5.758\times10^{-3^{\circ}}$, respectively, so that the radial motion of the FDB spindle system exceeds a track pitch of a 3.5' HDD with 90,000 TPI.

• 대한한의학회지
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• 제28권3호통권71호
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• pp.13-22
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• 2007

Objectives : To obtain pulse information, oriental medical doctors usually use the three finger pulse diagnosis method. Although the diagnostic positions are very important, the exact positions are not known because of the uncertain conversion of measures of length (bun, chon, chuk) and misunderstanding of the related concepts of oriental medicine. In this study, we proposed relative positions for the detection of three pulses with a pulse analyzer. Methods : The proposal was made based mainly on several literature reviews, especially the original texts, and the examination of anthropometric characteristics of 78 individuals. Results : The Kwan is the spot where the radial pulse can be felt well near the eminent head of the radius at wrist, high bone. The position of Chon should be apart from Kwan by 6/10 distance between the high bone and wrist joint of each individual. Finally, the position of Chuk is apart from Kwan by 6.5/100 distance between the high bone and the elbow joint of each individual. Conclusions : Adapting those proposed positions for measuring three pulses can provide more consistent information to what an oriental doctor obtains than a pulse analyzer applied to other positions.

• 한국자동차공학회논문집
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• 제12권3호
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• pp.59-65
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• 2004

In this paper a numerical study was performed for the effect of the wall curvature on the behaviors of fuel sprays impinging on the concave Surface. Actually, in the real diesel engines, a piston head has a curved shape for the purpose of the controlling the movement of fuel droplets and the mixture formation. For past decades, although many experimental and numerical works had been performed on the spray/wall impingement phenomena, the curvature effect of impinged wall was rarely investigated. The wall curvature affects on the behaviors of the secondary droplets generated by impingement and the concave wall obstructs the droplets to advance from the impinging site to outward. In present study, the simulation code was validated for the flat surface case and three cases of the different curvature were calculated and compared with the flat surface case for several parameters, such as the spray radius, the spray height and the position of vortex center of gas phase. The simulation results showed that the radial advance of the wall spray and the vortex is decreased with increasing the curvature. It was concluded that the curvature of the impinged wall significantly affects the behaviors of both the gas-phase and the droplet-phase.