• Title/Summary/Keyword: Radial flow

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Dynamic analysis of nanotube-based nanodevices for drug delivery in sports-induced varied conditions applying the modified theories

  • Shaopeng Song;Tao Zhang;Zhiewn Zhui
    • Steel and Composite Structures
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    • v.49 no.5
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    • pp.487-502
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    • 2023
  • In the realm of nanotechnology, the nonlocal strain gradient theory takes center stage as it scrutinizes the behavior of spinning cantilever nanobeams and nanotubes, pivotal components supporting various mechanical movements in sport structures. The dynamics of these structures have sparked debates within the scientific community, with some contending that nonlocal cantilever models fail to predict dynamic softening, while others propose that they can indeed exhibit stiffness softening characteristics. To address these disparities, this paper investigates the dynamic response of a nonlocal cantilever cylindrical beam under the influence of external discontinuous dynamic loads. The study employs four distinct models: the Euler-Bernoulli beam model, Timoshenko beam model, higher-order beam model, and a novel higher-order tube model. These models account for the effects of functionally graded materials (FGMs) in the radial tube direction, giving rise to nanotubes with varying properties. The Hamilton principle is employed to formulate the governing differential equations and precise boundary conditions. These equations are subsequently solved using the generalized differential quadrature element technique (GDQEM). This research not only advances our understanding of the dynamic behavior of nanotubes but also reveals the intriguing phenomena of both hardening and softening in the nonlocal parameter within cantilever nanostructures. Moreover, the findings hold promise for practical applications, including drug delivery, where the controlled vibrations of nanotubes can enhance the precision and efficiency of medication transport within the human body. By exploring the multifaceted characteristics of nanotubes, this study not only contributes to the design and manufacturing of rotating nanostructures but also offers insights into their potential role in revolutionizing drug delivery systems.

The Development of a Benthic Chamber (BelcI) for Benthic Boundary Layer Studies (저층 경계면 연구용 Benthic chamber(BelcI) 개발)

  • Lee, Jae-Seong;Bahk, Kyung-Soo;Khang, Buem-Joo;Kim, Young-Tae;Bae, Jae-Hyun;Kim, Seong-Soo;Park, Jung-Jun;Choi, Ok-In
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.15 no.1
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    • pp.41-50
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    • 2010
  • We have developed an in-situ benthic chamber (BelcI) for use in coastal studies that can be deployed from a small boat. It is expected that BelcI will be useful in studying the benthic boundary layer because of its flexibility. BelcI is divided into three main areas: 1) frame and body chamber, 2) water sampler, and 3) stirring devices, electric controller, and data acquisition technology. To maximize in-situ use, the frame is constructed from two layers that consist of square cells. All electronic parts (motor controller, pA meter, data acquisition, etc.) are low-power consumers so that the external power supply can be safely removed from the system. The hydrodynamics of BelcI, measured by PIV (particle image velocimetry), show a typical "radial-flow impeller" pattern. Mixing time of water in the chamber is about 30 s, and shear velocity ($u^*$) near the bottom layer was calculated at $0.32\;cm\;s^{-1}$. Measurements of diffusivity boundary layer thickness showed a range of $180-230\;{\mu}m$. Sediment oxygen consumption rate, measured in-situ,was $84\;mmol\;O_2\;m^{-2}\;d_{-1}$, more than two times higher than on-board incubation results. Benthic fluxes assessed from in-situ incubation were estimated as follows: nitrate + nitrite = $0.18\;{\pm}\;0.07\;mmol\;m^{-2}\;d^{-1}$ ammonium $23\;{\pm}\;1\;mmol\;m^{-2}\;d^{-1}$ phosphate = $0.09\;{\pm}\;0.02\;mmol\;m^{-2}\;d^{-1}$ and silicate = $23\;{\pm}\;1\;mmol\;m^{-2}\;d^{-1}$.

Result of Extracranial-Intracranial Bypass Surgery in the Treatment of Complex Intracranial Aneurysms : Outcomes in 15 Cases

  • Park, Eun-Kyung;Ahn, Jae-Sung;Kwon, Do-Hoon;Kwun, Byung-Duk
    • Journal of Korean Neurosurgical Society
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    • v.44 no.4
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    • pp.228-233
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    • 2008
  • Objective : The standard treatment strategy of intracranial aneurysms includes either endovascular coiling or microsurgical clipping. In certain situations such as in giant or dissecting aneurysms, bypass surgery followed by proximal occlusion or trapping of parent artery is required. Methods : The authors assessed the result of extracranial-intracranial (EC-IC) bypass surgery in the treatment of complex intracranial aneurysms in one institute between 2003 and 2007 retrospectively to propose its role as treatment modality. The outcomes of 15 patients with complex aneurysms treated during the last 5 years were reviewed. Six male and 9 female patients, aged 14 to 76 years, presented with symptoms related to hemorrhage in 6 cases, transient ischemic attack (TIA) in 2 un ruptured cases, and permanent infarction in one, and compressive symptoms in 3 cases. Aneurysms were mainly in the internal carotid artery (ICA) in 11 cases, middle cerebral artery (MCA) in 2, posterior cerebral artery (PCA) in one and posterior inferior cerebellar artery (PICA) in one case. Results : The types of aneurysms were 8 cases of large to giant size aneurysms, 5 cases of ICA blood blister-like aneurysms, one dissecting aneurysm, and one pseudoaneurysm related to trauma. High-flow bypass surgery was done in 6 cases with radial artery graft (RAG) in five and saphenous vein graft (SVG) in one. Low-flow bypass was done in nine cases using superficial temporal artery (STA) in eight and occipital artery (OA) in one case. Parent artery occlusion was performed with clipping in 9 patients, with coiling in 4, and with balloon plus coil in 1. Direct aneurysm clip was done in one case. The follow up period ranged from 2 to 48 months (mean 15.0 months). There was no mortality case. The long-term clinical outcome measured by Glasgow outcome scale (GOS) showed good or excellent outcome in 13/15. The overall surgery related morbidity was 20% (3/15) including 2 emergency bypass surgeries due to unexpected parent artery occlusion during direct clipping procedure. The short-term postoperative bypass graft patency rates were 100% but the long-term bypass patency rates were 86.7% (13/15). Nonetheless, there was no bypass surgery related morbidity due to occlusion of the graft. Conclusion : Revascularization technique is a pivotal armament in managing complex aneurysms and scrupulous prior planning is essential to successful outcomes.

A Numerical Study of Tumble Effect on Spray/wall Impingement in the D. I. Engines (직접분사식 엔진내의 분무/벽 충돌 현상에서 텀블 효과에 관한 연구)

  • Chae, Soo;Yang, Hyup;Ryou, Su-Yeal;Ryou, Hong-Sun
    • Transactions of the Korean Society of Automotive Engineers
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    • v.10 no.5
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    • pp.45-57
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    • 2002
  • In this paper, the results gained by applying many impingement models to the cylinder and flat plate were analyzed in comparison with the experimental data to study a spray/wall interaction phenomena. To begin with, the behavior of spray injected normal to the wall was analysed using three different impingement models ; Naber and Reitz model(NR model), Watkins and Wang model(WW model) and Park and Watkins model(PW model) in the present calculation. The results obtained from these models were compared with experimental data of Katsura et. al. The results indicated that PW model was in better agreement with experimental data than the NR and WW model. Also f3r spray injected at 30DEG , the result of three models were compared with experimental data of Fujimoto et. al. The results showed that m model overpredicted the penetration in the radial direction because this model was based on the inviscid jet analogy. WW model did not predicted the radius and height of the wall spray effectively. It might be thought that this discrepancy was due to the lack of consideration of spray film velocity occurred at impingement site. The result of PW model agrees with the experimental data as time goes on. In particular, a height of the spray droplets was predicted more closely to the experimental data than the other two models. The results of PW model in which the spray droplets were distributed densely around the edge of droplet distribution shaped in a circle had an agreement with the experimental data of Fujimoto et. al. Therefore, it was concluded that PW model performed better than M and WW model for prediction of spray behavior. The numerical calculation using PW model performed to the cylinder similar to the real shape of DI engine. The results showed that vortex strength near the wall in the cylinder was stronger than that in the case of flat plate. Contrary to the flat plat, an existence of the side wall in the cylinder caused the tangential velocity component to be reduced and the normal velocity component to be increased. The flow tends to rotate to the inside of cylinder going upward to the right side wall of cylinder gradually as time passes. Also, the results showed that as the spray angle increases, the gas velocity distribution and the tumble flow seemed to be formed widely.

Estimation of Permeability and Initial Pressure in Reservoir by DFIT Data Analysis (DFIT 자료 해석을 통한 저류층의 투과도 및 초기압력 추정)

  • Kim, Tae Hong;Lee, Sung Jun;Lee, Kun Sang
    • Tunnel and Underground Space
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    • v.23 no.3
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    • pp.169-179
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    • 2013
  • Well testing in unconventional reservoirs, such as tight or shale gas formations, presents considerable challenges. It is difficult to estimate the reservoir properties in ultra-low permeability formation because of poor inflow prior to stimulation and excessive test duration. Moreover, radial flow may not develop in hydraulically fractured horizontal wells. For these reasons, the cost of test is high and the accuracy is relatively low. Accordingly, industry is turning to an alternate testing method, diagnostic fracture injection test (DFIT), which is conducted prior to the main hydraulic fracture treatments. Nowadays, DFIT are regarded as the most practical way to obtain good estimates of reservoir properties in unconventional reservoirs. Various methods may be used for interpreting DFIT data. This paper gives an explanation of those methods in detail and examines three actual field data. These show how various analysis methods can be applied to consistently interpret fracture closure pressure and time, as well as before and after closure flow regimes and reservoir properties from field data.

Effect of Blood Donation on the Donor's Hemorheological Properties (헌혈이 헌혈자의 혈유변학적 지표에 미치는 영향)

  • Lee, Byoung Kwon
    • The Korean Journal of Blood Transfusion
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    • v.29 no.3
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    • pp.229-239
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    • 2018
  • The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.

Analysis of Effect on Camera Distortion for Measuring Velocity Using Surface Image Velocimeter (표면영상유속측정법을 이용한 유속 측정 시 카메라 왜곡 영향 분석)

  • Lee, Jun Hyeong;Yoon, Byung Man;Kim, Seo Jun
    • Ecology and Resilient Infrastructure
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    • v.8 no.1
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    • pp.1-8
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    • 2021
  • A surface image velocimeter (SIV) measures the velocity of a particle group by calculating the intensity distribution of the particle group in two consecutive images of the water surface using a cross-correlation method. Therefore, to increase the accuracy of the flow velocity calculated by a SIV, it is important to accurately calculate the displacement of the particle group in the images. In other words, the change in the physical distance of the particle group in the two images to be analyzed must be accurately calculated. In the image of an actual river taken using a camera, camera lens distortion inevitably occurs, which affects the displacement calculation in the image. In this study, we analyzed the effect of camera lens distortion on the displacement calculation using a dense and uniformly spaced grid board. The results showed that the camera lens distortion gradually increased in the radial direction from the center of the image. The displacement calculation error reached 8.10% at the outer edge of the image and was within 5% at the center of the image. In the future, camera lens distortion correction can be applied to improve the accuracy of river surface flow rate measurements.

Numerical Analysis of Fault Stability in Janggi Basin for Geological CO2 Storage (CO2 지중저장에 따른 장기분지 내 단층안정성 기초해석)

  • Jung-Wook Park;Hanna Kim;Hangbok Lee;Chan-Hee Park;Young Jae Shinn
    • Tunnel and Underground Space
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    • v.33 no.5
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    • pp.399-413
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    • 2023
  • The present study conducted a numerical modeling of CO2 injection at the Janggi Basin using the TOUGH-FLAC simulator, and examined the hydro-mechanical stability of the aquifer and the fault. Based on the site investigations and a 3D geological model of the target area, we simulated the injection of 32,850 tons of CO2 over a 3-year period. The analysis of CO2 plume with different values of the aquifer permeability revealed that assuming a permeability of 10-14 m2 the CO2 plume exhibited a radial flow and reached the fault after 2 years and 9 months. Conversely, a higher permeability of 10-13 m2 resulted in predominant westward flow along the reservoir, with negligible impact on the fault. The pressure changes around the injection well remained below 0.6 MPa over the period, and the influence on the hydro-mechanical stability of the reservoir and fault was found to be insignificant.

Multivessel Coronary Revascularization with Composite LITA-RA Y Graft (좌내흉동맥-요골동맥 복합이식편을 이용한 다중혈관 관상동맥우회술)

  • Lee Sub;Ko Mgo-Sung;Park Ki-Sung;Ryu Jae-Kean;Jang Jae-Suk;Kwon Oh-Choon
    • Journal of Chest Surgery
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    • v.39 no.5 s.262
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    • pp.359-365
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    • 2006
  • Background: Arterial grafts have been used to achieve better long-term results for coronary revascularization. Bilateral internal thoracic artery (ITA) grafts have a better results, but it may be not used in some situations such as diabetes and chronic obstructive pulmonary disease (COPD). We evaluated the clinical and angiographic results of composite left internal thoracic artery-radial artery (LITA-RA) Y graft. Material and Method: Between April 2002 and September 2004, 119 patients were enrolled in composite Y graft for coronary bypass surgery. The mean age was $62.6{\pm}8.8$ years old and female was 34.5%. Preoperative cardiac risk factors were as follows: hypertension 43.7%, diabetes 33.6%, smoker 41.2%, and hyperlipidemia 22.7%, There were emergency operation (14), cardiogenic shock (6), left ventricle ejection fraction (LVEF) less than 40% (17), and 17 cases of left main disease. Coronary angiography was done in 35 patients before the hospital discharge. Result: The number of distal anastomoses was $3.1{\pm}0.91$ and three patients (2.52%) died during hospital stay. The off-pump coronary artery bypass (OPCAB) was applied to 79 patients (66.4%). The LITA was anastomosed to left anterior descending system except three cases which was to lateral wall. The radial Y grafts were anastomosed to diagonal branches (4), ramus intermedius (21), obtuse marginal branches (109), posterolateral branches (12), and posterior descending coronary artery (8). Postoperative coronary angiography in 35 patients showed excellent patency rates (LITA 100%, and RA 88.5%; 3 RA grafts which anastomosed to coronary arteries <70% stenosed showed string sign with competitive flow). Conclusion: The LITA-RA Y composite graft provided good early clinical and angiographic results in multivessel coronary revascularization. But it should be cautiously used in selected patients.

Total Arterial Revascularization Using Y-composite Graft for Isolated Left Main Coronary Artery Disease (단독 좌주간 관동맥 협착병변에서 Y-도관을 이용한 완전 동맥도관 관상동맥우회로 조성술)

  • Ahn, Byong-Hee;Yu, Ung;Chun, Joon-Kyung;Ryu, Sang-Wan;Choi, Yong-Sun;Kim, Byong-Pyo;Hong, Sung-Bum;Bum, Min-Sun;Na, Kook-Ju;Jung, Myung-Ho;Kim, Sang-Hyung
    • Journal of Chest Surgery
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    • v.37 no.1
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    • pp.35-42
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    • 2004
  • Background: For the treatment of isolated left main coronary artery disease, twelve arterial revascularizations with Y-composite grafts using left internal thoracic artery and radial artery or right gastroepiploic artery were peformed. This study was performed to investigate whether V-composite graft can satisfy the blood flow required to make myocardium act properly or not. Borderline stenotic lesions on the left main coronary artery, which are very prone to remodel the bypassed vessels due to competitive flows, were also considered. Material and Method: Among 247 patients who underwent coronary artery bypass grafting from March 2000 to April 2003, 12 patients (4.7%) who had received total arterial revascularizations for the isolated left main coronary artery disease were studied retrospectively. Result: left anterior descending arteries were bypassed with left internal thoracic artery by off-pump technique in all patients, however, 2 cases of left obtuse marginal branches were bypassed under on-pump beating heart. Except for one patient, who did not have an obtuse marginal branch more than 1 mm in diameter, 11 patients had gone through complete arterial revascularizations by use of the Y shape arterial graft. Among five patients who had less than 75% stenosis, one patient showed string sign on left internal thoracic artery grafted to left anterior descending artery. However, two grafts to obtuse marginal blanches were completely obstructed and one showed slender sign. There were no graft-dominant flow in patients with stenotic lesion less than 75%. On the contrary to the result of patients with stenotic lesions less than 75%, all the patients with stenotic lesions more than 90% showed graft-dominant blood flow. Conclusion: In conclusion, it is assumed that, when stenotic lesions are over 90%, coronary artery bypass grafting with an Y shape arterial graft could possibly give enough help to the obstructed coronary arteries in blood supplying to myocardium, which needs massive quantity of blood to act well. However, when patients have borderline stenoses, through scrupulous examinations, more prudent and flexible decisions are required in choosing the treatment methods, such as, direct anastomosis of vein or artery to aorta, or adding supplementary treatment methods like percutaneous coronary intervention, rather than choosing a fixed treatment methods.