• BMB Reports
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• v.33 no.2
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• pp.184-187
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• 2000

Prostaglandin $E_2$ ($PGE_2$) plays an important role in the regulation of various gastric functions, and the growth-inhibitory activities on tumor cells are studied in vitro and in vivo. Although the mechanisms have attracted many researchers in the past decade, the molecular mechanisms of cell cycle arrest, or induction of apoptosis by $PGE_2$, is unclear. We investigated the effects of $PGE_2$ on the growth of the human gastric carcinoma cell line SNU1 and genes that are regulated by $PGE_2$ and isolated them using differential display RT-PCR (DD RT-PCR). FACS analysis suggested that SNU1 cells were arrested at the G1 phase by $PGE_2$ treatment. This growth inhibitory effect was in a time- and dose-dependent manner. Treatment of SNU1 cells with $10\;{\mu}g/ml$ $PGE_2$, followed by DD RT-PCR analysis, revealed differently expressed bands patterns from the control. Among the differently expressed clones, we found an unidentified cDNA clone (HGP-27) overexpressed in $PGE_2$-treated cells. The full-length cDNA of HGP-27 was isolated using RACE, which consisted of a 30-nt 5'-noncoding region, a 891-nt ORF encoding the 296 amino acid protein, and a 738-nt 3'-noncoding region including a poly(a) signal. This gene was localized on the short arm of chromosome number 11. Using the Motif Finder program, a myb-DNA binding repeat signature was detected on the ORF region. The COOH-terminal half was shown to have similarity with the $NH_3$-terminal domain of thioredoxin (Trx). This relation between HGP-27 and Trx implied a potential role for HGP-27 in modulating the DNA binding function of a transcription factor, myb.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.4091-4094
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• 2014

Background: This study used the receiver operating characteristic curve (ROC) to analyze Surveillance, Epidemiology and End Results (SEER) bronchioaveolar carcinoma data to identify predictive models and potential disparity in outcomes. Materials and Methods: Socio-economic, staging and treatment factors were assessed. For the risk modeling, each factor was fitted by a Generalized Linear Model to predict cause specific survival. The area under the ROC was computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of cause specific death was computed for the predictors for comparison. Results: There were 7,309 patients included in this study. The mean follow up time (S.D.) was 24.2 (20) months. Female patients outnumbered male ones 3:2. The mean (S.D.) age was 70.1 (10.6) years. Stage was the most predictive factor of outcome (ROC area of 0.76). After optimization, several strata were fused, with a comparable ROC area of 0.75. There was a 4% additional risk of death associated with lower county family income, African American race, rural residency and lower than 25% county college graduate. Radiotherapy had not been used in 2/3 of patients with stage III disease. Conclusions: There are socio-economic disparities in cause specific survival. Under-use of radiotherapy may have contributed to poor outcome. Improving education, access and rates of radiotherapy use may improve outcome.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.347-352
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• 2016

Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) adenosquamous carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for adenosquamous carcinoma. For the risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. An area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. Results: A total of 20,712 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 54.2 (78.4) months. Some 2/3 of the patients were female. The mean (S.D.) age was 63 (13.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.71). 13.9% of the patients were un-staged and had risk of cause specific death of 61.3% that was higher than the 45.3% risk for the regional disease and lower than the 70.3% for metastatic disease. Sex, site, radiotherapy, and surgery had ROC areas of about 0.55-0.65. Rural residence and race contributed to socioeconomic disparity for treatment outcome. Radiotherapy was underused even with localized and regional stages when the intent was curative. This under use was most pronounced in older patients. Conclusions: Anatomic stage was predictive and useful in treatment selection. Under-staging may have contributed to poor outcome.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.9-12
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• 2003

Clubroot disease of curcifer crops caused by Plasmodiophora brassicae had been first reported in 1920 in Korea, and maintained mild occurrence until 1980s. Since 1990s the disease has become severe in alpine areas of Kyonggi and Kangwon, gradually spread to plain fields throughout the country, and remains as the greatest limiting factor for its production. Researches on the disease has begun in late 1990s in our laboratory after experiencing severe epidemics. Survey of occurrence and etiological and ecological studies have been carried out, particularly, on the pathogen physiology, race identification, quantification of soil pathogen population, host spectrum of the pathogen, and control measures.(중략)

• Korean Journal of Health Education and Promotion
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• v.2 no.1
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• pp.115-132
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• 2000

The purpose of this study is to provide baseline information on the risk-taking health behavior of alcohol consumption in four ethnic groups, Caucasian, Chinese, Japanese, and Korean, residing in the State of Hawaii. Secondary data from the State-based Health Behavioral Risk Factor Surveillance System, designed by the Center for Disease Control, were used. The total sample analyzed for this study contained 6,068 persons. Univariate and logistic regression analysis were performed in order to determine sociodemographic profiles and the predictor variables to produce the findings of this study. The percentage distribution of six sociodemographic factors by race was very similar in all alcohol consumption factors, acute drinking, chronic drinking, and drinking and driving. In this study there were significant ethnic differences in alcohol consumption factors except drinking and driving.

• Journal of the Korea Furniture Society
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• v.19 no.4
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• pp.300-306
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• 2008

Nepal is rich country in terms of its vast array of biological diversity. The relationship between local communities and the biological diversity in Nepal is a very entangle one, whereby two-thirds of our population are heavily dependent upon the biodiversity for their survival. The destruction of biodiversity signifies the destruction of people's livelihoods and survival. Biodiversity and genetic resources conservation has been a most significant part of the Nepalese society due to its socio-economic and cultural importance and provides the human race trees for timber, fuel, food, industrial raw materials, pharmaceuticals, beverages and environmental stabilization. Threats to biodiversity at global level is of greater concern, specially, human activities are the greatest factor currently affecting biodiversity, through the use of natural resources by industry, agriculture, hunting, and energy generation.

• Journal of Contemporary Eastern Asia
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• v.20 no.2
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• pp.197-209
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• 2021

This article deals with the asymmetrical relations between Australia and China and explores their interdependence, tensions, and societal outlooks. Both countries are dependent on one another for trade to different degrees but attempt to diversify their supply chains. While there is no united position on China in Australia, there has been a bipartisan support for the counter-interference legislation there. The newly established security pact of the United States (US), the United Kingdom (UK) and Australia - 'AUKUS' - has brought a new dimension into these tensions and will most likely lead to an arms race. The author explores how a so-called middle power such as Australia balances the related economic and strategic interests and priorities. Although Australia has been vulnerable in its asymmetric relationship with China, it has shown that it is not a passive and helpless actor when facing an economic coercion. The interdependence has become a moderating factor in this strategic stand-off. Additionally, Australia demonstrates its tendency to reinforce its traditional reliance on its previous more powerful allies, the UK and the US.

• American Studies
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• v.42 no.2
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• pp.1-29
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• 2019

The recent census project that non-Hispanic White will be minority in thirty years has been accepted by the conservative media and politicians as the factor that threatens the authentic American national identity. The concerns about the majority-minority population chance influenced the election of Donald Trump who explicitly claimed the restriction of immigration, promising strong controls over the entry of undocumented immigrants. In the process, 'white-nationalism' based on the connection of racial whites and authentic American identity has been central issues in American society. In this sense, this paper examines who has been included/excluded from 'racial Whites' throughout the American history relating to the American identity politics and how these processes have shown the covert strategies of the whites for maintaining their privileges.

• BMB Reports
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• v.37 no.5
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• pp.538-545
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• 2004

A new CRT binding factor (CBF) gene designated Cbcbf25 was cloned from Capsella bursa-pastoris, a wild grass, by the rapid amplification of cDNA ends (RACE). The full-length cDNA of Cbcbf25 was 898 bp with a 669 bp open reading frame (ORF) encoding a putative DRE/CRT (LTRE)-binding protein of 223 amino acids. The predicted CbCBF25 protein contained a potential nuclear localization signal (NLS) in its N-terminal region followed by an AP2 DNA-binding motif and a possible acidic activation domain in the C-terminal region. Bioinformatic analysis revealed that Cbcbf25 has a high level of similarity with other CBF genes like cbf1, cbf2, and cbf3 from Arabidopsis thaliana, and Bncbf5, Bncbf7, Bncbf16, and Bncbf17 from Brassica napus. A cold acclimation assay showed that Cbcbf25 was expressed immediately after cold triggering, but this expression was transient, suggesting that it concerns cold acclimation. Our study implies that Cbcbf25 is an analogue of other CBF genes and may participate in cold-response, by for example, controlling the expression of cold-regulated genes or increasing the freezing tolerance of plants.

• The Southeast Asian review
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• v.28 no.1
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• pp.53-82
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• 2018

The $14^{th}$ general election which should be held by August 2018 has been a dominant factor for Malaysian politics, economy, social changes and foreign policy in 2017. UMNO, the dominant party within the ruling governmental coalition, has focused on securing Malay support, voters which made them to sought political cooperation with PAS, Malaysia's Islamist opposition party. A consequent event followed by the strategic ties between the two parties is the rise of political Islam in Malaysia though PAS' 'Islamization' or 'desecularization' has never been adopted by UMNO. The rise of political Islam and Malay support have become the most important factor for the next election, which increasingly enhanced the role of 3R of Malaysia politics; Race, Religion, and Royalty. The Pakatan Harapan (PH), the newly formed opposition coalition without PAS, has elected Mahathir Mohamad, the former Prime Minister, as its candidate for prime minister. Malaysian economy and foreign policy seem to be subordinated to politics. Stabilizing ringgit and restoring economic growth enabled the Najib's government to reveal 'election budget' for 2018. Najib has spoken out Islam-related international issues including the Rohingya crisis and Jerusalem issue. It is to some extent the extension of domestic politics. The rise of political Islam will be a highly influential not only in the coming election but in the political and social development in the aftermath of the election.