• Steel and Composite Structures
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• v.49 no.1
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• pp.91-107
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• 2023

An effective approach to promoting sustainability within the construction industry is the use of recycled aggregate concrete (RAC) as a substitute for natural aggregates. Ensuring the frost resilience of RAC technologies is crucial to facilitate their adoption in regions characterized by cold temperatures. The main aim of this study was to use the Random Forests (RF) approach to forecast the frost durability of RAC in cold locations, with a focus on the durability factor (DF) value. Herein, three optimization algorithms named Sine-cosine optimization algorithm (SCA), Black widow optimization algorithm (BWOA), and Equilibrium optimizer (EO) were considered for determing optimal values of RF hyperparameters. The findings show that all developed systems faithfully represented the DF, with an R² for the train and test data phases of better than 0.9539 and 0.9777, respectively. In two assessment and learning stages, EO - RF is found to be superior than BWOA - RF and SCA - RF. The outperformed model's performance (EO - RF) was superior to that of ANN (from literature) by raising the values of R² and reducing the RMSE values. Considering the justifications, as well as the comparisons from metrics and Taylor diagram's findings, it could be found out that, although other RF models were equally reliable in predicting the the frost durability of RAC based on the durability factor (DF) value in cold climates, the developed EO - RF strategy excelled them all.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.7-15
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• 2017

The purpose of this study was to evaluate the properties of recycled aggregate concrete (RAC) using low quality recycled aggregate with or without washing before usage. The recycled aggregate concrete evaluated in this study contained various amounts of low quality recycled aggregate, viz. 30%, 60% and 100%. To evaluate the performance of the recycled aggregate concrete, various test methods were employed to assess its compressive strength, absorption, surface resistance, ultrasound velocity, chloride ion resistance, etc. The properties of the RAC with 30% and 60% washed recycled aggregate were similar those of the natural aggregate. However, the properties of the RAC with 100% washed recycled aggregate were slightly lower than those of the other versions. Also, the RAC with the non-washed recycled aggregate exhibited lower performance results. The results showed that the RAC with washed recycled aggregate had similar properties to normal concrete (concrete using natural aggregate). This implies that the recycled aggregate should be washed to improve the RCA.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6305-6309
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• 2013

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and down-regulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.4
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• pp.347-352
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• 2007

This paper describes the design and implementation of PFM(Proto Flight Model, PFM) of DRE(Data Receiving Equipment, DRE) for Science and Technology Satellite 2(STSAT-2) and the results of integration performance test. DRE components are X-band receiver, DCE(Data Combine Equipment, DCE) and RAC(Receiving and Archiving Computer, RAC). DCE consists of I&Q data combiner and ECL signal distributor. RAC consists of DRC(Data Receiving Card) and ST2RAS(STSAT-2 Receiving and Archinving Software). X-band receiver receives 10Mbps QPSK I, Q satellite data and sends the data to DCE. DRC stores the I&Q combine data from DCE to RAID. The pre-processing program sorts and stores to satellite status data and payload data. The performance of DRE in the functional and space environments test satisfies the requirements of STSAT-2.

• Experimental and Molecular Medicine
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• v.51 no.2
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• pp.9.1-9.10
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• 2019

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. The proportion of ${\alpha}-SMA^+/PCNA^+$ cells was increased in the kidney cortex of db/db mice compared with control mice. Treatment with LPA concomitantly increased the proliferation of mouse mesangial cells (SV40 MES13) and the expression of cyclin D1 and CDK4. On the other hand, the expression of $p27^{Kip1}$ was decreased. The expression of $Kr{\ddot{u}}ppel$-like factor 5 (KLF5) was upregulated in the kidney cortex of db/db mice and LPA-treated SV40 MES13 cells. RNAi-mediated silencing of KLF5 reversed these effects and inhibited the proliferation of LPA-treated cells. Mitogen-activated protein kinases (MAPKs) were activated, and the expression of early growth response 1 (Egr1) was subsequently increased in LPA-treated SV40 MES13 cells and the kidney cortex of db/db mice. Moreover, LPA significantly increased the activity of the Ras-related C3 botulinum toxin substrate (Rac1) GTPase in SV40 MES13 cells, and the dominant-negative form of Rac1 partially inhibited the phosphorylation of p38 and upregulation of Egr1 and KLF5 induced by LPA. LPA-induced hyperproliferation was attenuated by the inhibition of Rac1 activity. Based on these results, the Rac1/MAPK/KLF5 signaling pathway was one of the mechanisms by which LPA induced mesangial cell proliferation in DN models.

• Steel and Composite Structures
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• v.9 no.1
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• pp.19-38
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• 2009

The present paper provides test data to evaluate the seismic performance of recycled aggregate concrete (RAC) filled steel square hollow section (SHS) beam-columns. Fifteen specimens, including 12 RAC filled steel tubular (RACFST) columns and 3 reference conventional concrete filled steel tubular (CFST) columns, were tested under reversed cyclic flexural loading while subjected to constant axially compressive load. The test parameters include: (1) axial load level (n), from 0.05 to 0.47; and (2) recycled coarse aggregate replacement ratio (r), from 0 to 50%. It was found that, generally, the seismic performance of RACFST columns was similar to that of the reference conventional CFST columns, and RACFST columns exhibited high levels of bearing capacity and ductility. Comparisons are made with predicted RACFST beam-column bearing capacities and flexural stiffness using current design codes. A theoretical model for conventional CFST beam-columns is employed in this paper for square RACFST beam-columns. The predicted load versus deformation hysteretic curves are found to exhibit satisfactory agreement with test results.

• Journal of Korean Medical classics
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• v.11 no.1
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• pp.396-413
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• 1998

The HyeolRacRon(血絡論) of the YoungChu(靈樞) is one of the section associate with the study of bloodletting(depletion of blood) by acupunture. The bloodletting therapy, one of the treatment of Oriental Medicine, has been advanced in civilization. By studying of this section, I could find some conculution as follows: 1. It is the superficial venules(血絡) that has been included blood stasis which has been interrupted by pathogenic factor(邪氣), and still could not enter into the meridian's line. 2. When bloodletting therapy, we should carefully study of patient's health condition, because doctor's missed acupuncure leads to very serious side effects. 3. External shape of HyeolRac(血絡) is like acu-niddle or muscle, so its thickness and location were not fixed position, its color is redish, and its quality is hard. 4. It is reason of heating that fixation of acu-niddle and muscle fiber.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2011.11a
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• pp.101-103
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• 2011

Various desired performances of concrete cannot be always obtained by current conventional mix proportion methods for recycled aggregate concrete (RAC). This paper suggests a new design method of mix proportion for RAC to reduce the number of trial mixes using genetic algorithm (GA) which has been an optimization technique to solve the multi-object problem. In mix design method by GA, several fitness functions for the required properties of concrete, i.e., slump, strength, price, and carbonation speed coefficient were considered based on conventional data or fitness function. As a result, various optimum mix proportions for RAC that meet required performances were obtained and the risk evaluation was also conducted for selected mixtures.

• Elastomers and Composites
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• v.54 no.4
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• pp.286-293
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• 2019

In this study, flexible poly(ethylene-ter-1-hexene-ter-divinylbenzene) was prepared using four types of metallocene catalysts (rac-Et(Ind)₂ZrCl₂, rac-SiMe₂(Ind)₂ZrCl₂, rac-SiMe₂(2-Me-Ind)₂ZrCl₂, (C₅Me₅)TiCl₂[O-2,6-ⁱPr₂(C₆H₃)]) and two types of borate catalysts (trityl tetrakisborate and dimethylanilinium tetrakisborate). The yield, catalytic activity, molecular weight, structure, composition, and thermal properties of the terpolymers prepared using the various catalysts and cocatalyst systems were evaluated. Epoxidation of the terpolymers was successfully performed and this transformation was studied by ¹H NMR and FTIR.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.165.2-165.2
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• 2003

Phosphatidylinositol 3-kinase (PI3K) and Rac play important roles that regulate cellular functions including cell survival and migration. In the present study, we investigated the functional roles of PI3K and Rac1 pathways in H-ras-induced invasive phenotype and motility of MCF10A cells. Akt, a downstream molecule of PI3K, was effectively activated not only by H-ras but also by N-ras, suggesting that the activation of PI3K pathway is not sufficient to induce metastatic potential of MCF10A cells. (omitted)