• Clinical and Experimental Reproductive Medicine
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• 제47권3호
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• pp.207-212
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• 2020

Objective: Glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) is a subunit of a ligand-gated ion channel that regulates the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by controlling the release of gonadotropin-releasing hormone. Few studies have investigated the association between the GRIA1 gene and human infertility. This study evaluated the association of the GRIA1 rs548294 C > T and rs2195450 G > A polymorphisms with the ovarian response to human menopausal gonadotropin (HMG) in Iranian women. Methods: One hundred women with histories of at least 1 year of infertility were included. On the second day of menstruation, patients were injected with HMG; on the third day, blood samples were collected. After hormonal analysis, the GRIA1 rs548294 C > T and rs2195450 G > A genotypes of samples were identified via the restriction fragment length polymorphism method, and on day 9, the number of follicles was assessed via ultrasound. Results: For the GRIA1 rs548294 C > T and rs2195450 G > A single nucleotide polymorphisms, the subjects with CT and GG genotypes, respectively, displayed the highest mean FSH level, LH level, and number of follicles on day 9 of the menstrual cycle (p< 0.05). Significant positive correlations were observed between LH and FSH (p< 0.01), LH and follicle count (p< 0.01), FSH and age (p< 0.05), follicle count and age (p= 0.048), and FSH and follicle count (p< 0.01). Conclusion: This study showed a significant relationship between GRIA1 polymorphisms and ovarian response to the induction of ovulation. Therefore, determining patients' GRIA1 genotype may be useful for improving treatment and prescribing suitable doses of ovulation-stimulating drugs.

• 대한전자공학회논문지TC
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• 제49권6호
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• pp.98-104
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• 2012

릴레이 간섭채널에서 하향링크 용량 극대화를 위한 전력할당 최적화 방안을 다룬다. 제 1 시간자원 영역에서 기지국은 단말과 릴레이 기지국에 직교채널을 통해서 전력전송을 한다. 제 2 시간자원 영역에서 기지국과 릴레이 기지국은 서로에게 간섭을 일으키면서 각각의 단말에게 전력을 전송한다. 본 논문에서 얻어진 전력 할당 최적화 방안은 제 2 시간자원 영역에서의 간섭 레벨이 낮을 경우, 기지국과 릴레이 기지국의 동시 전력전송을 허용하고, 반면에 간섭레벨이 높을 경우, 릴레이 기지국의 전력전송을 차단한다.

• 전기학회논문지
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• 제59권4호
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• pp.774-778
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• 2010

In this paper, the preliminary EMC analysis process between the Communication, Ocean and Meteorological Satellite (COMS) and the Geostationary Earth Orbit (GEO) launch vehicles in the frequency range is described. The considered launch vehicles are Arian Ⅴ, Sea Launch, Land Launch, Atlas III&Ⅴ, Delta IV, Proton M/breeze M, Soyuz, H II-Aa. The launch vehicle Radiated Susceptibility (RS) specifications have been compared to COMS satellite Radiated Emission (RE) limits. The COMS Radiated Emission (RE) level is determined by calculating the radiated field equal to the quadratic sum of radiated emissions of each equipment switched "ON" during launch. As a result, The RS requirements of Arian V, Atlas III&V and Delta IV lauchers are compliant with COMS RE limits. The negative margins appear between the others launch vehicle RS (Sea Launch, Land Launch, Proton M/Breeze M, Soyuz and H II-A) and COMS RE. Then, if the launchers that have negative margin were chosen by the customer, The EMC tests should be performed at satellite level in order to demonstrate the compatibility with respect to launch vehicles requirements.

• Food Science and Biotechnology
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• 제17권4호
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• pp.755-760
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• 2008

The aim of this study was to produce resistant starch preparations from acid-modified com starches prepared at various hydrolysis levels (0.5-4.0 hr). Effect of autoclaving cycles on resistant starch (RS) formation was investigated. Molecular weight distribution, pasting and functional properties of acid-modified com starches were determined. For RS formation native and acid-modified starch samples were gelatinized and autoclaved (1 or 2 cycles). While native and acid-modified starches did not contain any RS, the levels increased to 9.0-13.5% as a result of storage at $95^{\circ}C$ after first autoclaving cycle. Second autoclaving cycle together with storage at $95^{\circ}C$ brought final RS contents of the samples incubated at 4 and $95^{\circ}C$ after the first cycle to comparable level. As acid modification level increased, the amount of high molecular weight fractions decreased, resulting in significant decreases in viscosities (p<0.05). The samples produced in this study had low emulsion stability and capacity values.

• 한국가정과학회지
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• 제5권1호
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• pp.62-70
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• 2002

The objective of this study was to evaluate the effects of processing parameters of co-rotating twin screw extruder and dry methods on the level of resistant starch (RS) and the properties of extrudate prepared from normal maize starch. The processing parameters were used 90, 110, 130$^{\circ}C$ in temperature, 25.0~30.0% in moisture content, 150, 200, 250 rpm in screw speed and hot and cool air drying and drying after refrigerating in drying methods. The barrel temperature and drying methods had affected the level of resistant starch of extrudate. RS levels of extrudates were ranged from 2.4 to 15.5% by AOAC method. The extrudates, extruded at 110$^{\circ}C$ and then stored at 4$^{\circ}C$, showed the highest level of RS level (15.5%). Water absorption index increased with increasing moisture content and peak temperatures and viscosities of extudates decreased compare to that of raw starch from 94$^{\circ}C$ to 50~65$^{\circ}C$ and from 220 to 46~98 RVU, respectively. Extudates treated in 90$^{\circ}C$ and 110$^{\circ}C$ showed strong peak at $2{\theta}=6.7{\sim}17.0^{\circ}$ by X-ray diffractometry and had ~150$^{\circ}C$ endotherm like as that of RS3 starch by differential scanning calorimetry. In case of 130$^{\circ}C$, extrudates showed strong peak at $2{\theta}=20.0^{\circ}$ and had 106$^{\circ}C$ endotherm.

• Journal of Microbiology
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• 제35권4호
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• pp.277-283
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• 1997

Promoters inducible by paraquat, a superocide-generating agent, were isolated from Escherichia coli using a promoter-probing plasmid pRS415 with promoterless lacA gene. Twenty one promoters induced by paraquat were selected and further characterized. From sequence analysis, thirteen of the promoters were mapped to their specific loci on the Escherichia coli chromosome. Several promoters were mapped to the upstream of known genes such as usgl, katG, and mglB, whose relationships with superoxide response have not been previously reported. Other promoters were mapped to the upstream region of unknown open reading frames. Downstream of HC 96 promoter are uncharacterized ORFs whose sequences are homologous to ABC-transporter subunits. Downstream of HC84 promoter is an ORF encoding a transcriptional regulator-like protein, which contains a LysR family-specific HTH (helix-turn-helix) DNA bindign motif. We investigated whether these promoters belong to the soxRS regulon. All promoters except HC96 were found to belong to the soxRS regulon. The HC96 promoter was significantly induced by paraquat in the soxRS deletion mutant strain. The basal transcription level of three promoters (HE43, HC71, HD94) significantly increased at the stationary phase, implying that they are regulated by RpoS. However, paraquat inducibility of all promoters disappeared in the stationary phase, suggesting that SoxRS regulatory system is active only in rapidly growing cells.

• 대한본초학회지
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• 제35권6호
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• pp.43-53
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• 2020

Objective : Reflux esophagitis is a disease caused by reflux of stomach contents, stomach acid, and pepsin into the esophagus, and is currently increasing worldwide. This study was conducted to evaluate the effect of a mixture of Rhei Rhizoma and Scutellariae Radix (RS) extract on acute reflux esophagitis in rats. Methods : Rats were divided into five groups for examination: Normal group (Nor, n=8), water-treated acute reflux esophagitis rats (Con, n=8), tocopherol 30 mg/kg body weight/day-treated acute reflux esophagitis rats (Toco, n=8), RS 100 mg/kg body weight/day-treated acute reflux esophagitis rats (RS100, n=8), RS 200 mg/kg body weight/day-treated acute reflux esophagitis rats (RS200, n=8). All rats fasted for 18 h and then were derived by linking the metastatic junction between pylorus and forestomach and corpus. And rats were sacrificed 5 h after surgery. We analyzed the expression of NADPH, MAPK, inflammatory, anti-inflammatory, and tight junction related proteins by western blot in esophageal tissue and observed the level of reactive oxygen species (ROS), alanine aminotransferanse (ALT), and aspartate aminotransferase (AST) in serum. Results : RS administration significantly protected the esophageal mucosal damage of reflux esophagitis, and ROS, AST, and ALT levels were significantly reduced in RS administration compared to Con group. In addition, RS administration effectively suppressed MAPK and NF-κB pathways and upregulated protein expressions of tight junction protein. Conclusions : These results suggest that RS protected the esophageal mucosa by inhibiting the MAPK and NF-κB pathways and upregulating tight junctions.

• 한국식품조리과학회지
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• 제12권2호
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• pp.207-213
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• 1996

옥수수빵(CON)과 그 구성 성분중 옥수수 전분을 Amylomaize Vll starch로 대체한 제품(AMZ)을 제조하였다 또한 AMZ의 구성 성분중 지방의 일부를 RS 로 대체한 제품(지방의 15%대체시 RSl5, 30%대체 RS30)을 제조하여 총 네 가지 제품에 있어서 품질 특성을 살펴본 결과는 다음과 같다. 1. Sievert and Pomeranz의 방법에 따라 열처리-냉각 과정을 3번 반복하여 제조한 시료에서 분리된 RS의 수율은 28.96%였다. 2.옥수수빵의 텍스쳐 특성 표현어를 Szczesniak의 방법에 따라 분류한 결과 가장 많이 언급된 항목은 시료의 수분 함량에 관련된 촉촉하다였으며 깨짐성 및 검성에 관련된 표현어로서 푸석푸석하다, 부슬부슬하다 및 입자 크기와 관련된 용어로서 부드럽다, 꺼끌꺼 끌하다, 모래같다 등이었다 3. 관능검사 결과 기공의 크기는 지방을 RS로 대체 한 경우 유의적으로 증가하였고 CON에 비해 AMZ, RSl5및 RS30의 견고성이 유의적으로 증가하고 탄성은 유의적으로 감소되는 것을 알 수 있었다. 4. Texture analyser를 이용하여 deformation 30％로 기계적 texture를 관찰한 결과 견고성은 시간이 경과함에 따라 유의적으로 차이가 없거나 증가하는 경향을 보였으며 응집성은 변화가 없거나 감소하였고 탄성은 CON이 AMZ, RSl5 및 RS3O과 비교하여 항상유의적으로 높은 값을 보여 관능검사 결과와 일치하였다. 5. 50% 변형시킨 경우에도 30% 변형시킨 경우와 비슷한 경향을 보였으며 특히 지방의 30%를 RS로 치환했을 경우 물성에 유의적인 변화를 가져온다는 것을 알 수 있었다.

• Asian-Australasian Journal of Animal Sciences
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• 제5권3호
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• pp.487-494
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• 1992

This experiment was conducted to study the effect of addition of Lucerne juice (LJ) obtained by mechanical extraction of freshly harvested crop on the nutritive value of rice straw silage. Rice straw (RS) was ensiled with intact, NaOH or $NH_3$ treated LJ at 3:7 ratio on fresh weight basis (LJ RS, LJ NaOH RS and LJ $NH_3$ RS, respectively). Each alkali was mixed with fresh juice at a level of 4% of rice straw dry matter just before ensiling. Rice straw ensiled with water was prepared as the control (W RS). In the digestion trial, goats were allocated in a $4{\times}4$ Latin-square design and fed the diet containing three parts of RS silage and one part of wheat bran (DM basis). For the goats receiving the control silage, urea was supplemented at feeding time so as to adjust the nitrogen intake except for goats on LJ $NH_3$ RS silage. Crude protein content of RS silage was increased from 5.2 to 9.1% (DM basis) by the addition of intact LJ and to about 24% by $NH_3$ treated LJ. The control W RS silage contained only trace amount of lactic acid and was dominated by acetic and butyric acid. The addition of intact LJ reduced butyric acid content and $NH_3-N/TN$ of the silage whereas the addition of alkalized LJ increased those values and shifted to a butyrate type fermentation. Nutrient digestibilities and nitrogen balance of goats were almost the same when they were fed W RS and LJ RS silage indicating the addition of intact LJ did not improve the nutritive value. The addition of alkalized LJ significantly increased the fiber digestibilities of RS silage and $NH_3$ treatment was more effective than NaOH treatment. Postprandial ruminal $NH_3-N$ and blood urea nitrogen (BUN) concentrations were decreased by feeding LJ NaOH RS silage suggesting ruminal protein synthesis was enhanced along with the increase of energy supply for supply for rumen microbes by the alkali treatment. The advantageous fiber digestibilities of LJ $NH_3$ RS silage compared with those of LJ NaOH RS silage might be attributable to a sufficient nitrogen supply for microbial fiber digestion in the rumen.

• 산업공학
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• 제3권2호
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• pp.39-51
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• 1990

One of the most important and powerful tools available for design and/or study of the operation of complex systems and processes is simulation. Since automated material handling systems like AS/RS are often quite complex, a network-based simulation model is developed to analyze an automobile part supplier's automated storage and retrieval system(AS/RS). The network simulation model is implemented in the SLAM Ⅱ on a VAX 8800 computer. Performance of the AS/RS was tested for 3 dispatching rules, 3 work load levels, 2 storage policies, 3 levels of stacker crane break-down, and 2 conveyor system layouts. Results indicate that the AS/RS performance is primarily affected by the dispatching rule and work load level.