• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1879-1883
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• 2014

Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. Result: The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Conclusion: Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.6C
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• pp.544-561
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• 2002

In this paper, we propose a new hybrid type of the routing protocol (Virtual Cluster-based Routing Protocol: VCRP) for mobile ad-hoc networks, based on a virtual cluster, which is defined as a narrow-sense network to exchange the basic information related to the routing among the adjacent nodes. This particular approach combines advantage of proactive routing protocol (PRP), which immediately provides the route collecting the network-wide topological and metric information, with that of reactive routing protocol, which relies on the route query packet to collect the route information on its way to the destination without exchanging any information between nodes. Furthermore, it also provides the back-up route as a byproduct, along with the optimal route, which leads to the VCBRP (Virtual Cluster-based Routing Protocol with Backup Route) establishing the alternative route immediately after a network topology is changed due to degradation of link quality and terminal mobility, Our simulation studies have shown that the proposed routing protocols are robust against dynamics of network topology while improving the performances of packet transfer delay, link failure ratio, and throughput over those of the existing routing protocols without much compromising the control overhead efficiency.