• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4335-4339
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• 2012

Background: Whether sirolimus is useful in the prevention of non-melanoma skin cancer (NMSC) remains unclear and we therefore performed this meta-analysis of randomized controlled trials to test the hypothesis that Sirolimus-based immunosuppression is associated with a decrease in NMSC. Methods: The main outcomes were NMSC, squamous-cell carcinoma and basal-cell carcinoma. The pooled risk ratio (RR) with its 95% confidence interval (95%CI) were used to assess the effects. Results: 5 randomized trials involving a total of 1499 patients receiving kidney transplantation were included. Patients undergoing Sirolimus-based immunosuppression had much lower risk of NMSC (RR = 0.49, 95%CI 0.32-0.76, P = 0.001). Subgroup analyses by tumor type showed that Sirolimus-based immunosuppression significantly decreased risk of both squamous-cell carcinoma (RR = 0.58, 95%CI 0.43-0.78, P < 0.001) and basal-cell carcinoma (RR = 0.56, 95%CI 0.37-0.85, P = 0.006). The quality of evidence was high for NMSC, and moderate for squamous-cell carcinoma and basal-cell carcinoma. No evidence of publication bias was observed. Conclusion: High quality evidence suggests that Sirolimus-based immunosuppression decreases risk of non-melanoma skin cancer, and Sirolimus has an antitumoral effect among kidney-transplant recipients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3477-3482
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• 2014

Objective: Patients with inflammatory bowel disease (IBD) have an increased risk of extra-intestinal cancer, whereas its impact on cholangiocarcinoma (CC) remains unknown. The aim of this study was to obtain a reliable estimate of the risk of CC in IBD patients through a meta-analysis of clinical observational studies. Methods: Relevant studies were retrieved by searching PUBMED, EMBASE and Web of Science Databases up to Dec 2013. Four population-based case-control and two cohort studies with IBD were identified. Summary relative risk (RR) and its corresponding 95% confidence interval (CI) were calculated using a random-effects model. Potential sources of heterogeneity were detected using subgroup analyses. Results: The pooled risk estimate indicated IBD patients were at increased risk of CC (RR = 2.63, 95%CI = 1.47-4.72). Moreover, the increased risk of CC was also associated with Crohn's disease (RR = 2.69, 95%CI = 1.59-4.55) and ulcerative colitis (RR = 3.40, 95%CI = 2.50-4.62). In addition, site-specific analyses revealed that IBD patients had an increased risk of intrahepatic CC (ICC) (RR = 2.61, 95%CI = 1.72-3.95) and extrahepatic CC (ECC) (RR = 1.47, 95%CI = 1.10-1.97). Conclusions: This study suggests the risk of CC is significantly increased among IBD patients, especially in ICC cases. Further studies are warranted to enable definite conclusions to be drawn.

• Archives of Plastic Surgery
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• v.51 no.2
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• pp.163-168
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• 2024

Background The study determined to compare the clinical outcomes of traditional gold weight implantation for the correction of paralytic lagophthalmos with those of a newly designed model. Methods In this retrospective cohort study, we enrolled 30 patients (76% females; average age 60.8 ± 12 years) with facial palsy who underwent implantation of either the traditional pretarsal gold weight (PT group; n = 15) or a new supratarsal model (ST group; n = 15) from May 2014 to April 2019. The main outcome measures were the 12-month postoperative weight prominence, weight migration, improvement of lagophthalmos, upper eyelid contour, and upper eyelid ptosis. The secondary outcome was long-term (24 months) reoperative rate. Results The new model group had significantly better eyelid contour (risk ratio [RR] 3.16, 95% confidence interval [CI] 1.62-6.15, p = 0.001), less weight prominence (RR 1.74, 95% CI 1.13-2.70, p = 0.013), less weight migration (RR 1.31, 95% CI 1.12-1.54, p = 0.001), and less eyelid ptosis (RR 2.36, 95% CI 1.21-4.59, p = 0.011) than the traditional model group. Improvement of lagophthalmos was not statistically significant between the two groups (RR 1.44, 95% CI 0.72-2.91, p = 0.303). The 24-month reoperative rate was 53.3% in the PT group versus 13.3% in the ST group (RR 2.00, 95% CI 1.15-3.49, p = 0.015). Conclusion The newly designed supratarsal gold weight showed superior postoperative outcomes than the standard traditional model.

• Journal of Preventive Medicine and Public Health
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• v.57 no.2
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• pp.120-127
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• 2024

Objectives: The coronavirus disease 2019 (COVID-19) pandemic led to increased mortality rates. To assess this impact, this ecological study aimed to estimate the excess death counts in southern Iran. Methods: The study obtained weekly death counts by linking the National Death Registry and Medical Care Monitoring Center repositories. The P-score was initially estimated using a simple method that involved calculating the difference between the observed and expected death counts. The interrupted time series analysis was then used to calculate the mean relative risk (RR) of death during the first year of the pandemic. Results: Our study found that there were 5571 excess deaths from all causes (P-score=33.29%) during the first year of the COVID-19 pandemic, with 48.03% of these deaths directly related to COVID-19. The pandemic was found to increase the risk of death from all causes (RR, 1.26; 95% confidence interval [CI], 1.19 to 1.33), as well as in specific age groups such as those aged 35-49 (RR, 1.21; 95% CI, 1.12 to 1.32), 50-64 (RR, 1.38; 95% CI, 1.28 to 1.49), and ≥65 (RR, 1.29; 95% CI, 1.12 to 1.32) years old. Furthermore, there was an increased risk of death from cardiovascular diseases (RR, 1.17; 95% CI, 1.11 to 1.22). Conclusions: There was a 26% increase in the death count in southern Iran during the COVID-19 pandemic. More than half of these excess deaths were not directly related to COVID-19, but rather other causes, with cardiovascular diseases being a major contributor.

• 대한예방의학회:학술대회논문집
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• 1994.02a
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• pp.660-680
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• 1994

• Korean Journal of Acupuncture
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• v.24 no.2
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• pp.185-191
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• 2007

목 적 : 전침 자극은 최근에 임상연구와 더불어 기초연구에서 자주 사용하는 방법으로 경락이론에 의거하여 신체에 분포되어 있는 경락상의 각종경혈부위에 인위적인 전기 자극을 통하여 질병을 치료, 예방 혹은 완화하는 방법이다. 이에 본 연구에서는 정상적인 쥐의 상태에서 일정한 전침 자극을 주었을 때, 심박변이도의 변화를 측정 하였다. 방 법 : 쥐의 정상적인 마취상태에서 태충혈에 4 Hz와 80 Hz의 5 V 크기로 10 mA 강도의 사각파 파형으로 자극을 주었으며 대조조로 비경혈 부위에 4 Hz의 동일한 파형으로 자극을 주어 심박 변이도의 변화정도를 측정하였다. 결 과 : 본 실험에서 RR Interval의 경우 태충혈 4 Hz 보다 80 Hz일때 RR Interval의 파형이 더 크게 나타났으며, PSD의 분석에서도 자극 전후를 비교하였을 때 $1{\sim}3$ Hz 사이에 높은 피크가 보였으며 4 Hz의 비경혈 부위에서는 큰 변화를 보이지 않았다. 결 론 : 이번 실험연구를 통하여 정상적인 쥐의 상태에서 일정한 전침 자극을 주었을 때, 심박 변이도 변화를 도출할 수 있었으며, 이번 실험을 통해 비수술적인 방법으로 치료효과와 심박 변이도를 측정할 수 있었고, 이를 통해 전침자극의 기전 연구에 있어 과학적 근거를 제시할 수 있다고 사료된다.

• Journal of Veterinary Clinics
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• v.5 no.2
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• pp.61-71
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• 1988

This study was performed to compare the antagonistic effects of intravenous(0.125mg / kg) and subcutaneous(0.25mg /kg) administration of yohimbine on xylazine-induced immobilized(4.5mg/ kg) dog and to investigate the effectiveness of yohimbine compound(0.25mg / kg) in clinical practice. Mean arousal time(MAT), mean walk time(MWT), and time to return to normal electroencephalograms were remarkably decreased in all yohimbine-treated groups compared with the control. In electroencephalograms(A-B$\sub$I/ lead), there were no significant alteration, except RR interval. RR interval was decreased in all yohimbine-treated groups compared with the control. Second-degree heart blocks(41.7%) shown after xylazine administration disappeared within 2 min after yohimbine administration. The frequency of electroencephalograms(RO-RF trace) was recovered faster to normal in yohimbine-treated groups than that of the control. In histopathological changes of ICR mice given yohimbine compound subcutaneously, edema with inflammatory cells of hypodermis was slightly shown on the 1st day, but this findings were not observed on the 5th day. It was considered that no difference in the antagonistic effects of intravenous and subcutaneous administration of yohimbine on xylazine- induced immobilized dog were observed and yohimbine compound was usable in clinical practice for antagonistic agent to the xylazine.

• Journal of IKEEE
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• v.25 no.1
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• pp.212-217
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• 2021

Premature contraction arrhythmia is the most common disease among arrhythmia and it may cause serious situations such as ventricular fibrillation and ventricular tachycardia. Most of arrhythmia clasification methods have been developed with the primary objective of the high detection performance without taking into account the computational complexity. Also, personalized difference of ECG signal exist, performance degradation occurs because of carrying out diagnosis by general classification rule. Therefore it is necessary to design efficient method that classifies arrhythmia by analyzing the persons's physical condition and decreases computational cost by accurately detecting minimal feature point based on only QRS features. We propose method for personalized specific classification of premature contraction arrhythmia based on QRS features in smart healthcare environments. For this purpose, we detected R wave through the preprocessing method and SOM and selected abnormal signal sets.. Also, we developed algorithm to classify premature contraction arrhythmia using QRS pattern, RR interval, threshold for amplitude of R wave. The performance of R wave detection, Premature ventricular contraction classification is evaluated by using of MIT-BIH arrhythmia database that included over 30 PVC(Premature Ventricular Contraction) and PAC(Premature Atrial Contraction). The achieved scores indicate the average of 98.24% in R wave detection and the rate of 97.31% in Premature ventricular contraction classification.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.2
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• pp.437-444
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• 2016

Most methods for detecting arrhythmia require pp interval, diversity of P wave morphology, but it is difficult to detect the p wave signal because of various noise types. Therefore it is necessary to use noise-free R wave. In this paper, we propose algorithm for premature contraction arrhythmia classification through ECG pattern analysis and template threshold. For this purpose, we detected R wave through the preprocessing method using morphological filter, subtractive operation method. Also, we developed algorithm to classify premature contraction wave pattern using weighted average, premature ventricular contraction(PVC) and atrial premature contraction(APC) through template threshold for R wave amplitude. The performance of R wave detection, PVC classification is evaluated by using 6 record of MIT-BIH arrhythmia database that included over 30 PVC and APC. The achieved scores indicate the average of 99.77% in R wave detection and the rate of 94.91%, 95.76% in PVC and APC classification.

• Journal of Preventive Medicine and Public Health
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• v.56 no.5
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• pp.413-421
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• 2023

Objectives: This study explored the effect of the coronavirus disease 2019 (COVID-19) pandemic on psychosocial stress in prime working-age individuals in Korea, focusing on gender inequalities. We hypothesized that the impact of COVID-19 on mental health would differ by age and gender, with younger women potentially demonstrating heightened vulnerability relative to men. Methods: The study involved data from the Korea Community Health Survey and included 319 592 adults aged 30 years to 49 years. We employed log-binomial regression analysis, controlling for variables including age, education, employment status, marital status, and the presence of children. The study period included 3 phases: the period prior to the COVID-19 outbreak (pre-COVID-19), the early pandemic, and the period following the introduction of vaccinations (post-vaccination). Results: The findings indicated that women were at a heightened risk of psychosocial stress during the early pandemic (relative risk [RR], 1.01; 95% confidence interval [CI], 0.98 to 1.05) and post-vaccination period (RR, 1.07; 95% CI, 1.04 to 1.10) compared to men. This pattern was prominent in urban women aged 30-34 years (pre-COVID-19: RR, 1.06; 95% CI, 1.02 to 1.10; early pandemic: RR, 1.16; 95% CI, 1.08 to 1.25; post-vaccination period, RR, 1.22; 95% CI, 1.14 to 1.31). Conclusions: The COVID-19 pandemic has exerted unequal impacts on psychosocial stress among prime working-age individuals in Korea, with women, particularly those in urban areas, experiencing a heightened risk. The findings highlight the importance of addressing gender-specific needs and implementing appropriate interventions to mitigate the psychosocial consequences of the pandemic.