• BMB Reports
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• 제47권5호
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• pp.292-297
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• 2014

Age-related macular degeneration (AMD) is the leading cause of blindness in the world. Evidence indicates that the suppression of the ubiquitin-proteasome system (UPS) contributes to the accumulation of toxic proteins and inflammation in retinal pigment epithelium (RPE), the functional abnormalities and/or the degeneration of which are believed to be the initiators and major pathologies of AMD. To identify new protein associations with the altered UPS in AMD, we used LC-ESI-MS/MS to perform a proteomic analysis of the aqueous humor (AH) of AMD patients and matched control subjects. Six UPS-related proteins were present in the AH of the patients and control subjects. Four of the proteins, including 26S proteasome non-ATPase regulatory subunit 1 (Rpn2), were increased in patients, according to semi-quantitative proteomic profiling. An LC-MRM assay revealed a significant increase of Rpn2 in 15 AMD patients compared to the control subjects, suggesting that this protein could be a biomarker for AMD.

• 한국화재소방학회논문지
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• 제27권4호
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• pp.56-60
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• 2013

본 연구에서는 소방방열복 착용시 작업강도가 신체에 미치는 영향을 조사하여 소방공무원의 안전을 위한 기초자료 제공을 목적으로 하며 연구에서 얻어진 결과를 제시하면 다음과 같다. 작업종료시(20분)에 작업강도가 4 METs에서 8METs로 증가함에 따라 평균피부온도차(33.3 %), 고막온도차(57.1 %), 심박수(32.5 %), 운동자각도(75.6 %) 등은 통계적으로 유의하게 높게 나타났으며, 온냉감과 체중감소는 유의한 차이가 나타나지 않았다. 이상의 결과 소방방열복 착용시 작업강도의 증가는 신체에 많은 영향을 미치는 것으로 판단된다.

• 생명과학회지
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• 제22권8호
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• pp.1085-1091
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• 2012

본 연구는 실내 외 운동 환경의 차이가 노년기 여성의 골밀도와 신체구성에 미치는 영향을 규명하는데 그 목적이 있다. 연구대상은 65세 이상 노년기 여성으로 실내운동집단 13명, 실외운동집단 13명 두 그룹으로 나누었으며, 20주간 운동프로그램을 실시하였다. 운동강도는 주3회, 1회 60분 동안 HRmax 50~70%, RPE 11~15로 점진적으로 증가시켰다. 결과는 다음과 같다. 첫째, 골밀도의 결과 집단 내 변화에서는 실외운동집단에서 유의하게 증가하였고, 집단 간 변화에서는 실외운동집단이 실내운동집단보다 유의하게 증가하였다. 둘째, 신체구성의 결과 집단 내 변화에서는 실내운동집단에서 체지방량이 유의하게 감소하였고, 실외운동집단에서 체중, 체질량지수, 체지방량이 유의하게 감소하였다. 집단 간의 변화에서는 체질량지수에서 실외운동집단이 실내운동집단보다 유의하게 감소하였다. 이와 같은 연구 결과들을 살펴볼 때 20주간 실외운동환경에서의 운동프로그램은 골밀도와 신체구성에 긍정적인 영향을 미친 것으로 나타났다.

• 생명과학회지
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• 제27권7호
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• pp.817-825
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• 2017

본 연구는 체지방률 30% 이상인 비만 중년여성을 대상으로 복합운동 영양교육군(n=7), 복합운동군(n=7), 대조군(n=7) 총21명을 대상으로 연구한 결과 다음과 같은 결론을 얻었다. 12주간 복합운동과 영양교육의 실시는 비만 중년 여성의 체지방률, 제지방량, GOT, TC, TG, HDL-C, 인슐린 저항성을 개선시키는 효과를 나타냈다. 이러한 결과는 복합운동과 영양교육이 비만중년여성의 신체조성, 간기능, 혈중지질, 및 인슐린 저항성에 긍정적인 영향을 미쳐 중년여성의 비만을 개선하는데 효과적인 프로그램 사료되며, 추후에도 비만중년여성의 운동방법, 운동빈도, 식이방법 등을 고려한 다양한 연구가 필요할 것으로 사료된다.

• 한국응용과학기술학회지
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• 제39권6호
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• pp.906-915
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• 2022

본 연구의 목적은 12주간 수중걷기운동이 비만 노인 여성의 신체조성, hs-CRP, HOMA-IR 및 혈압에 미치는 영향을 알아보기 위하여 실시하였다. 체지방률 30% 이상인 비만 노인 여성 중 운동군(10명), 대조군(10명)으로 총 20명으로 실시하였으며, 모든 검사항목은 동일한 방법과 조건으로 신체조성, hs-CRP, HOMA-IR 및 혈압을 사전, 사후 총 2회 측정하였다. 수중걷기운동은 12주간, 주 3회, 1회 50분, RPE 11-14 강도로 실시하였다. 측정변인에 대해 평균값과 표준편차(M±SD)를 산출한 후 사전 운동군과 대조군의 신체적 특성과 각 측정변인에 대한 동질성 검정을 위하여 독립 t-test를, 집단 내의 사전·사후 평균치 변화에 대한 차이 검증은 종속 t-test를, 집단 간 차이에 대한 주효과 검정 및 집단 간 시기 간 상호작용 효과는 반복측정 분산분석을 이용하였다. 본 연구결과 운동군에서 신체조성, 체지방률(p<.05), 인슐린(p<.01), HOMA-IR(p<.01) 및 수축기 혈압(p<.05)이 유의하게 감소하였다. 따라서 수중걷기운동이 비만 노인 여성의 비만 및 심혈관질환의 개선에 도움을 줄 수 있을 것으로 사료된다.

• Toxicological Research
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• 제16권2호
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• pp.141-146
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• 2000

Phthalate esters are used extensively as a plasticizer in the manufacture of plastic products such as PVC bags and medical devices. Recently, phthalate esters have been shown to induce endocrine system mediated responses. However. only a Jew studies have been conducted for estrogenic activity of phthalate esters. In this study estrogenic activities of seven phthalate esters. butyl benzyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), di-n-butylphthalate (DBP), diethylphthalate (DEP), di-n-pentylphthalate (DPP), di-n-propylphthalate (DPrP) and dicyclohexylphthalate (DCHP), were examined in vitro using E-screen assay and competitive binding assay. From the E-screen assay, BBP. DEHP. DBP and DEP showed weak estrogenic activity at the concentration of 5 $\mu\textrm{M}$. The relative proliferative effect (RPE) and the relative proliferative potency (RPP) were 50~70% and 0.01%. respectively, when compared with 500 pM of 17$\beta$-estradiol (E2). In competitive binding assay with the rat uterine estrogen receptor (ER), BBP and DEP showed weak binding potency ［(l/$10^4$~1/$10^5$ of E2］ while DEHP and DBP scarcely bound to ER. These results suggest that some phthalate esters have weak estrogenic activities in vitro.

• Journal of Nutrition and Health
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• 제28권9호
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• pp.904-913
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• 1995

The purpose of this study is to determine the effects of exercise programs on the treatment of chronic diseases. For this purpose, nine middle-aged women suffering from such chronic diseases as obesity, hypertension and coronary heart disease(CHD) were sampled to perform a 4-month-long exercise program which required the lactate threshold(LT) level corresponding to 70% of maximal oxygen uptake(VO2max). Thereupon, their physiques, physical fitness, blood components and physiological varibles were compared pre and post of exercise program. The results were summarized as follows ; 1) After the 4-month-long exercise program, %fat was significantly decreased, while such variables as grip strength, side step, trunk flexion and leg balance were significantly increased. 2) Blood components such as TG, TC, HDL-C, LDL-C, hemoglobin and hematocrit did not show and change in after exercise program. 3) Physiological varables such as HR, SBP, DBP, HR/LT, SBP/LT, DBP/LT, RPE/LT, VE/LT, VO2/LT and VO2 max showed significant increase after 4-month exercise program. These results suggest that regular aerobic exercise in a long period might help to decrease % fat and to increase aerobic capacity in middle-aged women suffering from chronic diseases.

• 산업공학
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• 제17권1호
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• pp.46-55
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• 2004

Various characteristics of the object being lifted are known to affect the biomechanical, physiological, and psychophysical stresses. The object characteristics to be considered in the design process of lifting tasks are weight, shape, stiffness, and availability of handles and similar coupling devices. In this study, a prototype Polypropylene laminated bag with carrying handles was designed to decrease the physical stress of people who handle these bags. Physiological and psychophysical approaches as well as subjective ratings were applied to evaluate the effects of handles provided on the designed PP laminated bag. Statistical analysis showed that the VO2, heart rate, blood pressure, and Borg-RPE score for PP laminated fertilizer bag with carrying handles were significantly lower than those bags without handles. Moreover, Maximum Acceptable Lifting Endurance Time(MALET) measure, newly developed in this study, for bags with handles was significantly higher than those for bags without handles. It is thus recommended that the various types of bags and boxes be equipped with handles to reduce the musculoskeletal, physiological, psychophysical, and subjective perceived stresses.

• 대한심미치과학회지
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• 제10권1호
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• pp.8-15
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• 2001

The Class III malocclusion classified in two types of Skeletal Class III and Pseudo Class III. In the case of the maxillary deficiency, the protraction H-G(facemask) with Bonded RPE can be used. For children with A-P and vertical maxillary deficiency, the preferred treatment is to move the maxilla into a more anterior and inferior position, which also increases its size as bone is added at the posterior and superior sutures. Successful forward repositioning of the maxilla can be accomplished before age 8. To resist tooth movement as much as possible, the maxillary teeth should be splinted together as a single unit. The maxillary appliance must have hooks for attachment to the facemask that are located in the canine-primary molar area above the occlusal plane. The facemask usually worn until a positive overjet of 2-5mm is achieved interincisally. Occipital chin cup is successful in those patients who can bring their incisors close to an edge-to-edge position when in centric relation. This treatment is particularly useful in patients who begin treatment with a short lower anterior facial height, as this type of treatment can lead to an increase in lower anterior facial height. If the pull of the chin cup is directed below the condyle, the force of the appliance may lead to a downward and backward rotation of the mandible.

• 지역사회간호학회지
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• 제19권4호
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• pp.600-610
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• 2008

Purpose: The purpose of this study is to find the effects of an exercise program on body composition, serum lipids, and menopausal symptoms in Korean menopausal women. Methods: This research used none qui valent control group pretest-posttest design. The participants were 30 middle-aged women who were divided into two groups, an experimental group (n = 16) who participated in the exercise program and a control group (n = 14). The exercise program was composed of gymnastic-ball exercises with RPE $12{\sim}13$ intensity, 50 minutes' duration and three times a week for 12 weeks from April 1 to June 30, 2008. The dependent variables (body composition, serum lipids, menopause symptoms, self-efficacy, and life satisfaction) were measured before and after exercise program. Results: There were statistically significant difference in weight (F=2.92, p=.049), percent body fat (F=4.22, p=.040), total cholesterol (F=2.63, p= .017) and high density lipoprotein (F=6.74, p= .015) between the two groups. Psychological menopausal symptoms also decreased significantly (F=7.01. p=.014) after the exercise in the experimental group. Conclusions: Regular gymnastic-ball exercises are helpful for menopausal women. They have positive effects not only on body composition and serum lipids but also on the decrease of menopausal symptoms. The results of this study suggest that gymnastic-ball exercise programs are effective in health promotion of Korean middle-aged women, and thus it is necessary to develop exercise programs for women.