• Structural Engineering and Mechanics
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• v.47 no.4
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• pp.471-493
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• 2013

This paper presents a framework for seismic damage evaluation for Algerian buildings adapted from HAZUS approach (Hazard-United States). Capacity and fragility curves were adapted to fit the Algerian building typologies (Reinforced Concrete structures, Confined or Non-Confined Masonry, etc). For prediction purposes, it aims to estimate the damages and potential losses that may be generated by a given earthquake in a prone area or country. Its efficiency is validated by comparing the estimated and observed damages in Boumerd$\grave{e}$s city, in the aftermath of Boumerd$\grave{e}$s earthquake (Algeria: May $21^{st}$ 2003; $M_w$ = 6.8). For this purpose, observed damages reported for almost 3,700 buildings are compared to the theoretical predictions obtained under two distinct modelling of the seismic hazard. In one hand, the site response spectrum is built according to real accelerometric records obtained during the main shock. In the other hand, the effective Algerian seismic code response spectrum (RPA 99) in use by the time of the earthquake is considered; it required the prior fitting of Boumerd$\grave{e}$s site PGA (Peak Ground Acceleration) provided by Ambraseys' attenuation relationship.

• Journal of Microbiology and Biotechnology
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• v.27 no.12
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• pp.2104-2111
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• 2017

A new series comprising phenylacetyl-homoserine lactones (HSLs), caffeoyl-HSL and feruloyl-HSL, was biologically synthesized using an artificial de novo biosynthetic pathway. We developed an Escherichia coli system containing artificial biosynthetic pathways that yield phenylacetyl-HSLs from simple carbon sources. These artificial biosynthetic pathways contained the LuxI-type synthase gene (rpaI) in addition to caffeoyl-CoA and feruloyl-CoA biosynthetic genes, respectively. Finally, the yields for caffeoyl-HSL and feruloyl-HSL were $97.1{\pm}10.3$ and $65.2{\pm}5.7mg/l$, respectively, by tyrosine-overproducing E. coli with a $\text\tiny{L}$-methionine feeding strategy. In a quorum sensing (QS) competition assay, feruloyl-HSL and p-coumaroyl-HSL antagonized the QS receptor TraR in Agrobacterium tumefaciens NT1, whereas caffeoyl-HSL did not.

• Journal of ILASS-Korea
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• v.21 no.4
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• pp.214-222
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• 2016

Changes in road infrastructure affect driving patterns and pollutant emission characteristics. we analyzed the changes in driving patterns and pollutant emission characteristics of the driving route via measured driving patterns at year 2009 and 2016. Since 2009, there has been an increase in population and traffic demand, including residential areas and industrial facilities. Traffic conditions were improved such as the opening of the highway Inter-Change to Seoul and the construction of underground driveway. As a result, the average vehicle speed increased. More detail comparisons have made on the changes of the underground driveway section and the crossroad section, which are expected to have significant changes in the transportation infrastructure. The vehicle speed distribution of the underground driveway changed from low speed to high speed, and the increase of the time spent at the high speed and high load caused the increase of NOx emissions. The vehicle speed also increased at the crossroad section, and the consequence NOx and $CO_2$ emissions decreased. It is mainly because the decreased time spent at idle, which results from the proper traffic demand management at this area.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.22 no.1
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• pp.22-31
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• 2014

Military UAV(Unmanned Aerial Vehicle) operated as a RC(Remotely Control) model level within the limit of the military special use airspace until now. However, the high and medium altitude of URA(Unmanned Reconnaissance Aircraft) which the ROKAF have been trying to import recently is at the UAV level and needs the criteria for the classified airspace flights. The required flight criteria includes operator location, mission operation limit, equipment, etc., which are the principle and standard applied based on the airspace use for UAV. Also, the general flight rules, visual flight rules, instrument flight rules are required in order to have to be applied to the actual flight. Besides, an appliance regulation needs to be arranged regarding two-way communication, ATC and communication issue, airspace and area in-flight between UAS( Unmanned Aircraft System) users. An operation of the UAV in the air significantly requires the guarantee of the aircraft's capacity, and also the standardized flight criteria. A safe and smooth use is ensured only if this criteria is applied and understood by the entire airspace users. For the purpose, a standardized military UAV flight operations criteria that is to be applied for each airspace by UAV is to be prepared through analysis of the present state, a legend UAV system, and a special character analysis.

• Journal of Chest Surgery
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• v.28 no.3
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• pp.237-246
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• 1995

Between March 1989 and December 1994, one-stage repair was performed for correction of the intracardiac malformations associated with aortic coarctation in 34 patients or interrupted aortic arch in 8 patients via median sternotomy. There were 26 male and 16 female patients, and their body weight ranged from 1.8 to 8 kg [mean weight, 4.0 1.4 kg . The age at the operation ranged from 7 days to 18 months [mean age, 3.1 $\pm$ 3.8 months . The repair of aortic coarctation or interrupted aortic arch was performed using extended end-to-end anastomosis in most of the patients [86%, 36/42 , and six patients underwent ductal tissue excision and patch aortoplasty. Intracardiac defects were corrected concomitantly through the right atrium unless the anatomy dictated otherwise. Obstructive outlet septum was resected whenever necessary. There were seven early deaths [16.8 % , and three late deaths with a mean follow-up period of 25 months [range from 1 to 65 months . Three patients were reoperated upon residual subaortic stenosis, stenosis at the RPA origin, and subacute bacterial endocarditis respectively. None showed any significant residual or anastomotic stenosis postoperatively. One stage repair of the aortic coarctation and interrupted aortic arch associated with intracardiac defect leaves no native coarctation shelf tissue or residual hypoplasia in the repaired segment, has low incidence of recurrent or residual stenosis, minimizes reoperation and incisions, and manages arch hypoplasia easily. We concluded that surgical results of one-stage repair for the intracardiac malformation associated with aortic coarctation or interrupted aortic arch are reasonable.

• Genomics & Informatics
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• v.3 no.1
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• pp.8-14
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• 2005

Although much is known about the molecular biology of platelets, the megakaryocytes' (MKs) molecular biology was not understood so well because of their rareness. By the cloning and characterization of thrombopoietin (TPO), which is the principal regulator of the growth and development of the MKs, researches on the MKs have been growing rapidly. To understand megakaryocytopoiesis, we investigated the gene expression profile of the MKs using oligonucleotide microarray where 10,108 unique genes were spotted. Comparing the fluorescence intensities of which ratio is $\ge$ ${\mid}2{\mid}$, 372 genes were up-regulated and 541 genes were down-regulated in MKs. For confirmatory expression, RNase protection assay (RPA) establishing abundant apoptotic gene expression was carried out. In MKs, many of the known genes, including several platelet related genes, GATA binding protein were highly expressed. Particularly, TGF beta, clusterin (complement lysis inhibitor), and thymosin beta 4 (actin-sequestering molecules) were expressed highly in MKs. As MKs specific expressed genes may regulate normal and pathologic platelet (and/or MK) functions, the transcript profiling using microarray was useful on molecular understanding of MKs,

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1995-1997
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• 2012

Background: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Methods: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. Results: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. Conclusion: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

• Molecules and Cells
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• v.42 no.12
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• pp.836-839
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• 2019

A tumor is an abnormal mass of tissue that arises when cells divide more than they should or do not die when they should. The cellular decision regarding whether to undergo division or death is made at the restriction (R)-point. Consistent with this, an increasingly large body of evidence indicates that deregulation of the R-point decision-making machinery accompanies the formation of most tumors. Although the R-point decision is literally a matter of life and death for the cell, and thus critical for the health of the organism, it remains unclear how a cell chooses its own fate. Recent work demonstrated that the R-point constitutes a novel oncogene surveillance mechanism operated by R-point-associated complexes of which RUNX3 and BRD2 are the core factors (Rpa-RX3 complexes). Here, we show that not only RUNX3 and BRD2, but also other members of the RUNX and BRD families (RUNX1, RUNX2, BRD3, and BRD4), are involved in R-point regulation.

• Journal of Chest Surgery
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• v.21 no.1
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• pp.10-16
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• 1988

Ten patients with tetralogy of Fallot were studied angiocardiographically before a modified Blalock-Taussig shunt and again 25*3.2 months after the previous shunt. All of ten patients had patent previous shunt at the time of follow up examination. Pre-and postoperative diameters of left and right pulmonary artery and descending aorta were measured and pulmonary artery index [the sum of the crossectional areas of the right and left pulmonary arteries standardized by the body surface area] was calculated. The ratio of mean diameter of left and right pulmonary arteries to the diameter of the descending aorta [LPA+RPA/2xDA] was increased postoperatively by 0.20*0.068 [p=0.020]. Mean PAI [pulmonary artery index] increased from 283.8*178.4 mm/m2 BSA to 345.8~144.5 mm/m2 BSA after shunt operation [p=0.019]. This results suggested that the modified Blalock-Taussig shunt was effective to help growth of the pulmonary arteries in most cases of the study populations but the ones with the PAI>233mm*/m* BSA appeared less benefited by Blalock Taussig shunt. Calculation of PAI could be an aid to making a decision whether to perform a one stage corrective surgical procedure or a palliative shunt procedure in the patient with small pulmonary arteries.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.12
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• pp.5191-5211
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• 2016

It is essential to satisfy class-specific QoS constraints to provide broadband services for new generation networks. The present study proposes a QoS-driven multicast scheme for wireless networks in which the transmission rate and end-to-end delay are assumed to be bounded during a multiple multicast session. A distributed algorithm was used to identify a cost-efficient sub-graph between the source and destination which can satisfy QoS constraints of a multicast session. The model was then modified as to be applied for wireless networks in which satisfying interference constraints is the main challenge. A discrete power control scheme was also applied for the QoS-aware multicast model to accommodate the effect of transmission power level based on link capacity requirements. We also proposed random power allocation (RPA) and gradient power allocation (GPA) algorithms to efficient resource distribution each of which has different time complexity and optimality levels. Experimental results confirm that the proposed power allocation techniques decrease the number of unavailable links between intermediate nodes in the sub-graph and considerably increase the chance of finding an optimal solution.