• The Korean Journal of Community Living Science
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• v.26 no.2
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• pp.261-274
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• 2015

Although fasting programs have recently attracted close attention because of benefits of detoxification, few studies have examined these programs. This study investigates the effects of a modified juice-based fasting program on lipid metabolism. A total of 33 volunteers fasted for 10 days and participated in program lectures, exercise programs, water bath regimens, and enemas. Pre- and post-program blood samples were obtained to evaluate lipoprotein levels. A paired t-test was conducted using SPSS 18.0. Changes in the lipid profile were observed during the juice-based fasting program and attending 3 degrees. All lipid profiles decreased significantly, including total cholesterol (TC) (p<0.001), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (p<0.05). Program participation was documented by assessing attendance levels as high, moderate, and low. TC decreased significantly in all programs and levels (p<0.05), TG decreased proportionally only in enemas according to the attending degree: high (48 %), moderate (20 %), and low (10 %). HDL-C decreased at all low levels, but moderate exercise ($53.8{\pm}12.5mg/dL$ to $55.6{\pm}10.2mg/dL$) and a high enema ($54.9{\pm}14.1mg/dL$ to $55.0{\pm}9.4mg/dL$) showed small increases. The antioxidant property of the juice-based fasting program in terms of the blood vessel, enemas, and exercise played an important role in preventing cardiovascular disease from increased levels of HDL-C. These results suggest that juice-based fasting and combined lifestyle programs may help improve lipid metabolism and protect against dyslipidemia.

• Journal of Ginseng Research
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• v.39 no.4
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• pp.398-405
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• 2015

Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin. Gintonin induces $[Ca^{2+}]_i$ transient in animal cells via lysophosphatidic acid receptor activation. Gintonin-mediated $[Ca^{2+}]_i$ transient is linked to anti-Alzheimer's activity in transgenic Alzheimer's disease animal model. The previous method for gintonin preparation included multiple steps. The aim of this study is to develop a simple method of gintonin fraction with a high yield. Methods: We developed a brief method to obtain gintonin using ethanol and water. We extracted ginseng with fermentation ethanol and fractionated the extract with water to obtain water-soluble and water-insoluble fractions. The water-insoluble precipitate, rather than the water-soluble supernatant, induced a large $[Ca^{2+}]_i$ transient in primary astrocytes. We designated this fraction as gintonin-enriched fraction (GEF). Results: The yield of GEF was approximately 6-fold higher than that obtained in the previous gintonin preparation method. The apparent molecular weight of GEF, determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis, was equivalent to that obtained in the previous gintonin preparation method. GEF induced $[Ca^{2+}]_i$ transient in cortical astrocytes. The effective dose (ED50) was $0.3{\pm}0.09{\mu}g/mL$. GEF used the same signal transduction pathway as gintonin during $[Ca^{2+}]_i$ transient induction in mouse cortical astrocytes. Conclusion: Because GEF can be prepared through water precipitation of ginseng ethanol extract and is easily reproducible with high yield, it could be commercially utilized for the development of gintoninderived functional health food and natural medicine.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.129-136
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• 2010

Objective : Sinapis alba L. (SA) is a korean traditional herbal medicine that is usually used to prevent or treat inflammatory diseases, such as respiratory infection and rheumatoid arthritis. However, the effects of SA supplementation in vitro on serum antibody levels, splenocyte and peritoneal macrophage immune responses have not yet been determined. In this study, we examined the effect of SA on the production of Th1/Th2 cytokines. Methods : Splenocytes were isolated from naive C57BL/6 mice. Cells were enriched for CD4+ cell populations by first staining the cells with anti-CD4 (BD PharMingen, Calif, USA). CD4+ T cells were selected on a (CS) column, and the flow-through was collected as CD4+ T cells. Isolated cells were activated by overnight incubation on 24-well plates coated with $1{\mu}g/mL$ anti-CD3, $1{\mu}g/mL$ anti-CD28 and with SA ($100{\mu}g/mL$). Primary macrophages were collected from the peritoneal cavities of mice (8-week-old female C57BL/6). The peritoneal macrophages were washed and plated with RPMI-1640 overnight for the experiments. After 48-hours cultures, samples were centrifuged at 2000 rpm for 10 minutes, and the supernatants were stored at $-80^{\circ}C$. Mouse IL-4, IFN-$\gamma$ and TNF-$\alpha$ were quantified using ELISA kits (BioSource International, Camarillo, Calif, USA) according to the manufacturer's protocols. Results : SA at 100ug/ml decreased the generation of Th1 cytokine (IFN-$\gamma$) by 0.5-fold. However, SA has no effect on Th2 (IL-4) production. Conclusions : These results suggest that SA may play an important role in the control of T-cell-mediated autoimmunity by down-regulation of Th1 cytokine (especially IFN-$\gamma$, TNF-$\alpha$). These data may contribute to the design of new immunomodulating treatments for a group of autoimmune diseases.

• Korean journal of communication and information
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• v.36
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• pp.324-347
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• 2006

`Youthism` is pushing the youth research field into a trap of binarism fallacy. It tends to divide the whole population into the young and the old, and further gives an acceleration toward moving the division into the discursive realm of generation gap. The discursive transference is not taking place without any reasonable grounds. The series of discourse is based on two significant phenomena: changes in media background and longer schooling than ever before. Media environment overriding youth culture binds the young in a group and makes them enjoy homogeneous cultural genres. And schooling also seems to play an important role for the youth to have same cultural menus regardless of region, social strata, cultural background. But we need to recognize that after getting into the adulthood, they are not existing in the form of alliance. The youth are not in a homogeneous group. Neither are their culture. The youth are consisted of a variety of groups along such variables as gender, class of their parents. They tend to make distinction not only from the older generation but from the other peer groups. Unless avoiding the trap of youthism, we are blamed for closing eyes to the youth's desire to be distinctive among themselves. Youthism seems to be an active myth even in our academic society.

• Journal of Korea Port Economic Association
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• v.32 no.2
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• pp.1-24
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• 2016

Northeast Asia is changing rapidly, including becoming an increasingly important part of the world economy. Various logistical systems and networks are being established in this area, including South and North Korea, China, Japan, Russia, and Mongolia. Thus, a new systematic logistical network and development strategy is required. The division of the Korean peninsula has for a long time made the region ineffective in terms of land logistics. South Korea's connection to Eurasia is blocked by North Korea, which means it is essentially treated as an island. Furthermore, South Korea does not have an efficient logistics system or effective vision and strategy. Northeast Asia has the potential to be one of the largest economic communities in the world, similar to the EU and North America. Thus, a united Korea can play an important role as the land bridge of Northeast Asia and the logistical hub of the region. This study reviews the logistical position, tasks, and problems of the Korean peninsula and suggests a desirable development strategy and vision. Specifically, after examining the conditions for a land logistical system, focusing on railways, this study proposes several future-oriented development strategies and tactics that will position the peninsula as a logistical hub in Northeast Asia. We anticipate that this study will serve as the basis for future research that will investigate the topics presented here in more detail.

• Journal of Korea Water Resources Association
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• v.39 no.2 s.163
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• pp.109-120
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• 2006

Permeable pavement and release of treated wastewater into streams can increase streamflow of urban streams for a dry weather period. A SWMM code was modified to have a permeable pavement option. The modified SWMM was applied to continuous simulations of urban runoff from Hakuicheon watershed and it was used to analyse the effect of a permeable pavement installation and the reuse of treated wastewater. A critical error in the pan coefficient multiplication was also corrected in the modification. The analysis results of the reuse of treated wastewater is as follows: The low flow ($Q_{275}$) increases by 1.63 times as much as the current one and the drought flow ($Q_{355}$) increases by 3.57 times as much as the current one. If the impervious area in the Hakuicheon watershed is replaced with the permeable pavement area by 10 percent, the low flow and the drought flow increases by 3 percent and 17 percent, respectively. The results shows the effectiveness of the release of treated wastewater into stream to increase urban streamflow. The permeable pavement installation also play a minor role in the drought flow increase.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.2
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• pp.225-234
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• 2009

Real-time Aerial Monitoring System (RAMS) is to perform the rapid mapping in an emergency situation so that the geoinformation such as orthophoto and/or Digital Elevation Model is constructed in near real time. In this system, the GPS/INS plays an very important role in providing the position as well as the attitude information. Therefore, in this study, the performance of an IMU sensor which is supposed to be installed on board the RAMS is evaluated. And the integration algorithm of GPS/INS are tested with simulated dataset to find out which is more appropriate in real time mapping. According to the static and kinematic results, the sensor shows the position error of 3$\sim$4m and 2$\sim$3m, respectively. Also, it was verified that the sensor performs better on the attitude when the magnetic field sensor are used in the Aerospace mode. In the comparison of EKF and UKF, the overall performances shows not much differences in straight as well as in curved trajectory. However, the calculation time in EKF was appeared about 25 times faster than that of UKF, thus EKF seems to be the better selection in RAMS.

• Korean Journal of Materials Research
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• v.25 no.8
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• pp.391-397
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• 2015

NiO catalysts/$Al_2O_3$/FeCrAl alloy foam for hydrogen production was prepared using atomic layer deposition (ALD) and subsequent dip-coating methods. FeCrAl alloy foam and $Al_2O_3$ inter-layer were used as catalyst supports. To improve the dispersion and stability of NiO catalysts, an $Al_2O_3$ inter-layer was introduced and their thickness was systematically controlled to 0, 20, 50 and 80 nm using an ALD technique. The structural, chemical bonding and morphological properties (including dispersion) of the NiO catalysts/$Al_2O_3$/FeCrAl alloy foam were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, field-emission scanning electron microscopy and scanning electron microscopy-energy dispersive spectroscopy. In particular, to evaluate the stability of the NiO catalysts grown on $Al_2O_3$/FeCrAl alloy foam, chronoamperometry tests were performed and then the ingredient amounts of electrolytes were analyzed via inductively coupled plasma spectrometer. We found that the introduction of $Al_2O_3$ inter-layer improved the dispersion and stability of the NiO catalysts on the supports. Thus, when an $Al_2O_3$ inter-layer with a 80 nm thickness was grown between the FeCrAl alloy foam and the NiO catalysts, it indicated improved dispersion and stability of the NiO catalysts compared to the other samples. The performance improvement can be explained by optimum thickness of $Al_2O_3$ inter-layer resulting from the role of a passivation layer.

• The Korean Journal of Mycology
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• v.26 no.1 s.84
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• pp.8-15
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• 1998

The present research was undertaken to investigate the activity of ligninolytic enzymes and the decolorization capability of some dyes with Irpex zonatus BN2, isolated from nature and identified. For the assay of enzyme activities, the isolate did not produce lignin peroxidase (LiP) and veratryl alcohol oxidase (VAO), but laccase and manganese dependent peroxidase (MnP). While the activity for MnP was low $(61.6\;nmol/mg{\cdot}protein)$, its laccase activity was very high $(1185.9\;nmol/mg{\cdot}protein)$. Moreover, laccase had appeared earlier than MnP. When the isolate was incubated with each dye for 10 days, the decolorization rates of azo dyes, such as orange II, orange G, tropaeolin O and congo red were 98.0%, 97.4%, 99.0% and 95.3%, respectively. In case of heterocyclic dyes, eosin Y, toludine blue, methyl blue and azur B were 97.4 %, 98.7%, 99.9% and 94.0% respectively. Finally the results of triphenylmethane dye such as basic fuchsin, malachite green and crystal violet were 98.5%, 95.7% and 99.4%, respectively. The results suggest that laccase of Irpex zonatus BN2 should be played an important role in the decolorization of the dyes.

• Korean Journal of Clinical Pharmacy
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• v.23 no.1
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• pp.42-48
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• 2013

Background: Patients diagnosed with cancer tend to have multiple risk factors for drug related problems such as old age, comorbid conditions, self-medication, additional medications for supportive therapy, and the cancer treatment itself. Objective: The aim of this study was to investigate notable polypharmacy and related problems in oncology patients during hospitalization or following clinic visit. Method: The electronic medical records of patients who were discharged from oncology division at Seoul National University Hospital (SNUH) from June $1^{st}$ to June $30^{th}$, 2011 were retrospectively reviewed. Results: A total of 334 discharged patients were included in this study. Among them, 221 patients had pre-admission medications. Forty percent of the patients, including 60.3% of elderly patients (over 65 years of age) were prescribed more than 5 kinds of medications. Twenty percent of the patients were prescribed to take medications more than 7 times a day. Medication duplications were observed in 2.4% of patients. In 10.5% of the reviewed patients, 47 cases of potential drug-drug interaction including 3 cases of contraindication and 17 cases of major clinical implication according to Micromedex were detected. Medication changes were made in 88% of patients during hospitalization and in 94.7% of patients at their first visit after discharge. Antidiarrheal agent (loperamide) was prescribed along with laxatives in 18.5% of the prescriptions and inadequate instructions on how to take it were observed in 63% of the prescriptions. Conclusion: This study identified the prevalence of polypharmacy and related problems in cancer patients, which presents the need for an active role of pharmacists in pharmaceutical care in oncology wards.