• Biomolecules & Therapeutics
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• v.24 no.3
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• pp.320-327
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• 2016

Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions mediated by CBN was investigated in HCT-116 human colon cancer cells. CBN effectively suppressed the growth of colon cancer cells. Low concentration (up to $25{\mu}M$) of CBN induced apoptosis, and high concentration ($50{\mu}M$) of CBN induced necroptosis. The induction of apoptosis by CBN was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis was related with RIP-3, and caspase-8. In addition, CBN induced the accumulation of ROS and imbalance in the intracellular antioxidant enzymes such as SOD-1, SOD-2, catalase and GPx-1. These findings demonstrate that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.

• Proceedings of the Korean Society for Quality Management Conference
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• 2006.11a
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• pp.294-301
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• 2006

This study attempts to investigate a general service sector model which aims to describe the extent to which customer repurchase intention is influenced by customer satisfaction, Customer loyalty, switching cost. This study attempts to investigate different group. Brand group 1 is higher Brand loyalty than Brand group 2. Brand Group 1 is 276 and Brand Group 2 is 271 consumers in service sector that they were used into data analysis. The data were analyzed by factor analysis and Structural Equation Model using SPSS and AMOS program. The results show that nearly all of the hypothesized relationships construct are supported. First, the direct effects of customer satisfaction on customer loyalty and switching cost were confirmed. The service company not only strengthens customer loyalty, but also strategically makes the most use of switching cost to satisfy customer satisfaction and create sustainable company advantages. Second, the interactive relationships among switching cost and customer loyalty were very significant. The proper management of these mediating variables plays key roles in connecting customer satisfaction with repurchase intention. Third, the effects of customer loyalty and brand preference on repurchase intention were supported but switching cost rejected in the path analysis. Implications of the results for path analysis are discussed and future research directions are offered.

• Journal of the Korean Society of Clothing and Textiles
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• v.21 no.8
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• pp.1261-1274
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• 1997

Contemporary costume by the 'Deconstruction' from the outside has shown disclosure, destruction, poverty and analysis. The conclusion of this thesis as follows, 1. The Deconstruction of disclosure by infra disclosed the underwear and inner structure outside, which has deconstructed a fixed idea i.e.'underwear must be in outwear', modesty versus immodesty and disclosure versus concealment. 2. The Deconstruction of destruction originated in punk look has rejected traditional manners and utility, at the same time, it has shown the ambivalence i.e. completeness versus incompleteness, making versus destructing by slashes, rips, fringes. 3. The Deconstruction of poverty has appeared as French avangarde mode, little black dress by Chanel, second hand style by hippy, blue jean, granny look, especially Rei Kawakubo's poor look influenced by Zen Aesthetics and post punk. It has looked like old and worn out dress by doing patchwork, dye, decolor, rip, fray, which has shown the decentring by concealing the body than disclosing, rejecting snobbery. 4. The Deconstruction of analysis, seemingly partial and patched is a violation only of our expectation of clothing's unbroken entity though it has looked like a fragment. The completeness and coherence of it is made more evident by its breach, void, and bond like a poetic language. As the result, disclosed, destructed, poor, and analytical costumes has expressed as an escape from the appearance which traditional aesthetic concept had pursued.

• Journal of the Korean Graphic Arts Communication Society
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• v.29 no.1
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• pp.1-21
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• 2011

Because of high demand of color quality of the prints, proof prints are more important for end-user to predict and correct the final prints directly as an intermediate. Thus, proof prints can be used as a reference to take minimum ${\Delta}E^*ab$between the originals and finals in the field. The advantage of proof prints is to predict and correct color easily through the RIP(Raster Image Processor) without printing plates and plate making steps. While, it is thought that the proof systems are almost equivalent to the press in the past, present proof systems are more simple to take proof prints more easily due to the automation and digitalization. This paper addresses a method to perform an accurate profiling according to proof paper types and find optimal proof papers which meet proofing requirement. Although proof papers are matched with ISO 12647-7, we were trying to reduce ${\Delta}E^*ab$, In addition to the above, through the Gamut Mapping and Iteration, We were trying to find optimal proofing conditions.

• Journal of Ginseng Research
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• v.43 no.2
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• pp.282-290
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• 2019

Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects. However, the effect of G-Rg3 on mast cell-mediated allergic inflammation has not been investigated. Method: The antiallergic effects of G-Rg3 on allergic inflammation were evaluated using the human and rat mast cell lines HMC-1 and RBL-2H3. Antiallergic effects of G-Rg3 were detected by measuring cyclic adenosine monophosphate (cAMP), detecting calcium influx, and using real-time reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and in vivo experiments. Results: G-Rg3 decreased histamine release from activated mast cells by enhancing cAMP levels and calcium influx. Proinflammatory cytokine production was suppressed by G-Rg3 treatment via regulation of the mitogen-activated protein kinases/nuclear factor-kappa B and receptor-interacting protein kinase 2 (RIP2)/caspase-1 signaling pathway in mast cells. Moreover, G-Rg3 protected mice against the IgE-mediated passive cutaneous anaphylaxis reaction and compound 48/80-induced anaphylactic shock. Conclusion: G-Rg3 may serve as an alternative therapeutic agent for improving allergic inflammatory disorders.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.185-191
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• 2008

Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to the tumor necrosis factor (TNF) or the genotoxic stress including DNA damaging agents. Although it is known that JNK is activated in response to genotoxic stress, neither the pathways to transduce signals to activate JNK nor the primary sensors of the cells that trigger the stress response have been identified. Here, we report that the receptor interacting protein (RIP), a key adaptor protein of TNF signaling, was required to activate JNK in the cells treated with certain DNA damaging agents such as adriamycin (Adr) and 1-${\beta}$-D-arabinofuranosylcytosine (Ara-C) that cause slow and sustained activation, but it was not required when treated with N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and short wavelength UV, which causes quick and transient activation. Our findings revealed that this sustained JNK activation was not mediated by the TNF (tumor necrosis factor) receptor signaling, but it required a functional ATM (ataxia telangiectasia) activity. In addition, JNK inhibitor SP-600125 significantly blocked the Adr-induced cell death, but it did not affect the cell death induced by MNNG. These findings suggest that the sustained activation of JNK mediated by RIP plays an important role in the DNA damage-induced cell death, and that the duration of JNK activation relays a different stress response to determine the cell fate.

• Journal of Korean Society for Quality Management
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• v.28 no.4
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• pp.16-28
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• 2000

Recently days, High Accelerated Life Test of electrical and electronic parts is increasing its importance. This study set the hypothesis to develop the method that was analysis and application of HALT for the automotive electrical and electronic parts, it used Arrhenius's Model and Eyring's Model, and ESS theory. Validity of application is proved by other test data. Especially, this study emphasis on utility of acceleration to temperature, humidity, voltage, mechanical stress and other stress. In this study set the pattem of practical application. Therefore, this study emphasis on the application of the HALT and the use of other parameter by acceleration reliability test data. The result of this study is as follows. 1) There is relationship between molar weight and material constant. 2) Characteristic of material is operating acceleration factor as well as parts failure factors. Of course, according to the characteristic of material, activation energy is often more important than molar weight. But it will be defined by more testing and improvements in practical application.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.6
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• pp.151-158
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• 2012

This study will not only prove experimental dynamic properties which are classified to slump, compressed strength, bending strength and toughness index blast-furnace cement concrete with polypropylene (PP) fiber that refer properties and volume of it, but also establish a basic data in order to use PP fiber reinforced blast-furnace cement concrete. The slump didn't changed by PP fiber volume $5kgf/m^3$ because of flexibility of fiber in despite of loose mixing. The reason why the slump decreased steadily by PP fiber volume $3kgf/m^3$ was rising contact surface of water. The compressed strength indicated a range of 19.49~26.32 MPa. The tensile strength indicated a range of 2.10~2.44 MPa. The bending strength was stronger about 3~16 % in case of mixing with PP fiber volume than normal concrete. The flexure strength indicated a range of 4.30~4.83 MPa. The toughness indicated a range of $0{\sim}19.88N{\cdot}mm$ and was stronger about 6.7 times in case of PP fiber volume $9kg/m^3$ than PP fiber volume $1kg/m^3$. The pavement with PP fiber volume over such a fixed quantity in the roads of a respectable amount load can have a effect to prevent not only resistance against clack but also rip off failures.

• The Transactions of the Korea Information Processing Society
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• v.6 no.1
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• pp.57-65
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• 1999

The simulation which is larger scale, complex and interactive with clients treat a lot of messages. It can be thinking more efficient distributed simulation than sequential one. The training simulation with multi-users is geographically distributed, and required high cost to operate and maintain system as increasing user requirements. The adaptation of web technology to the simulation can be a way to solves it without cost added. But dynamic web environment can causes causality error of events. This paper is concerned with client-server model, which supports interaction between distributed simulation server and web browser, and it is implemented by Java distributed object model. the result have shown that the distributed simulation is performed correctly on dynamic environment.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.31A no.10
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• pp.119-131
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• 1994

In this paper, we first propose a new FPGA routing method in which seversal netw are routed concurrently by applying the readitional maze routing method. We then introduce CMRF (concurrent maze Router for FPGA) which can be used for the routing of FpGAs of symmetrical array type by applying our new routing method. Given a set of nets, the proposed routing method performas the maze propagation and backtracing independently for each net and determines the routing paths concurrently by competition among nets. In CMRF, using this routing method, q nets are selected from the nets to be routed and they are routed concurrently, where q is the user given parameter determined by considering the computing environment. This process is repeated until either all the nets are routed or the remaining unrouted nets fail to their maze propagations. The routing of these nets are completed using the rip-up and rerouting technique. We apply our routing method to ten randomly generated test examples in order to check its routing performance. The results show taht as we increase the value of q, the routing completion rate increases for all the examples. Note that when q=1, our method is similar to the conventinal maze routing method. We also compare CMRF with the CGE method which has been proposed by Brown et.al. For the five benchmark examples, CMRF complete the routing with less wire segments in each connection block than the wire segments needed in the CGE method of 100% routing.