• Journal of Environmental Science International
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• v.22 no.10
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• pp.1353-1361
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• 2013

The objectives of this paper are the characterization of the pretreatment of wastewater by microfiltration (MF) membranes for river maintenance and water recycling. This is done by investigation of the proper coagulation conditions, such as the types and doses of coagulants, mixing conditions (velocity gradients and mixing periods), pH, etc., using jar tests. The effluent water from a pore control fiber (PCF) filter located after the secondary clarifier at Kang-byeon Sewage Treatment Plant (K-STP) was used in these experiments. Two established coagulants, aluminum sulfate (Alum) and poly aluminum chloride (PAC), which are commonly used in sewage treatment plants to treat drinking water, were used in this research. The results indicate that the optimal coagulation velocity gradients (G) and agitation period (T) for both Alum and PAC were 200-250 $s^{-1}$ and 5 min respectively, but the coagulation efficiencies for both Alum and PAC were lower at low values of G and T. For a 60 min filtration period on the MF, the flux efficiencies ($J/J_0$ (%)) at the K-STP effluent that were coagulated by PAC and Alum were 92.9 % and 79.9 %, respectively, under the same coagulation conditions. It is concluded that an enhanced membrane process is possible by effective filtration of effluent at the K-STP using the coagulation-membrane separation process.

• BMB Reports
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• v.31 no.5
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• pp.419-426
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• 1998

The nuclear hormone receptor superfamily currently includes approximately equal numbers of conventional receptors and orphan receptors, which do not have known ligands. Here, we review recent progress from this laboratory on three orphans, two of which are moving from orphan to conventional receptor status. Perhaps the most unusual is CAR, which is a constitutive transactivator in the absence of ligands but becomes transcriptionally inactive in the presence of its ligands, which are androgen metabolites. The response of CAR to its ligands is thus opposite to that of the conventional receptor paradigm. RIP14 (also known as FXR) is activated by both all-trans retinoic acid and a synthetic retinoid previously thought to specifically target the retinoic acid receptors (RARs), and thus appears to be a novel retinoid receptor. Finally, SHP is a novel orphan that lacks a DNA binding domain and interacts with a number of other receptor superfamily members. While it generally inhibits its targets, including CAR, the retinoid X receptor (RXR), and the estrogen receptor (ER), it stimulates transactivation by the orphan SF-1.

• Journal of Conservation Science
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• v.4 no.1 s.4
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• pp.11-42
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• 1995

Stone-monuments, distributed in this area, have been investigated and studied on the characteristics and the rock phases in the geological and conservational points of view. Most of them may have been built from the end of the Shilla Kingdom to the Koryeo Kingdom, which are based on the typical characteristics of the form. The used rocks in these monuments are mainly biotite granite of the Jurassic age which is widely distributed around the area. Black slate and marbles are also used in some monuments, which may be obtained from other areas. The biotite granite of massive and coarse texture contains often inclusions of biotite aggregates or fragments of dioritic rock phase. However, the biotite granite in the area may be very weak to the chemical weathering so that irregular rock surface shows generally $2\~3mm$ relief. The irregular relief is mainly due to different relative degree on the chemical weathering according to the kind of minerals especially quartz, feldspar and biotite. The chemical weathering is also influenced by organisms. For conservation, they must be scientifically considered based on the characteristics, kind of the rock phase, factors on the weathering process, situation in situ or being transported, and protection.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.6
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• pp.119-133
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• 2013

The purpose of this study is to develop riverbed techniques to activating ecological function of hyporheic zone. Hyporheic zone maybe simply defined as an active eco-tone between surface water and groundwater, which facilitates to exchange water, nutrients and aquatic habitat occur in response to variation in discharge and bed geomorphology. The aim of this study is to evaluate the effectiveness of an applied riverbed technique for two years since its installation in the hyporheic zone. The experimental riverbed technique has been implemented on Anyang stream penetrating Anyang city in Gyunggi province. The dimension of the installed structure is 5.0 m in width, 46 m in length. Bottom layer is filled with rip-rap covered with gabion. After the implementation of the technique, the study conducts follow-up monitoring in two years of between 2011 and 2012. The results of follow-up monitoring for two years are as follows:1) In Hydro geomorphic process, the riverbed technique maintains hydraulic stability despite of several flood events in 2011, 2012. 2) After transformation to form pool-and-riffle habitat, for aquatic community composed of freshwater fish, macro invertebrate, and attached algae, the species diversity and population gradually increased. 3) The riverbed technique achieved desired effect on enhancement of ecological function in hyporheic zone.

• Journal of Mechanical Science and Technology
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• v.15 no.9
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• pp.1257-1267
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• 2001

For efficient mechanical system optimization, a new two-point approximation method is presented. Unlike the conventional two-point approximation methods such as TPEA, TANA, TANA-1, TANA-2 and TANA-3, this introduces the shifting level into each exponential intervening variable to avoid the lack of definition of the conventional exponential intervening variables due to zero-or negative-valued design variables. Then a new quadratic approximation whose Hessian matrix has only diagonal elements of different values is proposed in terms of these shifted exponential intervening variables. These diagonal elements are determined in a closed form that corrects the typical error in the approximate gradient of the TANA series due to the lack of definition of exponential type intervening variables and their incomplete second-order terms. Also, a correction coefficient is multiplied to the pre-determined quadratic term to match the value of approximate function with that of the previous point. Finally, in order to show the numerical performance of the proposed method, a sequential approximate optimizer is developed and applied to solve six typical design problems. These optimization results are compared with those of TANA-3. These comparisons show that the proposed method gives more efficient and reliable results than TANA-3.

• Journal of Microbiology and Biotechnology
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• v.24 no.7
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• pp.914-920
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• 2014

Triple-negative breast cancer (TNBC) possesses a higher rate of distant recurrence and a poorer prognosis than other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to unfavorable factors of TNBC patients. 17-Demethoxy-reblastatin (17-DR), a novel non-benzoquinone-type geldanamycin analog, exhibited potent Hsp90 ATPase inhibition activity. In this study, the anticancer effects of 17-DR on TNBC MDA-MB-231 cells were investigated. These results showed that 17-DR inhibited cell proliferation, induced apoptosis, and suppressed cell invasion and migration in the MDA-MB-231 cells. Down-regulation of the key Hsp90-dependent tumor-driving molecules, such as RIP1 and MMP-9, by 17-DR may be related to these effects. Taken together, our results suggest that 17-DR has potential as a therapeutic agent for the treatment of TNBC.

• Proceedings of the Korean Society for Quality Management Conference
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• 2006.04a
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• pp.375-380
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• 2006

Recently European Council(EU) published the RoHS(restriction of the use of certain hazardous substances in electrical and electronic equipment) which is prohibit the use of Pb, Hg, Cd, $Cr^{+6}$, PBB or PBDE in the electrical and electronic equipments. So EU member States shall ensure that, from 1 July 2006, new electrical and electronic equipment put on the market does not contain 6 hazardous substances. So many kinds of projects is proceeding to ensure the reliability of Pb-free electronics in the worlds. Especially it is necessary to evaluate of Pb-free solder joints in electronics. Therefore, on this paper, we compared with solder joint strength of chip components, respectively SnPb, Pb-free solder as follows reliability test methods. We also measured the shear strength of solder joint and also compared the effects of environmental test methods. In this results, we analyzed and compared the shear strength variation as follows solder materials and reliability test conditions.

• Journal of Korean Clinical Nursing Research
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• v.17 no.3
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• pp.319-328
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• 2011

Purpose: This study was done to identify nursing interventions clinically applicable to relieve displeasure and anxiety of patients having an operation in which loud noise was unavoidable. Methods: Participants were 34 patients scheduled to have a total knee replacement. They were assigned to either the control (17 patients) or experimental (17 patients) group. Data were collected from September to November 2010. The instruments used for the survey included noise-control earplugs, a noise level meter (TES-1358) and a structured scale measuring degree of noise perception, displeasure and anxiety. Data were analyzed using frequency, percentage, standard deviation, $x^2$-test, and t-test with the SPSS WIN 18.0 program. Results: Hypothesis 1: 'The displeasure levels of the experimental group of patients wearing earplugs will be lower than the control group patients without earplugs' was accepted (t=-20.769, p<.001). Hypothesis 2: 'The anxiety levels of the experimental group of patients wearing earplugs will be lower than the control group patients without earplugs' was accepted (t=-6.298, p<.001). Conclusion: Based on these findings, the wearing of earplugs for patients having a surgical operation with loud noises is recommended as an effective nursing intervention to relieve patient displeasure and anxiety during their surgical operations.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.529-541
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• 2022

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.

• Molecules and Cells
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• v.45 no.8
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• pp.588-602
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• 2022

Various RNA-binding proteins (RBPs) are key components in RNA metabolism and contribute to several neurodevelopmental disorders. To date, only a few of such RBPs have been characterized for their roles in neocortex development. Here, we show that the RBP, Rbms1, is required for radial migration, polarization and differentiation of neuronal progenitors to neurons in the neocortex development. Rbms1 expression is highest in the early development in the developing cortex, with its expression gradually diminishing from embryonic day 13.5 (E13.5) to postnatal day 0 (P0). From in utero electroporation (IUE) experiments when Rbms1 levels are knocked down in neuronal progenitors, their transition from multipolar to bipolar state is delayed and this is accompanied by a delay in radial migration of these cells. Reduced Rbms1 levels in vivo also reduces differentiation as evidenced by a decrease in levels of several differentiation markers, meanwhile having no significant effects on proliferation and cell cycle rates of these cells. As an RNA binding protein, we profiled the RNA binders of Rbms1 by a cross-linked-RIP sequencing assay, followed by quantitative real-time polymerase chain reaction verification and showed that Rbms1 binds and stabilizes the mRNA for Efr3a, a signaling adapter protein. We also demonstrate that ectopic Efr3a can recover the cells from the migration defects due to loss of Rbms1, both in vivo and in vitro migration assays with cultured cells. These imply that one of the functions of Rbms1 involves the stabilization of Efr3a RNA message, required for migration and maturation of neuronal progenitors in radial migration in the developing neocortex.