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http://dx.doi.org/10.22246/jikm.2022.43.4.529

Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells  

Hwang, Jong-hyun (College of Korean Medicine, Gachon University)
Kim, Seung-man (College of Korean Medicine, Gachon University)
Hwang, Gwi-seo (College of Korean Medicine, Gachon University)
Jeon, Chan-yong (College of Korean Medicine, Gachon University)
Kang, Ki-sung (College of Korean Medicine, Gachon University)
Publication Information
The Journal of Internal Korean Medicine / v.43, no.4, 2022 , pp. 529-541 More about this Journal
Abstract
Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.
Keywords
Acanthopanax senticosus; breast cancer; MCF-7; MDA-MB-231;
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Times Cited By KSCI : 2  (Citation Analysis)
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