• Archives of Pharmacal Research
• /
• 제18권5호
• /
• pp.336-339
• /
• 1995

Ephedra distachya cultures have been known to accumulate two major $\rho-coumaroylamino$ acids (p-coumaroylgicine and $\rho-coumaroylamino$ -D-alanine) by D-Ala treament. When D-Ala was added together with serial concentrations of yeast-derived elicitor, the accumulation of $\rho-coumaroylamino$ -D-Ala $(\rho-CDA)$ was geatly increased in an additive manner. In feeding experiments, $[1-^14C]$-D-Ala was incorporated into $\rho-CDA$at a rate of 2.2% or 2.3% of added radioactivity, indicating that exogenous D-Ala served as a precursor of the conjugate. $[1-^14C]$-L-Ala wasalso incorporated into p-CDA (0.23%) in the elicitor treated cultures. This fact suggested that at least a part of $(\rho-CDA)$ was produced from active conversion of L-Ala by the elecitation. In order to investigate a possible role of D-Ala as an elicitor of $\rpo-coumaroylamino$ acids $(\rpo-CAA)$, cold D-Ala was added together with labeled L-Ala. Although L-Ala seemed to be incorporated into $\rho-CDA$ by this treatment, the incorporation ratio was too small (0.054%) to draw a clear conclusion. However, the amount of $\rpo-coumaroylglycine$, which did not use D-Ala as a substrate, was also sightly increased by D-Ala treatment irrespective of the presence of elicitor, suggesting that exogenous D-Ala might act as an elicitor of$\rpo-CAA$ as well as a precusor substrate of $\rho-CDA$.

• 한국수산과학회지
• /
• 제30권4호
• /
• pp.543-549
• /
• 1997

본 연구에서는 그물어구의 모형수칙에 관한 기존의 연구 결과들을 종합하고, 지금까지 가장 많이 이용되어 온 Tauti의 수칙을 중심으로 하여 이들 수칙이 지니는 간제점에 대해 주로 검토하였다 그 결과, 지금까지의 수칙들은 그물의 유수저항을 정확하게 해석하지 못하였고 그것의 수중 형상을 결정하는 중요 인자로써 그물감의 수중 무게를 택한 것에 문제가 있다는 것을 알 수 있었다. 따라서, 이러한 견해 대신에 그물을 그것의 영역권 내로 물을 유입한 후 영역권 밖으로 투과시키는 하나의 유공성 구조물로 간주하고, 그것에 대한 물의 유입${\cdot}$유출 특성을 이용하여 유수저항을 해석한 전보의 결과를 기초로 하여 실물과 모형과의 상사 관계를 새로히 구하였다. 즉, 그물의 각 변의 길이를 L, 그물실의 지름을 d, 그물코의 크기 및 전개각을 각각 2l 및 2$\varphi$, 뼈대줄의 지름과 길이 및 비중을 각각 $d_r,\;l_r$ 및 $\rho_r$, 뜸, 발돌 등의 부속구 하나의 수중 무게 및 갯수를 각각 $w_a$ 및 Na, 물의 비중을 $\rho_w$, 유속을 $\nu$, 그물의 유수저항을 R이라 할 때, 실물 (첨자 1)과 모형 (첨자 2)이 상사를 이루기 위해서는 $$\frac{d_2}{d_1}=\sqrt{\frac{l_2}{l_1}},\;\frac{N_2}{N_1}=(\frac{d_1}{d_2})^{1.5}\frac{L_2}{L_1},$$ $$\;\varphi_1=\varphi_2,\;\frac{d_{r2}}{d_{r1}}=\sqrt{\frac{L_2{(\rho_{r1}-\rho_{w1})}}{{L_1{(\rho_{r2}-\rho_{w2})}}$$ $$\frac{N_{a2}}{N_{a1}}=\frac{W_{a1}}{W_{a2}}(\frac{L_2}{L_1})^2$$, $$\nu_1=\nu_2$$ 및 $$\frac{R_2}{R_1}=(\frac{L_2}{L_1})^2$$ 을 만족해야 하고, 조작 유속이 매우 작은 값으로 한정되는 그물에 있어서 구성 재료의 변화에 따른 수중 형상의 변화를 조사할 때와 같이 그물감의 수중 무게의 영향 자체를 조사 대상으로 하는 경우에는 위의 조건들 외에 $$\frac{\rho_2-\rho_{w2}}{\rho_1-\rho_{w1}}=\frac{d_1}{d_2}$$를 추가로 만족해야 한다는 젓을 알 수 있었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권7호
• /
• pp.3311-3317
• /
• 2014

Background: The consequence of Rho GDP dissociation inhibitor alpha (RhoGDI${\alpha}$) activity on migration and invasion of estrogen receptor positive ($ER^+$) and negative ($ER^-$) breast cancer cells has not been studied using the proteomic approach. Changes in expression of RhoGDI${\alpha}$ and other proteins interacting directly or indirectly with RhoGDI${\alpha}$ in MCF7 and MDA-MB-231, with different metastatic potentials is of particular interest. Materials and Methods: $ER^+$ MCF7 and ER- MDA-MB-231 cell lines were subjected to two-dimensional electrophoresis (2-DE) and spots of interest were identified by matrix-assisted laser desorption/ionization time of- flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS) analysis after downregulation of RhoGDI${\alpha}$ using short interfering RNA (siRNA) and upregulated using GFP-tagged ORF clone of RhoGDI${\alpha}$. Results: The results showed a total of 35 proteins that were either up- or down-regulated in these cells. Here we identifed 9 and 15 proteins differentially expressed with silencing of RhoGDI${\alpha}$ in MCF-7 and the MDA-MB-231 cells, respectively. In addition, 10 proteins were differentially expressed in the upregulation of RhoGDI${\alpha}$ in MCF7, while only one protein was identified in the upregulation of RhoGDI${\alpha}$ in MDA-MB-231. Based on the biological functions of these proteins, the results revealed that proteins involved in cell migration are more strongly altered with RhoGDI-${\alpha}$ activity. Although several of these proteins have been previously indicated in tumorigenesis and invasiveness of breast cancer cells, some ohave not been previously reported to be involved in breast cancer migration. Hence, these proteins may serve as useful candidate biomarkers for tumorigenesis and invasiveness of breast cancer cells. Conclusions: Future studies are needed to determine the mechanisms by which these proteins regulate cell migration. The combination of RhoGDI${\alpha}$ with other potential biomarkers may be a more promising approach in the inhibition of breast cancer cell migration.

• 수산해양기술연구
• /
• 제19권1호
• /
• pp.57-62
• /
• 1983

접지전지 설계를 위한 Zn, Al 및 Mg의 합급양극의 특성을 실험적으로 조사한 결과를 다음과 같이 요약할 수 있다. 1. 환경비저항 1000 $\Omega$.cm 이하에서는 Zn합금양극이, 1000 $\Omega$.cm 이상에서는 Mg합금양극이 접지전지 설계에 좋다. 2. 비저항 500 $\Omega$.cm 이하에서는 Al합금양극이 Mg 합금양극보다 접지전지 설계를 위한 유전양극 특성이 좋으나 모든 비저항에서 Zn합금양극보다 특성이 떨어진다. 3. 배유전유밀도가 급격히 증가하는 일정인가전압은 다음과 같다. \circled1 E 하(Zn)=log (4.9465/$\rho$상(0.0639))+11$\times$10 상(-6)$\rho$상(0.8923i) \circled2 E 하(Al)=log (4.9306/$\rho$상(0.0525))+13$\times$10 상(-6)$\rho$상(0.9314i) \circled3 E 하(Mg)= log (3.7086/$\rho$상(0.0988))+181$\times$10 상(-6)$\rho$상(0.5406i) 4. 유전양극의 종류 및 환경의 비저항에 따라 인가전압과 배유전유밀도의 관계는 다음과 같은 일반식으로 표시할 수 있다. logi=g+root(n.E+r)

• Korean Journal of Mathematics
• /
• 제22권1호
• /
• pp.29-36
• /
• 2014

The limiting diffusion of special diploid model can be defined as a discrete generator for the rescaled Markov chain. Choi([2]) defined the operator of projection $S_t$ on limiting diffusion and new measure $dQ=S_tdP$. and showed the martingale property on this operator and measure. Let $P_{\rho}$ be the unique solution of the martingale problem for $\mathcal{L}_0$ starting at ${\rho}$ and ${\pi}_1,{\pi}_2,{\cdots},{\pi}_n$ the projection of $E^n$ on $x_1,x_2,{\cdots},x_n$. In this note we define $$dQ_{\rho}=S_tdP_{\rho}$$ and show that $Q_{\rho}$ solves the martingale problem for $\mathcal{L}_{\pi}$ starting at ${\rho}$.

• Journal of applied mathematics & informatics
• /
• 제33권3_4호
• /
• pp.235-246
• /
• 2015

In this paper, a vector optimization problem over cones is considered, where the functions involved are $\eta$-semidifferentiable. Necessary and sufficient optimality conditions are obtained. A dual is formulated and duality results are proved using the concepts of cone $\rho$-semilocally preinvex, cone $\rho$-semilocally quasi-preinvex and cone $\rho$-semilocally pseudo-preinvex functions.

• Journal of applied mathematics & informatics
• /
• 제23권1_2호
• /
• pp.321-327
• /
• 2007

We say that a triangle ${\Delta}$ tiles the polygon ${\rho}\;if\;{\rho}$ can be decomposed into finitely many non-overlapping triangles similar to ${\Delta}$. Let ${\rho}$ be a parallelogram with angles ${\delta}\;and\;{\pi}-{\delta}\;(0<{\delta}{\leq}{\pi}/2)$ and let ${\Delta}$ be a triangle with angles ${\alpha};{\beta},\;{\gamma}\;({\alpha}{\leq}{\beta}{\leq}{\gamma})$. We prove that if ${\Delta}$ tiles ${\rho}$ then either ${\delta}{\in}\;({\alpha},\;{\beta},\;{\gamma},\;{\pi}-{\gamma},\;{\pi}-2{\gamma})\;or\;dimL_{\rho}=dimL_{{\Delta}}$. We also prove that for every parallelogram P, and for every integer n $(where\;n{\geq}2,\;n{\neq}3)$ there is a triangle ${\Delta}$ so that n similar copies of ${\Delta}\;tile\;{\rho}$.

• Archives of Pharmacal Research
• /
• 제19권3호
• /
• pp.219-222
• /
• 1996

Ephedra olistachya cultures have been known to accumulate $rho-coumaroylamino$ acids by elicitor treatment. Based on their chemical structures, the biosynthetic pathway of$rho-coumaroylamino$acids was postulated and phenylalanine ammonia-lyase (PAL), cinnamic acid 4-hydroxylase (4-CH) and p-coumaroyl CoA: D-Ala p-coumaroyltransferase ($rho-CT$) were supposed to be involved in the pathway. The time course inductions of these enzymes were investigated after treatment of yeast extract, yeast-derived mannan glycopeptide and D-Ala. They were detectable at only 4 hours and reached to their maximum level at 9 hours after onset of elicitor treatment. The activities of PAL and 4-CH were almost disappeared within 24 hours, however, that of $rho-CT$was remained up to 48 hours irrespective of the kind of elicitors. $rho-CT$ showed substrate specificity to D-Ala at crude enzyme extract level.

• Journal of Mechanical Science and Technology
• /
• 제20권2호
• /
• pp.271-277
• /
• 2006

A numerical study is made of the spin-up from rest of a three-layer fluid in a closed, vertically-mounted cylinder. The densities in the upper layer $\rho_1$, middle layer $\rho_2$ and lower layer $\rho_3\;are\;\rho_3\;>\;\rho_2\;>\;\rho_1$, and the kinematic viscosities are left arbitrary. The representative system Ekman number is small. Numerical solutions are obtained to the time-dependent axisymmetric Navier-Stokes equations, and the treatment of the interfaces is modeled by use of the Height of Liquid method. Complete three-component velocity fields, together with the evolution of the interface deformations, are depicted. At small times, when the kinematic viscosity in the upper layer is smaller than in the middle layer, the top interface rises (sinks) in the central axis (peripheral) region. When the kinematic viscosity in the lower layer is smaller than in the middle layer, the bottom interface rises (sinks) in the periphery (axis) region. Detailed shapes of interfaces are illustrated for several cases of exemplary viscosity ratios.

• Bulletin of the Korean Chemical Society
• /
• 제15권7호
• /
• pp.576-581
• /
• 1994

The secondary deuterium kinetic isotope effects (SDKIE) involving deuterated aniline nucleophiles are reported for the reactions of benzyl bromides and chlorides and benzoyl chlorides in acetonitrile. The benzyl systems behave normally as to the trend of changes in SDKIE with the magnitude of ${\rho}X({\rho}_{nuc})$, whereas benzoyl system shows ananomaly; ${\mid}{\rho}_X{\mid}$ decreases with increase in the extent of bond making estimated by the SDKIE. This has been ascribed to the negative charge accumulation at the reaction center carbon in the transition state. The magnitude of ${\rho}_{XY}$ is found to decrease by ca. 0.03 with ten degree rise in the reaction temperature.