• Title/Summary/Keyword: RCT(randomized controlled trials)

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알레르기 비염에 대한 소청용탕(小靑龍湯)의 효과 평가 연구 : 체계적 문헌고찰과 메타분석 (A Study on Effectiveness of Socheongryong-tang for Allergic Rhinitis : A Systematic Review and Meta-analysis)

  • 민경진;신선호;강정인;이동효
    • 한방안이비인후피부과학회지
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    • 제33권4호
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    • pp.74-99
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    • 2020
  • Objectives : The purpose of this study is to assess the effectiveness and safety of Socheongryong-tang(SCRT) for allergic rhinitis(AR). Methods : We searched randomized controlled trials(RCTs) that used SCRT for AR in 8 databases(PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) from their inception until August 2019. The primary outcome was effective rate and scores evaluating the improvement of AR symptoms. The secondary outcome was quality of life scale, adverse events, recurrence rate, and laboratory indicators. Two researchers assessed the risk of bias in the included trials through the Cochrane Risk of Bias tool independently. The study synthesized outcomes using RevMan 5.3. Results : Eighteen RCTs involving 1686 participants were included in this review. The risk of bias was unclear for the majority of the included studies. Meta-analysis of 12 RCTs showed that there was no statistically significant difference between the SCRT group and usual care group in the effective rate(RR 1.18, 95% CI(0.98, 1.41), p=0.09, I2=46%). Meta-analysis of 5 RCTs showed that the combination treatment group of SCRT and usual care was significantly higher than the usual care group in the effective rate(RR 1.24, 95% CI(1.12, 1.38), p<0.0001, I2=0%). The SCRT group was more effective in improving nasal symptoms and quality of life than the placebo group according to one RCT. Mild adverse events such as dry mouth were identified in 5 RCTs, but no serious adverse events were reported. Conclusion : This review showed that in terms of the effective rate for AR, there was no statistically significant difference between SCRT and usual care and the combination treatment of SCRT and usual care was more effective than usual care. There were no serious adverse events. However, it is difficult to make a definite conclusion because of few included studies and heterogeneity between studies, and the quality of included studies was mostly insufficient. Further well-designed randomized controlled trials are needed.

극상근 건병증의 한의학적 치료에 대한 연구 동향: 체계적 문헌 고찰과 메타 분석 (The Effect of Oriental Medicine Treatments for Supraspinatus Tendinopathy: Systematic Review and Meta-Analysis)

  • 강동협;이도훈;유상준;양석규;손자연;정설;김혜주;권민진;권오빈;장선우;조현우
    • 한방재활의학과학회지
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    • 제33권4호
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    • pp.45-59
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    • 2023
  • Objectives The aim of this study was to analyze the trends of researches on oriental medicine treatments for supraspinatus tendinopathy. Methods We used five databases for searching researches; Korean studies Information Service System, Oriental Medicine Advanced Searching Integrated System, Research Information Sharing Service, PubMed, and China National Knowledge Infrastructure. Only randomized controlled trials suitable for the subject were selected. The methodological quality of included randomized controlled trials (RCTs) was assessed by the Cochrane risk of bias tool. Results Twenty randomized controlled trials were analyzed. There were 9 types of treatment interventions; acupuncture, acupotomy, pharmacopuncture, electroacupuncture, fire needling, warming needle, catgut-embedding therapy, herbal medicine, cupping. The most frequently used treatment intervention was acupuncture and acupotomy. There were 9 outcome measurements including visual analog scale (VAS), Constant-Murley Score (CMS), and range of motion. The most used measurement was VAS. As a result of meta-analysis, acupuncture was more effective than control group in VAS. Additionally, acupotomy was clinically significant compared to control groups in VAS and CMS. Conclusions In this review, we analyzed researches on effectiveness of oriental medicine for supraspinatus tendinopathy. A provisional conclusion can be produced that acupuncture and acupotomy showed beneficial effect to supraspinatus tendinopathy. Although there were some RCT studies, many of them had a high risk of bias, so it is hard to conclude that our study can include overall clinical status. Further well-designed trials are needed.

여성 성기능장애 관련 최근 국내외 한의학 연구 동향에 대한 고찰 (A Review of Recent Oriental Medicine Studies on Female Sexual Dysfunction)

  • 최민선;김동일
    • 대한한방부인과학회지
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    • 제24권3호
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    • pp.171-189
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    • 2011
  • Objectives: Female Sexual Dysfuction(FSD) is a common gynecologic condition and its prevalence is more higher than men. Despite its high prevalence and clinical importance, research on FSD is not enough in both of oriental and western medicine. The purpose of this study is to review research tendency of recent oriental medicine studies on FSD and to suggest the following research on FSD. Methods: We searched oriental medicine papers related to FSD published in the last 10 years(2001-2011) through Korean Medicine Gynecology Society database, KISS, RISS, NDSL, CNKI(China National Knowledge Infrastructure), and Pubmed. Results: 26 papers were searched, then 18 papers of them were related to Traditional Chinese Medicine(TCM), 8 papers of them were related to Korean Medicine(KM). In classification according to paper type, 16 papers were clinical study, 1 paper was experimental study, 2 papers were bibliographic study, and 7 papers were the other study. Then 5 papers of clinical study was Randomized Controlled Trial(RCT). Conclusion: There was a lack of oriental medicine research on FSD. On the base of this study, so further research is needed. Especially, Clinical trials such as RCT have strong objective evidence power in the viewpoint of Evidence Based Medicine(EBM) are needed.

삼차신경통에 대한 추나와 침 복합치료의 효과: 체계적 문헌고찰 (Chuna Manual Therapy Combined Acupuncture for Trigeminal Neuralgia: A Systematic Review)

  • 김찬영;허인;황의형
    • 한방재활의학과학회지
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    • 제26권4호
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    • pp.37-44
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    • 2016
  • Objectives To determine the effectiveness of Chuna manual therapy combined acupuncture for trigeminal neuralgia. Methods We searched 6 electronic databases (Pubmed, CAJ, Oasis, RISS, DBPIA, KoreanTK) and 2 journals up to August 2016. We included randomized controlled trials (RCTs) using Chuna manual therapy combined acupuncture for trigeminal neuralgia. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results 3 RCT studies were eligible in our review. The meta-analysis of 3 studies showed favorable results for the use of Chuna manual therapy combined acupuncture. High risk of bias were observed in all studies. Conclusions Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CAJ. Now limited evidence is available to support Chuna manual therapy combined acupuncture for trigeminal neuralgia and further well-designed RCTs should be encouraged.

추나요법이 턱관절 증후군에 미치는 영향: 체계적 문헌 고찰 (Chuna Manual Therapy for Temporomandibular Joint Disorder: Systematic Review)

  • 배동렬;조형준;김희나;황의형
    • 한방재활의학과학회지
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    • 제27권3호
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    • pp.71-79
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    • 2017
  • Objectives To determine the effectiveness of Tuina for temporomandibular joint disorder. Methods We searched 10 electronic databases (Pubmed, CNKI, EMBASE, Cochrane Library, KISS, KISTI, NDSL, RISS, KMBASE, DBpia) up to May 2017. We included randomized controlled trials (RCTs) using Tuina for temporomandibular joint disorder. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results 14 RCT studies were eligible in our review. 14 studies were divided into 4 groups, and meta-analysised. The meta-analysis of 6 studies showed favorable results for the use of Tuina. High risk of bias were observed in 9 studies. Conclusions Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CNKI. Now limited evidence is available to support Tuina for temporomandibular joint disorder and further well-designed RCTs should be encouraged.

팔단금 도인 운동이 고혈압에 미치는 영향 : 체계적 문헌 고찰 (Baduanjin for Hypertension : Systematic Review)

  • 조형준;배동렬;김희나;황의형
    • 척추신경추나의학회지
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    • 제12권1호
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    • pp.43-56
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    • 2017
  • Objectives : To determine the effectiveness of Baduanjin for hypertension Methods : We searched 8 electronic databases(Pubmed, CAJ, EMBASE, Cochrane Library, KISS, KISTI, NDSL, RISS) up to April 2017. We included randomized controlled trials(RCTs) using Badanjin for hypertension. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results : 14 RCT studies were eligible in our review. 14 studies were divided into 4 groups, and 2 of them were meta-analysised. The meta-analysis of 10 studies showed favorable results for the use of Baduanjin with Usual care than Usual care. But, meta-analysis of 2 studies showed Baduanjin and Usual care has no difference. High risk of bias were observed in all studies. Conclusions : Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CAJ. Now limited evidence is available to support Baduanjin combined usual care for hypertension and further well-designed RCTs should be encouraged.

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탈모에 대한 레이저의 안전성 및 유효성 : 체계적 문헌 고찰 (Safety and Efficacy of Low Level Laser for Alopecia : A Systematic Review)

  • 이보람;이마음;고경숙;서형식
    • 한방안이비인후피부과학회지
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    • 제32권4호
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    • pp.90-100
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    • 2019
  • Objectives : The purpose of this study is to determine the safety and efficacy of low level laser. Methods : We searched 11 electronic databases(Pubmed, CAJ, EMBASE, Medline, Cochrane Library, KMBASE, KISS, KISTI, NDSL, RISS, Oasis) up to March 2019. We included randomized controlled trials(RCTs) using low level laser for alopecia. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results : 8 RCT studies were eligible in our review. The meta-analysis of 2 studies showed favorable results for the use of low level laser with minoxidil 5% than minoxidil 5% and 6 studies showed favorable results for the use of low level laser than placebo light. The results of meta-analysis showed that low-level laser has an efficacy on alopecia. There were no serious side effects or adverse effects. High risk of bias were observed in all studies. Conclusion : Now limited evidence is available to support low level laser for alopecia and further well-designed RCTs should be encouraged.

자궁내막증의 혈위 첩부 치료에 대한 체계적 문헌고찰 (Acupoint Sticking Therapy for Endometriosis ; Systematic Review)

  • 배주은;박경덕;윤영진
    • 대한한방부인과학회지
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    • 제32권3호
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    • pp.162-173
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    • 2019
  • Objectives: The purpose of this review was to overview and evaluate the efficacy of acupoint sticking therapy for women with endometriosis. Methods: We searched for randomized controlled clinical trials (RCTs) using acupoint sticking therapy on endometriosis in 5 electronic databases such as EMBASE, Pubmed, and CAJ. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias tool. Results: Two RCTs were included for analysis. In the selected studies, Treatment group was higher effective cure rate than any control group. In one RCT, Acupoint sticking therapy was only used, but the other RCT was treated acupoint sticking therapy combined with acupuncture. So, Interventions in 2 studies were not same, Quantitative synthesis was impossible. Conclusion: The limitation of this review is that the number of studies included is small. However, our systematic review provides a basis for acupoint sticking therapy for endometriosis. Acupoint sticking therapy was considered as one of external treatment method for patients with endometriosis.

척추측만증의 추나치료에 대한 문헌 고찰 연구 보고 (Chuna Manual Therapy for Spinal Scoliosis : A Review of Clinical Study)

  • 허인
    • 척추신경추나의학회지
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    • 제14권1호
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    • pp.39-47
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    • 2019
  • Objectives : The purpose of this study was to evaluate the scientific literature demonstrating the effectiveness of Chuna manual therapy (CMT) in the treatment of spinal scoliosis. Methods : A literature search was conducted using eight electronic databases to identify all randomized controlled clinical trials (RCTs) that investigated CMT as a treatment for spinal scoliosis. The Cochrane risk of bias tool was used to assess the methodological quality of each RCT. Results : Five RCTs met our inclusion criteria and were included in the analysis. These studies demonstrated positive results of CMT with respect to the reduction of Cobb's angle, vertebral rotation angle score, bending test score, and efficacy rate compared with brace treatment. Positive results were also assured, in terms of the reduction of Cobb's angle, pulmonary function, and efficacy rate when comparing CMT combined with other therapy with brace treatment, gymnastic training, or traction therapy. Conclusions : This review has identified encouraging and limited evidence of CMT for the treatment of spinal scoliosis. However, to obtain stronger evidence, without the disadvantages of study design and quality, we recommend that treatment effectiveness of CMT for spinal scoliosis is investigated further using a well-designed RCT.

장요근을 대상으로 한의학적 치료를 시행한 국내외 임상연구 동향 분석 (An Analysis of Domestic and International Clinical Research Trends on Korean Medicine Treatments for Iliopsoas Muscle)

  • 황보승윤;김형석;송미연;정원석;조재흥
    • 한방재활의학과학회지
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    • 제34권1호
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    • pp.39-47
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    • 2024
  • Objectives The objective of this study was to investigate clinical the trends of Korean medicine treatments for iliopsoas muscle. Methods 6 Korean and foreign on-line databases were researched for articles discussing Korean medicine treatments for iliopsoas muscle. The included studies were classified according to the published years, study designs, techniques of treatment and evaluation method. Results The total number of studies selected was 12, which included 8 case reports, 2 randomized controlled trials (RCT), and 2 non-RCT. In these studies, acupuncture, pharmacopuncture, Chuna, and herbal medicine were used for treatment. Most studies used visual analogue scale as primary outcome. Conclusions Based on the results of the collected studies, we analyzed the clinical trends of Korean medicine treatments for iliopsoas muscle. The results showed that a variety of Korean medicine treatments can be applied to the iliopsoas muscle and positive effects can be confirmed.