• Korean Journal of Food Science and Technology
• /
• v.45 no.3
• /
• pp.356-363
• /
• 2013

Clinical and preclinical trials of involving drugs with anti-obesity effects have focused on screening for herbal medicines suspected to have anti-obesity activities. In this study, an extract of Aster scaver Thunb., which was prepared in 80% methanol (ASE), was assessed for its total phenol content, total flavonoid content, antioxidant activity ability to scavenge the ${\alpha}-{\alpha}$-diphenyl-${\beta}$-picrylhydrazyl, 2,2'-azino-bis-[3-ethylbenzthiazoline]-6-sulfonic acid radical, and anti-adipogenic effects. The anti-adipogenic effect of ASE on the differentiation of 3T3-L1 pre-adipocytes to adipocytes was investigated by assaying the suppression of adipocyte differentiation and lipid accumulation by using western blot analysis and the Oil Red-O assay, respectively. The staining results showed that ASE significantly inhibited 3T3-L1. Western blot analysis results showed that ASE decreased the levels of peroxisome proliferator-activated receptor-${\gamma}$, CCAAT/enhancer-binding protein ${\alpha}$, and sterol regulatory element-binding protein 1c. These results demonstrate that ASE directly inhibits the differentiation of preadipocytes, and might be an important adjunct in the therapeutic efforts to reduce adipogenesis.

• Magazine of the Korea Concrete Institute
• /
• v.10 no.4
• /
• pp.113-124
• /
• 1998

Numerical study using nonlinear finite element analysis is done for investigating behavior of isolated reinforced concrete walls subject to combined in-plane and out-of-plane bending moments and axial force. A method for estimating the ultimate strength of wall is developed, based on the analytical results. For the nonlinear finite element analysis, a computer program addressing material and geometric nonlinearities is developed. An existing unified method combining plasticity theory and damage model is used for material model of reinforced concrete. By numerical studies, the internal force distribution in the cross section is idealized, and a new method for estimating the ultimate strength of wall is developed. According to the proposed method, variation of the interaction curve of in-plane bending moment and axial force depends on the range of the permissible axial force per unit length that is determined by the given amount of out-of-plane bending moment. As the out-of-plane bending moment increases, the interaction curve shrinks, which indicates a decrease in the ultimate strength. The proposed method is compared with an existing method using the general assumption that strain shall be directly proportional to the distance from the neutral axis. Compared with the proposed method, the existing method overestimates the ultimate strength for walls subject to low out-of-plane bending moments, and it underestimates the ultimate strength for walls subject to high out-of-plane bending moments.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.21 no.1
• /
• pp.80-90
• /
• 2001

The aim of this study is to develop the methodology which enables to identify the mechanical properties of element such as stress intensity factor by using the AE parameters. Considering the multivariate and nonlinear properties of AE parameters such as ringdown count, rise time, energy, event duration and peak amplitude from fatigue cracks of machine element the principal component regression(PCR) and artificial neural network(ANN) models for the estimation of stress intensity factor were developed and validated. The AE parameters were found to be very significant to estimate the stress intensity factor. Since the statistical values including correlation coefficients, standard mr of calibration, standard error of prediction and bias were stable, the PCR and ANN models for stress intensity factor were very robust. The performance of ANN model for unknown data of stress intensity factor was better than that of PCR model.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.4
• /
• pp.220-227
• /
• 2021

PCT (Power Cable Tunnel) and UT (Utility Tunnel), which are non-transport underground infrastructures, are mostly RC (Reinforced Concrete) structures, and their durability decreases due to the deterioration caused by carbonation over time. In particular, since the rate of carbonation varies by use and region, a predictive model based on actual carbonation data is required for individual maintenance. In this study, a carbonation prediction model was developed for non-transport underground infrastructures, such as PCT and UT. A carbonation prediction model was developed using multiple regression analysis and deep neural network techniques based on the actual data obtained from a safety inspection. The structures, region, measurement location, construction method, measurement member, and concrete strength were selected as independent variables to determine the dependent variable carbonation rate coefficient in multiple regression analysis. The adjusted coefficient of determination (Ra2) of the multiple regression model was found to be 0.67. The coefficient of determination (R2) of the model for predicting the carbonation of non-transport underground infrastructures using a deep neural network was 0.82, which was superior to the comparative prediction model. These results are expected to help determine the optimal timing for repair on carbonation and preventive maintenance methodology for PCT and UT.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.7 no.2
• /
• pp.109-115
• /
• 2019

In case of the cracks in concrete, the penetration of deterioration ions such as chloride ions in to cracks is accelerated. According to the penetration of chloride ions, structural and durability problems to RC(Reinforced Concrete) structures are caused. In this study, the accelerated chloride diffusion coefficient which is in steady state is evaluated for 2 year aged normal and high strength FA(Fly Ash) concrete, after a range of crack depths are induced up to 1.0 mm in 56 aged day. Considering crack effect by linear regression analysis, high strength concrete has slightly less increasing ratio of diffusion coefficient by crack than normal strength concrete, and diffusion coefficient increases non-linearly as crack width is increased. Also, In two types of concrete, crack effect decrease as the curing period increase. In the case of quantifying crack and curing effect by using exponential function form, the coefficients of determination are higher than those of linear regression analysis. Under steady state, it is thought that there is not a high correlation between the crack effect and the curing effect, and considering the two independent effects, it is believed that reasonable prediction equation for diffusion of concrete with crack can be proposed.

• Steel and Composite Structures
• /
• v.48 no.1
• /
• pp.43-57
• /
• 2023

The impacts of waste tire rubber (WTR) on the bending conduct of reinforced concrete beams (RCBs) are investigated in visualization of experimental tests and 3D finite element model (FEM) using both ANSYS and SAP2000. Several WTR rates are used in total 4 various full scale RCBs to observe the impact of WTR rate on the rupture and bending conduct of RCBs. For this purpose, the volumetric ratios (Vf) of WTR were chosen to change to 0%, 2.5%, 5% and 7.5% in the whole concrete. In relation to experimental test consequences, bending and rupture behaviors of the RCBs are observed. The best performance among the beams was observed in the beams with 2.5% WTR. Furthermore, as stated by test consequences, it is noticed that while WTR rate in the RCBs is improved, max. bending in the RCBs rises. For test consequences, it is clearly recognized as WTR rate in the RCB mixture is improved from 0% to 2.5%, deformation value in the RCB remarkably rises from 3.89 cm to 7.69 cm. This consequence is markedly recognized that WTR rates have a favorable result on deformation values in the RCBs. Furthermore, experimental tests are compared to 3D FEM consequences via using ANSYS software. In the ANSYS, special element types are formed and nonlinear multilinear misses plasticity material model and bilinear misses plasticity material model are chosen for concrete and compression and tension elements. As a consequence, it is noticed that each WTR rates in the RCBs mixture have dissimilar bending and rupture impacts on the RCBs. Then, to observe the impacts of WTR rate on the constructions under near-fault ground motions, a reinforced-concrete building was modelled via using SAP2000 software using 3-D model of the construction to complete nonlinear static analysis. Beam, column, steel haunch elements are modeled as nonlinear frame elements. Consequently, the seismic impacts of WTR rate on the lateral motions of each floor are obviously investigated particularly. Considering reduction in weight of structure and capacity of the members with using waste tire rubber, 2.5% of WTR resulted in the best performance while the construction is subjected to near fault earthquakes. Moreover, it is noticeably recognized that WTR rate has opposing influences on the seismic displacement behavior of the RC constructions.

• The Korean Journal of Food And Nutrition
• /
• v.24 no.4
• /
• pp.528-534
• /
• 2011

This study was conducted to investigate the changes in saponin content and antioxidant activity of crude ginseng and extruded ginseng by using different solvent extraction methods. Each of the fractions was first extracted by 80% ethanol followed by ether treatment to remove the lipid components. Water soluble components were separated by ethylacetate and water saturated butanol. Four fraction, including 80% ethanol, ethylacetate, butanol and water were obtained from crude and extruded ginsengs to analyze saponin content and antioxidant activity. Saponin content and antioxidant capacity of each of the four fractions were measured by LC/MS analysis and ORAC(Oxygen Radical Absorbance Capacity) assay, respectively. It was found that a major portion of saponin was present in ethyl acetate and water saturated butanol fractions. When extracted by 80% ethanol, ginsenoside Rb1 and Rg1 were mostly found in crude ginseng, while ginsenoside Re and Rb1 were detected in extruded ginseng. Even though Rh1 and Rg3 were found in a very small quantity in crude ginseng, there was a significant quantity of both in extruded ginseng when extracted by 80% ethanol. Similar tendency was also observed in extruded ginseng fraction when extracted with ethyl acetate and butanol. In crude ginseng, the level of Rg1 was the highest among other ginsenosides upon extraction by ethyl acetate, while Rh1 and Rg3 were predominantly found by employing similar solvent extraction in the extruded ginseng. Also, Rg1, Re and Rb1 were also found in the extruded ginseng with small quantity. Rg1, Re and Rb1 were found in crude ginseng by butanol extraction, while Rb1 and Re were extracted from the extruded ginseng. Overall, there was no difference in the saponin content between crude ginseng and extruded ginseng when extracted by butanol and water, but twice as much of saponin was obtained by 80% ethanol extraction and 6 times more saponin were obtained in ethyl acetate fraction in the extruded ginseng. Antioxidant capacity of crude ginseng as determined by ORAC assay was higher in 80% ethanol(high in many different kinds of biological compounds) and water saturated butanol(high in polar saponin) fractions than the ethyl acetate and water fractions. No difference in antioxidant capacity was observed between crude and extruded ginseng. However, antioxidant capacity of ethyl acetate and water fractions in extruded ginseng was significantly higher than crude ginseng($P$ >0.05). All the fractions in both, crude and extruded ginseng possessed antioxidant capacity and even water fractions that contained almost no saponin had some antioxidant capacity. While determining correlation coefficient between fractions in extruded ginseng by Pearson correlation, it was observed that 80% ethanol fraction was in correlation with ethyl acetate($P$ >0.01) and ethanol($P$ >0.001) and in the case of ethylacetate, correlation was observed only with butanol fraction($P$ >0.05).

• Investigative Magnetic Resonance Imaging
• /
• v.10 no.2
• /
• pp.98-107
• /
• 2006

Magnetization Transfer (MT) imaging generates contrast dependent on the phenomenon of magnetization exchange between free water proton and restricted proton in macromolecules. In biological materials in knee, MT or cross-relaxation is commonly modeled using two spin pools identified by their different T2 relaxation times. Two models for cross-relaxation emphasize the role of proton chemical exchange between protons of water and exchangeable protons on macromolecules, as well as through dipole-dipole interaction between the water and macromolecule protons. The most essential tool in medical image manipulation is the ability to adjust the contrast and intensity. Thus, it is desirable to adjust the contrast and intensity of an image interactively in the real time. The proton density (PD) and T2-weighted SE MR images allow the depiction of knee structures and can demonstrate defects and gross morphologic changes. The PD- and T2-weighted images also show the cartilage internal pathology due to the more intermediate signal of the knee joint in these sequences. Suppression of fat extends the dynamic range of tissue contrast, removes chemical shift artifacts, and decreases motion-related ghost artifacts. Like fat saturation, phase sensitive methods are also based on the difference in precession frequencies of water and fat. In this study, phase sensitive methods look at the phase difference that is accumulated in time as a result of Larmor frequency differences rather than using this difference directly. Although how MT work was given with clinical evidence that leads to quantitative model for MT in tissues, the mathematical formalism used to describe the MT effect applies to explaining to evaluate knee disorder, such as anterior cruciate ligament (ACL) tear and meniscal tear. Calculation of the effect of the effect of the MT saturation is given in the magnetization transfer ratio (MTR) which is a quantitative measure of the relative decrease in signal intensity due to the MT pulse.

• Journal of Science Education
• /
• v.41 no.3
• /
• pp.334-350
• /
• 2017

The purposes of this study are to develop scientific-inquiry based on STEAM education program and to investigate the effects of the program on middle-school students' interests, self-efficacy, and career choice about science, technology/engineering, and mathematics. In order to develop this program, the literature investigation and previous studies were conducted, so that finally the developmental direction was based on scientific inquiry and the developmental theme and model were selected. A total 92 first-graders in G middle-school of Daegu city were participated in this study. A single group pre-post test paired t-test was conducted to figure out changes of students' interest, self-efficacy, and career choices before or after applying this program. In addition, in-depth interviews were conducted with 14 students to find their specific responses. The results of this study were as follows. First, STEAM education program on the theme of 'RC Airplane' was developed on the basis of the 'ADBA' model. Second, the developed STEAM educational program not only results a decisive difference statistically but also has significant effects on middle-school students' interests, self-efficacy, and career choice in science, technology/engineering, and mathematics, who are involved in the free-semester program, across the overall affective domain. In conclusion, the STEAM educational program in this study could affect significant meanings to middle-school students during the free-semester. It could contribute to facilitate middle-school students' education for happiness and to grow the creative STEAM talents.

• The Korean Journal of Food And Nutrition
• /
• v.27 no.2
• /
• pp.175-182
• /
• 2014

This study investigates the free radical-scavenging activities of Amaranth (Amaranthus spp. L.) red and purple flower extracts. The methanol and hot water extracts of flower are being evaluated for its total polyphenol and flavonoid contents, scavenging activities by the DPPH and ABTS analysis, SOD-like activity, and inhibition activities of superoxide radical on the HL-60 cells and nitric oxide of the RAW 264.7 cells. The PFM (purple flower extracted with MeOH) showed the highest total phenolic and flavonoid content, 606.95 mg GAE/100 g and 254.69 mg CE/100 g, respectively. Amongst the scavenging activities of the DPPH radicals, PFM($RC_{50}=155.06{\mu}g/m{\ell}$) is the highest of all the samples. The ABTS radical-scavenging activity is also highest for PFM (53.16%) at the $250{\mu}g/m{\ell}$ concentration. But, the SOD-like activity of the PFW (purple flower extracted with hot water) increases more than 3 folds of the PFM. In the leukemia HL-60 cell, the PFM shows strongly inhibited superoxide radical generations at a concentration of $200{\mu}g/m{\ell}$ at 72.34%, which increases with 1.79 folds more than the RFW (red flower extracted with hot water). The inhibition activity of nitric oxide in Raw 264.7 cells is the highest for PMF (46.90%) at a $250{\mu}g/m{\ell}$ concentration. In conclusion, PMF show the highest flavonoid contents and the most powerful free radical-scavenging activity. Our results suggest that the increase of antioxidant activities depend on flavonoid contents. Thus, Amaranth flower can be useful for natural antioxidant compounds.