• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.75-75
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• 2020

하천법에 의거하여 국내 하천들에는 상당한 국가예산으로 하천정비기본계획이 5-10년 주기로 수립되고 있으며, 홍수위 계산을 위한 HEC-RAS 모의에 필요한 하천단면 등 다양한 하천측량이 실시되고 있다. 그러나, 하천측량자료들은 하천관리지리정보시스템(RIMGIS)에 pdf 보고서 형태로만 제공되고, 원자료는 CAD 형식으로 하천정비계획을 수행한 설계사 등이 분산 소유하고 있어 관리부재로 망실의 우려도 있어, 다른 용도로의 활용성이 상당히 저하되어 있는 실정이다. 그리고, 측량된 CAD 형식의 단면자료 등을 HEC-RAS에 활용할 때, 'Dream'과 같은 툴을 활용하나 거의 수작업에 가까운 시간과 비용이 소요되는 현실에 있다. 본 연구에서는 이러한 문제들을 해결할 수 있는 툴인 RAUT(River information Auto Upload Tool)를 개발하였다., RAUT 툴은 첫째, 실무에서 하천기본계획 수립 시 활용되는 HEC-RAS 1차원 모형의 입력자료를 CAD 측량자료를 직접수기로 입력 및 모의를 실시하는 복잡한 단계를 자동화시키고자 하였다. 둘째, 하천공간정보인 CAD측량 자료를 직접 읽어 표준 데이터 모델 (Arc River)기반 하천공간정보 DB에 자동 업도드하여 전국단위의 하천정비계획의 하천측량자료 관리가 가능하게 할 수 있다. 즉, 만약 RIMGIS가 RAUT와 같은 툴을 사용하면 하천단면과 같은 전국단위 하천측량 자료를 체계적으로 관리할 수 있게 된다는 의미이다. 개발한 RAUT는 제주도 한천유역을 대상으로 하천정비기본계획의 하천공간정보 CAD자료를 읽어들여 mySQL기반 공간 DB로 구축하고, 구축된 DB로부터 HEC-RAS 1차원 모의 실시하기 위한 지형자료를 자동으로 생성시키는 과정을 시범적으로 구현하였다.

• Journal of Korea Water Resources Association
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• v.54 no.12
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• pp.1339-1348
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• 2021

In accordance with the River Law, the basic river maintenance plan is established every 5-10 years with a considerable national budget for domestic rivers, and various river surveys such as the river section required for HEC-RAS simulation for flood level calculation are being conducted. However, river survey data are provided only in the form of a pdf report to the River Management Geographic Information System (RIMGIS), and the original data are distributedly owned by designers who performed the river maintenance plan in CAD format. It is a situation that the usability for other purposes is considerably lowered. In addition, when using surveyed CAD-type cross-sectional data for HEC-RAS, tools such as 'Dream' are used, but the reality is that time and cost are almost as close as manual work. In this study, RAUT (River Information Auto Upload Tool), a tool that can solve these problems, was developed. First, the RAUT tool attempted to automate the complicated steps of manually inputting CAD survey data and simulating the input data of the HEC-RAS one-dimensional model used in establishing the basic river plan in practice. Second, it is possible to directly read CAD survey data, which is river spatial information, and automatically upload it to the river spatial information DB based on the standard data model (ArcRiver), enabling the management of river survey data in the river maintenance plan at the national level. In other words, if RIMGIS uses a tool such as RAUT, it will be able to systematically manage national river survey data such as river section. The developed RAUT reads the river spatial information CAD data of the river maintenance master plan targeting the Jeju-do agar basin, builds it into a mySQL-based spatial DB, and automatically generates topographic data for HEC-RAS one-dimensional simulation from the built DB. A pilot process was implemented.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.10
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• pp.5035-5048
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• 2016

Nano scale networks are futuristic networks deemed as enablers for the Internet of Nano Things, Body area nano networks, target tracking, anomaly/ abnormality detection at molecular level and neuronal therapy / drug delivery applications. Molecular communication is considered the most compatible communication technology for nano devices. However, connectivity in such networks is very low due to inter-symbol interference (ISI). Few research papers have addressed the issue of ISI mitigation in molecular communication. However, many of these methods are not adaptive to dynamic environmental conditions. This paper presents an enhancement over original Memory-1 ISI cancellation scheme using maximum likelihood estimation of a channel parameter (λ) to make it adaptable to variable channel conditions. Results of the Monte Carlo simulation show that, the connectivity (P_conn) improves by 28% for given simulation parameters and environmental conditions by using enhanced Memory-1 cancellation method. Moreover, this ISI mitigation method allows reduction in symbol time (Ts) up to 50 seconds i.e. an improvement of 75% is achieved.

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.685-693
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• 2017

Candidiasis involving the biofilms of Candida albicans is a threat to immunocompromised patients. Candida biofilms are intrinsically resistant to the antifungal drugs and hence novel treatment strategies are desired. The study intended to evaluate the anti-Candida activity of allyl isothiocyanate (AITC) alone and with fluconazole (FLC), particularly against the biofilms. Results revealed the concentration-dependent activity of AITC against the planktonic growth and virulence factors of C. albicans. Significant (p <0.05) inhibition of the biofilms was evident at ${\leq}1mg/ml$ concentrations of AITC. Notably, a combination of 0.004 mg/ml of FLC and 0.125 mg/ml of AITC prevented the biofilm formation. Similarly, the preformed biofilms were significantly (p <0.05) inhibited by the AITC-FLC combination. The fractional inhibitory concentration indices ranging from 0.132 to 0.312 indicated the synergistic activity of AITC and FLC against the biofilm formation and the preformed biofilms. No hemolytic activity at the biofilm inhibitory concentrations of AITC and the AITC-FLC combination suggested the absence of cytotoxic effects. The recognizable synergy between AITC and FLC offers a potential therapeutic strategy against biofilm-associated Candida infections.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2997-3004
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• 2012

Background: This cross-sectional observational study was undertaken to identify the epidemiological characteristics of patients with gynecological malignancies in India, in relation to gynecological cancer risk. Methods: In the gynecology out-patient clinic of a tertiary care hospital in Kolkata, India, the patients with suggestive symptoms of gynecological malignancies were screened. One hundred thirteen patients with histopathologically confirmed gynecological malignancies were interviewed. Results: More than two-thirds of the cases (69.0%) occurred in the age range of 35-64 years and the same proportion of patients was from rural areas. Almost all the patients were "ever-married" (96.5%). More than half (54.9%) were illiterate/just literate. Nearly two-thirds (64.6%) were parity 3 or higher. Among the 18 patients with history of multiple sexual partners of the husband, 94.4% (17) were suffering from cervical malignancy, along with all the 3 patients with history of STD syndromes (sexually transmitted diseases) of their husbands. No one had given a history of condom use by her husband. Most of the patients (91.1%) used old / reused cloth pieces during menstruation. Conclusions: There is a need to increase awareness among women and the broader community about different epidemiological factors that may be responsible for increased risk of gynecological malignancies.

• Korean Journal of Pharmacognosy
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• v.6 no.1
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• pp.43-47
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• 1975

Attempts were made to determine the characteristics of the morphology of Codonopsis lanceolata $T_{RAUT's}$ root. Its saponin and crude powder were examined by foaming and hemolytic tests and by observing transverse sections: 1) The cork-layer was consisted of multiple cells, and some of the cork cells contained monoclinic prism crystals of calcium oxalates. 2) The vascular bundle was formed of radial arrangement by the preminentic bursting pith and the irregular cambium ring with the abnormal growth. 3) The latex vessel and latex of the cortex were brown-gray or yellowish-brown. The latex vessel and sieve tube were consisted of the independent aggregates which had a number of layers. It had much more independent aggregates than Platycodi Radix. 4) The xylem was less than the phloem portion. The thick-walled vessels which had one to five lines ware more distributed than in Platycodi Radix. 5) The inulin distribution on a piece of section which is dipped in alcohol was observed through out the tissues, but starch grain was not found in it. 6) The duration time of foaming reaction of the crude powder in test tubes was shorter than that of Platycodi Radix. Foaming index of the foaming test of five percent decoctions was 3.33, 7) In the hemolytic test which used 10 percent decoction and one percent saponin solution, hemolytic action was very weak.

• Journal of applied mathematics & informatics
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• v.39 no.1_2
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• pp.197-214
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• 2021

In this paper, we have studied dynamics of fractional order mathematical model of malaria transmission for two groups of human population say semi-immune and non-immune along with growing stages of mosquito vector. The present fractional order mathematical model is the extension of integer order mathematical model proposed by Ousmane Koutou et al. For this study, Atangana-Baleanu fractional order derivative in Caputo sense has been implemented. In the view of memory effect of fractional derivative, this model has been found more realistic than integer order model of malaria and helps to understand dynamical behaviour of malaria epidemic in depth. We have analysed the proposed model for two precisely defined set of parameters and initial value conditions. The uniqueness and existence of present model has been proved by Lipschitz conditions and fixed point theorem. Generalised Euler method is used to analyse numerical results. It is observed that this model is more dynamic as we have considered all classes of human population and mosquito vector to analyse the dynamics of malaria.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3541-3547
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• 2013

Background: This cross-sectional observational study was undertaken to establish clinico-pathological characteristics of patients with gynecological malignancies, focusing mainly on symptoms, histological type and stage of the disease at presentation, in a tertiary care setting in Eastern India. Materials and Methods: In the gynecology out-patient clinic of a tertiary care hospital in Kolkata, India, the patients with suggestive symptoms of gynecological malignancies were screened. Their diagnoses were confirmed by histopathology. One hundred thirteen patients with histopathologically confirmed gynecological malignancies were interviewed. Results: The most frequently reported symptoms by the patients with histopathologically confirmed gynecological malignancies were excessive, offensive with or without blood stained vaginal discharge (69.0%), irregular, heavy or prolonged vaginal bleeding (36.3%) and postmenopausal bleeding (31.9%). The majority of the patients (61.0%) had squamous cell carcinoma on histopathological examination, followed by adenocarcinoma (30.1%). Nearly half of the patients (48.7%) were suffering from the Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage III, followed by stage II (40.7%) malignancy. Conclusions: This study highlights that most of the patients with gynecological malignancies present late at an appropriate health care facility. Ovarian cancer may often have non-specific or misleading symptomatic presentation, whereas cervical cancer often presents with some specific symptoms. These observations point to the need for increasing awareness about gynecological malignancies in the community and providing easily accessible adequate facilities for early detection and treatment of the disease by optimal use of available resources, i.e. strengthening the primary health care system.

• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1216-1225
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• 2014

Biofilm-related infections of Candida albicans are a frequent cause of morbidity and mortality in hospitalized patients, especially those with immunocompromised status. Options of the antifungal drugs available for successful treatment of drug-resistant biofilms are very few, and as such, new strategies need to be explored against them. The aim of this study was to evaluate the efficacy of phenylpropanoids of plant origin against planktonic cells, important virulence factors, and biofilm forms of C. albicans. Standard susceptibility testing protocol was used to evaluate the activities of 13 phenylpropanoids against planktonic growth. Their effects on adhesion and yeast-to-hyphae morphogenesis were studied in microplate-based methodologies. An in vitro biofilm model analyzed the phenylpropanoid-mediated prevention of biofilm development and mature biofilms using XTT-metabolic assay, crystal violet assay, and light microscopy. Six molecules exhibited fungistatic activity at ${\leq}0.5mg/ml$, of which four were fungicidal at low concentrations. Seven phenylpropanoids inhibited yeast-to-hyphae transition at low concentrations (0.031-0.5 mg/ml), whereas adhesion to the solid substrate was prevented in the range of 0.5-2 mg/ml. Treatment with ${\leq}0.5mg/ml$ concentrations of at least six small molecules resulted in significant (p < 0.05) inhibition of biofilm formation by C. albicans. Mature biofilms that are highly resistant to antifungal drugs were susceptible to low concentrations of 4 of the 13 molecules. This study revealed phenylpropanoids of plant origin as promising candidates to devise preventive strategies against drug-resistant biofilms of C. albicans.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.56-56
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• 2021

하천단면이나 하상변동 추적 등 하천공간정보는 유량이나 강우 등 수문시계열 정보와 더불어 계획홍수위 산정이나 하천구조물 신설로 인한 하천의 변화를 추적하는 데 있어 근간을 이루는 주요 정보로 국가차원의 유지 및 관리가 필요하다. 국내의 하천공간정보는 RIMGIS, WAMIS, 하천 일람, WINS와 같은 웹기반 시스템에서 정보화 되어 관리되고 있다. 그러나, RIMGIS는 여러 가지 문제점을 노정하고 있어 개선을 적극적으로 검토해볼 시점이라고 볼 있다. 우선, RIMGIS는 구축이 10년 이상된 기술로 구성되어 온라인 시스템 실행속도가 느리고, 물관리 일원화 와중에 관리주체가 불분명해진 상태이며, 제공되는 정보도 하천망이나 유역 정도로 차원 및 정확도도 낮고 활용도 및 현행화도 부족한 상태이다. 또한 공간정보 관리 DB표준으로 효율적인 관계형 구조 대신 하천대장 등을 수치화한 개념의 레이어 단위의 주제도로 관리하다보니 자료중복이 불가피하여 시스템이 무겁고, 자료간 연관검색이 거의 불가하고, 신속한 하천지형 변화 업데이트가 어려운 상태이다. 최근 진행되고 있는 RIMGIS 개선 사업은 여전히 종래의 레이어 단위의 주제도들을 추가하거나 개정하는 데 머물고 있는 상태이다. 이러다 보니 현재 우리나라의 대표적인 하천정보시스템인 RIMGIS의 실무 활용도는 낮은 것으로 알려져 있다. 가장 실무활용도를 저하시키고 현행화 상의 문제로 지적되는 부분은 하천정비기본계획 수립 시 발생한 공간자료 관리 부실이다. 현재 RIMGIS에서는 하천기본계획보고서만 PDF 형태로 제공할 뿐, 실제 지형자료는 과업을 수행한 설계사에 개별 보관되어 활용도뿐만아니라 망실의 우려가 높은 상황이다. 본 연구에서는 하천기본계획수립 시 측량되는 단면을 포함한 다양한 공간자료를 관계형으로 표준화 DB에 효율적으로 저장할 수 있게 하는 방안을 제시하고자 한다.