• Neonatal Medicine
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• 제25권3호
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• pp.126-130
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• 2018

Parkes Weber syndrome is a rare congenital vascular anomaly, related to the RAS p21 protein activator 1 (RASA1) gene. It is characterized by capillary cutaneous malformations, bony and soft tissue hyperplasia, and multiple arteriovenous fistulas throughout the affected upper or lower extremity. These arteriovenous fistulas can be associated with life-threatening complications such as bleeding, thrombosis, and high output heart failure. In this report, we present a neonate who had a disproportionately hypertrophied left upper limb with port-wine stain, dystrophy of the left humerus, and hypertrophy of the left clavicle on X-ray, and arteriovenous malformation and massive dilatation of the left subclavian artery on magnetic resonance angiography. Exome sequencing analysis revealed a novel heterozygous splicing mutation (c.1776+2T>A) in the RASA1 gene. To the best of our knowledge, this report is the first case of RASA1-related Parkes Weber syndrome in Korea.

• 셀메드
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• 제10권1호
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• pp.4.1-4.4
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• 2020

Ayurveda scholars have well described about the physio-anatomical aspect of mammary gland (Stana), physiology of lactation, importance of breast milk (Stanya) in growth and development of baby, various factors affecting the lactation and causing changes in property of milk, Galactogouge (Stanyajanana), and drugs for purification of mother milk (Stanya Shodhana). The recent studies provide evidence for above descriptions of Ayurveda. Breast milk (Stanya) is the nearly complete sole source of nourishment for infants. It has been considered as subsidiary tissue (Upadhatu) of blood plasma (Rasa Dhatu) as it is formed out of Rasa Dhatu (Plasma) and its quality and quantity gets affected by quality of nutrient fraction of food formed after complete digestion (Aahar Rasa). It provides health (Aarogya), strength and immunity (Bala) to the feeding child and gives innumerable beneficial effects like protection against not only acute infections like URTI, diarrhoea but also on chronic illnesses like CVD, metabolic disorders too. The Ayurveda description related to Mammary gland and physiology of lactation still need a better understanding for its implementation on promotion of health. Thus an attempt has been made to compile and analyze the view of Ayurveda scholars on Breast (Stana), Breast milk (Stanya) and physiological aspect of lactation as well as to draw a possible scientific understanding for the relevance.

• 생명과학회지
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• 제28권9호
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• pp.1100-1117
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• 2018

Ras superfamily에 속하는 monomeric small GTPase는 현재까지 170여 종이 알려져 있으며 이들은 세포 신호전달에 있어서 분자 스위치(molecular switch)로 작용하고 있다. Ras GTPase는 guanosine diphosphate (GDP)와 결합하여 불활성화 되거나 혹은 guanosine triphosphate (GTP)와 결합하여 활성화되는 guanosine nucleotide 결합단백질로서 세포내의 수많은 생리작용을 조절하고 있다. 즉, 쉬고 있던 불활성화 상태의 Ras-GDP는 외부 신호에 반응하여 활성화 된 guanine nucleotide exchange factor (GEF)에 의하여 활성형인 Ras-GTP상태로 전환되어 그 하류로 신호를 전달하는 효과기로 작용하게 된다. 신호전달을 마친 Ras-GTP는 다시 불활성형인 Ras-GDP로 전환되어야 하는데 Ras 자체의 GTPase 활성이 미약하여 RasGTPase activating protein (RasGAP)의 도움을 받아야만 한다. 이와 같이 Ras GTPase는 GEF와 GAP의 활성으로 세포 안의 스위치를 켜고 끄게 된다. 현재까지 알려진 인간 암(cancer)의 30% 이상이 돌연변이를 포함하는 Ras switch의 비정상적인 작동에 기인한다는 점이 밝혀져 있으므로 Ras GTPase의 구조와 생리적 기능에 대한 최근의 연구결과들을 요약하였다. 나아가 GTPase activating protein으로서의 기능을 상실한 RasGAP분자의 돌연변이는 세포 안의 Ras 스위치를 계속 켜 두는 상태인 Ras-GTP 상태를 유발함으로서 종국에는 암의 발생을 촉발하게 된다. 이에, 본고에서는 최근에 와서 tumor suppressor로서 알려지면서 암의 치료 표적단백질로 떠오르게 된 RasGAP의 인체생리학적 기능을 고찰하였다. 인간 게놈 안에는 RASA1, NF1, GAP1 family 및 SynGAP family 등에 속하는 14종의 RasGAP 분자들이 존재하는데 이들 GAP분자들의 이상과 인간 질병의 연관성에 대한 최근의 연구결과들에 대해 고찰하였다.

• 실천공학교육논문지
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• 제15권1호
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• pp.73-80
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• 2023

21세기 들어 온라인 테크놀로지의 활성화로 온라인 강좌와 웹기반 커뮤니케이션의 사용이 고등교육 분야에서 증가되어 왔다. 시간과 장소에 구애받지 않는 온라인 교육의 특성은 대학 캠퍼스를 국내외로 확대하고 대학교육의 수혜자도 일반인과 타대학 학생으로 확대할 수 있는 가능성을 열어주었다. 또한 학령인구의 감소, 대학 구조의 재편과 같은 변화도 온라인 교육에 대한 인식을 바꾸는 계기가 되었다. 본 논문에서는 K대학교 재학생, 고등학교 3학년 학생, 일반인을 대상으로 설문조사를 실시하여 온라인 강좌에 대한 만족도, 대형 온라인 강좌를 필요로 하는 영역, 현재 개설된 대형 온라인 강좌의 운영에 대한 학생들의 니즈 등에 대하여 살펴보았다. K대학교 재학생의 온라인 강좌에 대한 만족도는 높게 나타나고 있다. 다만, 각각의 온라인 강좌에 대한 만족도는 높으나 온라인 강좌의 체계 통일성을 높여야 함과 온라인 강좌를 원활하게 수강할 수 있는 환경 개선이 필요함을 알 수 있다. 고등학생의 경우 자연과학에 대한 선호도에서 일반인과 재학생에 비해 상당히 높게 나오고 있는데 수학, 물리와 같은 과목을 선수과목으로 하고 온라인 강좌로 만들어서 전공 수업에 대비하게 해야 할 필요성이 있다고 생각된다. 일반인의 경우 인문학 분야에 대한 선호도가 고등학생과 재학생에 비해 상당히 높게 나타나고 있는데 이는 교양함양이라는 강의 목적을 통해서도 확인할 수 있다.

• 한국의사학회지
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• 제27권1호
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• pp.135-156
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• 2014

Through a simple translation and analysis of the "Su$\acute{s}$uta-saṃhit$\bar{a}$(The fascinating tales) S$\bar{u}$trasth$\bar{a}$na(The Introduction)", I have summarized the results of the research into the $\bar{A}$yurveda Herbal theory. 1. The title of chapter 40 is "dravya-rasa-guṇa-vip$\bar{a}$ka-vij$\tilde{n}$anīya(Medcation Taste Nature Effects Digestion)", and it states theoretical knowledge on materia medica. It says that 'matter' is the most important thing, and that it decides the curing effect. Although it does acknowledge the reason behind the doctors that emphasized things like 'taste', it mainly has a critical tone. The difference in philosophies and medical theory can be seen when we compare this to the "Caraka-saṃhit$\bar{a}$", 'theory on taste'. 2. The title of chapter 41 is "dravya-vi$\acute{s}$eṣa-vij$\tilde{n}$anīya(A Discussion on the Characteristics of Materia Medica)", and the contents of the chapter have a similar tone to the thoughts of the S$\bar{a}$mkhya(數論派). All 'matter' was created by the combination of the five elements of earth, water, fire, wind, and ether, and the predominant element makes it have an earth, water, fire, wind, or ether nature. Earth has an unmoving and down going nature, and makes the body strong. Water has an irrigating nature, and moistens the tissue and induces secretion and excretion. Fire has an upward-going nature, and improves sight and complexion. Wind relaxes and dries the body, and makes the mind and body agile. Ether gives flexibility, porosity, and candidness. The title of chapter 42 is "rasa-vi$\acute{s}$eṣa-vij$\tilde{n}\bar{a}$nīya(A Discussion on the Types of Rasa(taste))". "Rasa" is an important concept in $\bar{A}$yurveda. Sometimes it is translated as 'one of the seven types of bodily tissue' and seen as chyle, and sometimes it is seen as the tastes that can be felt with the tongue such as spicy, sweet, sour, bitter, salty, and astringent(澁). Volume 1, chapter 42 of the "Caraka-saṃhit$\bar{a}$" is dedicated to the "types of taste", and in chapter 26, it theorizes the concept of 'taste'.

• 디지털산업정보학회논문지
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• 제19권1호
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• pp.129-138
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• 2023

The purpose of this study is to explore factors that directly affect the employment of college graduates. To this end, employment data of graduates of private four-year university in Daegu metropolitan area and Gyeongsangbuk-do province were collected from 2019 to 2021, filtered data using a RapidMiner, and analyzed by applying a decision tree model. As a result of the study, long-term internship for more than 12 weeks, TOEIC score of 787.5 or higher was advantageous for employment, and if there was no TOEIC score, the graduation average score was 3.67 or higher, so the possibility of employment was high. Even if the TOEIC score was low, it was advantageous for employment if participating in the contest and continuous professor counseling, and even if the average graduation score was low, the possibility of employment was high if actively participating in the comparison program. This study can present a job education guide based on actual data to university management and use it to establish policies to support employment of college students.

• 셀메드
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• 제7권2호
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• pp.9.1-9.6
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• 2017

Recurrent Acute Pancreatitis/ Chronic Pancreatitis (RAP/ CP) is generally marked by sudden onset of symptoms like severe abdominal pain, vomiting and weight loss that needs emergency hospitalization. Owing to irreversible and progressive nature of the disease and limitations of conventional treatment, many patients look for an alternative solution. Here, we report data of 250 well diagnosed cases of acute recurring/ chronic pancreatitis, enrolled in between January 1997 to August 2016, in our Ayurvedic clinical practice in Northern part of India. Ayurveda is well recognized as an independent medical system parallel to conventional medicines in India and a subject is free to opt for any system of medicine for the prevention and treatment of any ailment. The subjects were treated with a complex herbo-mineral formulation based on the principles of Rasa Shastra in Ayurveda that deals with the therapeutics of processed metals in the prevention and treatment of diseases. They were also prescribed a regulated balanced diet and lifestyle. Significant improvement has been noted in subjects who have completed the treatment.

• 실천공학교육논문지
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• 제15권1호
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• pp.133-142
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• 2023

본 연구는 블록체인 기술이 현재 각 영역에서 어떻게 적용되고 있는지와 함께 그 블록체인을 구성하는 방법과 한계를 살펴보고, 이어 블록체인 기술이 제시하는 미래의 모습을 가늠해 보는 것을 목적으로 한다. 이 같은 블록체인 기술이 함축하고 있는 지향은 일정 부분 기술적 난제를 얼마나 빨리 극복하느냐에서 그 성공적 적용이나 실현 여부가 결정된다. 이 논문에서는 블록체인 기술의 진보를 기반으로 투명성과 신뢰성이 향상될 때, 산업의 영역뿐만 아닌, 경제나 정치적 영역에서 세상을 바꾸는 주요한 힘으로 작용하게 될 것이라는 점에 주목한다. 설사 블록체인 기술이 보여주는 문제의식이 현실의 문제를 해결하는 가장 효율적인 최선의 길이 될 수 없다고 하더라도, 이것이 제시하는 틀은 우리가 대면한 현실의 문제를 이해하는 주요한 창이 되어줄 것이다.

• 대한한방부인과학회지
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• 제23권2호
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• pp.71-84
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• 2010

Purpose: In the theory of traditional medicine, Glenditsia spina(GS) can resolve carbuncle, relive swelling, dispel wind and destroy parasites. This study was designed to investigate the effects of GS on gene expression of ovarian tissue in polycystic ovary syndrome(PCOS) rats. Methods: In this experiment, female rats injected with a single dose of 2 mg estradiol valerate(EV) and GS was given for 5 weeks. The genetic profile for the effects on ovarian tissue in PCOS rats was measured using microarray technique, and the functional analysis on these genes was conducted. Results: 985 genes were increased in control and restored to normal level in GS group. (B), 733 genes were decreased in control group and restored to normal level in GS group. (F). Metabolic pathways related in B group genes were Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Small cell lung cancer, Type I diabetes mellitus. Metabolic pathways related in F group genes were Antigen processing and present, Adipocytokine signalling pathway, Focal adhesion, ECM-receptor interaction, Pancreatic cancer, Notch signalling pathway, Tight junction. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as c-Fos, c-Myc, ABL1 related in B group, MAPK8, RASA1, CALR related in F group that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: These results suggest possibility of GS as anti-cancer and anti-hyperplasia drug in PCOS. In addition, the present author also suggests that related mechanisms are involved in suppression of proto-oncogene such as c-Fos, c-Myc and ABL1, and in regulation of cell cycle such as RASA1.

• 셀메드
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• 제6권1호
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• pp.5.1-5.5
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• 2016

Combating anaemia is a global public health challenge of the developing world. Nutritional anaemia is a serious health problem faced by Indian school children. An investigation was taken up to study the effect of non iron containing Ayurvedic preparation Sootshekhar Rasa (SR) plus Sitopaladi Churna (SC) along with iron and folic acid (IFA) for improving nutritional anaemia among adolescent school going students of Dehradun district in Northern India. The blinded, controlled randomized trial comprised of 820 adolescents anaemic students aged 11 - 18 years. The anaemic students were randomly divided into 4 groups, students of group I (control) received starch, group II, III, and IV students received daily dose of (SR 250 mg + SC 400 mg), IFA and (SR 250 mg + SC 400 mg) + IFA, respectively. All the students received treatment for 90days and were followed up for next 180days. At the end of follow-up (day 270), significant increase of haemoglobin (Hb) level from the base line was recorded in all treatment groups. The maximum gain in Hb concentration was noted in group IV (10.1 ± 0.6 g/L), which was significantly higher than any other group. There were 123 drop-outs; however, no major side effect of treatment was noted in any student. We conclude that daily dose of (SR 250 mg + SC 400 mg) along with IFA can produce sustainable improvement of nutritional anaemia in adolescent students.