• Journal of Gastric Cancer
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• v.23 no.2
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• pp.289-302
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• 2023

Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM-) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM-: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM-: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan-Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM- subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM- (OS HR, 0.71 [LM+] vs. 0.88 [LM-]; PFS HR, 0.47 [LM+] vs. 0.76 [LM-]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.

• Journal of the Korean Society of Systems Engineering
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• v.7 no.2
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• pp.13-19
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• 2011

A LRT(Light Rail Transit) is one of the Future Urban Railway Development Project. The project's goal is to reduce a transportation congestion in the center of the city. New transportation is intensely required in order to overcome a limit of the ground transportation that is the existing public transportation, A LRT(Light Rail Transit) construction project to be based on an unmanned driving system is the large composition system that a vehicle, a signal, communication, electric, track etc. were organically integrated as echo-friendly urban transportation systems. It also put a huge budget, which is a large-scale infrastructure projects. It is international trend that Light Rail Transit projects apply a technique in System Engineering for a schedule, cost, quality elevations, and to approach in viewpoints of life-cycle from initial construction steps to operation, abolition. This paper intends to analyze RAM requirements taking into consideration ISO/IEC 15288 throughout life-cycle from concept, design, manufacture, operation and maintenance to the final phase, decommissioning, and the study seeks to suggest directions of efficient use to domestic LRT projects.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.2
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• pp.157-164
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• 2012

When designing a multifunctional system consisting of many components performing many functions or missions, it is important to determine the reliability, availability, and maintainability (RAM) of the system and components, and we consider system availability to be the optimization criterion. For given intervals of mean time between failure (MTBF) and mean time to repair (MTTR) of the components, we want to determine the values of MTBF and MTTR for all components that satisfy the target availability. A heuristic method is proposed for finding near-optimal solutions through simulation. We also study numerical examples to check effects of model parameters on the optimal solutions.

• Electrical & Electronic Materials
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• v.10 no.4
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• pp.349-354
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• 1997

This paper aims at studying the improvement of test method for t-weight sensitive fault (t-wsf) detect. The development of RAM fabrication technology results in not only the increase at device density on chips but also the decrease in line widths in VLSI. But, the chip size that was large and complex is shortened and simplified while the cost of chips remains at the present level, in many cases, even lowering. First of all, The testing patterns for RAM fault detect, which is apt to be complicated , need to be simplified. This new testing method made use of Local Lower Bound (L.L.B) which has the memory with the beginning pattern of 0(l) and the finishing pattern of 0(1). The proposed testing patterns can detect all of RAM faults which contain stuck-at faults, coupling faults. The number of operation is 6N at 1-weight sensitive fault, 9,5N at 2-weight sensitive fault, 7N at 3-weight sensitive fault, and 3N at 4-weight sensitive fault. This test techniques can reduce the number of test pattern in memory cells, saving much more time in test, This testing patterns can detect all static weight sensitive faults and pattern sensitive faults in RAM.

• Economic and Environmental Geology
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• v.49 no.3
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• pp.243-248
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• 2016

This study was conducted to evaluate the applicability and efficiency of water supply using hydraulic ram pump. Study area is the Imgok-ri, Hwanam-myeon, Sanju-si, Kyeongsangbuk-do. There is an abandoned coal mine, where groundwater is discharged from its entrance with a flow rate of approximately $260m^3/day$. Hydraulic ram pump uses the waterhammer phenomenon and utilizes the power of falling water for pumping part of that water to a higher elevation than the water sources without electric power. To determine the efficiency of hydraulic ram pump, the flow rate was measured at three points according to the altitude difference (${\Delta}h=19m$ (point 1), 30 m (point 2), 40 m (point 3)). Flow rate measured at 1, 2, and 3 were about $8.6{\sim}10.8m^3/day$, $3.98{\sim}4.39m^3/day$, and $2.35{\sim}2.59m^3/day$, respectively. The current results suggested that, hydraulic ram pump could be applicable for the water supply system in mountain areas without external power supply.

• Korean Chemical Engineering Research
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• v.55 no.4
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• pp.520-529
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• 2017

Viscosity data were measured at 298.15 K and 308.15 K for formamide + 1-propanol, 2-propanol, 1-butanol, 2-methyl-1-propanol or 2-methyl-2-propanol mixtures. For an equimolar mixture, deviation in viscosity follows the sequence: 2-methyl-2-propanol >2-methyl-1-propanol>1-butanol>2-propanol>1-propanol. The viscosity data were further analyzed in terms of graph theory. Free energy of activation was also calculated from experimental viscosity data along with previously reported excess volume data. The deviation in viscosity and free energy of activation were fitted to Redlich-Kister polynomial equation. The viscosity data were also correlated by correlations like Grunberg-Nissan, Tamura-Kurata, HindMcLaughlin-Ubbelohde, and Katti-Chaudhari relation. Various adjustable parameters, $G_{12}$, $T_{12}$, $H_{12}$, and $W_{vis}/RT$, of various correlations were used to predict viscosity deviation of binary mixtures. Positive value of $G_{12}$ indicates strong interaction in the studied systems. Grunberg-Nissan relation has lowest deviation among the four correlations for formamide + 1-propanol or 2-propanol mixtures; and for mixtures of formamide with 1-butanol or 2-methyl-1-propanol, TamuraKurata has lowest deviation. Grunberg-Nissan gives lowest deviation for formamide + 2-methyl-2-propanol mixtures.

• Journal of Korea Technology Innovation Society
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• v.19 no.4
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• pp.711-735
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• 2016

Drug Development is very important for promoting public health and pharmaceutical industry. There has been many studies on the efficiency of drug development, but there are few studies on the drug development R&D performed by government. Since CCR model assumes unidirectional influence of input and output, it is not appropriate to analyze the efficiency of R&D due to the time-lag and spill-over effect. Also, BBC model which assumes variable returns to scale has difficulty in deriving priorities between decision making units. Recently, Range Adjusted Measure (RAM) model has been suggested in R&D efficiency analysis. RAM model measures the efficincy by eliminating inefficiencies under variable returns to scale assumption, and its strong monotonicity enables to provide clear priorities between decision making units. In this study, we analyzed the efficiency of national R&D programs for drug development using the two-step approach, including RAM model and Tobit regression analysis, and discussed major policy implications.

• Clinical and Experimental Pediatrics
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• v.65 no.5
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• pp.254-261
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• 2022

Background: The use of systemic steroids for 6+ weeks in children is associated with decreased bone mineral content (BMC) and density (BMD). However, the effects of a shorter duration of use on BMD are unknown. Purpose: To determine the effect of the use of systemic steroids for 2-6 weeks on BMD and BMC in pediatric patients. Methods: Twenty-five pediatric patients (21 with tuberculosis, 2 with systemic juvenile idiopathic arthritis, 1 with inflammatory bowel disease, 1 with autoimmune hemolytic anemia) who received systemic steroids for 2-6 weeks and 25 age- and sex-matched controls were enrolled. BMC, BMD, and z scores of the whole body (WB), lumbar spine (LS), nondominant distal radius (DR), and total body less the head (TBLH) were determined by dual-energy x-ray absorptiometry at baseline, the end of steroid therapy or 6 weeks (whichever was earlier; first follow-up), and at the end of 3 months from baseline (second follow-up) in patients and at baseline in controls. The values were adjusted for confounding variables. Continuous and categorical variables were compared using Student t test and the chi-square test or Fisher exact test, respectively. Pairwise comparisons employed Bonferroni correction. Results: Statistically significant decreases in BMC, BMD, and all z scores were observed. BMC declined by 5.37%, 2.08%, 1.82%, and 2.27%, and 11.42%, 3.75%, 3.34%, and 4.17% for WB, LS, DR, and TBLH, respectively, at the first and second follow-ups, respectively. Similarly, BMD declined by 2.01%, 2.31%, 2.18%, and 1.70% and 4.59%, 3.76%, 3.14%, and 3.50% for the WB, LS, DR, and TBLH, respectively, at the first and second follow-ups, respectively. A significant negative correlation was found among bone densitometric parameters, duration, and cumulative dose. Conclusion: The use of systemic steroids for 2-6 weeks in pediatric patients decreased the BMD and BMC of trabecular and cortical bones, an effect that persisted after discontinuation.

• The KIPS Transactions:PartC
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• v.10C no.2
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• pp.233-240
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• 2003

In this paper, an improved architecture of turbo codec for IMT-2000 is proposed. The encoder consists of an interleaver using an on-the-fly type address generator and a modified shift register instead of an external RAM, and the decoder uses a decreased number of RAM. The proposed architecture is simulated with C/VHDL languages, where BER (bit-error-rate) performances are generally in agreement with previous data by varying interaction numbers, interleaver block sizes and code rates.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6871-6879
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• 2014

Background: The purpose of this study was to evaluate the potential association of five (p.P47S, p.R72P, PIN3 Ins16bp, p.R213R and r.13494g>a) polymorphisms of TP53 with the risk of developing breast cancer in North Indian Punjabi population. Methods: We screened DNA samples of 200 sporadic breast cancer patients (197 females and 3 males) and 200 unrelated healthy, gender and age matched individuals for the polymorphisms. Results: For the p.P47S polymorphism, we observed the PP genotype in 99.5% of the patients and PS genotype in only 1 patient. All the controls had the wild type PP genotype. The frequency of RR, RP and PP genotype of p.R72P was 23.5% vs 33.5%, 51.5% vs 45.5% and 25% vs 21% in patients and controls respectively. Heterozygous (RP) genotype was increased in breast cancer patients as compared to controls (51.5 vs 45.5%) and showed 1.61 fold significantly increased risk for breast cancer (OR=1.61, 95% CI, 1.01-2.58, p=0.04). In breast cancer patients the frequencies of A1A1, A1A2 and A2A2 genotypes of PIN3 Ins16bp polymorphism were 67%, 26% and 7% respectively whereas in controls the genotype frequencies were 68.5%, 27.5% and 4% respectively, with no significant difference. For p.R213R (c.639A>G), all individuals had homozygous wild type genotype. The frequencies of GG, GA and AA genotypes of TP53 r.13494g>a polymorphism were 62 vs 67.5%, 33 vs 28% and 5 vs 4.5% in patients and controls respectively, again without significant difference. We observed that RP-A1A1 genotype combination of p.R72P and PIN3 Ins16bp and RP-GG combination of p.R72P and r.13494g>a polymorphism showed significant risk of breast cancer (OR=1.65, 95%CI: 0.98-2.78, p=0.05; OR=1.72, 95%CI: 1.01-2.92, p=0.04). Conclusion: The results of present study indicated that among the five TP53 polymorphisms investigated, the p.R72P polymorphism, and the RP-A1A1 and RP-GG genotype combination contribute to breast cancer susceptibility in North Indians.