• Title/Summary/Keyword: RAGE

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The Effects of LR3 and SP6 Acupuncture on Liver Damage of Streptozotocin-induced Diabetic Mice (태충혈과 삼음교혈의 침 자극이 Streptozotocin으로 유발된 당뇨쥐의 간 손상에 미치는 영향)

  • Kim, Sung Jin;Lee, Yun Kyu;Lee, Hyun Jong;Kim, Jae Soo
    • Journal of Acupuncture Research
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    • v.33 no.3
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    • pp.29-43
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    • 2016
  • Objectives : The purpose of this study was to investigate the effect of LR3 and SP6 acupuncture on liver damage of streptozotocin-induced diabetic mice. Methods : Male ICR mice were divided into four groups, consisting of the normal mice group(N), acupuncture-free diabetic mice group(Con), LR3-acupuncture diabetic mice group(LR3) and SP6-acupuncture diabetic mice group(SP6). The following measurements were taken: Body weight, food intake and water intake for 2 weeks; liver weight, and glucose levels in the serum and liver; ALT and AST in the serum; reactive oxygen species(ROS), reduced glutathione(GSH) and oxidized glutathione(GSSG) in the liver; and lastly, receptor for advanced glycation endproducts( RAGE), $N{\varepsilon}-carboxymethyl$ lysine(CML), $N{\varepsilon}-carboxyethyl$ lysine(CEL), phosphorylation of inhibitory kappa B alpha($p-I{\kappa}B{\alpha}$), nuclear factor-kappa B($NF-{\kappa}B$), activator protein-1(AP-1), cyclooxygenase-2(COX-2), inducible nitric oxide synthase(iNOS), tumor necrosis factor-alpha($TNF-{\alpha}$), ${\beta}-actin$, cytochrome c and caspase in the liver. Results : The liver weight and GSH/GSSG ratio were significantly increased in SP6 compared to Con. The glucose levels in the liver were significantly decreased in LR3 compared to Con. The generation of ROS and GSSG were significantly decreased in SP6 compared to Con. The expressions of RAGE, CML, AP-1, $TNF-{\alpha}$, cytochrome c and caspase 3 were significantly decreased in LR3 compared to Con. The expressions of $p-I{\kappa}B{\alpha}$, $NF-{\kappa}B$, AP-1, COX-2, iNOS and caspase 3 were significantly decreased in SP6 compared to Con. Conclusion : It is predicted that LR3 acupuncture is related to reduced glucose levels in the liver and expressions of AGE, and that, SP6 acupuncture is related to reduced oxidative stress-related transcription factors and inflammation-related proteins. Therefore, we suggest that LR3 and SP6 acupuncture have protective effects on the liver of streptozotocin-induced diabetic mice by preventing apoptosis.

Three-Dimensional Brain Surface Rendering Imaging of Cortical Dysplasia (뇌피질 이형성증의 3차원 뇌표면 연출영상)

  • Hwang, Seung-Bae;Kwak, Hyo-Sung;Lee, Sang-Yong;Jin, Gong-Yong;Han, Young-Min;Chung, Gyung-Ho
    • Investigative Magnetic Resonance Imaging
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    • v.14 no.2
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    • pp.126-133
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    • 2010
  • Purpose : The study was to evaluate the localization of the abnormal gyral and sulcal patterns obtained by means of brain surface rendering imaging. Materials and Methods : Nineteen patients with cortical dysplasia who underwent brain surface rendering MR imaging were included in this study. We acquired MP-RAGE sequence and created the 3-D surface rendering MR images by using $VoxelPlus^{(R)}$. Anatomical locations and configurations of abnormal gyri and sulci were reviewed. Results : Abnormal gyral and sulcal patterns were seen 18 in 19 patients. The configuration and orientation of affected gyri and sulci were clearly evaluated in the brain surface rendering images. In a lissencephaly, the a cortex was not delineated and showed markedly thick and smooth gyral pattern. In a schizencephaly, there were wheel shaped broad gyral pattern around the cleft. In a hemimegalencephaly, an affected hemisphere were enlarged and displayed thick and wide gyral pattern. In CBPS, the insular cortex was exposed and the gyri of the lesion were thickened. In focal cortical dysplasia, there were irregular serrated or thick and enlarged gyri. Conclusion : Brain surface rendering MR imaging is useful for the evaluation of a detailed gyral pattern and accurate involvement site of abnormal gyri.

Investigation on the Egg Quality of the Ostrich Farming in Korea (우리 나라 농장 사육 타조 알의 난질 조사)

  • Song, Kwang-Taek;Oh, Hong-Rock
    • Korean Journal of Agricultural Science
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    • v.29 no.1
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    • pp.44-54
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    • 2002
  • The fresh eggs of African ostrich in Korea were used in this study to investigate their interior and exterior quality characteristics. In ostrich egg shape characteristics, long and short length were measured as 15.1~16.1 cm and 12.1~13.6 cm, respectively. The egg shape index was calculated as 81.0 and the egg shell showed a more g loss white in color than that of hen egg. Calculated breaking strength of egg shell and egg shell surface based on the equation were $41.155kg/cm^3$ and $804.7cm^2$, respectively. Average egg shell thickness including egg shell membrane was 1.89 mm and there are no differences among parts of the shell. The egg shell membrane thickness was 0.10 mm showing relatively thick in equator compared with that of blunt end. The ave rage number of egg shell pores was counted as $19.7/cm^2$ showing relatively high number of egg shell pores at point end and the total number of egg shell pores in an egg was estimated as 15,241. The relative port ion of each parts based on egg weight was estimated as 25.1% for egg yolk, 58.2% for egg white, 16.7% for egg shell and the ratio of egg yolk to egg white (Y/W) was 0.43. The average diameter and the ave rage height of ostrich egg white were 19.7 cm and 13.2 mm, respectively. Calculated the H.U (Haugh Unit) was -69.7 and the pH was 8.3. In ostrich egg yolk, the diameter, the height, the egg yolk index, and it's pH were calculated as 14.4 cm, 29.4 mm, 0.20, and 6.6, respectively. And the egg yolk color showed a more thin in yellow chroma compared with that of hen egg as due to it's thicker membrane.

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Envy and Jealousy in Roth's The Dying Animal and Bumshin Park's Eungyo (젊음에 대한 시기와 질투: 로스의 『죽어가는 동물』과 박범신의 『은교』를 중심으로)

  • Oh, Bonghee
    • Cross-Cultural Studies
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    • v.49
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    • pp.151-179
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    • 2017
  • This paper explores envy and jealousy caused by conflicts between youth and old age in Philip Roth's The Dying Animal and Bumshin Park's Eungyo. In Roth's Novel, David became envious and jealous of a fictional man when he imagined "the pornography of jealousy." In this pornography, his imagined rival was a young man who was once David himself but was no longer young who might steal Consuela away from him. In this sense, David's envy towards this young rival can be called "self-envy." David considered sex an act of revenge on death. But his envy and jealousy undermined his power and effect. In Eungyo, envy and jealousy arose between Lee and Seo when they came into conflict because of Lee's literary talent and Eungyo. At first, Seo admired Lee. But he grew envious of Lee's talent when he gained popularity and success by publishing Lee's novels under his own name. He was engulfed in jealousy when he detected Lee's sexual desire for Eungyo. He even insulted Lee's old age, which enraged Lee. Lee's rage was mixed with his envy toward the young and his sense of betrayal against Seo. With Seo's death, all these negative feelings disappeared. Instead, Lee was captivated by the pulsing breath of life and its beauty he observed in Eungyo.

Five-stage Anger Model Approach to Narrative and Protagonist's Revolt Action Mechanism in the Movie, "The Man Standing Next" ('분노의 5단계 모델'관점의 영화 <남산의 부장들> 서사와 주인공의 거사 결행 기제)

  • Kim, Jeong-Seob
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.3
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    • pp.285-294
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    • 2020
  • "The Man Standing Next" was a 'anger-character movie' that shows a fierce psychological game between the characters. Inspired by this point, it was analyzed the narrative structure of this film based on scene unit applying the 'Five-stage Anger Model' formulated by Lakoff and Kövecses and others. The results showed that the causality and feasibility of the protagonist's anger behavior were highly reflected above the model. In particular, among the five steps, the film-maker spent the longest time on 'anger control' justifying the hero's motivation for punishment or retaliation, while giving the shortest time to 'loss of control' to maximize the urgentness of the punitive actions. The detonator causing his anger at each stage was disposed two to six times each stage with neglect, contempt, arrogance, ostentation, mockery, unauthorized intervention, etc. Sneering of "Chief Security Officer" and insulting of "The President" make the protagonist feel the scorn of a terrible friend-murderer each functioned as a "rage trigger." In conclusion, the film follows the above sophisticated model in its narrative structure. Though it was a political drama that sets up a lot of anger scheme caused from public reasons, it reflects ordinary people's routine anger, which corresponds to 24 percent of the list of Nobaco's Provocation Inventory (PI). The producers elaborately reflected the anger procedure theory and balanced the public and private drivers of rage. It was considered to be derived from the intention to enhance communication with the audience increasing their understanding and aspiration for political movie that are usually heavy and unfamiliar.

Grain Evolution during Bulge Blow forming of AZ31 Alloy (AZ31 합금의 온간 부풀림 성형시 결정립 변화에 관한 연구)

  • Baek, S.G.;Lee, Y.S.;Lee, J.H.;Kown, Y.N.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2008.10a
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    • pp.452-455
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    • 2008
  • In the present study, blow forming characteristics of commercially roiled AZ31 alloy sheets were investigated. Two different kinds of AZ31 sheets were originally fabricated by using direct casting and strip casting methods respectively. Both sheets have similar grain sizes of about $7{\mu}m$ with a relatively equiaxed structure after rolling. A series of tensile tests were carried out to get flow behavior in terms of temperature and strain rate. Also, grain size effect was investigated by annealing as-received sheet at elevated temperatures. Elongation increased with temperature increment as well expected. However, the differences in tensile test condition did not give much difference in elongation even at the temperature range where a large elongation would be expected with such as fine grain of $7{\mu}m$. Blow forming experiments showed that forming condition did not result in higher difference in dome height. However, the interesting feature from this study was that formability of this AZ31 alloy got different with stress condition. Firstly, biaxial stress condition might result in lower temperature and strain rate dependencies compared to uniaxial tension results for both DC and SC sheets. Secondly, DC showed slower grain growth in uniaxial tension than in biaxial stress state while SC has much higher grain growth rage in uniaxial tension than in bulging.

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Observations on Normal Body Temperatures in Differently Climate Conditions

  • Nguyen, My-Hang;Hiromi Tokura
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.406-408
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    • 2002
  • In order to know the characteristics of circadian rhythms in core temperature in tropical inhabitants, we measured rectal temperatures every 10 min for 24 hrs in 6 Vietnamese, 20 - 22 yrs (5 males and I females) under natural conditions. Average light intensity was 16000 lx. Ambient temperatures ranged from 33 to 36 oC. These data obtained were compared with those in Japanese setters and the Polish inhabitants. The participants were sitting mostly during wakefulness and lying in bed during sleep. The results obtained are summarized as follows: I) The average maximum value was 37.7 oC, which was significantly higher than in the Japanese and Polish as well. 2) The average minimum value was 36.4 oC, which was also lower. 3) A range of oscillation was 1.3 oC, which was clearly greater than in the people living in the temperate areas. The higher maximum value of core temperature, which was actively regulated under warm temperature, seemed of adaptive significance in order to reduce water consumption. A greater rage of oscillation in tropical Vietnamese people might have ecological significance for efficient acclimatization in the environment with strong light intensity and high ambient temperature, suggesting that the setpoint of core temperature could show a greater range of oscillation.

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A Study on Improvements and Types of Accidents of Kindergarten in Cheongju, Chung-buk Area (충북 청주지역 유치원 내 안전사고 현황과 개선에 관한 연구)

  • Jung, Eu-Gene;Jung, Jin-Ju
    • Journal of the Korean Institute of Rural Architecture
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    • v.16 no.3
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    • pp.1-8
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    • 2014
  • Nowadays, the degree of women participation in society is increasing due to modern society's industrialization and urbanization. Already enrollment of kingdergarten is nearly 30 percent higher already since 2005. Moreover, the figure is swing upward this 2014. therefore, including nursery and day care center have to consider to the highest rate. On the other hand, toddlers in our country spend most of their time in the kindergarten center. So people have to take look at possibility of accidents and we are aware about it. As a result, It was announced that the standard of education for the prevention of accident should be implemented in the toddler's facilities. Despite of accompanying education, The percentage of infant's accident is consistently growing every year. in accordance with that, we need to study about architectural planning considering the rage of the activities for child. Externally, infant safety training is being implemented on current regulation. but, the standard of toddler safety is not internally executed in that facilities. In this study, I analyzed the types of toddler's accident on statistics. I visited different web sites about kindergarten and I also made a research through an interview with a preschool teacher.

An Implementation of a RFID Reader Firmware for EPC Class 1 Generation 2 Specification (EPC Class 1 Generation 2 규격에 적합한 리더 펌웨어 개발)

  • Choi, Il-Ho;Bae, Sung-Woo;Jung, Myung-Sub;Jang, Byung-Jun;Kim, Jun-O;Park, Jun-Seok;Seong, Yeong-Rak;Oh, Ha-Ryoung
    • Proceedings of the IEEK Conference
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    • 2005.11a
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    • pp.1063-1066
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    • 2005
  • In this paper, we developed the UHF RFID system for EPC Class1 Generation 2 specification. The RFID is a technique of identifying an object using radio frequency transmission. UHF band RFID system communication between Reader and Tag for provide the power to tag when be active when reader’s command finished the transfer. RFID technology can be applied to the supply chain, security, logistics industry and etc. Especially, UHF RFID is worth noticing because of its relatively long identification rage and commercial UHF RFID systems are under development.

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Annealing Effect on the Crystal Structure of $TiO_2$ Thin Film (이산화티타늄 박막의 열처리에 따른 결정구조 분석)

  • Kim, Seon-Hoon;Yang, Myung-Hak;Kim, Tae-Un;Ki, Hyun-Chul;Kim, Doo-Gun;Han, Myung-Soo;Ko, Hang-Ju;Kim, Hyo-Jin;Kim, Hwe-Jong
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2009.06a
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    • pp.213-213
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    • 2009
  • Titanium dioxide ($TiO_2$) thin films were prepared on glass substrates by ion-assisted electron-beam evaporation with 200nm thickness and subsequently crystallized by rapid thermal annealing at the rage of $200{\sim}700^{\circ}C$ in flowing $N_2$ gas. The crystal structure of the films were examined by X-ray diffractometer. As-deposited $TiO_2$ films were amorphous. After annealing, anatase and rutile phase of $TiO_2$ films were observed together.

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