• 한국지반공학회논문집
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• 제35권12호
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• pp.35-44
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• 2019

본 연구에서는 수직증축 공동주택 하부 신설 보강말뚝의 축강성(K_vr)을 기존말뚝의 열화를 고려한 이론적인 접근과 수치해석을 통하여 산정하였다. 3차원 유한요소 수치해석을 수행하는 과정에서, 이론적인 접근과 38본의 시험 말뚝계측 결과를 통하여 제안된 열화를 고려한 기존말뚝 축강성(K_ve)의 상한 값을 적용하였다. 이를 통해, 수직증축 리모델링으로 인하여 증가된 하중을 안정적으로 지지하기 위한 신설 보강말뚝의 최소 축강성을 산정하였다. 신설 보강말뚝의 축강성 제안은 선단지지 말뚝과 마찰말뚝에 대해 수행하였고, 다양한 세장비(L/D)에 따라 제안하였다. 해석기법은 기존말뚝의 설계 당시의 양호한 상태를 고려한 말뚝지지 전면기초 거동 해석과 열화가 고려된 기존말뚝의 축강성을 적용한 말뚝지지 전면기초 거동 해석을 수행하였다. 두 해석기법에 대한 검증을 수행한 결과 말뚝지지 전면기초 거동해석이 가능한 것으로 확인되었고, 이를 통하여 기존말뚝의 열화가 발생하였을 때 선단지지 신설 보강말뚝 축강성이 44 - 67% 증가되어야 수직증축 구조물의 안정성이 확보됨을 알 수 있었다.

• 한국지반공학회논문집
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• 제35권12호
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• pp.25-33
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• 2019

본 연구에서는 수직증축 구조물의 기존말뚝의 축강성(K_ve)을 이론적인 접근과 현장 계측 결과를 바탕으로 추정하였다. 이론적인 접근에는 Randolph와 Wroth(1978)가 제안한 축강성 공식을 적용하여, 지중에 설치된 강성 및 연성말뚝의 세장비(L/D)에 따른 축강성의 범위를 도출하였다. 여기에, 1995 - 1997년 사이에 설치된 38본 말뚝의 계측된 시공 당시 축강성을 이론적으로 도출한 축강성 범위에 중첩해서 고려하였다. 이를 통하여, 노후화와 열화에 의하여 감소한 기존말뚝의 축강성의 최대값을 세장비에 따라 제안하였고, 도출된 값을 통계적인 기법을 통하여 상위 95% 값을 제안하여 신설 보강말뚝 설계 시 필요한 최소 축강성(K_vr)을 산정하는 데에 활용할 수 있도록 하였다.

• Earthquakes and Structures
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• 제15권3호
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• pp.335-350
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• 2018

This paper presents numerical modelling, modal testing, finite element model updating, linear and nonlinear earthquake behavior of a reinforced concrete building model. A 1/2 geometrically scale, two-storey, reinforced concrete frame model with raft base were constructed, tested and analyzed. Modal testing on the model using ambient vibrations is performed to illustrate the dynamic characteristics experimentally. Finite element model of the structure is developed by ANSYS software and dynamic characteristics such as natural frequencies, mode shapes and damping ratios are calculated numerically. The enhanced frequency domain decomposition method and the stochastic subspace identification method are used for identifying dynamic characteristics experimentally and such values are used to update the finite element models. Different parameters of the model are calibrated using manual tuning process to minimize the differences between the numerically calculated and experimentally measured dynamic characteristics. The maximum difference between the measured and numerically calculated frequencies is reduced from 28.47% to 4.75% with the model updating. To determine the effects of the finite element model updating on the earthquake behavior, linear and nonlinear earthquake analyses are performed using 1992 Erzincan earthquake record, before and after model updating. After model updating, the maximum differences in the displacements and stresses were obtained as 29% and 25% for the linear earthquake analysis and 28% and 47% for the nonlinear earthquake analysis compared with that obtained from initial earthquake results before model updating. These differences state that finite element model updating provides a significant influence on linear and especially nonlinear earthquake behavior of buildings.

• Journal of Microbiology and Biotechnology
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• 제24권12호
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• pp.1744-1754
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• 2014

The hepatitis C virus (HCV) RNA genome is replicated by an RNA replicase complex (RC) consisting of cellular proteins and viral nonstructural (NS) proteins, including NS5B, an RNA-dependent RNA polymerase (RdRp) and key enzyme for viral RNA genome replication. The HCV RC is known to be associated with an intracellular membrane structure, but the cellular components of the RC and their roles in the formation of the HCV RC have not been well characterized. In this study, we took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with HCV NS5B. Co-immunoprecipitation and co-localization studies confirmed the interaction between stomatin and NS5B. We demonstrated that the subcellular fraction containing viral NS proteins and stomatin displays RdRp activity. Membrane flotation assays with the HCV genome replication-competent subcellular fraction revealed that the HCV RdRp and stomatin are associated with the lipid raft-like domain of membranous structures. Stomatin silencing by RNA interference led to the release of NS5B from the detergent-resistant membrane, thereby inhibiting HCV replication in both HCV subgenomic replicon-harboring cells and HCV-infected cells. Our results identify stomatin as a cellular protein that plays a role in the formation of an enzymatically active HCV RC on a detergent-resistant membrane structure.

• 한국지반신소재학회논문집
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• 제17권2호
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• pp.1-7
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• 2018

해안지대나 습지와 같은 연약지반에 도로나 철도 건설이 빈번해지면서 이를 위한 연약지반 개량 사례가 증가하고 있다. 일반적으로 연약지반 개량시 작업조건만을 고려하거나 경제성만을 고려한 공법은 다수 존재하나 작업조건과 경제성을 함께 고려할 경우 적용 가능한 공법은 제한적이다. 이러한 경우 표층부와 심층부를 병용하여 개량하는 공법이 적용되어지는데, 이에 대한 기초적인 연구가 부족한 현실이다. 따라서, 본 연구에서는 연약지반에서 표층부 개량과 심층부 개량을 병용하는 경우에 대해 모형시험을 수행하여 지오그리드 보강 효과를 확인하고자 하였으며, 이때 표층부의 두께, 심층부 개량체의 직경 및 길이가 지오그리드 보강 효과에 미치는 영향을 파악하고자 하였다. 그 결과 표층부의 두께가 심층부의 직경보다 보강효과가 크다는 것을 확인하였고, 또한 표층부를 지오그리드로 보강한 경우 표층부의 강도가 증진되어 침하량이 저감됨을 확인하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권4호
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• pp.249-256
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• 2003

The lack of sufficient oral mucosa available for intra-oral reconstruction has been dealt with by the use of skin or oral mucosa grafts harvested from donor sites but grafts requires more than one surgical procedures and could cause donor site morbidity. Many investigators have attempted to increase available soft tissue by tissue engineered skin or oral mucosa replacements for clinical applications. But, reconstructed mucosa by several methods have low physical properties such as rolling and contraction. The aims of this study were to develope an in vitro experimental model that maintains an epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally cultured oral mucosa embedded with Polydioxanone mesh by histological and immunohistochemical analysis. The results were as follows; 1. Oral mucosa reconstructed by three-dimensional organotypic culture revealed similar morphologic characteristics to equvalent normal oral mucosa in the point that they show stratification and differentiation. 2. The expression of cytokeratin 10/13 and involucrin in the cultured tissue showed the same pattern with normal oral mucosa suggesting that organotypic co-culture condition is able to induce cellular differentiation. 3. After insertion of polydioxanone mesh, increased tensile strength were observed. These results suggest that three-dimensional organotypic co-culture of the oral mucosa cell lines with the dermal equvalent consisting type I collagen and fibroblasts reproduce the morphologic and immunohistochemical characteristics similar to those in vivo condition. And increased physical properties by use of polydioxanone mesh will helpful for clinical applications.

• 한국수산과학회지
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• 제5권1호
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• pp.17-22
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• 1972

본 시험은 일본 Miyagi Ken 굴 연구소에서 1969년 채묘된 O. lurida 및 C. angulata를 항공편으로 우송하여 1970년 1월 20일부터 12월까지 경남 거제군 하청면 연구리 옥계지선에서 수하식으로 성육시켜 조사한 것이며 그 결과는 다음과 같다. 1. O. lurida는 평균 각고 36.4mm 각장 29,5mm인 둥근모양으로서 소형굴로 자랐고, C. angulata는 각고 87.4mm, 각장 52.3mm인 타원형으로서 대형굴 형태로 성장했다. 2. O. lurida, C. angulata는 다같이 수온이 $16^{\circ}C$ 이상일 때 6, 7월시에 성장도가 좋았으며, 이때의 비중은 $1.01717\~1.02368$ 사이였다. 3. 각고 각장간의 상대적인 변화는 O. lurida는 년간 큰 차가 없었으나, C. angulata는 7월에서부터 현저한 차를 이루어 11월에 35.8mm로 그 차가 가장 컸다. 4. 치사율은 O. lurida는 $35.2\%$였으며, C. angulata는 $21.7\%$를 나타냈다.

• Coupled systems mechanics
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• 제6권3호
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• pp.229-249
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• 2017

A new technique to mitigate irregular buildings with soil structure interaction (SSI) effect subjected to critical seismic waves is presented. The L-shape in plan irregular building for various reasons was selected, subjected to seismic a load which is a big problem for structural design especially without separation gap. The L-shape in plan building with different dimensions was chosen to study, with different rectangularity ratios and various soil kinds, to show the effect of the irregular building on the seismic response. A 3D building subjected to critical earthquake was analyzed by structural analysis program (SAP2000) fixed and with SSI (three types of soils were analyzed, soft, medium and hard soils) to find their effect on top displacement, base shear, and base torsion. The straining actions were appointed and the treatment of the effect of irregular shape under critical earthquake was made by using tuned mass damper (TMD) with different configurations with SSI and without. The study improve the success of using TMDs to mitigate the effect of critical earthquake on irregular building for both cases of study as fixed base and raft foundation (SSI) with different TMDs parameters and configurations. Torsion occurs when the L-shape in plan building subjected to earthquake which may be caused harmful damage. TMDs parameters which give the most effective efficiency in the earthquake duration must be defined, that will mitigate these effects. The parameters of TMDs were studied with structure for different rectangularity ratios and soil types, with different TMD configurations. Nonlinear time history analysis is carried out by SAP2000 with El Centro earthquake wave. The numerical results of the parametric study help in understanding the seismic behavior of L-shape in plan building with TMDs mitigation system.

• Nuclear Engineering and Technology
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• 제52권2호
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• pp.397-416
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• 2020

Investigations of the commercial aircraft impact effect on nuclear island infrastructures have been drawing extensive attention, and this paper aims to perform the safety assessment of Generation III nuclear power plant (NPP) buildings subjected to typical commercial aircrafts crash. At present Part II, based on the verified finite element (FE) models of aircrafts Airbus A320 and A380, as well as the NPP containment and auxiliary buildings in Part I of this paper, the whole collision process is reproduced numerically by adopting the coupled missile-target interaction approach with the finite element code LS-DYNA. The impact induced damage of NPP plant under four impact locations of containment (cylinder, air intake, conical roof and PCS water tank) and two impact locations of auxiliary buildings (exterior wall and roof of spent fuel pool room) are evaluated. Furthermore, by considering the inner structures in the containment and raft foundation of NPP, the structural vibration analyses are conducted under two impact locations (middle height of cylinder, main control room in the auxiliary buildings). It indicates that, within the discussed scenarios, NPP structures can withstand the impact of both two aircrafts, while the functionality of internal equipment on higher floors will be affected to some extent under impact induced vibrations, and A380 aircraft will cause more serious structural damage and vibrations than A320 aircraft. The present work can provide helpful references to assess the safety of the structures and inner equipment of NPP plant under commercial aircraft impact.

• Journal of Acupuncture Research
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• 제25권6호
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• pp.23-33
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• 2008

Objectives : The study was accomplished to find out how korean medical doctor take oriental medical service for hypertension patients in clinical practice Methods : Survey questions were developed based on consensus of 2 clinician, 2 oriental internal medicine specialist and 1 acupuncture specialist. The list of the Korean oriental medical doctors is provided by the Association of the Korean Oriental Medicine. The questionnaire were distributed via E-mail to 9,465 members of Korean oriental medical doctors from 19th August 2008 to 11th September 2008. One thousand sixty three(11.24% of 9,465) members completed answer and the computerized data were analyzed by SAS statistical program Results : Fifty-one percent of Korean oriental medical doctors has experienced hypertension treatment. The most common medical diagnosis method was pattern diagnosis(64.2%). Saam and five element acupuncture were as frequent as 32.3% of acupuncture prescription principle. The most common acupuncture points were region of shoulder and back acupoints inclued $GB_{21}$, $GV_{14}$(25%). The most common herbs prescription principle were 'constitution prescription'(35.4%), 'pattern prescription'(12.6%). The most common opinion for the revitalization of oriental medical service were 'medical insurance system of herbal medicine'(28.8%) and 'research of oriental medical treatments in hypertensive patients'(26.8%). Conclusions : This survey provides unique insight into the perception, treatment method of the Korea medical doctor at oriental medical service for hypertension patient. This study provides a wealth of information and a fresh raft of questions which will inform future research and policy-making.