• Journal of the Korean Geotechnical Society
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• v.35 no.12
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• pp.35-44
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• 2019

In this study, the axial stiffness of reinforcing piles (K_vr) for the vertical extension remodeling structures was estimated through 3D finite element analysis. In the computation of the minimum required axial stiffness of reinforcing piles, proposed maximum axial stiffness of old and deteriorated existing piles (K_ve) based on theoretical and experimental approaches will be applied. Through this, the required increase rate of axial stiffness of reinforcing piles in order to support the increased structural loading was proposed for end-bearing and friction piles by different slenderness ratio (L/D). The numerical model was validated by comparing the computed results with actual field measurements. Based on the computed results, it was concluded that the end-bearing reinforcing pile needs 44% - 67% increase in axial stiffness to deal with the deterioration of existing piles and support the additional structural load due to vertical extension remodeling.

• Journal of the Korean Geotechnical Society
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• v.35 no.12
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• pp.25-33
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• 2019

In this study, the axial stiffness of existing piles (K_ve) of vertical extension remodeled building was quantified through theoretical and experimental approaches. Theoretically induced upper and lower boundary of the pile axial stiffness was estimated by using the formula proposed by Randolph and Wroth (1978), which can estimate the axial stiffness of rigid and flexible pile subjected under soil confinement. In addition, 38 cases of field measurement data on deteriorated piles with various diameters constructed in the period between 1995 - 1997 were taken in to account by overlapping the field data with the theoretical boundary of the axial stiffness. Through this the maximum axial stiffness of existing pile due to deterioration and long service time was presented for various slenderness ratio (L/D), which can be used in estimating the necessary axial stiffness of reinforcing piles(K_vr) for the vertical extension remodeling. The lower 95% value of the estimated axial stiffness of existing pile will be induced through statistical processing.

• Earthquakes and Structures
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• v.15 no.3
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• pp.335-350
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• 2018

This paper presents numerical modelling, modal testing, finite element model updating, linear and nonlinear earthquake behavior of a reinforced concrete building model. A 1/2 geometrically scale, two-storey, reinforced concrete frame model with raft base were constructed, tested and analyzed. Modal testing on the model using ambient vibrations is performed to illustrate the dynamic characteristics experimentally. Finite element model of the structure is developed by ANSYS software and dynamic characteristics such as natural frequencies, mode shapes and damping ratios are calculated numerically. The enhanced frequency domain decomposition method and the stochastic subspace identification method are used for identifying dynamic characteristics experimentally and such values are used to update the finite element models. Different parameters of the model are calibrated using manual tuning process to minimize the differences between the numerically calculated and experimentally measured dynamic characteristics. The maximum difference between the measured and numerically calculated frequencies is reduced from 28.47% to 4.75% with the model updating. To determine the effects of the finite element model updating on the earthquake behavior, linear and nonlinear earthquake analyses are performed using 1992 Erzincan earthquake record, before and after model updating. After model updating, the maximum differences in the displacements and stresses were obtained as 29% and 25% for the linear earthquake analysis and 28% and 47% for the nonlinear earthquake analysis compared with that obtained from initial earthquake results before model updating. These differences state that finite element model updating provides a significant influence on linear and especially nonlinear earthquake behavior of buildings.

• Journal of Microbiology and Biotechnology
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• v.24 no.12
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• pp.1744-1754
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• 2014

The hepatitis C virus (HCV) RNA genome is replicated by an RNA replicase complex (RC) consisting of cellular proteins and viral nonstructural (NS) proteins, including NS5B, an RNA-dependent RNA polymerase (RdRp) and key enzyme for viral RNA genome replication. The HCV RC is known to be associated with an intracellular membrane structure, but the cellular components of the RC and their roles in the formation of the HCV RC have not been well characterized. In this study, we took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with HCV NS5B. Co-immunoprecipitation and co-localization studies confirmed the interaction between stomatin and NS5B. We demonstrated that the subcellular fraction containing viral NS proteins and stomatin displays RdRp activity. Membrane flotation assays with the HCV genome replication-competent subcellular fraction revealed that the HCV RdRp and stomatin are associated with the lipid raft-like domain of membranous structures. Stomatin silencing by RNA interference led to the release of NS5B from the detergent-resistant membrane, thereby inhibiting HCV replication in both HCV subgenomic replicon-harboring cells and HCV-infected cells. Our results identify stomatin as a cellular protein that plays a role in the formation of an enzymatically active HCV RC on a detergent-resistant membrane structure.

• Journal of the Korean Geosynthetics Society
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• v.17 no.2
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• pp.1-7
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• 2018

The number of construction of roads and railroads in soft ground such as coastal areas and wetlands is getting increased. For this reason cases that soft ground improvement is applied are increasing. In general, many ground improvement methods consider only the working conditions at the time or only economy. But if the working condition and economy are taken into consideration together, the number of applicable construction method gets limited. In such a case, a ground improvement method using both the surface layer portion and the deep layer portion is applied. But the basic research on this is still insufficient in practice. Therefore, in this study the reinforcement effect of geogrid was investigated by carrying out the model test realizing the case in which soft surface ground improvement and depth improvement are simultaneously applied. And it was intened to understand the effect of the thickness of surface layer, the diameter and length of the improvement body on the reinforcement effect of geogrid. The result showed that the effect of the surface layer thickness is greater than the effect of the deep layer diameter. Moreover, when the surface layer is reinforced with a geogrid, the strength of the surface layer part is enhanced and this effect of a geogrid reinforcement caused the reduction of surface settlement.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.4
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• pp.249-256
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• 2003

The lack of sufficient oral mucosa available for intra-oral reconstruction has been dealt with by the use of skin or oral mucosa grafts harvested from donor sites but grafts requires more than one surgical procedures and could cause donor site morbidity. Many investigators have attempted to increase available soft tissue by tissue engineered skin or oral mucosa replacements for clinical applications. But, reconstructed mucosa by several methods have low physical properties such as rolling and contraction. The aims of this study were to develope an in vitro experimental model that maintains an epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally cultured oral mucosa embedded with Polydioxanone mesh by histological and immunohistochemical analysis. The results were as follows; 1. Oral mucosa reconstructed by three-dimensional organotypic culture revealed similar morphologic characteristics to equvalent normal oral mucosa in the point that they show stratification and differentiation. 2. The expression of cytokeratin 10/13 and involucrin in the cultured tissue showed the same pattern with normal oral mucosa suggesting that organotypic co-culture condition is able to induce cellular differentiation. 3. After insertion of polydioxanone mesh, increased tensile strength were observed. These results suggest that three-dimensional organotypic co-culture of the oral mucosa cell lines with the dermal equvalent consisting type I collagen and fibroblasts reproduce the morphologic and immunohistochemical characteristics similar to those in vivo condition. And increased physical properties by use of polydioxanone mesh will helpful for clinical applications.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.5 no.1
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• pp.17-22
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• 1972

This results concerning the growth of transplanting of the oyster seed, Crassostrea angulata and Ostrea Iurida, which were transplanted from Japan by air, and cultivated by the raft suspended method at the coast of Yeongoo-Ri, Koje-Goon, located on the southern coast of Korea from January to December 1970, are as follows, 1. The mean shell height of O. lurida was 36.4mm, and the shape of the shell was round and small. On the other hand, the mean shell height of C. angulata was 87.4mm and the shell length was 52.3mm, and the shape of the shell was oval and large, 2. O. lurida and C. angulata oysters grew well when the water temperature was above $16^{\circ}C$ and the specific gravity ranged from 1.0171 to 1.0236 from June to July. 3. There was a little difference in relative valiance between shell length and height of O, lurida but significant difference was shown in C. angulata from July to November. 4. The mortality rate of O. lurida was $35.2\%$ and that of C. angulata was $21.7\%$ respectively.

• Coupled systems mechanics
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• v.6 no.3
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• pp.229-249
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• 2017

A new technique to mitigate irregular buildings with soil structure interaction (SSI) effect subjected to critical seismic waves is presented. The L-shape in plan irregular building for various reasons was selected, subjected to seismic a load which is a big problem for structural design especially without separation gap. The L-shape in plan building with different dimensions was chosen to study, with different rectangularity ratios and various soil kinds, to show the effect of the irregular building on the seismic response. A 3D building subjected to critical earthquake was analyzed by structural analysis program (SAP2000) fixed and with SSI (three types of soils were analyzed, soft, medium and hard soils) to find their effect on top displacement, base shear, and base torsion. The straining actions were appointed and the treatment of the effect of irregular shape under critical earthquake was made by using tuned mass damper (TMD) with different configurations with SSI and without. The study improve the success of using TMDs to mitigate the effect of critical earthquake on irregular building for both cases of study as fixed base and raft foundation (SSI) with different TMDs parameters and configurations. Torsion occurs when the L-shape in plan building subjected to earthquake which may be caused harmful damage. TMDs parameters which give the most effective efficiency in the earthquake duration must be defined, that will mitigate these effects. The parameters of TMDs were studied with structure for different rectangularity ratios and soil types, with different TMD configurations. Nonlinear time history analysis is carried out by SAP2000 with El Centro earthquake wave. The numerical results of the parametric study help in understanding the seismic behavior of L-shape in plan building with TMDs mitigation system.

• Nuclear Engineering and Technology
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• v.52 no.2
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• pp.397-416
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• 2020

Investigations of the commercial aircraft impact effect on nuclear island infrastructures have been drawing extensive attention, and this paper aims to perform the safety assessment of Generation III nuclear power plant (NPP) buildings subjected to typical commercial aircrafts crash. At present Part II, based on the verified finite element (FE) models of aircrafts Airbus A320 and A380, as well as the NPP containment and auxiliary buildings in Part I of this paper, the whole collision process is reproduced numerically by adopting the coupled missile-target interaction approach with the finite element code LS-DYNA. The impact induced damage of NPP plant under four impact locations of containment (cylinder, air intake, conical roof and PCS water tank) and two impact locations of auxiliary buildings (exterior wall and roof of spent fuel pool room) are evaluated. Furthermore, by considering the inner structures in the containment and raft foundation of NPP, the structural vibration analyses are conducted under two impact locations (middle height of cylinder, main control room in the auxiliary buildings). It indicates that, within the discussed scenarios, NPP structures can withstand the impact of both two aircrafts, while the functionality of internal equipment on higher floors will be affected to some extent under impact induced vibrations, and A380 aircraft will cause more serious structural damage and vibrations than A320 aircraft. The present work can provide helpful references to assess the safety of the structures and inner equipment of NPP plant under commercial aircraft impact.

• Journal of Acupuncture Research
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• v.25 no.6
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• pp.23-33
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• 2008

Objectives : The study was accomplished to find out how korean medical doctor take oriental medical service for hypertension patients in clinical practice Methods : Survey questions were developed based on consensus of 2 clinician, 2 oriental internal medicine specialist and 1 acupuncture specialist. The list of the Korean oriental medical doctors is provided by the Association of the Korean Oriental Medicine. The questionnaire were distributed via E-mail to 9,465 members of Korean oriental medical doctors from 19th August 2008 to 11th September 2008. One thousand sixty three(11.24% of 9,465) members completed answer and the computerized data were analyzed by SAS statistical program Results : Fifty-one percent of Korean oriental medical doctors has experienced hypertension treatment. The most common medical diagnosis method was pattern diagnosis(64.2%). Saam and five element acupuncture were as frequent as 32.3% of acupuncture prescription principle. The most common acupuncture points were region of shoulder and back acupoints inclued $GB_{21}$, $GV_{14}$(25%). The most common herbs prescription principle were 'constitution prescription'(35.4%), 'pattern prescription'(12.6%). The most common opinion for the revitalization of oriental medical service were 'medical insurance system of herbal medicine'(28.8%) and 'research of oriental medical treatments in hypertensive patients'(26.8%). Conclusions : This survey provides unique insight into the perception, treatment method of the Korea medical doctor at oriental medical service for hypertension patient. This study provides a wealth of information and a fresh raft of questions which will inform future research and policy-making.