• Title/Summary/Keyword: RAD6

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Ceruloplasmin Gene Expression in U-937 Cells exposed to ${\gamma}$-Irradiation and $H_2$O_2 (U-937 세포에서 방사선 및 $H_2$O_2$에 의한 ceruloplasmin의 mRNA 유전자 발현)

  • 오연경;박선영;김인규;윤병수
    • Environmental Mutagens and Carcinogens
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    • v.22 no.2
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    • pp.76-82
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    • 2002
  • In human U-937 cell exposed to ${\gamma}$-irradiation and $H_2O$$_2$, the level of mRNA efrpression in ceruloplasmin gene was measured by using comparative RT.PCR (reverse transcriptase-polymerase chain reaction). At the normal growth condition, the level of ceruloplasmin transcript was estimated as 8.2% and 0.0068% of hprt (hypoxantine phosphoribosyl transferase) transcript and of $\beta$-actin transcript, respectively. In U-937 cells exposed to a dose of 100 rad ${\gamma}$-irradiation, the level of ceruloplasmin transcript was increased about 2.7 and 1.6 fold compared to un-treated cell by using compensation with the levels of hprt and $\beta$-actin transcript. By contrast, the expression of ceruloplasmin gene in U-937 cells exposed to $H_2O$$_2$(50 $\mu$M, 24 h), was shown no significant difference compared to un-treated cell. These results indicated that the expression system of ceruloplasmin gene may react only some specific oxygen species, such as reactive oxygen species induced by ${\gamma}$-irradiation.

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Small and Large Deformation Rheological Behaviors of Commercial Hot Pepper-Soybean Pastes

  • Choi, Su-Jin;Kang, Kyoung-Mo;Yoo, Byoung-Seung
    • Food Science and Biotechnology
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    • v.15 no.6
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    • pp.871-876
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    • 2006
  • Rheological behavior of commercial hot pepper-soybean paste (HPSP) was evaluated in small amplitude oscillatory and steady shear tests. Storage modulus (G'), loss modulus (G"), and complex viscosity (${\eta}^*$) as a function of angular frequency (${\omega}$), and shear stress (${\sigma}$) as a function of shear rate (${\gamma}$) data were obtained for 5 commercial HPSP samples. HPSP samples at $25^{\circ}C$ exhibited a non-Newtonian, shear-thinning flow behavior with high yield stresses and their flow behaviors were described by power law, Casson, and Herschel-Bulkley models. Time-dependent flow properties were also described by the Weltman, Hahn, and Figoni & Shoemaker models. Apparent viscosity over the temperature range of $5-35^{\circ}C$ obeyed the Arrhenius temperature relationship with activation energies (Ea) ranging 18.3-20.1 kJ/mol. Magnitudes of G' and G" increased with an increase in ${\omega}$, while ${\eta}^*$ decreased. G' values were higher than G" over the most of the frequency range (0.63-63 rad/sec), showing that they were frequency dependent. Steady shear viscosity and complex viscosity of the commercial HPSP did not fit the Cox-Merz rule.

Result of Post Operative Radiotherapy of Carcinoma of the Rectum (직장암의 수술후 방사선치료 성적)

  • Huh S. J.;Ha S. W.;Park C. I.;Choi K. J.;Kim J. P.
    • Radiation Oncology Journal
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    • v.2 no.2
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    • pp.229-235
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    • 1984
  • Surgery remains the mainstay in the management of carcinoma of the rectum. However, local recurrence and systemic metastasis remain the challenge. It appears that post operative radiotherapy has a very definite role in the reduction of local recurrence. Minty two patients of carcinoma of the rectum after curative surgery received post operative radiotherapy $5,000rad/5\~6weeks$ to whole pelvis at the Department of Therapeutic Radiology, Seoul National University Hospital between March 1979 and December 1982. Fifty three percent of patients show modified Astler-Coiler stage C2. Actuarial disease free survival rate of rectal cancer was : stage B1, 2 $75\%$, stage C1 $81\%$ stage C2 $39\%$, and stage C3 $20\%$, Twelve percent shows local recurrence and distant metastasis occurred in $28\%$. Prognostic significance of nodal metastasis is also analysed. Incidence of small bewel obstruction, requiring surgery, is $8\%$, occurring between 5th month to 12 th month after operation. It is suggested that post operative radiotherapy of the rectal cancer following curative surgery has a significant role in the reduction of local recurrence.

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Numerical Study on the Flow Characteristics according to the Ventilation Holes Shape of the Carbon Composite Brake Disk (탄소복합재 브레이크 디스크의 통풍구 형상에 따른 유동특성에 관한 해석적 연구)

  • Ko, Dongguk;Yoon, Suckju
    • Transactions of the Korean Society of Automotive Engineers
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    • v.23 no.2
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    • pp.191-198
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    • 2015
  • In this study, the flow characteristics at the ventilation holes was analyzed by using numerical method when carbon composite brake disk was rotated at a constant speed. In order to ensure the validity of the analysis results, grid dependency test was performed by considering the accuracy and appropriateness, and 4mm mesh size was selected for decrease of the maximum error rate 63.6%. As a result, the outside air flows in the clearance between the disk and shaft in case of B model. whereas, the outside air flows in the clearance or the outlet of the ventilation holes in case of A and C models. And also average static pressure at the outlet was changed depending on shape of the ventilation holes and rotational speed of the disk in case of A and C models. Besides, in the B model, intake air according to the clearance goes with side surface of ventilation hole, and so increased by mean velocity of 4.64m/s and mean pressure of 0.58pa in the ventilation hole outlet, in case of disk rotational speed of 146.21rad/s.

Dynamic Rheological Studies on Mixtures of Hot Pepper-Soybean Paste and Xanthan Gum

  • Choi, Su-Jin;Yoo, Byoung-Seung
    • Food Science and Biotechnology
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    • v.16 no.1
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    • pp.146-149
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    • 2007
  • Dynamic rheological properties of hot pepper-soybean paste (HPSP) mixed with xanthan gum were evaluated at different gum concentrations (0.3, 0.6, and 0.9%) and fermentation times (12 and 24 week). Magnitudes of storage (G') and loss moduli (G") in the HPSP-xanthan gum mixture systems increased with an increase in frequency ($\omega$), while complex viscosity (${\eta}^*$) decreased. G' values were higher than the G" values over most of the frequency range (0.63-63 rad/sec), and were frequency-dependent. The dynamic moduli (G', G", and ${\eta}^*$) of the HPSP-xathan mixtures were lower than those of the control (0% gum). The differences between the dynamic moduli values at 12-week and 24-week fermentation decreased with increasing gum concentration, showing that xanthan gum can be used to stabilize and improve the viscoelastic rheological properties of HPSP. The G' value of the HPSP-xathan mixtures increased with an increase in gum concentration from 0.3 to 0.9%, whereas the G" decreased. The ability of xanthan gum to increase the elastic properties in the HPSP-xanthan mixture systems seemed to be the result of the incompatibility phenomena existing between xanthan gum and glutinous rice starch.

Effect of Gum Addition on the Rheological Properties of Rice Flour Dispersions

  • Chun, So-Young;Kim, Hyung-Il;Yoo, Byoung-Seung
    • Food Science and Biotechnology
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    • v.15 no.4
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    • pp.589-594
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    • 2006
  • The effect of five commercial gums (carboxylmethylcellulose, CMC; guar gum, GG; hydroxypropylmethyl-cellulose, HPMC; locust bean gum, LBG; and xanthan gum) at a concentration of 0.25% on the rheological properties of rice flour (RF) dispersions was investigated in steady and dynamic shear. The steady shear rheological properties showed that RF gum mixture dispersions (5%, w/w) at $25^{\circ}C$ had high shear-thinning flow behavior (n=0.20-0.31) exhibiting a yield stress. Magnitudes of consistency index (K), apparent viscosity (${\eta}_{a,100}$), and Casson yield stress (${\sigma}_{oc}$) of RF-gum mixtures were much higher than those of RF dispersion with no added gum (control). Activation energy values (6.67-10.8 kJ/mole) of RF-gum mixtures within the temperature range of $25-70^{\circ}C$ were lower than that (11.9 kJ/mole) of the control. Dynamic rheological data of log (G', G") versus log frequency (${\omega}$) of RF-gum mixtures had positive slopes (0.15-0.37) with G' greater than G" over most of the frequency range (0.63-63 rad/sec), demonstrating a frequency dependency. Tan ${\delta}$ (G"/G') values of RF-gum mixtures, except for xanthan gum, were much higher than that of the control.

The Mediating Effect of Dementia Recognition on the Number of Chronic Diseases and Dementia Prevention Behaviors of Elders in Rural Communities (농촌 지역사회노인의 만성질병수와 치매예방행위에 미치는 치매인식의 매개효과)

  • Park, Pilnam
    • Journal of Korean Academy of Rural Health Nursing
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    • v.15 no.2
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    • pp.41-48
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    • 2020
  • Purpose: This study was a descriptive study to identify the factors affecting the dementia prevention behavior of elders in rural communities. Methods: The participants in this study were 125 elders aged 60 or older who lived in Eup or Myeon areas of P city. For data analysis, SPSS/WIN 22.0 was used to perform descriptive statistics, t-test, ANOVA, Pearson correlation, and linear multiple regression and mediated effects. Results: Scores for dementia recognition, dementia attitude and dementia prevention behavior averaged 5.6±2.50 points in the 0~11 range, 38.8±4.59 in 14~56 and 20.2±3.59 in 10~30 respectively. Dementia recognition (a), dementia attitude (b), dementia prevention behavior (c) and the number of chronic diseases of the elders (d) were positively or negatively correlated with each other (rab=.29, p<.01; rbc=.26, p<.01; rac=.36, p<.01; rad=-.29, p<.01; rcd=.19, p<.05). Factors affecting dementia prevention behavior were dementia recognition, dementia attitude, and degree of dementia interest. When the number of chronic diseases affects dementia prevention behavior, dementia recognition has a mediating effect. Conclusion: In order to prevent dementia among elders in rural areas, appropriate management of chronic diseases and provision of appropriate dementia-related education and information to enhance dementia recognition should be provided.

A Study on the Effect of Low Pass Filter and Drive Train Damper for the NREL 5MW Wind Turbine Control (NREL 5MW 풍력터빈 제어용 저주파 통과 필터와 드라이브 트레인 댐퍼의 효과 고찰)

  • Lim, Chae-Wook
    • Journal of the Korean Society of Industry Convergence
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    • v.24 no.4_2
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    • pp.443-451
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    • 2021
  • It is essential to examine and analyze the power output and load responses together using real-world turbulent wind speeds. In this paper, the power controller and the drive train damper are simultaneously considered using the NREL 5MW wind turbine model, and the damage equivalent load(DEL) of the low speed shaft torque and power output responses according to the natural frequency of the second order low pass filter are simultaneously investigated. Numerical testing is carried out above rated wind speed using commercially available Bladed software. From the viewpoints of DEL reduction of the drive train shaft torque and power output responses, it is shown that the natural frequency of the low pass filter is appropriately about 6 to 10rad/s. And the reduction ratio of the DEL of the low-speed shaft torque decreases as the wind speed becomes higher, and it is confirmed that the reduction ratio is limited to about 20% at high wind speeds.

First Detection of 350 Micron Polarization from 3C 279

  • Lee, Sang-Sung;Kang, Sincheol;Byun, Do-Young;Chapman, Nicholas;Novak, Giles;Trippe, Sascha;Algaba, Juan-Carlos;Kino, Motoki
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.36.2-36.2
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    • 2015
  • We report the first detection of linearly polarized emission at an observing wavelength of 350 mum from the radio-loud active galactic nucleus 3C 279. We conducted polarization observations for 3C 279 using the SHARP polarimeter in the Caltech Submillimeter Observatory on 2014 March 13 and 14. For the first time, we detected the linear polarization with the degree of polarization of $13.3%{\pm}3.4%$ (3.9sigma) and the electric vector position angle (EVPA) of $34.^{\circ}7{\pm}5.^{\circ}6$. We also observed 3C 279 simultaneously at 13, 7, and 3.5 mm in dual polarization with the Korean very long baseline interferometry (VLBI) Network on 2014 March 6 (single dish) and imaged in milliarcsecond (mas) scales at 13, 7, 3.5, and 2.3 mm on March 22 (VLBI). We found that the degree of linear polarization increases from 10% to 13% at 13 mm to 350 mum and the EVPAs at all observing frequencies are parallel within < $10^{\circ}$ to the direction of the jet at mas scale, implying that the integrated magnetic fields are perpendicular to the jet in the innermost regions. We also found that the Faraday rotation measures RM are in a range of $-6.5{\times}102{\sim}-2.7{\times}103$ rad m-2 between 13 and 3.5 mm, and are scaled as a function of wavelength:| {RM}| ${\backslash}propto$ {lambda }-2.2. These results indicate that the millimeter and sub-millimeter polarization emission are generated in the compact jet within 1 mas scale and affected by a Faraday screen in or in the close proximity of the jet.

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IRRADIATION EFFECT ON SECRETING FUNCTION, AMYLASE ACTIVITY AND NUCLEIC ACID CONTENTS OF RAT PAROTID GLAND (방사선 조사가 이하선 기능에 미치는 영향에 관한 연구)

  • Cho Yong Jin;Park Tae-Won
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.20 no.1
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    • pp.53-62
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    • 1990
  • This experiment was performed to clarify the effects of /sup 60/Co gamma irradiation on secretory function, amylase activity and contents of nucleic acids of parotid gland in rat. Experimental animals were divided into 6th hours, 3rd, 7th, 14th and 28th days after irradiation and control. The experimental animals are singly irradiated with 20Gy (2,000rad) through protective lead block. Secretory function of parotid gland was evaluted by uptake and clearance of /sup 99m/TcO₄. /sup 99m/TcO₄. 0.2μ ci/gm, was injected into peritonium in uptake groups. Rats were sacrified with cervical dislocation after 30 minutes and gland was excised. In the clearance group. pilocarpine nitrate (8㎎/㎏) was intraperitoneally injected at 30 minutes after /sup 99m/TcO₄ injection and rats were sacrified 30 minutes after pilocarpine injection. Radioactivity of excised parotid gland was measured by using of gamma counter and stimulation-secretion coefficients, uptake radioactivity divided by clearance radioactivity, was calculated. Amylase activity and contents of DNA and RNA were determined by spectrophotometry. The results obtained were as follows: 1. In the uptake test, the radioactivity of /sup 99m/TcO₄ per unit weight increase in experimental group except 6th hours group, compared with control groups and showed a peak at 3rd days after irradiation. 2. In the clearance test, the radioactivity of /sup 99m/cO₄per unit weight rose to a peak at 3rd days after irradiation and gradually recovered thereafter. 3. Stimulation-secretion coefficient of parotid gland decreased at 6th hours, 3rd and 7th days after irradiation, and gradually increased. 4. Amylase activity of parotid gland decreased in 3rd and 7th days group, and especially lowest in 3rd days after irradiation. 5. The contents of DNA showed no definite difference in all the experimental groups, but RNA was seemed to decrease with time after irradiation.

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