• The Korean Journal of Physiology and Pharmacology
• /
• v.23 no.1
• /
• pp.37-45
• /
• 2019

To study the effect of nicorandil pretreatment on ketone body metabolism and Acetyl-CoA acetyltransferase (ACAT1) activity in hypoxia/reoxygenation (H/R)-induced cardiomyocytes. In our study, we applied H9c2 cardiomyocytes cell line to evaluate the cardioprotective effects of nicorandil. We detected mitochondrial viability, cellular apoptosis, reactive oxygen species (ROS) production and calcium overloading in H9c2 cells that exposed to H/R-induced cytotoxicity. Then we evaluated whether nicorandil possibly regulated ketone body, mainly ${\beta}$-hydroxybutyrate (BHB) and acetoacetate (ACAC), metabolism by regulating ACAT1 and Succinyl-CoA:3-ketoacid coenzyme A transferase 1 (OXCT1) protein and gene expressions. Nicorandil protected H9c2 cardiomyocytes against H/R-induced cytotoxicity dose-dependently by mitochondria-mediated anti-apoptosis pathway. Nicorandil significantly decreased cellular apoptotic rate and enhanced the ratio of Bcl-2/Bax expressions. Further, nicorandil decreased the production of ROS and alleviated calcium overloading in H/R-induced H9c2 cells. In crucial, nicorandil upregulated ACAT1 and OXCT1 protein expressions and either of their gene expressions, contributing to increased production of cellular BHB and ACAC. Nicorandil alleviated cardiomyocytes H/R-induced cytotoxicity through upregulating ACAT1/OXCT1 activity and ketone body metabolism, which might be a potential mechanism for emerging study of nicorandil and other $K_{ATP}$ channel openers.

• Journal of the Korean Mathematical Society
• /
• v.59 no.2
• /
• pp.353-365
• /
• 2022

Let 𝓐 be the collection of analytic functions f defined in 𝔻 := {ξ ∈ ℂ : |ξ| < 1} such that f(0) = f'(0) - 1 = 0. Using the concept of subordination (≺), we define $$S^*_{\ell}\;:=\;\{f{\in}A:\;\frac{{\xi}f^{\prime}({\xi})}{f({\xi})}{\prec}{\Phi}_{\ell}(\xi)=1+{\sqrt{2}{\xi}}+{\frac{{\xi}^2}{2}},\;{\xi}{\in}{\mathbb{D}}\}$$, where the function 𝚽_ℓ(ξ) maps 𝔻 univalently onto the region Ω_ℓ bounded by the limacon curve (9u² + 9v² - 18u + 5)² - 16(9u² + 9v² - 6u + 1) = 0. For 0 < r < 1, let 𝔻_r := {ξ ∈ ℂ : |ξ| < r} and 𝒢 be some geometrically defined subfamily of 𝓐. In this paper, we find the largest number 𝜌 ∈ (0, 1) and some function f₀ ∈ 𝒢 such that for each f ∈ 𝒢 𝓛_f (𝔻_r) ⊂ Ω_ℓ for every 0 < r ≤ 𝜌, and $${\mathcal{L} _{f_0}}({\partial}{\mathbb{D}_{\rho})\;{\cap}\;{\partial}{\Omega}_{\ell}\;{\not=}\;{\emptyset}$$, where the function 𝓛_f : 𝔻 → ℂ is given by $${\mathcal{L}}_f({\xi})\;:=\;{\frac{{\xi}f^{\prime}(\xi)}{f(\xi)}},\;f{\in}{\mathcal{A}}$$. Moreover, certain graphical illustrations are provided in support of the results discussed in this paper.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.9 no.8
• /
• pp.883-888
• /
• 2014

Simulation is now using in various area as an effective decision analysis tool in complex environment of today. But, There is a focus to the simulation model development and execution better than result analysis. This article will emphasis to the importance of result analysis apart from model development in simulation, and will use R package for profit optimization simulation. R has a various function in statistic analysis and data manipulation, graphic display. So this research can show the value of R as a tool for simulation.

• STI Policy Review
• /
• v.9 no.1
• /
• pp.1-29
• /
• 2018

With the constant growth of R&D investment, it has been increasingly necessary to evaluate the effectiveness of R&D performance and there is a high emphasis on ensuring the accountability and effectiveness of R&D programs. The evaluation of performance of a firm is especially necessary in times of economic downturn to justify R&D investment. However, there is a marked shortage of clear guidelines as to where and how particular metrics are used to measure the output and outcome of R&D activity in firms. Many firms have difficulties in selecting appropriate indicators for their R&D and financial performances. To fill this gap, this article discusses and presents the findings from the literature in such a way that they become useful for researchers or managers who are in charge of measuring the R&D and business performances arising from innovation activities. Finally, based on the findings about metrics of R&D performance, this article proposes the hypothetical framework to investigate the relationship between technology forecasting, strategic technology planning, and business performance. The framework of this article will assist policy makers, universities, research institutes/national laboratories, and companies to enhance their decision making process in technology development.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.28 no.4
• /
• pp.421-427
• /
• 1995

To know the variation in the growth of the sea urchin, Pseudocentrotus depressus according to their localities, three different populations including the culture populations, the released populations, and the wild populations were investigated using the cluster analysis. For this purpose, pigment banding pattern on the genital plate was used as an age character. The population composed of the same year class was born between September 25th and October 5th every year. The population of 9 to 10 months old had no $r_1,\;whereas\;r_1$, was observed in the population of either 1 year and 10 or 11 months old, and both $r_1,\;and\;r_2$ in the population of either 2 year and 9 or 10 months old. Therefore, $r_1,\;and\;r_2$ radius were regarded as an annual ring. Growth in the culture populations was much better than that In either the released or the wild populations. However, when the cultured populations composed of 8 to 12 mm in test diameter was released to the shove near a culture farm, its growth appeared to be similar to that of the wild Populations. The wide distribution patterns of test diameter measured from the same year class of both the cultured and the wild populations were probably due to either long spawning period or growth differences between individuals. Except Yamaguchi and Cheju populations, the move closely located populations showed the more similar growth pattern. However, the growth of Cheju population appeared to be similar to that of Aba, Mogi, Toishi rather than Kasiwazima although Cheju Island was more closely located with Kasiwazima than other localities. In addition, the population of Yamaguchi, located at the highest latitute, revealed the similar growth pattern to that of Nomozaki, located at the lowest latitute.

• The Korean Journal of Ecology
• /
• v.27 no.3
• /
• pp.165-171
• /
• 2004

Weight loss and nutrients dynamics during decomposition of oak roots (diameter classes: R₁〈0.2㎝, 0.5㎝〈R₂〈1㎝, 1㎝〈R₃〈2㎝, 2㎝.〈R₄〈4㎝) (Quercus acutissima) were studied for 33-months in Kongiu, Korea. After 33-months, decomposition rate of R₁, R₂, R₃ and R₄ was 49.6%, 47.5%, 66.4% and 66.1%, respectively. The decomposition constant(k) for R₁, R₂, R₃, and R₄ was 0.249/yr, 0.234/yr, 0.397/yr and 0.393/yr, respectively. Larger diameter class of the root lost more weight than smaller diameter class. N concentration in decomposing oak roots increased in all diameter classes. After 33-months, remaining N in R₁, R₂, R₃ and R₄ was 66.5%, 80.7%, 84.4% and 44.4%, respectively. K concentration in decomposing oak roots decreased in early part of decomposition and then increased in later stage of decomposition. After 33-months, remaining P in R₁, R₂, R₃ and R₄ was 64.7%, 62.4%, 93.1% and 30.7%, respectively. K concentration in decomposing oak roots decreased rapidly in early stage of decomposition. Remaining K in R₁, R₂, R₃ and R₄ was 11.6%, 10.6%, 5.9% and 7.7%, respectively. Ca concentration in decomposing oak roots showed different among diameter classes. After 33-months, remaining Ca in R₁, R₂, R₃ and R₄ was 66.2%, 51.0%, 39.1% and 48.3%, respectively. Initial concentration of Mg in oak root was higher in smaller diameter class. After 33-months, remaining Mg in R₁, R₂, R₃ and R₄ was 15.3%, 29.9%, 24.5% and 69.4%, respectively.

• Journal of agriculture & life science
• /
• v.45 no.6
• /
• pp.95-108
• /
• 2011

The food quality characterization and safety Japanese flying fish roe (JFF-R), capelin roe (C-R), Pacific herring roe (PH-R) were investigated. The size of JFF-R was 1.48-1.93 mm, which was longer than those of C-R and PH-R. The moisture content of JFF-R imported from Peru (JFF-R-P) was 70.3%, which was higher than that of JFF-R imported from China (JFF-R-C) (67.4%), while was lower than that of JFF-R imported from Indonesia (JFF-R-I) (83.3%). However, the salinity of JFF-R-P was 13.6%, which was lower than that of JFF-R-C, while was higher that of JFF-R-I (1.8%). The moisture contents and salinities of the other fish roes were 80.4% and 3.2%, respectively, for capalin roe, and 65.4% and 20.0%, respectively, for Pacific herring roe. According to the results of pH, volatile basic nitrogen content, heavy metal content, viable cell count and coliform group, the fish roes could be used as sanitary sources for preparation of seasoned JFF-R. The major fatty acids of fish roes were 16:0 (27.8-30.5%), 18:1n-9 (7.2-8.0%), 20:5n-3 (5.6-8.2%) and 22:6n-3 (22.0-25.6%) in JFF-R, and 16:1n-7 (6.7-9.3%) as well as these fatty acids in C-R and PH-R. Total amino acid contents of fish roes ranged from 9.44 g/100 g to 10.39 g/100 g and their major amino acids were aspartic acid, glutamic acid, leucine and lysine. The mineral content of JFF-R were higher than those of the other fish roes expected for zinc of JFF-R-I. According to the results of sensory evaluation, the color and texture of JFF-R-P were superior to those of the other fish roes. No difference was, however, found in flavor, among JFF-R-P and the other fish roes.

• Restorative Dentistry and Endodontics
• /
• v.13 no.2
• /
• pp.265-282
• /
• 1988

The pulp response of posterior composite resins in relation to the thickness of remaining dentin was studied with 120 teeth from 6 dogs, Class V. cavities were prepared on the cervical area of facial surfaces. The thickness of remaining dentin was controlled with Caries Meter$^{(R)}$. The cavities of group A were prepared to show the electrical impedance of 22-26$K{\Omega}$(thickness of remaining dentin:0.4-0.5mm). The cavities of group B, 50-55$K{\Omega}$(thickness of remaining dentin: 0.8-0.9mm). Zinc - Oxide Eugenol cement, Estilux$^{(R)}$ posterior, Heliomolar$^{(R)}$ radiopaque, P-30$^{(R)}$ and Scotchbond$^{(R)}$+P-30$^{(R)}$ were filled in each cavity. After 3days, 1 week, 2 weeks, 4 weeks, 9 weeks and 13 weeks, the teeth and pulp tissue were processed routinely and stained with Hematoxylin and Eosin. Pathological tissue changes were observed with light microscope. The following results were obtained. I. The pulp response of group A cavties was severer than that of group B cavities. 2. In the pulp of group A cavities which were filled with Zinc-Oxide Eugenol Cement, only vascular changes were observed after 3 days and 1 week, severe acute inflammation after 4 weeks, moderate acute inflammation after 9 weeks, and chronic inflammation and formation of granulation tissue after 13 weeks. 3. In the pulp of group A cavities which were filled with Estilux$^{(R)}$ posterior, only vascular changes were observed after 3 days and 1 week. But the inflammatory response has became much severer with the elapsed experimental period. 4. In the pulp of group A cavities which were filled with Heliomolar$^{(R)}$ radiopaque, the inflammatory response with the elapsed experimental period was not severer than that of the pulp of group A cavities which were filled with other materials. 5. In the group B cavities, the difference of pulp response by filling materials was not recognizable. In the group A cavities, the pulp response of Estilux$^{(R)}$ posterior was severest and in order P-30$^{(R)}$, Heliomolar$^{(R)}$ radiopaque was slighter.

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• v.9 no.2
• /
• pp.83-93
• /
• 2009

Recently, El-Naschie has shown that the notion of fuzzy topology may be relevant to quantum paretical physics in connection with string theory and E-infinity space time theory. In this paper, we study the concepts of r-fuzzy semi-I-open, r-fuzzy pre-I-open, r-fuzzy $\alpha$-I-open and r-fuzzy $\beta$-I-open sets, which is properly placed between r-fuzzy openness and r-fuzzy $\alpha$-I-openness (r-fuzzy pre-I-openness) sets regardless the fuzzy ideal topological space in Sostak sense. Moreover, we give a decomposition of fuzzy continuity, fuzzy ideal continuity and fuzzy ideal $\alpha$-continuity, and obtain several characterization and some properties of these functions. Also, we investigate their relationship with other types of function.

• Journal of Digital Convergence
• /
• v.9 no.3
• /
• pp.145-163
• /
• 2011

This study aims to mediating effects of trust on the relationships between R&D organizational culture and organizational- performance. Additionally, This study is to examine the impact of R&D organizational culture to organizational performance. The findings are as follows : First, R&D organizational culture had a significant positive effects on the organizational performance. Second, the mediating effects of trust had a significant effects on all relationships. The means that attaining trust contribute to member's attitude and organization performance, therefore supervisor should make efforts to maintain and enhance trust in organization.