• 컴퓨터교육학회논문지
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• 제14권5호
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• pp.9-18
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• 2011

컴파일러 교과목에서 수행하는 컴파일러 개발 프로젝트는 많은 경험과 기술을 얻을 수 있다. 그러나 한 학기에 이수하기 부족한 강의 시간과 컴파일러 개발의 높은 난이도 때문에 수업에 어려움을 겪는다. 그리고 컴파일러 목적시스템은 대게 인터프리터로 구현되기 때문에 학생의 흥미를 유도하기도 어렵다. 이에 따라서 컴파일러 교육은 이론 위주의 교육이 되기 쉽다. 이러한 한계를 극복하기 위하여 본 논문에서는 컴파일러의 이론과 실제를 보다 쉽게 습득할 수 있는 통합개발환경을 제시한다. 개발된 통합개발환경에는 마인드스톰 NXT 로봇을 목적시스템으로 하는 레퍼런스 컴파일러와 컴파일러 제작 도구, 목적언어 테스트 도구, 코드생성 시각화 도구가 포함되며 이클립스 플러그인 기반으로 개발되어 편의성과 확장성이 뛰어나다. 개발된 통합개발환경은 학생들이 컴파일러를 보다 쉽게 이해하고 개발할 수 있도록 도와준다.

• 한국해양학회지
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• 제26권3호
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• pp.291-294
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• 1991

이 컴퓨터는 프로그램은 생물량의 변화와 광합성율로부터 해조류의 년 생산량을 계산하기 위해 작성한 것이다. 서로 다른 광도, 온도조건 아래서 측정된 해조류의 단 위무게 당 광합성율을 광도, 수온의 년 변화와 연결시켜 광합성율의 년 변화를 계산하 였다. 이 때 해조류의 광합성율을 1년간 짧은 시간간격으로 측정한다면 좀더 정확한 값을 얻을 수 있을 것이다. 광합성율의 시간에 따른 변화를 생물량의 시간에 따른 변 화와 연결시켜 년 총생산량을 계산하였다. 어느 주어진 시간에서의 생물량을 알고 이 때의 단위무게당 광합성율을 알면 이들 값을 곱하여 이 시간에서의 총 생산량을 알 수 있기 때문이었다. 프로그램은 개인용을 이용하는데 편리하도록 파스칼 언어를 사용하 였으며, 계산결과를 데이터 베이스에 옮길 수 있도록 하여 다양한 프린터 사양을 가지게 한 것도 하나의 특징이다. 강원도 고성군 오호리에 서식하는 알쏭이 모자반을 대상으로 측정한 생물량, 광합성율의 값들을 이 프로그램에서 예로 사용하였다.

• Archives of Plastic Surgery
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• 제48권5호
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• pp.559-567
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• 2021

The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study's goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years.

• Neonatal Medicine
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• 제25권4호
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• pp.178-185
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• 2018

Purpose: We aim to assess the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III), Adaptive Behavior (AB) and Social-Emotional (SE) scales at 18 to 24 months of corrected age (CA) to examine their associations with school-age cognitive and behavioral outcomes in children born preterm. Methods: Eighty-eight infants born with a very low birth weight (<1,500 g) or a gestational age of less than 32 weeks who were admitted to the neonatal intensive care unit from 2008 to 2009 were included. Of the 88 children who completed school-age tests at 6 to 8 years of age, 37 were assessed using the Bayley-III, including the AB and SE scales, at 18 to 24 months of CA. Correlation, cross-tabulation, and receiver operating characteristic analyses were performed to assess the longitudinal associations. Results: A significant association was observed between communication scores on the Bayley-III AB scale at 18 to 24 months of CA and the Korean version of the Wechsler Intelligence Scale for Children (K-WISC) full-scale intelligence quotient (FSIQ) at school age (r=0.531). The total behavior problem scores of the Korean version of the Child Behavior Checklist (K-CBCL) at school age were significantly negatively related to the Bayley-III SE and AB scales but not to the cognitive, language, or motor scales. Conclusion: Our findings encourage AB and SE assessments during the toddler stage and have important implications for the early identification of children in need of intervention and the establishment of guidelines for follow-up with high-risk infants.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권1호
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• pp.35-40
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• 2021

Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating clinical efficacy in randomized control trials. Here, we investigate the clinical efficacy of ESDM intervention in young children with ASD in a community setting within Japan. Methods: All subjects were children with ASD who received ESDM intervention during the study period. Each ESDM session lasted 75 min and occurred once per week for at least 12 weeks. The outcome measures consisted of the Kyoto Scale of Psychological Development (K-test), Aberrant Behavior Checklist-Japanese version (ABC-J), and the Clinical Global Impression-Severity scale (CGI-S). Results: Twenty-seven subjects (29.4±6.4 months old) received ESDM intervention that lasted for 8.0±2.6 months on average. The score on Language and Social developmental quotient on the K-test increased significantly after the intervention. The total scores on the ABC-J and CGI-S significantly decreased after completion of the ESDM intervention. Conclusion: Our results suggest that ESDM intervention could reduce the severity of distinct clinical features of ASD, such as impairments in social interaction and communication assessed by the K-test, and maladaptive behavior rated by the ABC-J and CGI-S. We believe that the ESDM adapted to each institution might become one of the standard options for children with ASD in Japan.

• Journal of Microbiology and Biotechnology
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• 제32권3호
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• pp.365-377
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• 2022

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biological functions by transcriptional and translational control. mTOR is a downstream mediator in the PI3K/Akt signaling pathway and plays a critical role in cell survival. In cancer, this pathway can be activated by membrane receptors, including the HER (or ErbB) family of growth factor receptors, the insulin-like growth factor receptor, and the estrogen receptor. In the present work, we congregated an electronic network of mTORC1 built on an assembly of data using natural language processing, consisting of 470 edges (activations/interactions and/or inhibitions) and 206 nodes representing genes/proteins, using the Cytoscape 3.6.0 editor and its plugins for analysis. The experimental design included the extraction of gene expression data related to five distinct types of cancers, namely, pancreatic ductal adenocarcinoma, hepatic cirrhosis, cervical cancer, glioblastoma, and anaplastic thyroid cancer from Gene Expression Omnibus (NCBI GEO) followed by pre-processing and normalization of the data using R & Bioconductor. ExprEssence plugin was used for network condensation to identify differentially expressed genes across the gene expression samples. Gene Ontology (GO) analysis was performed to find out the over-represented GO terms in the network. In addition, pathway enrichment and functional module analysis of the protein-protein interaction (PPI) network were also conducted. Our results indicated NOTCH1, NOTCH3, FLCN, SOD1, SOD2, NF1, and TLR4 as upregulated proteins in different cancer types highlighting their role in cancer progression. The MCODE analysis identified gene clusters for each cancer type with MYC, PCNA, PARP1, IDH1, FGF10, PTEN, and CCND1 as hub genes with high connectivity. MYC for cervical cancer, IDH1 for hepatic cirrhosis, MGMT for glioblastoma and CCND1 for anaplastic thyroid cancer were identified as genes with prognostic importance using survival analysis.

• 대한치과교정학회지
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• 제52권3호
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• pp.220-235
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• 2022

Objective: To evaluate the available evidence regarding the clinical effectiveness of different types of anchorage devices. Methods: A comprehensive literature search of different electronic databases was conducted for systematic reviews investigating different anchorage methods published up to April 15, 2021. Any ongoing systematic reviews were searched using PROSPERO, and a grey literature search was undertaken using Google Scholar and OpenGrey. No language restriction was applied. Screening, quality assessment, and data extraction were performed independently by two authors. Information was categorized and narratively synthesized for the key findings from moderate- and high-quality reviews. Results: Fourteen systematic reviews were included (11 were of moderate/high quality). Skeletal anchorage with miniscrews was associated with less anchorage loss (and sometimes with anchorage gain). Similarly, skeletal anchorage was more effective in retracting anterior teeth and intruding incisors and molars, resulting in minor vertical skeletal changes and improvements in the soft tissue profile. However, insufficient evidence was obtained for the preference of any anchorage method in terms of the duration of treatment, number of appointments, quality of treatment, patient perception, or adverse effects. The effectiveness of skeletal anchorage can be enhanced when: directly loaded, used in the mandible rather than the maxilla, used buccally rather than palatally, using dual rather than single miniscrews, used for en-masse retraction, and in adults. Conclusions: The level of evidence regarding anchorage effectiveness is moderate. Nevertheless, compared to conventional anchorage, skeletal anchorage can be used with more anchorage preservation. Further high-quality randomized clinical trials are required to confirm these findings.

• 말소리와 음성과학
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• 제14권3호
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• pp.11-25
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• 2022

From simultaneous recordings of the external photoglottography, intra-oral air pressure (P_io), airflow and acoustic data from four native Seoul Korean speakers (2 male and 2 female), we have found that the two fricatives are not significantly different in glottal opening peak and airflow peak height either word-initially or word-medially and that the duration of aspiration is significantly reduced in word-medial /s/, compared to those in word-initial /s/, not in /s'/. We have also found that the duration of a high P_io plateau is significantly longer in /s/ than in /s'/ both word-initially and word-medially and that airflow resistance (R=P_io/U) at the onset and offset of a P_io plateau and at the time of airflow peak height is significantly higher in /s'/ than in /s/ across the contexts. However, the differences in P_io peak and F0 are not significant. In addition, the transition time to reach airflow peak height from the offset of a P_io plateau is found to be significantly longer in /s/ than /s'/ in both word-initial and word-medial positions. No significant differences in glottal opening peak and airflow peak height confirm that /s/ is specified as [-spread glottis] like /s'/. As for the other significant differences, we propose that /s/ is [-tense], and /s'/ [+tense].

• 한국식생활문화학회지
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• 제37권5호
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• pp.418-428
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• 2022

Research on the birth (起源) and names (語源) of foods such as kimchi is important to understand traditional food culture. kimchi, an 'add flavored, fermented, pickled, vegetable food' was initially prepared with the simple purpose of increasing storage capabilities, but later, through a complex process of change, morphological diversification occurred. In addition to the basic name of 'kimchi', each variety has its unique name and history. This study was conducted through qualitative research using various research methods, such as oral records and interviews, as well as investigation of data from literature, including ancient literature, modern cookbooks, newspapers, magazines, papers, and videos. The study sought to investigate the context and the meaning of the name Chonggak kimchi. In addition, it is a compilation of how the name spread through the ages and evolved to its current name. The name Chonggak kimchi did not exist during the Joseon Dynasty and Japanese occupation and first appeared in the records in the late 1950s. Nevertheless, the original name of 'Altarimu kimchi' evolved and finally became a part of the standard Korean language (標準語) in 1988. In the process of the name spreading and becoming popular, the movie "Chonggak kimchi (1964)," starring Shin, S.I., and Eom, A.R. played a significant role. It was also confirmed that this was a meaningful and valuable case of contentization of traditional food culture, regardless of the intention behind the same.

• 한국지진공학회논문집
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• 제25권2호
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• pp.71-81
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• 2021

This paper presents a real-time, false-pick filter based on deep learning to reduce false alarms of an onsite Earthquake Early Warning (EEW) system. Most onsite EEW systems use P-wave to predict S-wave. Therefore, it is essential to properly distinguish P-waves from noises or other seismic phases to avoid false alarms. To reduce false-picks causing false alarms, this study made the EEWNet Part 1 'False-Pick Filter' model based on Convolutional Neural Network (CNN). Specifically, it modified the Pick_FP (Lomax et al.) to generate input data such as the amplitude, velocity, and displacement of three components from 2 seconds ahead and 2 seconds after the P-wave arrival following one-second time steps. This model extracts log-mel power spectrum features from this input data, then classifies P-waves and others using these features. The dataset consisted of 3,189,583 samples: 81,394 samples from event data (727 events in the Korean Peninsula, 103 teleseismic events, and 1,734 events in Taiwan) and 3,108,189 samples from continuous data (recorded by seismic stations in South Korea for 27 months from 2018 to 2020). This model was trained with 1,826,357 samples through balancing, then tested on continuous data samples of the year 2019, filtering more than 99% of strong false-picks that could trigger false alarms. This model was developed as a module for USGS Earthworm and is written in C language to operate with minimal computing resources.