• Journal of Periodontal and Implant Science
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• v.44 no.2
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• pp.71-78
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• 2014

Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity of immune function through the regulation of informational molecules such as cytokines. In the current study, we tested the hypothesis that herbal immunomodulator drugs act as an adjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improving clinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitis were enrolled in a double-blind, placebo-controlled, double-masked randomised controlled trial. The control group was treated with SRP and a placebo, whereas the test group was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated for all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the control group were found to be statistically significant only after 3 weeks (P<0.001). In contrast, the decrease in the sulcus bleeding index and pocket depth scores was statistically highly significant in the test group as compared to the control group after 3 weeks and 6 weeks (P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in the test group as compared to the control group, were not found to be statistically significant after both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementation with herbal immunomodulatory agents may be a promising adjunct to SRP and may aid in improving periodontal treatment outcomes.

• Journal of Dental Anesthesia and Pain Medicine
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• v.20 no.4
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• pp.241-250
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• 2020

Background: Placement of full-coverage restorations such as stainless steel crowns (SSCs) for pulpectomy treated primary molars is essential for successful outcomes. The tooth preparation process for SSCs can cause discomfort to gingival tissues since the crown should be seated 1 mm subgingivally. The purpose of this prospective trial was to compare the effectiveness of subgingival and transmucosal application of topical anesthetics on dental pain during SSC tooth preparation among 6- to 8-year-old children. Methods: A consecutive sample of 27 children, aged 6-8 years, who required an SSC after pulp therapy in primary molars were randomly divided into three groups. Group A received infiltration anesthesia before tooth preparation for SSC placement, whereas in Group B and C, only topical anesthesia was applied subgingivally and transmucosally. Wong-Bakers Faces pain rating scale (WBFPS) scores were recorded after tooth preparation. Faces, Legs, Activity, Cry and Consolability (FLACC) scores were evaluated by two blinded and calibrated investigators through video recordings of the patient during tooth preparation. Data were tabulated, and inter-group comparisons were performed using the Kruskal-Wallis and analysis of variance tests. Results: Out of the 27 participants, 48% were boys and 52% were girls, with an overall mean age of 6.83 years. Group A showed the least pain scores according to both the scales, followed by Group B and Group C. The pain intensity was statistically significant on both the pain scales with P = 0.003 for FLACC and P < 0.001 for WBFPS. Conclusion: Subgingival application of topical anesthesia reduced pain to a certain extent but not as effectively as infiltration anesthesia during SSC tooth preparation in primary molars. Transmucosal application of topical anesthesia did not reduce discomfort when compared to the other two interventions.

• Journal of Labour Economics
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• v.43 no.3
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• pp.101-121
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• 2020

The purpose of this study, reflecting the characteristics of recent R&D activities, where knowledge convergence and exchange and the growth of researchers are becoming more important, is to promote the growth of outstanding researchers by establishing a support system for researcher career development (intensifying expertise) and career fluidity (change in core research topics). Using the results of a survey of 548 researchers from government-funded research institutes, this study analyze environmental factors of research that promotes career development suitable for the growth of researchers after quantitatively verifying the effects of career development and career mobility on research outcomes. As a result of the analysis, it is more desirable to strengthen career liquidity after stable career development, but the human resources and career development support systems of research institutes are insufficient. Therefore, in this study, policy measures to support researcher career development and liquidity were proposed in four stages.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.9
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• pp.427-434
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• 2018

As noted by Pavitt (1984) and Malerbar (2002), previous studies have focused on identifying differences in industry characteristics between the machinery industry and other manufacturing industries. This study considered quantitative and qualitative aspects of performance of product innovation in analyzing what factors determine those outcomes. In particular, this study examined stepwise selection processes embedded in innovation activities by applying a hurdle negative binomial model as well as the Heckman two-step selection model. Results show that factors affecting performance improvement and patents differ, and the threshold effect and the intensity effect of innovation were also distinguished. These results imply that the R&D capability should be enhanced and external innovation is required to be effectively embodied in the organization. Furthermore, motivating employees plays a pivotal role in this technology and skill-intensive sector.

• Journal of Information Management
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• v.39 no.4
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• pp.1-20
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• 2008

The purpose of this study is to scrutinize the copyright issue under Open Access environment. A survey has been carried out to investigate researchers' awareness and recognitions about such issues. For this, bioinformatics researchers were selected and surveyed. Descriptive statistics method is employed for analysis of collected data. The findings of this study summarized as follow. (1) Although the researchers regarded the Open Access a positive initiative, the perceptions about open access were very low. (2) The researchers demanded possession of copyright depending on type of research information. (3) Many agencies did not required the transfer of copyright to the researcher. Thus, there is a possibility of dispute regarding copyright issues between researchers and agencies. (4) The researchers are willing to participate in open access activity on the assumption that their study is used in legitimate objective. On the basis of these findings, suggestions are added in as an impetus to lower the barrier against a copyright and higher the approach to information seekers and information providers.

• Journal of Global Scholars of Marketing Science
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• v.16 no.4
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• pp.13-38
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• 2006

This study is concerned with the factors that influence the radicalness of new product development by firms. The innovativeness of firms' new product development differs in their frequency and radicalness. Based on previous research on product innovations, this study provides a hypothetical model that links firms' internal variables and external relations variables to the radicalness of product innovation, which in turn is linked to marketing performance. For an empirical analysis, the data were collected from South Korean firms. The result of this study provides evidence that the stronger is firms' management attitude toward risk taking, marketing competency, and technical competency, the higher is the possibility of radical product innovation. It also shows that, contrarily to the hypothesis, firms with collective reward system rather than individual reward system are more likely to develop radically new products. This study also shows that the better are firms' R & D collaboration with suppliers and interfaces with customers, the higher is the possibility of radical product innovation.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.9 no.7
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• pp.891-900
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• 2019

In this paper, we investigate the relationship between IPR creation and export activity. And we try to examine the effects of IPR use as innovation on export performance. The dataset used in the empirical analysis are the annual "Survey of Business Activity(2006~2014)" panel data which include total of 6,144 samples of firms. Data set includes the sample characteristic such as employee, industry, export performance, possession/use/development of IPR. According to analysis results, this paper confirms that R&D and export activities of firms make positive effects on IPR creation. In addition, this paper finds that IPR use of firms make positive effects on firm's export performance. Exporting firms achieve higher export performance by developing new products and processes to enter and compete in overseas markets. In addition, exporting firms can achieve higher performance by using intellectual property rights to appropriate innovation outcomes in foreign markets and to exclude the possibility of patent disputes in advance.

• Journal of Veterinary Science
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• v.21 no.4
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• pp.52.1-52.11
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• 2020

Background: Intradural-intramedullary intervertebral disc extrusion (IIVDE) is a rare condition of intervertebral disc disease. However, the diagnosis of IIVDE is challenging because the prognosis and imaging characteristics are poorly characterized. Objectives: We aimed to describe the clinical and imaging characteristics of tentatively diagnosed IIVDE in dogs to assess the prognostic utility of neurological grade and magnetic resonance imaging (MRI) findings. Methods: Twenty dogs were included in this retrospective cohort study. Results: Nonchondrodystrophic breeds (n = 16) were more predisposed than chondrodystrophic breeds. Most dogs showed acute onset of clinical signs. Neurological examination at admission showed predominant non-ambulatory paraparesis (n = 9); paresis (n = 16) was confirmed more frequently than paralysis (n = 4). Follow-up neurological examination results were only available for 11 dogs, ten of whom showed neurological improvement and 8 showed successful outcomes at 1 month. The characteristic MRI findings include thoracic vertebra (T)2 hyperintense, T1 hypointense, intramedullary linear tracts with reduced disc volume, and cleft of the annulus fibrosus. None of the MRI measurements were significantly correlated with neurological grade at admission. Neurological grade did not differ according to the presence of parenchymal hemorrhage, parenchymal contrast enhancement, and meningeal contrast enhancement. Neurological grades at admission showed a statistical correlation with those observed at the 1-month follow-up (r = 0.814, p = 0.02). Conclusions: IIVDE is a rare form of disc extrusion commonly experienced after physical activity or trauma and most frequently affects the cranial-cervical and thoracolumbar regions of nonchondrodystrophic dog breeds. Neurological score at admission emerged as a more useful prognostic indicator than MRI findings in dogs with suspected IIVDE.

• Korean Journal of Exercise Nutrition
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• v.24 no.3
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• pp.25-31
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• 2020

[Purpose] Epidemiological evidence has shown that leisure-time physical activity and structured exercise before and after breast cancer diagnosis contribute to reducing the risk of breast cancer recurrence and mortality. Thus, in this review, we aimed to summarize the physical activity-dependent regulation of systemic factors to understand the biological and molecular mechanisms involved in the initiation, progression, and survival of breast cancer. [Methods] We systematically reviewed the studies on 1) the relationship between physical activity and the risk of breast cancer, and 2) various systemic factors induced by physical activity and exercise that are potentially linked to breast cancer outcomes. To perform this literature review, PubMed database was searched using the terms "Physical activity OR exercise" and "breast cancer", until August 5th, 2020; then, we reviewed those articles related to biological mechanisms after examining the resulting search list. [Results] There is strong evidence that physical activity reduces the risk of breast cancer, and the protective effect of physical activity on breast cancer has been achieved by long-term regulation of various circulatory factors, such as sex hormones, metabolic hormones, inflammatory factors, adipokines, and myokines. In addition, physical activity substantially alters wholebody homeostasis by affecting numerous other factors, including plasma metabolites, reactive oxygen species, and microRNAs as well as exosomes and gut microbiota profile, and thereby every cell and organ in the whole body might be ultimately affected by the biological perturbation induced by physical activity and exercise. [Conclusion] The understanding of integrative mechanisms will enhance how physical activity can ultimately influence the risk and prognosis of various cancers, including breast cancer. Furthermore, physical activity could be considered an efficacious non-pharmacological therapy, and the promotion of physical activity is probably an effective strategy in primary cancer prevention.

• Journal of Technology Innovation
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• v.31 no.2
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• pp.135-172
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• 2023

When discussing a company's technology management, manufacturing companies' innovation strategy is vital because it is connected to each company's competitive advantage in various ways, such as technology acquisition, R&D, and product innovation. The research on manufacturing companies' innovation strategies has been studied in various ways, such as performance and resources for innovation; however, very little research has been done to synthesize existing research outcomes. In this study, we conduct a systematic literature review of 51 articles related to manufacturing companies' innovation strategies. By doing so, we synthesized the results of extant studies based on three perspectives: the research target, the research focus, and the types of innovation strategies. In addition, I derived the unique properties of the research on manufacturing companies' innovation strategies. The analysis indicated that Korea's research on manufacturing companies' innovation strategies had been unequally distributed. Based on this, we suggested research agendas for future research on manufacturing companies' innovation strategies.