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Compound K Activates Hyaluronan Synthase 2 in transformed human Keratinocytes and Fibroblasts and Increases hyaluronan in hairless mouse skin

  • Kim, Su-Jong;Kang, Byung-Yang;Cho, Si-Yang;Sung, Dae-Suk;Shin, Eiu-Suk;Chang, Hui-Kyung;Yeom, Myung-Hun;Woo, Kwang-Sik;Kim, Duk-Hee;Sim, Young-Chul;Lee, Yong-Sung
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.741-762
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    • 2003
  • Ginsenosides, the major active ingredients of ginseng, show a variety of biomedical efficacies such as anti-aging, anti oxidation and anti-inflammatory activities. To understand the effects of compound K (20-O-D-glucopyranosyl-20 (S)-protopanaxadiol), one of the major metabolite of ginsenosides on the skin, we assessed the expression level of ∼ 100 transcripts in compound K-treated HaCaT cells using cDNA microarray analysis. Compound K treatment induced differential expression of 21 genes, which have been reported to be involved in the organization of ECM structure as well as defense responses in human skin cells. One of the most interesting findings is 2-fold increase in hyaluronan synthase2 (HAS2) gene expression by compound K. We found that change in expression of HAS2 gene represents a specific response of HaCaT cells to compound K because hyaluronan synthase 1, 3 was not changed by treatment with compound K. We also demonstrated that the compound K effectively induced hyaluronan synthesis in human skin cells and hairless mouse skin. The human clinical study indicates that topical application of compound K-containing oil-in-water emulsion showed improvement of xerosis, wrinkle and fine lines in the aged skin. We concluded that compound K has anti-aging effects by the induction of HAS2 gene expression and following hyaluronan synthase.

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Characteristics of Non-nano Needle Type Zinc Oxide and Its Application in Sunscreen Cosmetics (Non-nano 막대형 산화아연의 특성 및 자외선 차단용 화장품에의 응용)

  • Chong, Kyo Un;Xuan, Song Hua;Yoon, Yeo Min;Kim, Sang-uk;Choi, Bou Kun;Lee, Sung Ho;Park, Soo Nam;Lee, Jong Sung
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.1
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    • pp.1-7
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    • 2021
  • With increasing interest in the effectiveness and safety of sunscreen worldwide, research on the development of new inorganic sunscreen is also gaining momentum. In the present study, non-nano sized needle type zinc oxide, which can meet the regulation of nano-material as a recent problem, has been synthesized and surface-modified with cetyl alcohol to obtain needle type zinc oxide powder. Here, we also investigated their physical properties and evaluated their potential application as sunscreens. As a result of the experiment, the sunscreen with needle type zinc oxide powder, which was non-nano, showed similar UV-protection properties and transparency compare to that of 40nm size zinc oxide. It was further confirmed that the UV blocking effect was significantly increased when the needle type zinc oxide dispersion was applied to the sunscreen. Therefore, although the needle type zinc oxide is non-nano (200 nm) material, it has the potential to be applied to the product as an excellent transparency (improvement of whiteness), UV protection efficacy and smooth texture.

Effects of $H_2$ vs. $O_2$ Plasma Pretreatment of Gate Oxide on the Degradation Phenomenon of Low-Temperature Polysilicon Thin-Film Transistors

  • Lee, Seok-Woo;Kang, Ho-Chul;Yang, Joon-Young;Kim, Eu-Gene;Kim, Sang-Hyun;Lim, Kyoung-Moon;Kim, Chang-Dong;Chung, In-Jae
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.1254-1257
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    • 2004
  • Comparative study on the effects of $H_2$ vs. $O_2$ plasma pretreatment of gate oxide on the degradation phenomenon of p-channel low-temperature polysilicon (LTPS) thin-film transistors (TFTs) were performed. After high drain current stress (HDCS) with $V_{gs}$ = $V_{ds}$, the p-channel TFTs pretreated by $O_2$ plasma showed increased immunity to the degradation of device characteristics such as threshold voltage and maximum field effect mobility because of the higher binding energy of Si-O bond than that of Si-H bond. The investigation of degradation phenomenon of these parameters with the applied power suggests that self-heating can be the major cause of degradation of polysilicon TFTs.

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A New Field Sequential Stereoscopic LCDs by use of Dual-Directional-Backlight

  • Yuuki, A.;Agari, M.;Iwsaki, N.;Sasagawa, T.;Tahata, S.;Satake, T.;Murakami, O.;Oda, K.;Ito, A.;Miyake, S.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.255-258
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    • 2004
  • We have developed the Scan-backlight Stereoscopic LCD that is a kind of field-sequential -Stereoscopic LCD combining the Dual-Directional-Backlight and the fast-response OCB panel. The Dual-Directional-Backlight using a double-sided prism sheet can change the direction of light by switching the LED light sources. The OCB panel using Feed-Forward Drive can realize frame rate of 120 Hz. As a result, the Scan-backlight Stereoscopic display works at its original resolving power, and produces flicker-free stereoscopic images. This auto stereoscopic display can resolved the problems of the double images and the pseudoscopic images in case of watching at oblique angles.

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Development of the 30/50kW LSPV Photovoltaic Inverter for 3Phases (3상 30/50kW LSPV 태양광 인버터 개발)

  • Park, Tae-Bum;Kim, Sung-Hwan;Park, Ju-Hyun;Kim, Hee-Jung;Lee, Ki-Su;Jon, Yuong-Soo;Yoon, Sun-Jae;Kim, Ho-Yeol
    • Proceedings of the KIEE Conference
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    • 2011.07a
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    • pp.1153-1154
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    • 2011
  • 본 논문은 3상 30kW 및 50kW 계통연계형 태양광 인버터의 개발에 관한 것으로, 그에 대한 제어기 및 성능에 대해 소개한다. 본 논문에 소개되는 3상 30/50kW LSPV 태양광 인버터는 태양전지에서 발생하는 가변성 직류에너지를 한전계통에 최적으로 주입시키는 계통연계형 전력변환장치이며 국내의 발전사업자용으로 개발되었다. 3상 380V의 한전계통에 절연형으로 연계되며 낮은 THD 와 높은 역률로 고효율을 달성하였다. DC입력측의 개방전압은 900V로 태양전지모듈 조합의 편의성 및 DC과전압등에 대한 안전성을 향상하였고, EMI 전도노이즈에 대한 Filter를 장착하여 노이즈성분을 크게 개선하였다.

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Implementation of high performance communication for industrial robot controllers (고기능 로봇통신)

  • 전재욱;김진기;김형철;최상진;송철호;김성진;김동일;김성권
    • 제어로봇시스템학회:학술대회논문집
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    • 1993.10a
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    • pp.1136-1140
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    • 1993
  • A communication system in an industrial robot controlle is proposed for the implementation of an efficient FA system. Different from existing industrial robot controllers which use binary I/O for the communication with external systems, the robot controllers having the proposed communication system can exchange various information with external systems. Furthermore, the robot motion and the communication with external systems can be performed simultaneously. The structure of hardware and software in the communication system is explained to show how to acheive these two operations simultaneously.

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Novel AC bias compensation scheme in hydrogenated amorphous silicon TFT for AMOLED Displays

  • Parikh, Kunjal;Chung, Kyu-Ha;Choi, Beom-Rak;Goh, Joon-Chul;Huh, Jong-Moo;Song, Young-Rok;Kim, Nam-Deog;Choi, Joon-Hoo
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.1701-1703
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    • 2006
  • Here we describe a novel driving scheme in the form of negative AC bias stress (NAC) to compensate shift in the threshold voltage for hydrogenated amorphous silicon (${\alpha}$-Si:H) thin film transistor (TFT) for AMOLED applications. This scheme preserves the threshold voltage shift of ${\alpha}$-Si:H TFT for infinitely long duration of time(>30,000 hours) and thereby overall performance, without using any additional TFTs for compensation. We briefly describe about the possible driving schemes in order to implement for real time AMOLED applications. We attribute most of the results based on concept of plugging holes and electrons across the interface of the gate insulator in a controlled manner.

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