• Journal of Applied Biological Chemistry
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• 제49권1호
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• pp.21-23
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• 2006

As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)-5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp. These compounds showed strong in vitro antiproliferative effects on promastigotes of Leishmania mexicania, flagellate protozoan that causes leishmaniasis. Structures were assumed by interpretation of NMR spectroscopic data and optical rotation. Both compounds exhibited significant antileishmanial activities in vitro with $IC_{50}$ of 1.0-23.0 ${\mu}g/ml$.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 춘계학술대회
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• pp.732-733
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• 2014

본 연구에서는 특허분석을 통해 빅데이터 분야의 R&D 트렌드를 살펴본 후, 향후 우리나라의 기술개발 방향성을 제시하였다. 특허 분석 결과에 따르면, 빅데이터 분야의 R&D 트렌드는 크게 두 가지 특징을 지니고 있는 것으로 나타났다. 첫째는 미국의 독과점 현상으로 미국은 모든 기술분야에서 비교적 고른 출원 활동을 전개하고 있으며, 기술별 평균 점유율이 40% 이상으로 나타나 세계 시장을 독과점하고 있는 것으로 나타났다. 둘째는 R&D 트렌드의 변화로 과거에는 데이터 분석 및 처리 분야의 기술이 주를 이룬 반면, 최근에는 데이터 운영 및 관리 분야의 기술이 대종을 이루고 있다. 하지만 우리나라의 경우 빅데이터 분야의 특허 출원이 주로 저장기술에 집중되어 있으며, 데이터 운영 및 관리기술에 대한 출원은 상대적으로 저조해 관련 기술에 대한 연구가 시급한 것으로 나타났다.

• 대한산업공학회지
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• 제43권2호
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• pp.112-119
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• 2017

Korea's national R&D projects are increasing year by year. However, it is necessary to improve the quality of R&D result. In this paper, we introduce the developing and adjusting the R&D standard process based on process approach in ETRI. It is expected that the definition of R&D standard process will contribute to improve customer satisfaction and quality of R&D result through standardization and continuous improvement activities.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.106-110
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• 2004

The antioxidant activities of Acanthopanax senticosus stems were evaluated in $CCl_4$-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by $CCl_4$-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effection DPPH, its scavenging potency as indicated in $IC_{50}$ value, being 58.5$\mu$ M. These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.

• 산업경영시스템학회지
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• 제41권4호
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• pp.101-110
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• 2018

This study aims to objectively measure the efficiency of nanotechnology R&D programs by systematically evaluating the inputs and outputs of nanotechnology R&D activities and to find implications for improving the efficiency of nanotechnology R&D programs. Data on input factors such as R&D investment, R&D manpower, R&D period, and output factors such as paper, patent, and commercialization for R&D projects which started from 2008 or afterwards and ended by 2011 are gathered through National Science and Technology Knowledge Information Service, which are used for efficiency evaluation. In this study, we analyzed R&D efficiency in detailed technology units in depth. The process taken in this study is as follows. First, the basic statistics of input and output factors to compare and analyze R&D investment, R&D manpower, R&D period, paper, patent, and commercialization status by technology unit are analyzed. Next, DEA models are utilized to derive the overall efficiency, pure technology efficiency, and scale efficiency by conducting the efficiency evaluation for each technology unit, from which implications for strategic budget allocation are derived. In addition, partial efficiency evaluation is conducted to identify advantages and disadvantages of each technology unit. In turn, cluster analysis is performed to identify similar technology units, from which implications for efficiency improvement are derived.

• 한국콘텐츠학회논문지
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• 제15권8호
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• pp.37-45
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• 2015

최근 정보기술과 모바일 환경의 발전에 따라 서비스의 패러다임이 웹에서 앱 중심으로 다시 변화하고 있다. 또한 R&D 투자 증대에 따라 연구자의 R&D 생산성 제고를 위한 노력들이 중요하게 인식되고 있다. 본 연구에서는 연구자의 R&D활동을 지원할 수 있는 연구지원 도구 개발을 위한 개인화 서비스 모델을 설계하였다. 이를 위하여 R&D 과정에서 연구자들의 정보활동 관점에서 기존의 연구지원 서비스들을 비교하였다. 또한 정보와 데이터의 공개 개방, 개인정보보호 강화, 소셜 네트워킹 서비스 대중화, 콘텐츠의 최대형화, 웹 플랫폼 기술 진화 등의 정보환경 변화를 개인화 관점에서 분석하고, 개인화 서비스 개발의 방향성을 정의하였다. 이를 바탕으로 연구지원 도구의 개인화 서비스 모델을 기능, 콘텐츠, 운영 뷰로 구분하여 설계하고, 이를 구현하기 위한 개인화 설계 목표와 원칙들을 표준, 참여, 개방으로 정의하였다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1990년도 Proceedings of International Symposium on Korean Ginseng, 1990, Seoul, Korea
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• pp.49-57
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• 1990

It has been well known that extended exposure to reactive oxygens causes severe damage to susceptible biomolecules. In this study, the effects of flavonoids including trifling and kaempferol from Ginseng leaves on single oxygen induced photohemolysis of erythrocytes and free radical scavenging activities were investigated . Each flavonoid aglycone (5-50UM) such as kaempferol, quercetin or baicalein exhibited a high protective effect against the photohemolysis. They protected the cells by scavenging 102 and free radicals. Although the free radical scavenging activities of the flavonoid glycosides were not much lower than those of their corresponding aglycones, their insolubility into lipid bilayers of membrane made them less effective in preventing the photohemolysis induced by 1O2. The 102 and free radical scavenging activities of flavonoids were estimated by the decomposition of the flavonoid by 1O2 and the bleaching of free radicals by the flavonoid, respectively. The solubilization of the flavonoid into micelle or erythrocytes was deduced from spectrophotometric and microscopic observations. The cooperation of L-ascorbic acid and a flavonoid, and a possible involvement of lipoxygenase or cyclooxygenase in the photohemolysis mechanism were discussed. Keywords Panax ginseng C.A Meyer, ginseng leaves, flavonoids, singe1 oxygen, Photohemolysis.

• 기술혁신학회지
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• 제13권1호
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• pp.124-139
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• 2010

본 연구는 과학기술정책연구원이 지난 2008년도에 조사한 '기술혁신조사(KIS) 2008'의 원자료를 활용하여, 2005년부터 2007년까지 국내 제조업 기업들이 이루어낸 혁신의 결정요인에 대해 분석하였다. Probit 모형을 활용한 실증분석 결과 기업규모와 시장집중도가 기업의 기술혁신 활동을 유인하는 주요 결정요인이라는 슘페터 가설을 지지하는 연구결과를 얻었다. 또한 기업이 수행하는 연구개발 활동 역시 혁신을 촉진할 수 있는 요인으로 나타났다. 이와 함께 시장에 있어서 소비자지향성의 척도라 할 수 있는 광고 선전비 집약도가 혁신이 일어날 확률에 긍정적인 영향을 주는 것으로 추정되었다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.173.2-173.2
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• 2003

Vanilloid receptor I (VR1) is a nonselective cation ion channel placed in the plasma membrane of peripheral sensory neurons that is potential target for analgesia A series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG. Their structure-activity relationship in reveals that not only the two oxygens and amide hydrogen of sulfonamido group but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.

• 기술혁신학회지
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• 제3권3호
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• pp.67-84
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• 2000

This paper expanded the usefulness of technology relation analysis by applying to R&D activities of Korea Gas Corporation (Kogas) at the corporate level. Technology relation analysis has been applied to assessment of R&D investments in telecommunication and construction industries in Korea. As empirical findings, technology map and technology spillover matrix of Kogas have been derived by technology similarity analysis. It has bee found that various useful information for R&D assessment could be acquired from the technology relation analysis at the corporate level.