Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anti-Oxidant Activities of Acanthopanax senticosus Stems and Their Lignan Components

  • Lee, Sang-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Son, Dong-Wook (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd.) ;
  • Ryu, Ji-Young (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd.) ;
  • Lee, Yeon-Sil (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.) ;
  • Jung, Sang-Hoon (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang, Jung-Il (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd.) ;
  • Lee, Sang-Yun (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd.) ;
  • Kim, Hyun-Su (R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd.) ;
  • Shin, Kuk-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
  • Published : 2004.01.01
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Abstract

The antioxidant activities of Acanthopanax senticosus stems were evaluated in $CCl_4$-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by $CCl_4$-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effection DPPH, its scavenging potency as indicated in $IC_{50}$ value, being 58.5$\mu$ M. These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.

Keywords

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